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Id: biblio-1039204
Autor: Macedo, Alexandre Casimiro de; Cunha Jr, José Evandro; Yaochite, Juliana Navarro Ueda; Tavares, Clodis Maria; Nagao-Dias, Aparecida Tiemi.
Título: Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age
Fonte: Braz. j. infect. dis;21(5):557-561, Sept.-Oct. 2017. tab, graf.
Idioma: en.
Projeto: MCTI/CNPq/MS-SCTIE.
Resumo: Abstract Considering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4-16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alagoas State - Brazil. Salivary anti-PGL-1 antibodies were quantified by modified ELISA method. The frequency of contact and clinical form of the index case were significantly associated with salivary antibody levels. High frequency of IgM positivity strongly suggests active transmission of M. leprae in these communities. We suggest in the present work that salivary anti-PGL IgA and IgM are important biomarkers to be used for identifying communities with probable active transmission of M. leprae.
Descritores: Glicolipídeos/análise
Família
Busca de Comunicante
Hanseníase Multibacilar/diagnóstico
Anticorpos Antibacterianos/administração & dosagem
Antígenos de Bactérias/análise
-Saliva/imunologia
Saliva/química
Ensaio de Imunoadsorção Enzimática
Glicolipídeos/imunologia
Hanseníase Paucibacilar/diagnóstico
Mycobacterium leprae/imunologia
Antígenos de Bactérias/imunologia
Limites: Humanos
Masculino
Feminino
Pré-Escolar
Criança
Adolescente
Responsável: BR1.1 - BIREME


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Rotta, Osmar
Id: lil-222031
Autor: Brasil, Mitie Tada L. R. F; Oliveira, Luiz Roberto de; Mello, Carmem Silva de; Nakamura, Paulo Mutuko; Manini, Marli P; Steiner, Denise; Rotta, Osmar.
Título: Estudo da sensibilidade e especificidade do teste Elisa anti PGL-1 no Estado de Säo Paulo / Sensibility study and specificity of ELISA test anti PGL-1 at Säo Paulo State
Fonte: Hansen. int;22(2):35-43, jul.-dez. 1997. tab, graf.
Idioma: pt.
Resumo: Os testes sorológicos para diagnóstico de hanseníase, usando o glicolipídeo-fenólico, considerado antígeno específico do M. leprae têm aberto algumas possibilidades de estudo do comportamento epidemiológico desta doença. Foi realisado um estudo para medir a sensibilidade e especificidade de um teste de ELISA anti PGL-1, usando material e técnica proveniente de Cuba (UMELISA). Foram testados 84 doentes e 112 controles sadios. A sensibilidade do teste foi maior para o grupo de doentes multibacilares, sendo mais alto entre os casos classificados como virchovianos (V), seguido dos dimorfos (D). No grupo de multibacilares, considerando o limiar de reatividade de 0,200, observou-se que apenas 75,0(por cento) de pacientes V e 50,0(por cento) de D foram positivos ao teste e, no limiar de 0,300, apenas 64,3(por cento) dos V e 40,0(por cento) dos D ainda mostravam positividade. Os doentes indeterminados apresentaram maior proporçäo de soropositivos do que os tuberculóides e isto talvez traduza a polarizaçäo de alguns casos para formas multibacilares. A especificidade do teste foi de 87,5(por cento) no limiar de 0,200 e de 99,1(por cento) no de 0,300. Este teste, à semelhança de outros, apresentou alta especificidade e baixa sensibilidade, resultando em grande percentual de falso-negativos. Para uma doença em que os testes sorológicos säo escassos, apesar de näo se recomendar o uso indiscriminado do teste para triagem de casos na populaçäo geral, a comunidade de seu aprimoramento tecnológico deve ser estimulada. Conseguir-se-ia, assim, avançar na pesquisa de instrumentos cada vez mais sensíveis e específicos para melhorar o diagnóstico precoce e, desse modo intervir mais oportunamente na cadeia de transmissäo
Descritores: Ensaio de Imunoadsorção Enzimática
Glicolipídeos/efeitos adversos
Hanseníase/diagnóstico
-Testes de Sensibilidade Microbiana
Estudos Epidemiológicos
Testes Sorológicos
Responsável: BR91.2 - Centro de Documentação


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Id: lil-519335
Autor: Barreto, Jaison Antônio; Nogueira, Maria Esther Salles; Diorio, Suzana Madeira; Bührer-Sékula, Samira.
