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Pesquisa : D09.301.915.500 [Categoria DeCS]
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Id: biblio-1042009
Autor: Sevcikova, Silvie; Durila, Miroslav; Vymazal, Tomas.
Título: Rotational thromboelastometry assessment of ballanced crystalloid, hydroxyethyl starch and gelatin effects on coagulation: a randomized trial / Tromboelastometria rotacional na avaliação dos efeitos de cristaloides balanceados, hidroxietilamido e gelatina na coagulação: estudo randômico
Fonte: Rev. bras. anestesiol;69(4):383-389, July-Aug. 2019. tab, graf.
Idioma: en.
Projeto: Ministry of Health for conceptual development Research organization.
Resumo: Abstract Background and objectives Modern crystalloid and colloid solutions are balanced solutions which are increasingly used in perioperative period. However, studies investigating their negative effect on whole blood coagulation are missing, and vivid debate is going on about which solution has the minimal coagulopathy effect. The aim of our study was to assess the effect of modern fluid solutions on whole blood coagulation using rotational thromboelastometry. Methods Blood samples were obtained from 30 patients during knee arthroscopy before and after administration of 500 mL of crystalloid, Hydroxyethyl Starch and gelatin according to the randomization. Rotational thromboelastometry (Extem, Intem and Fibtem tests) was used to assess negative effect of fluid solutions on whole blood coagulation. Results In Extem test, the initiation phase of fibrin clot formation represented by CT parameter was not influenced by any fluid solution (p > 0.05). The speed of clot formation represented by CFT and α angle was impaired by Hydroxyethyl Starch and gelatin but not by crystalloids (p < 0.05). The strength of formatted coagulum represented by MCF parameter was impaired both in Extem and Fibtem test by HES and in Fibtem also by crystalloids (p < 0.05). Intem test was not negatively influenced by any crystalloid or colloid solution in any parameter (p > 0.05). Conclusion Extem test appears to be sensitive to coagulopathy effect of modern colloids and crystalloids. Hydroxyethyl starch has the most obvious negative effect on clot formation followed by gelatin and finally by crystalloids. Intem test seems to be insensitive to adverse effect of modern colloids and crystalloids.

Resumo Justificativa e objetivos Os cristaloides e coloides modernos são soluções balanceadas e cada vez mais utilizadas no período perioperatório. No entanto, não há estudos que avaliem seu efeito negativo na coagulação do sangue total e o intenso debate sobre a solução que cause um efeito mínimo na coagulopatia permanece. O objetivo de nosso estudo foi avaliar o efeito das soluções líquidas modernas na coagulação do sangue total com o uso da tromboelastometria rotacional. Métodos De acordo com a randomização, amostras de sangue foram colhidas de 30 pacientes durante a artroscopia de joelho, antes e após a administração de 500 mL de cristaloides, hidroxietilamido e gelatina. A tromboelastometria rotacional (testes Extem, Intem e Fibtem) foi utilizada para avaliar o efeito negativo das soluções líquidas na coagulação do sangue total. Resultados No teste Extem, a fase de iniciação da formação de coágulos de fibrina representada pelo parâmetro CT não foi influenciada por qualquer solução líquida (p > 0,05). A velocidade da formação de coágulos representada pelo CFT e pelo ângulo α foi prejudicada pelo hidroxietilamido e pela gelatina, mas não pelos cristaloides (p < 0,05). A força do coágulo formatado representado pelo parâmetro MCF foi prejudicada tanto no teste Extem quanto no teste Fibtem pelo HES e no teste Fibtem também pelos cristaloides (p < 0,05). O teste Intem não foi influenciado negativamente por nenhuma solução cristaloide ou coloide em nenhum parâmetro (p > 0,05). Conclusão O teste Extem parece ser sensível ao efeito de coagulopatia dos coloides e cristaloides modernos. O hidroxietilamido apresentou o efeito negativo mais óbvio na formação do coágulo, seguido pela gelatina e finalmente pelos cristaloides. O teste Intem parece ser insensível ao efeito adverso dos coloides e cristaloides modernos.