Título: Sorologia rápida para hanseníase (teste ML Flow) em pacientes dimorfos classificados como paucibacilares pelo número de lesões cutâneas: uma ferramenta útil / Leprosy serology (ml Flow test) in borderline leprosy patients classified as paucibacillary by counting cutaneous lesions: an useful tool
Fonte: Rev. Soc. Bras. Med. Trop;41(supl.2):45-47, 2008. tab.
Idioma: en; pt.
Projeto: CNPq.
Resumo: A hanseníase ainda é doença endêmica no Brasil, com cerca de 40.000 novos casos por ano. Devido à dificuldade na realização de exames laboratoriais em campo, classifica-se a forma clínica contando-se lesões, o que pode causar subdiagnóstico de casos multibacilares e falha terapêutica. Para avaliar uma nova ferramenta para diagnóstico de hanseníase multibacilar, o teste ML Flow, foi realizado em 21/77 (27,3%) pacientes com hanseníase dimorfa (6 DV e 15 DT) não tratados, com até cinco lesões de pele, avaliados de acordo com a classificação de Ridley & Jopling (R&J). O teste ML Flow foi positivo em 14/21 (66,6%) pacientes (4 DV e 10 DT); em 7/21 (33,3%) pacientes (5 DT e 2 DV) o resultado foi negativo. A classificação da hanseníase baseada somente na contagem de lesões pode falhar em diagnosticar casos MB. O ML Flow é ferramenta útil no diagnóstico de hanseníase dimorfa com até cinco lesões cutâneas.

Leprosy remains an endemic disease in Brazil, with almost 40,000 new cases diagnosed each year. As it is difficult to perform laboratory procedures in the field, operational classification is determined by counting lesions, which can cause underdiagnosis of multibacillary cases and failures in treatment. To evaluate a new tool to diagnose MB cases, the ML Flow test, 21/77 (27.3%) patients with untreated borderline leprosy (6 BL and 15 BT) with 1 to 5 cutaneous lesions were evaluated according to the R&J Classification. The ML Flow test was positive in 14/21 (66.6%) patients; 7/21 (33.3%) cases, 5 BT and 2 BL, showed negative results. Classification of leprosy based only on the number of lesions can fail to diagnose MB leprosy. The ML Flow test is a useful tool to diagnose borderline leprosy in patients with 1 to 5 cutaneous lesions.
Descritores: Anticorpos Antibacterianos/sangue
Antígenos de Bactérias
Glicolipídeos
Hanseníase/classificação
Mycobacterium leprae/imunologia
-Antígenos de Bactérias/imunologia
Glicolipídeos/imunologia
Imunoglobulina M/sangue
Hanseníase/diagnóstico
Hanseníase/imunologia
Pele/microbiologia
Pele/patologia
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Stefani, Mariane Martins de Araujo
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Id: biblio-1085423
Autor: Hungria, Emerith Mayra; Oliveira, Regiane Morillas de; Souza, Ana Lúcia Osório Maroclo de; Costa, Maurício Barcelos; Souza, Vânia Nieto Brito de; Silva, Eliane Aparecida; Vilani-Moreno, Fátima Regina; Nogueira, Maria Esther Salles; Costa, Maria Renata Sales Nogueira; Silva, Sônia Maria Usó Ruiz; Bührer-Sékula, Samira; Reed, Steven G; Duthie, Malcolm S; Stefani, Mariane Martins de Araújo.
Título: Seroreactivity to new Mycobacterium leprae protein antigens in different leprosy-endemic regions in Brazil.
Fonte: Rio de Janeiro; s.n; 2012. 8 p. ilus, map, tab, graf.
Idioma: en.
Resumo: New Mycobacterium leprae protein antigens can contribute to improved serologic tests for leprosy diagnosis/classification and multidrug therapy (MDT) monitoring. This study describes seroreactivity to M. leprae proteins among participants from three highly endemic leprosy areas in Brazil: central-western Goiânia/Goiás (GO) (n = 225), Rondonópolis/Mato Grosso (MT) (n = 764) and northern Prata Village/Pará (PA) (n = 93). ELISA was performed to detect IgG to proteins (92f, 46f, leprosy IDRI diagnostic-1, ML0405, ML1213) and IgM to phenolic glycolipid-I (PGL-I). Multibacillary (MB) leprosy had positive rates for PGL-I that were similar to those for proteins; however, some anti-PGL-I-negative subjects were positive for proteins, suggesting that adding protein antigen to PGL-I can enhance the sensitivity of MB leprosy detection. In MT, different degrees of seroreactivity were observed and ranked for MB, former patients after MDT, paucibacillary (PB) leprosy, household contact (HHC) and endemic control (EC) groups. The seroreactivity of PB patients was low in GO and MT. HHCs from different endemic sites had similar IgG antibody responses to proteins. 46f and 92f were not recognised by most tuberculosis patients, ECs or HHCs within GO, an area with high BCG vaccination coverage. Low positivity in EC and HHC was observed in PA and MT. Our results provide evidence for the development of an improved serologic test that could be widely applicable for MB leprosy testing in Brazil
Descritores: Anticorpos Antibacterianos/sangue
Antígenos de Bactérias/sangue
Doenças Endêmicas
Glicolipídeos/sangue
Hanseníase/diagnóstico
Hanseníase/epidemiologia
Mycobacterium leprae/imunologia
Proteínas de Bactérias/sangue
-Brasil/epidemiologia
Ensaio de Imunoadsorção Enzimática
Estudos de Casos e Controles
Imunoglobulina M/sangue
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR191.1 - Biblioteca e Centro de Documentação Luiza Keffer
BR191.1; 9462/s


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Id: lil-659742
Autor: Barreto, Josafá Gonçalves; Guimarães, Layana de Souza; Frade, Marco Andrey Cipriani; Rosa, Patricia Sammarco; Salgado, Claudio Guedes.
Título: High rates of undiagnosed leprosy and subclinical infection amongst school children in the Amazon Region
Fonte: Mem. Inst. Oswaldo Cruz;107(supl.1):60-67, Dec. 2012. ilus, mapas, tab.
Idioma: en.
Projeto: CNPq; . FAPESPA; . SESPA; . UFPA.
Resumo: Leprosy in children is correlated with community-level factors, including the recent presence of disease and active foci of transmission in the community. We performed clinical and serological examinations of 1,592 randomly selected school children (SC) in a cross-sectional study of eight hyperendemic municipalities in the Brazilian Amazon Region. Sixty-three (4%) SC, with a mean age of 13.3 years (standard deviation = 2.6), were diagnosed with leprosy and 777 (48.8%) were seropositive for anti-phenolic glycolipid-I (PGL-I). Additionally, we evaluated 256 house-hold contacts (HHCs) of the students diagnosed with leprosy; 24 (9.4%) HHC were also diagnosed with leprosy and 107 (41.8%) were seropositive. The seroprevalence of anti-PGL-I was significantly higher amongst girls, students from urban areas and students from public schools (p < 0.0001). Forty-five (71.4%) new cases detected amongst SC were classified as paucibacillary and 59 (93.6%) patients did not demonstrate any degree of physical disability at diagnosis. The results of this study suggest that there is a high rate of undiagnosed leprosy and subclinical infection amongst children in the Amazon Region. The advantages of school surveys in hyperendemic areas include identifying leprosy patients at an early stage when they show no physical disabilities, preventing the spread of the infection in the community and breaking the chain of transmission.