Descritores: Tromboelastografia/métodos
Soluções Cristaloides/administração & dosagem
Gelatina/administração & dosagem
-Artroscopia/métodos
Coagulação Sanguínea/efeitos dos fármacos
Testes de Coagulação Sanguínea
Derivados de Hidroxietil Amido/administração & dosagem
Substitutos do Plasma/administração & dosagem
Coloides/administração & dosagem
Articulação do Joelho/cirurgia
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adulto
Tipo de Publ: Estudo Comparativo
Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: biblio-837677
Autor: Li, Weiming; Xu, Pengyuan; Cen, Yunyun; Sun, Dali; Yang, Ting; Xu, Qingwen; Li, Shumin; Li, Yijun; Ding, Bo.
Título: Impacts of albumin synergized with hydroxyethyl starch on early microvascular albumin leakage after major abdominal surgery in rabbits
Fonte: Acta cir. bras;32(2):108-115, Feb. 2017. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the impacts of albumin synergized with hydroxyethyl starch (HES) on early microvascular albumin leakage after major abdominal surgery in rabbits. Methods: Forty male Japanese rabbits were randomly divided into four groups: the control group, the saline group, the albumin group, and the Syn group (hydroxyethyl starch+albumin). The latter three groups were performed gastrectomy plus resection of pancreatic body and tail and splenectomy. The serum albumin concentration was detected before and 48h after surgery, and the conditions of mesenteric microvascular leakage in these 4 groups were observed under microscope 48 h after surgery to calculate the leakage rate. Results: Compared with the saline group, the albumin group and the Syn group exhibited significantly increased serum albumin concentrations 48h after surgery (P<0.05). The albumin leakage rate was the most obvious in the albumin group, followed by the saline group, while that in the Syn group was the minimal, and there existed significant differences among these groups (P<0.05) . Conclusion: Simple administration of albumin in the early stage after major abdominal surgery could increase the albumin leakage, while the synergization of albumin and hydroxyethyl starch could reduce the albumin leakage.
Descritores: Albumina Sérica/administração & dosagem
Albumina Sérica/análise
Permeabilidade Capilar/fisiologia
Derivados de Hidroxietil Amido/administração & dosagem
-Albumina Sérica/metabolismo
Cloreto de Sódio
Distribuição Aleatória
Deslocamentos de Líquidos Corporais/fisiologia
Modelos Animais
Sinergismo Farmacológico
Abdome/cirurgia
Limites: Animais
Masculino
Coelhos
Responsável: BR1.1 - BIREME


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Id: lil-757424
Autor: Aguiar, João Hélder Ferreira de.
Título: Conservative treatment of Angle Class III malocclusion with anterior crossbite
Fonte: Dental press j. orthod. (Impr.);20(4):91-98, July-Aug. 2015. tab, ilus.
Idioma: en.
Resumo: Angle Class III malocclusion is characterized by anteroposterior dental discrepancy which might be associated or not with skeletal changes. Class III molar relationship is associated with vertical or lingually tipped mandibular incisors and a usually concave profile. These characteristics seriously affect facial esthetics and most frequently are the reason why patients seek orthodontic treatment. This case was presented to the committee of the Brazilian Board of Orthodontics and Facial Orthopedics (BBO) as part of the requisites to become a BBO Diplomate.

A má oclusão de Classe III de Angle é caracterizada por uma discrepância dentária anteroposterior, que pode ou não estar acompanhada por alterações esqueléticas. Observa-se uma relação molar de Classe III associada ao posicionamento vertical ou retroinclinado dos incisivos inferiores e, geralmente, perfil facial côncavo. Esse aspecto gera grande comprometimento estético na face, sendo justamente esse o fator que, na maioria das vezes, motiva o paciente a procurar pelo tratamento ortodôntico. O presente caso clínico foi apresentado à Diretoria do Board Brasileiro de Ortodontia e Ortopedia Facial (BBO) como parte dos requisitos para a obtenção do título de Diplomado pelo BBO.