Descritores: Hanseníase Multibacilar/diagnóstico
Hanseníase Paucibacilar/diagnóstico
-Anticorpos Antibacterianos/imunologia
Antígenos de Bactérias/sangue
Infecções Assintomáticas/epidemiologia
Brasil/epidemiologia
Estudos Transversais
Ensaio de Imunoadsorção Enzimática
Glicolipídeos/sangue
Hanseníase Multibacilar/epidemiologia
Hanseníase Paucibacilar/epidemiologia
Mycobacterium leprae/imunologia
Estudos Soroepidemiológicos
Estudantes
Limites: Humanos
Masculino
Feminino
Criança
Adolescente
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-519339
Autor: Brito, Maria de Fátima de Medeiros; Ximenes, Ricardo Arraes Alencar; Gallo, Maria Eugênia Noviski; Bührer-Sékula, Samira.
Título: Associação entre reação hansênica após alta e a carga bacilar avaliada utilizando sorologia anti PGL-I e baciloscopia / Association between leprosy reactions after treatment and bacterial load evaluated using anti PGL-I serology and bacilloscopy
Fonte: Rev. Soc. Bras. Med. Trop;41(supl.2):67-72, 2008. tab.
Idioma: en; pt.
Projeto: CNPq.
Resumo: As reações hansênicas são fenômenos imuno inflamatórios que ocorrem durante a evolução da hanseníase. Atualmente com os critérios de finalização de tratamento esta intercorrência pode ser observada após a alta da poliquimioterapia. Trata-se de um estudo caso-controle onde foram comparados, laboratorialmente, os casos de reação hansênica após alta da poliquimioterapia multibacilar (PQT/MB) com o grupo controle para analisar a possível associação entre a reação hansênica após alta e a carga bacilar, utilizando o ML Flow, teste sorológico para detecção de anticorpos contra o Mycobacterium leprae, e os resultados das baciloscopias cutâneas. O estudo foi realizado em dois serviços de referência na cidade de Recife - Pernambuco - Brasil, onde participaram 208 pacientes. Os resultados encontrados indicam que a reação após alta está estatisticamente associada à carga bacilar através da positividade do teste sorológico após alta. Conclui-se que existem fatores de riscos comuns entre a recidiva e a reação após alta.

Leprosy (Hansen's disease, HD) reactions are immune-inflammatory phenomena that occur during the evolution of the disease. Given the current criteria for treatment of the disease, this event is often observed after the patient has been released from treatment (RFT) from multi-drug therapy (MDT). A case-control study was conducted comparing laboratory results of cases of leprosy reactions after RFT from multibacillary MDT (MDT/MB) with a control group to analyze the possible association between posttreatment reactions and bacterial load using the ML Flow serological test for detection of antibodies to Mycobacterium leprae and the results of bacilloscopic skin smears. The study was conducted in two reference centers in Recife, Pernambuco State, Brazil, involving 208 patients. The results obtained indicate that posttreatment reaction is statistically associated with bacterial load through positive serology post-RFT. In conclusion, common risk factors exist between relapses and post-RFT reactions.
Descritores: Anticorpos Antibacterianos/sangue
Antígenos de Bactérias/imunologia
Glicolipídeos/imunologia
Hanseníase/microbiologia
Mycobacterium leprae/imunologia
-Antígenos de Bactérias
Biomarcadores
Estudos de Casos e Controles
Quimioterapia Combinada
Glicolipídeos
Imunoglobulina M/sangue
Hansenostáticos/uso terapêutico
Hanseníase/tratamento farmacológico
Hanseníase/imunologia
Recidiva
Fatores de Risco
Pele/microbiologia
Pele/patologia
Adulto Jovem
Limites: Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Humanos
Lactente
Recém-Nascido
Masculino
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Estudo Comparativo
Estudo Multicêntrico
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Lana, Francisco Carlos Felix
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Id: biblio-894878
Autor: Carvalho, Ana Paula Mendes; Coelho, Angélica da Conceição Oliveira; Correa-Oliveira, Rodrigo; Lana, Francisco Carlos Félix.
Título: Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts
Fonte: Mem. Inst. Oswaldo Cruz;112(9):609-616, Sept. 2017. tab, graf.
Idioma: en.
Resumo: BACKGROUND There is a lack of straightforward tests for field application and known biomarkers for predicting leprosy progression in infected individuals. OBJECTIVE The aim was to analyse the response to infection by Mycobacterium leprae based on the reactivity of specific antigens: natural disaccharide linked to human serum albumin via an octyl (NDOHSA), a semisynthetic phenolic glycolipid-I (PGL-I); Leprosy Infectious Disease Research Institute Diagnostic-1 (LID-1) and natural disaccharide octyl - Leprosy Infectious Disease Research Institute Diagnostic-1 (NDOLID). METHODS The study population consisted of 130 leprosy cases diagnosed between 2010 and 2015 and 277 household contacts. An enzyme-linked immunosorbent assay (ELISA) was used to analyse the reactivity of antibodies against NDOHSA, LID-1 and NDOLID. The samples and controls were tested in duplicate, and the antibody titer was expressed as an ELISA index. Data collection was made by home visits with application of questionnaire and dermatological evaluation of all household contacts to identify signs and symptoms of leprosy. FINDINGS Significant differences in the median ELISA results were observed among leprosy cases in treatment, leprosy cases that had completed treatment and household contacts. Higher proportions of seropositivity were observed in leprosy cases in treatment. Seropositivity was also higher in multibacillary in relation to paucibacillary, with the difference reaching statistical significance. Lower titers were observed among cases with a longer treatment time or discharge. For household contacts, the differences according to the clinical characteristics of the leprosy index case were less pronounced than expected. Other factors, such as the endemicity of leprosy, exposure outside the residence and genetic characteristics, appeared to have a greater influence on the seropositivity. MAIN CONCLUSIONS Serologic tests could be used as auxiliary tools for determining the operational classification, in addition to identifying infected individuals and as a strategy for surveillance of household contacts.
Descritores: Biomarcadores/sangue
Progressão da Doença
Hanseníase/diagnóstico
Hanseníase/sangue
Anticorpos Antibacterianos/sangue
Mycobacterium leprae/imunologia
-Ensaio de Imunoadsorção Enzimática
Glicolipídeos/sangue
Características da Família
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Id: biblio-987727
Autor: Baena, Andrés; Gomez Giraldo, Lina; Gómez, Wilton A; Pelaez, Carlos A.
Título: Murine invariant natural killer T cells recognize glycolipids derived from extracts of the lichen Stereocaulon ramulosum / Células T asesinas naturales invariantes murinas reconocen glicolipidos derivados de extractos del liquen Stereocaulon ramulosum
Fonte: Vitae (Medellín);22(1):13-26, 2015. Ilustraciones.
Idioma: en.
Resumo: Background: Invariant natural killer T cells (iNKT) can be activated by certain types of glycolipids that have the potential to generate adjuvant effects which could be used to develop effective and safe immunotherapies. Many of these glycolipids have been isolated from natural organisms, but there is a great amount of these organisms completely unexplored as a source of these types of compounds. Some of these organisms are lichens which are complex symbiotic organisms that have been showed to contain glycolipids. Objectives: We decide to test if glycolipids isolated from lichens would be able to activate iNKT cells in vitro and in vivo. Methods: We have used extracted glycolipids from 43 different species of lichens from Colombia. We have used iNKT hybridoma cells, C57BL/6 mice, IL-2 ELISA and the B16 melanoma to test for the adjuvant capabilities of glycolipids isolated from lichens. Results: In this study we have found two glycolipids with the capacity to activate iNKT cells in vivo. One of the glycolipids was able to activate iNKT cells in vivo, and was competent to induce protection against the B16 melanoma in the mouse model. Conclusions: We propose a possible chemical structure for a novel glycolipid called ß-GalCer-lich (1) derived from the lichen Stereocaulon ramulosum.