Descritores: Pressão Sanguínea/efeitos dos fármacos
Cães
Derivados de Hidroxietil Amido/farmacologia
Hipotensão/veterinária
Isoflurano/efeitos adversos
Soluções Isotônicas/farmacologia
-Anestésicos Inalatórios/efeitos adversos
Doenças do Cão/tratamento farmacológico
Derivados de Hidroxietil Amido/administração & dosagem
Hipotensão/terapia
Isoflurano/farmacologia
Substitutos do Plasma/administração & dosagem
Substitutos do Plasma/uso terapêutico
Limites: Animais
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Yoshida, Winston Bonetti
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Id: lil-749649
Autor: Ribeiro, Marcelo Eduardo; Sequeira, Julio; Trinca, Luzia Aparecida; Yoshida, Winston Bonetti.
Título: Effect of protective solutions and hydroxyethyl starch in the attenuation of the injuries of ischemia and reperfusion of splanchnic organs
Fonte: Acta cir. bras;30(6):407-413, 06/2015. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: PURPOSE: Vogt´s antioxidant solution (red blood cells, Ringer's solution, sodium bicarbonate, mannitol, allopurinol and 50% glucose) or its modification including hydroxyethyl starch (HES) were tested for the prevention of splanchnic artery occlusion shock. METHODS: Seventy rats were distributed in treatment (3), control (1), and sham (3) groups. Ischemia and reperfusion were induced by celiac, superior mesenteric and inferior mesenteric arteries occlusion for 40 min, followed by 60 min reperfusion or sham procedures. Controls received saline, both treatment and sham groups received the Vogt's solution, modified Vogt's solution (replacing Ringer's solution by HES), or HES. Mean arterial blood pressure (MABP), ileal malondialdehyde (MDA) and plasmatic MDA were determined, and a histologic grading system was used. RESULTS: At reperfusion, MABP dropped in all I/R groups. Only HES treatment was able to restore final MABP to the levels of sham groups. Plasmatic MDA did not show differences between groups. Ileum MDA was significantly higher in the control and treatment groups as compared to the sham group. Histology ranking was higher in the only in control group. CONCLUSIONS: Hydroxyethyl starch was able to prevent hemodynamic shock but not intestinal lesions. Both treatments with Vogt's solutions did not show any improvement. .
Descritores: Derivados de Hidroxietil Amido/farmacologia
Artérias Mesentéricas/efeitos dos fármacos
Oclusão Vascular Mesentérica/prevenção & controle
Substitutos do Plasma/farmacologia
Traumatismo por Reperfusão/prevenção & controle
-Modelos Animais de Doenças
Hemodinâmica/efeitos dos fármacos
Derivados de Hidroxietil Amido/uso terapêutico
Íleo/irrigação sanguínea
Íleo/patologia
Isquemia/prevenção & controle
Soluções Isotônicas/farmacologia
Soluções Isotônicas/uso terapêutico
Malondialdeído/análise
Artérias Mesentéricas/patologia
Oclusão Vascular Mesentérica/patologia
Substitutos do Plasma/uso terapêutico
Ratos Wistar
Reprodutibilidade dos Testes
Circulação Esplâncnica/efeitos dos fármacos
Fatores de Tempo
Resultado do Tratamento
Limites: Animais
Masculino
Tipo de Publ: Estudo Comparativo
Estudo de Avaliação
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-732390
Autor: Li, Yuhong; He, Rui; Ying, Xiaojiang; Hahn, Robert G..
Título: Dehydration, hemodynamics and fluid volume optimization after induction of general anesthesia
Fonte: Clinics;69(12):809-816, 2014. tab, graf.
Idioma: en.
Projeto: Qianjiang Talents Project of the Technology Office in Zhejiang province; . the Östergötland City Council.