Antecedentes: Las células asesinas naturales T (iNKT) pueden ser activadas por ciertos tipos de glicolípidos que tienen el potencial para generar efectos adyuvantes los cuales pueden ser usados para desarrollar inmunoterapias efectivas. Muchos de estos glicolípidos han sido aislados de organismos naturales, pero hay una gran cantidad de organismos completamente inexplorados como fuente de este tipo de compuestos. Algunos de estos organismos son los líquenes, los cuales son organismos simbiontes complejos para los que se ha mostrado que contienen glicolípidos. Objetivos: Nosotros decidimos probar si los glicolípidos aislados de líquenes podrían ser capaces de activar alas celulas iNKT in vitro e in vivo. Metodos: Nosotros hemos extraído glicolípidos de 43 especies de líquenes de Colombia. Nosotros hemos usado células de un hibridoma de iNKTs, ratones C57BL/6, ELISA para IL-2 y el melanoma B16 para probar la capacidad adyuvante de los glicolipidos aislados de los líquenes. Resultados: En este estudio nosotros hemos encontrado dos glicolípidos con la capacidad de activar iNKTs in vitro. Uno de los glicolípidos fue capaz de activar células iNKT in vivo, y fue competente para inducir protección contra el melanoma B16 en el modelo de ratón. Conclusiones: Nosotros proponemos una posible estructura química para el nuevo glicolípido llamado ß-GalCer-lich (1) derivado del liquen Stereocaulon ramulosum.
Descritores: Células Matadoras Naturais
-Glicolipídeos
Adjuvantes Imunológicos
Líquens
Limites: Humanos
Tipo de Publ: Artigo Clássico
Responsável: CO56.3 - Biblioteca


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Araujo, Sergio
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Id: lil-767834
Autor: Araujo, Sergio; Rezende, Marina Monteiro Figueiredo; Sousa, Diogo Carrijo Rodrigues de; Rosa, Maraísa Resende; Santos, Danielle Cristina dos; Goulart, Luiz Ricardo; Goulart, Isabela Maria Bernardes.
Título: Risk-benefit assessment of Bacillus Calmette-Guérin vaccination, anti-phenolic glycolipid I serology, and Mitsuda test response: 10-year follow-up of household contacts of leprosy patients
Fonte: Rev. Soc. Bras. Med. Trop;48(6):739-745, Nov.-Dec. 2015. tab, graf.
Idioma: en.
Resumo: Abstract: INTRODUCTION: Despite multidrug therapy, leprosy remains a public health issue. The intradermal Bacillus Calmette-Guérin (BCG) vaccine, Mitsuda test (lepromin skin test), and anti-phenolic glycolipid I (PGL-I) serology are widely used in leprosy studies and have shown great epidemiological value. METHODS: This longitudinal study evaluated the relative risks and benefits of these three tools by comparing results observed in household contacts (HHCs) of leprosy patients who developed leprosy with those of HHCs who did not in a population of 2,992 individuals monitored during a 10-year period. RESULTS : Seventy-five (2.5%) new leprosy cases were diagnosed, including 28 (0.9%) co-prevalent cases. Therefore, for the risk-benefit assessment, 47 (1.6%) HHCs were considered as truly diagnosed during follow-up. The comparison between healthy and affected contacts demonstrated that not only did BCG vaccination increase protection, but boosters also increased to 95% relative risk (RR) reduction when results for having two or more scars were compared with having no scars [RR, 0.0459; 95% confidence interval (CI), 0.006-0.338]. Similarly, Mitsuda reactions >7mm in induration presented 7-fold greater protection against disease development compared to reactions of 0-3mm (RR, 0.1446; 95% CI, 0.0566-0.3696). In contrast, anti-PGL-I ELISA seropositivity indicated a 5-fold RR increase for disease outcome (RR, 5.688; 95% CI, 3.2412-9.9824). The combined effect of no BCG scars, Mitsuda reaction of <7mm, and seropositivity to anti-PGL-I increased the risk for leprosy onset 8-fold (RR, 8.109; 95% CI, 5.1167-12.8511). CONCLUSIONS: The adoption of these combined assays may impose measures for leprosy control strategies.