Resumo: OBJECTIVES: Fluid volume optimization guided by stroke volume measurements reduces complications of colorectal and high-risk surgeries. We studied whether dehydration or a strong hemodynamic response to general anesthesia increases the probability of fluid responsiveness before surgery begins. METHODS: Cardiac output, stroke volume, central venous pressure and arterial pressures were measured in 111 patients before general anesthesia (baseline), after induction and stepwise after three bolus infusions of 3 ml/kg of 6% hydroxyethyl starch 130/0.4 (n = 86) or Ringer's lactate (n = 25). A subgroup of 30 patients who received starch were preloaded with 500 ml of Ringer's lactate. Blood volume changes were estimated from the hemoglobin concentration and dehydration was estimated from evidence of renal water conservation in urine samples. RESULTS: Induction of anesthesia decreased the stroke volume to 62% of baseline (mean); administration of fluids restored this value to 84% (starch) and 68% (Ringer's). The optimized stroke volume index was clustered around 35-40 ml/m2/beat. Additional fluid boluses increased the stroke volume by ≥10% (a sign of fluid responsiveness) in patients with dehydration, as suggested by a low cardiac index and central venous pressure at baseline and by high urinary osmolality, creatinine concentration and ...
Descritores: Anestesia Geral/métodos
Desidratação/fisiopatologia
Hidratação/métodos
Hemodinâmica/fisiologia
Volume Sistólico/fisiologia
-Análise de Variância
Volume Sanguíneo/fisiologia
Derivados de Hidroxietil Amido/uso terapêutico
Soluções Isotônicas/uso terapêutico
Monitorização Intraoperatória/métodos
Substitutos do Plasma/uso terapêutico
Curva ROC
Estatísticas não Paramétricas
Fatores de Tempo
Resultado do Tratamento
Limites: Adulto
Idoso
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Caruso, Pedro
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Id: lil-674240
Autor: Zampieri, Fernando Godinho; Ranzani, Otavio T.; Morato, Priscila Fernanda; Campos, Pedro Paulo; Caruso, Pedro.
Título: Effect of intraoperative HES 6% 130/0.4 on the need for blood transfusion after major oncologic surgery: a propensity-matched analysis
Fonte: Clinics;68(4):501-509, abr. 2013. tab, graf.
Idioma: en.
Resumo: OBJECTIVES: To evaluate the effect of the intraoperative use of hydroxyethyl starch on the need for blood products in the perioperative period of oncologic surgery. The secondary end-points included the need for other blood products, the clotting profile, the intensive care unit mortality and length of stay. METHODS: Retrospective observational analysis in a tertiary oncologic ICU in Brazil including 894 patients submitted to oncologic surgery for a two-year period from September 2007. Patients were grouped according to whether hydroxyethyl starch was used during surgery (hydroxyethyl starch and No-hydroxyethyl starch groups) and compared using a propensity score analysis. A total of 385 propensity-matched patients remained in the analysis (97 in the No-hydroxyethyl starch group and 288 in the hydroxyethyl starch group). RESULTS: A higher percentage of patients in the hydroxyethyl starch group required red blood cell transfusion during surgery (26% vs. 14%; p = 0.016) and in the first 24 hours after surgery (5% vs. 0%; p = 0.015) but not in the 24- to 48-hour period after the procedure. There was no difference regarding the transfusion of other blood products, intensive care unit mortality or length of stay. CONCLUSION: Hydroxyethyl starch use in the intraoperative period of major oncologic surgery is associated with an increase in red blood cell transfusions. There are no differences in the need for other blood products, intensive care unit length of stay or mortality. .
Descritores: Transfusão de Sangue
Derivados de Hidroxietil Amido/administração & dosagem
Neoplasias/cirurgia
Substitutos do Plasma/administração & dosagem
-Brasil
Coagulação Sanguínea/efeitos dos fármacos
Tempo de Internação
Neoplasias/mortalidade
Pontuação de Propensão
Estudos Retrospectivos
Fatores de Tempo
Limites: Adulto
Idoso
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-671422
Autor: Shao, Liujiazi; Wang, Baoguo; Wang, Shuangyan; Mu, Feng; Gu, Ke.
Título: Comparison of 7.2% hypertonic saline - 6% hydroxyethyl starch solution and 6% hydroxyethyl starch solution after the induction of anesthesia in patients undergoing elective neurosurgical procedures
Fonte: Clinics;68(3):323-328, 2013. tab.