Descritores: Antígenos de Bactérias/imunologia
Vacina BCG/imunologia
Busca de Comunicante/estatística & dados numéricos
Glicolipídeos/imunologia
Hanseníase/imunologia
-Ensaio de Imunoadsorção Enzimática
Estudos Longitudinais
Antígeno de Mitsuda/imunologia
Hanseníase/prevenção & controle
Hanseníase/transmissão
Medição de Risco
Limites: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Feminino
Humanos
Lactente
Recém-Nascido
Masculino
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-764594
Autor: Mizoguti, Danielle de Freitas; Hungria, Emerith Mayra; Freitas, Aline Araújo; Oliveira, Regiane Morillas; Cardoso, Ludimila Paula Vaz; Costa, Mauricio Barcelos; Sousa, Ana Lúcia Maroclo; Duthie, Malcolm S; Stefani, Mariane Martins Araújo.
Título: Multibacillary leprosy patients with high and persistent serum antibodies to leprosy IDRI diagnostic-1/LID-1: higher susceptibility to develop type 2 reactions
Fonte: Mem. Inst. Oswaldo Cruz;110(7):914-920, Nov. 2015. tab, graf.
Idioma: en.
Projeto: PRONEX/FAPEG/CNPQ; . PNPD; . CAPES; . CAPES; . CAPES; . CAPES; . CNPq.
Resumo: Leprosy inflammatory episodes [type 1 (T1R) and type 2 (T2R) reactions] represent the major cause of irreversible nerve damage. Leprosy serology is known to be influenced by the patient’s bacterial index (BI) with higher positivity in multibacillary patients (MB) and specific multidrug therapy (MDT) reduces antibody production. This study evaluated by ELISA antibody responses to leprosy Infectious Disease Research Institute diagnostic-1 (LID-1) fusion protein and phenolic glycolipid I (PGL-I) in 100 paired serum samples of 50 MB patients collected in the presence/absence of reactions and in nonreactional patients before/after MDT. Patients who presented T2R had a median BI of 3+, while MB patients with T1R and nonreactional patients had median BI of 2.5+ (p > 0.05). Anti-LID-1 and anti-PGL-I antibodies declined in patients diagnosed during T1R (p < 0.05). Anti-LID-1 levels waned in MB with T2R at diagnosis and nonreactional MB patients (p < 0.05). Higher anti-LID-1 levels were seen in patients with T2R at diagnosis (vs. patients with T1R at diagnosis, p = 0.008; vs. nonreactional patients, p = 0.020) and in patients with T2R during MDT (vs. nonreactional MB, p = 0.020). In MB patients, high and persistent anti-LID-1 antibody levels might be a useful tool for clinicians to predict which patients are more susceptible to develop leprosy T2R.
Descritores: Anticorpos Antibacterianos/sangue
Antígenos de Bactérias/imunologia
Glicolipídeos/imunologia
Imunoglobulina M/sangue
Hanseníase Multibacilar/diagnóstico
-Anticorpos Antibacterianos/imunologia
Suscetibilidade a Doenças
Ensaio de Imunoadsorção Enzimática
Imunoglobulina M/imunologia
Mycobacterium leprae/imunologia
Limites: Adolescente
Adulto
Idoso
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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