Idioma: en.
Resumo: OBJECTIVE: The ideal solution for fluid management during neurosurgical procedures remains controversial. The aim of this study was to compare the effects of a 7.2% hypertonic saline - 6% hydroxyethyl starch (HS-HES) solution and a 6% hydroxyethyl starch (HES) solution on clinical, hemodynamic and laboratory variables during elective neurosurgical procedures. METHODS: Forty patients scheduled for elective neurosurgical procedures were randomly assigned to the HS-HES group orthe HES group. Afterthe induction of anesthesia, patients in the HS-HES group received 250 mL of HS-HES (500 mL/h), whereas the patients in the HES group received 1,000 mL of HES (1000 mL/h). The monitored variables included clinical, hemodynamic and laboratory parameters. Chictr.org: ChiCTR-TRC-12002357 RESULTS: The patients who received the HS-HES solution had a significant decrease in the intraoperative total fluid input (p<0.01), the volume of Ringer's solution required (p<0.05), the fluid balance (p<0.01) and their dural tension scores (p<0.05). The total urine output, blood loss, bleeding severity scores, operation duration and hemodynamic variables were similar in both groups (p>0.05). Moreover, compared with the HES group, the HS-HES group had significantly higher plasma concentrations of sodium and chloride, increasing the osmolality (p<0.01). CONCLUSION: Our results suggest that HS-HES reduced the volume of intraoperative fluid required to maintain the patients undergoing surgery and led to a decrease in the intraoperative fluid balance. Moreover, HS-HES improved the dural tension scores and provided satisfactory brain relaxation. Our results indicate that HS-HES may represent a new avenue for volume therapy during elective neurosurgical procedures.
Descritores: Anestesia Intravenosa/métodos
Derivados de Hidroxietil Amido/administração & dosagem
Procedimentos Neurocirúrgicos/métodos
Substitutos do Plasma/administração & dosagem
Solução Salina Hipertônica/administração & dosagem
-Hidratação/métodos
Infusões Intravenosas
Período Intraoperatório
Resultado do Tratamento
Equilíbrio Hidroeletrolítico
Limites: Adulto
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Estudo Comparativo
Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Castiglia, Yara Marcondes Machado
Vianna, Pedro Thadeu Galväo
Módolo, Norma Sueli Pinheiro
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Id: lil-662341
Autor: Azevedo, Vera Lucia Fernandes de; Santos, Paulo Sergio Santana; Oliveira Jr, Gildàsio Silveira de; Módolo, Gabriel Pinheiro; Domingues, Maria Aparecida Custódio; Castiglia, Yara Marcondes Machado; Vianna, Pedro Thadeu Galvão; Vane, Luiz Antonio; Módolo, Norma Sueli Pinheiro.
Título: The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
Fonte: Acta cir. bras;28(1):5-9, jan. 2013. ilus, tab.
Idioma: en.
Projeto: Sao Paulo Research Foundation.
Resumo: PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.
Descritores: Injúria Renal Aguda/terapia
Derivados de Hidroxietil Amido/uso terapêutico
Isquemia/terapia
Soluções Isotônicas/uso terapêutico
Rim/irrigação sanguínea
Substitutos do Plasma/uso terapêutico
-Proteínas de Fase Aguda
Injúria Renal Aguda/patologia
Hidratação/métodos
Hemodinâmica
Isquemia/patologia
Rim/patologia
Lipocalinas/sangue
Proteínas Oncogênicas/sangue
Distribuição Aleatória
Ratos Wistar
Reprodutibilidade dos Testes
Fatores de Tempo
Resultado do Tratamento
Limites: Animais
Masculino
Ratos
Tipo de Publ: Estudo Comparativo
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-653478
Autor: Zhang, Jun; Qiao, Hui; He, Zhiyong; Wang, Yun; Che, Xuehua; Liang, Weimin.
Título: Intraoperative fluid management in open gastrointestinal surgery: goal-directed versus restrictive
Fonte: Clinics;67(10):1149-1155, Oct. 2012. ilus, tab.
Idioma: en.
Resumo: OBJECTIVE: The optimal strategy for fluid management during gastrointestinal surgery remains unclear. Minimizing the variation in arterial pulse pressure, which is induced by mechanical ventilation, is a potential strategy to improve postoperative outcomes. We tested this hypothesis in a prospective, randomized study with lactated Ringer's solution and 6% hydroxyethyl starch solution. METHOD: A total of 60 patients who were undergoing gastrointestinal surgery were randomized into a restrictive lactated Ringer's group (n = 20), a goal-directed lactated Ringer's group (n = 20) and a goal-directed hydroxyethyl starch group (n = 20). The goal-directed fluid treatment was guided by pulse pressure variation, which was recorded during surgery using a simple manual method with a Datex Ohmeda S/5 Monitor and minimized to 11% or less by volume loading with either lactated Ringer's solution or 6% hydroxyethyl starch solution (130/0.4). The postoperative flatus time, the length of hospital stay and the incidence of complications were recorded as endpoints. RESULTS: The goal-directed lactated Ringer's group received the greatest amount of total operative fluid compared with the two other groups. The flatus time and the length of hospital stay in the goal-directed hydroxyethyl starch group were shorter than those in the goal-directed lactated Ringer's group and the restrictive lactated Ringer's group. No significant differences were found in the postoperative complications among the three groups. CONCLUSION: Monitoring and minimizing pulse pressure variation by 6% hydroxyethyl starch solution (130/0.4) loading during gastrointestinal surgery improves postoperative outcomes and decreases the discharge time of patients who are graded American Society of Anesthesiologists physical status I/II.
Descritores: Procedimentos Cirúrgicos do Sistema Digestório/métodos
Hidratação/métodos
-Análise de Variância
Pressão Sanguínea
Derivados de Hidroxietil Amido/administração & dosagem
Período Intraoperatório
Soluções Isotônicas/administração & dosagem
Tempo de Internação
Período Pós-Operatório
Estatísticas não Paramétricas
Fatores de Tempo
Resultado do Tratamento
Limites: Adulto
Idoso
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: lil-646330
Autor: Topçu, I.; Çivi, M.; Öztürk, T.; Keleş, G.T.; Çoban, S.; Yentür, E.A.; Okçu, G..
Título: Evaluation of hemostatic changes using n thromboelastography after crystalloid or colloid fluid administration during major orthopedic surgery
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;45(9):869-874, Sept. 2012. ilus, tab.
Idioma: en.
Resumo: The effects of Ringer lactate, 6% hydroxyethyl starch (HES) (130/0.4) or 4% succinylated gelatin solutions on perioperative coagulability were measured by thromboelastography (TEG). Seventy-five patients (ASA I-III) who were to undergo major orthopedic procedures performed under epidural anesthesia were included in the study. Patients were randomly divided into three groups of 25 each for the administration of maintenance fluids: group RL (Ringer lactate), group HES (6% HES 130/0.4), and group JEL (4% gelofusine solution). Blood samples were obtained during the perioperative period before epidural anesthesia (t1, baseline), at the end of the surgery (t2), and 24 h after the operation (t3). TEG data, reaction time (R), coagulation time (K), angle value (α), and maximum amplitude (MA) were recorded. TEG parameters changed from normal values in all patients. In group RL, R and K times decreased compared to perioperative values while the α angle and MA increased (P < 0.05). In group HES, R and K times increased, however, the α angle and MA decreased (P < 0.05). In group JEL, R time increased (P < 0.05), but K time, α angle and MA did not change significantly. In the present study, RL, 6% HES (130/0.4) and 4% JEL solutions caused changes in the coagulation system of all patients as measured by TEG, but these changes remained within normal limits.
Descritores: Hemostasia/efeitos dos fármacos
Procedimentos Ortopédicos/métodos
Tromboelastografia
-Gelatina/administração & dosagem
Derivados de Hidroxietil Amido/administração & dosagem
Soluções Isotônicas/administração & dosagem
Distribuição Aleatória
Succinatos/administração & dosagem
Limites: Idoso
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde