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Id: biblio-1039066
Autor: Kaya, Kürsat; Çiftçi, Osman; Öztanir, Mustafa Namik; Taslidere, Elif; Türkmen, Nese Basak.
Título: Beta-glucan attenuates cerebral ischemia/reperfusion-induced neuronal injury in a C57BL/J6 mouse model
Fonte: Braz. J. Pharm. Sci. (Online);55:e18312, 2019. tab, ilus.
Idioma: en.
Resumo: Beta-glucans (ßg), that have many useful effects on human health, are natural polysaccharides. Our aim in this study was to determine useful effect of ßg against oxidative and neuronal damage caused by global cerebral ischemia/reperfusion (IR) in stroke imitated mice via surgical operation. A total of 40 mice divided into four equal groups randomly. The group 1 (sham operated) was kept as control. Bilateral carotid arteries of subjects in group 2 (I/R) and group 4 (I/ R + ßg) were clipped for 15 min, and the mice in group 4 (I/R + ßg) were treated with ßg (50 mg/kg/day), while the mice in group 2 (I/R) were treated with only vehicle for 10 days. The mice of group 3 (ßg) were treated with ßg for 10 days without carotid occlusion. Global cerebral I/R significantly increased oxidative stress and decreased members of anti-oxidant defense system. In addition, I/R caused histopathological damage in the brain tissue. However, ßg treatment ameliorated both oxidative and histopathological effects of I/R. Our present study showed that ßg treatment significantly ameliorated oxidative and histological damage in the brain tissue caused by cerebral I/R. Therefore, ßg treatment can be used as supportive care for ischemic stroke patients
Descritores: Estresse Oxidativo/fisiologia
beta-Glucanas/análise
-Isquemia Encefálica/induzido quimicamente
Degeneração Neural
Limites: Animais
Camundongos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-1048615
Autor: Santos, Joice Sifuentes dos; França, Vanessa Ribeiro de; Venâncio, Rafael Luiz; Hasegawa, Patricia Harumi; Oliveira, Admilton Gonçalves de; Costa, Giselle A. Nobre.
Título: ß -glucan from saccharomyces cereviseae in skim yogurt production / ß-Glucana de Saccharomyces cereviseae na produção de iogurte desnatado
Fonte: Biosci. j. (Online);35(2):620-628, mar./apr. 2019. tab, graf, ilus.
Idioma: en.
Resumo: The demand for functional foods has increased in recent years, following a market trend in which the consumer values foods associated with health improvements. Skim milk yogurts were produced with yeast ß-glucan (YBG, 0.5 and 1.0 %) isolated from Saccharomyces cerevisiae and compared with full fat (FFY) and skim milk (SMY) yogurt as controls. The samples were analyzed for physical, chemical, color,syneresis, culture starter count, textural, microstructure and sensory attributes. Yeast ß-glucan was not able to retain the serum of yogurts during cold storage. Skim yogurt firmness increased with the addition of 0.5% yeast ß-glucan, presenting a more compact microstructure. Yogurts containing yeast ß-glucan had low scores by the untrained panelists in the sensorial analysis (0.5% YBG overall acceptance 5.2, FFY 6.8, SY 6.3) and low purchase intention. Thus, although similar characteristics were observed, low scores in the sensorial analysis and purchase intention were a barrier to commercializing skim milk yogurt with yeast ß-glucan developed in the present study

A demanda por produtos funcionais tem aumentado recentemente, seguindo um padrão no qual os consumidores valorizam os alimentos que são associados a melhoria da saúde. Iogurte desnatado foi produzido com ß-glucana extraída de Saccharomyces cerevisiae e comparado com iogurte integral e iogurte desnatado. O iogurte desnatado contendo ß-glucana não reteve soro durante a estocagem refrigerada. A firmeza do produto aumentou com a adição de 0,5% de ß-glucana e sua microestrutura foi mais compacta. Iogurtes contendo ß-glucana apresentaram menor escore na análise sensorial. Assim, embora características semelhantes tenham sido observadas, os baixos escores da análise sensorial são uma barreira para a comercialização de iogurte desnatado contendo ß-glucana produzido no presente estudo
Descritores: Polissacarídeos
Iogurte
Laticínios
beta-Glucanas
-Saccharomyces cerevisiae
Alimento Funcional
Responsável: BR396.1 - Biblioteca Central


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Id: lil-777088
Autor: Kaya, Kürşat; Ciftci, Osman; Cetin, Aslı; Tecellioğlu, Mehmet; Başak, Neşe.
Título: Beneficial effects of glucan against cisplatin side effects on the nervous system in rats 1
Fonte: Acta cir. bras;31(3):198-205, Mar. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To investigate the protective effect of Bg on cisplatin (CP)-induced neurotoxicity in rats. METHODS: Twenty eight rats were randomly distributed into four groups. The first group was kept as a control. In the second group, CP was given at the single dose of 7 mg/kg intraperitoneally. In the third group, βg was orally administered at the dose of 50 mg/kg/day for 14 days. In the fourth group, CP and βg were given together at the same doses. RESULTS: CP treatment caused significant oxidative damage via induction of lipid peroxidation and reductions antioxidant defense system potency in the brain tissue. In addition, histopathological damage increased with CP treatment. On the other hand, βg treatment largely prevented oxidative and histopathological negative effects of CP. CONCLUSIONS: Cisplatin has severe neurotoxic effects in rats and βg supplementation has significant beneficial effects against CP toxicity depending on its antioxidant properties. Thus, it appears that βg might be useful against CP toxicity in patients with cancer in terms of nervous system.
Descritores: Encéfalo/efeitos dos fármacos
Encefalopatias/prevenção & controle
Cisplatino/efeitos adversos
beta-Glucanas/farmacologia
Antineoplásicos/efeitos adversos
-Encéfalo/metabolismo
Encéfalo/patologia
Encefalopatias/induzido quimicamente
Encefalopatias/patologia
Distribuição Aleatória
Córtex Cerebral/efeitos dos fármacos
Córtex Cerebral/metabolismo
Córtex Cerebral/patologia
Cisplatino/metabolismo
Ratos Sprague-Dawley
Estresse Oxidativo
Substâncias Protetoras/farmacologia
Modelos Animais
Antineoplásicos/metabolismo
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: lil-787095
Autor: Quitral R, Vilma; Atalah S, Eduardo; Jara C, María Fernanda; Echeverría G, Francisca; Vivanco L, Juan P; López A, Ximena.
Título: Estudio de aceptabilidad y saciedad de barritas de cereal altas en fibra dietética en escolares de una escuela rural de Chile / Acceptability and saciety study of cereal bars high in dietetic fiber in schoolage children of a Chilean rural school
Fonte: Rev. chil. nutr;43(1):68-74, mar. 2016. ilus.
Idioma: es.
Projeto: InnovaChile-CORFO. Desarrollo de consorcio entre entidades tecnológicas de vanguardia para el desarrollo de nuevos productos funcionales en base a cereal con aporte significativo en la salud humana.
Resumo: Cereal bars for infant collation in two flavors were developed: apple and red fruits. The bars were made with oatmeal and dried fruit, low in saturated fat, total sugars and sodium. The effect of the addition of 2.5% of β-glucan in the bars on the sensory acceptability, satiety and digestive tolerance in primary school children were evaluated. The results showed high sensory acceptability to all bars (both flavors, with and without β-glucan), being higher in children from 1st to 4th grade and in men (p <0.05). Consumption of the bars produced satiety in children without stumbling significant differences due to thepresence of β-glucan. Regarding the digestive tolerance, no cases of discomfort were presented, indicating that all cereal bars were well tolerated. The addition of β-glucan in the bars does not affect the sensory acceptability of these and does not affect satiety compared to bars without β-glucan.

RESUMEN Se desarrollaron barritas de cereal destinadas a la colación infantil en dos sabores: manzana y frutos rojos. Las barritas se elaboraron con avena y frutos deshidratados, con bajo contenido de grasas saturadas, azúcares totales y sodio. Se evaluó el efecto de la incorporación de 2.5% de β-glucano en las barritas sobre la aceptabilidad sensorial, saciedad y tolerancia digestiva en escolares de educación básica. Los resultados obtenidos demostraron alta aceptabilidad sensorial para todas las barritas (ambos sabores, con y sin β-glucano), siendo mayor en niños de 1° a 4° básico y en hombres (p<0.05). El consumo de las barritas produjo saciedad en los niños, sin encontrase diferencias significativas por efecto de la presencia de β-glucano. Respecto a la tolerancia digestiva, no se presentaron casos de malestar, lo que indica que todas las barritas de cereal fueron bien toleradas. La incorporación de β-glucano en las barritas no afecta la aceptabilidad sensorial de éstas y tampoco afecta la saciedad respecto a barritas sin β-glucano.
Descritores: Saciação
Estudantes
Fibras na Dieta
Consumo de Alimentos
Grãos Comestíveis
Alimentos Integrais
Ensino Fundamental e Médio
beta-Glucanas
Limites: Seres Humanos
Tipo de Publ: Artigo Clássico
Responsável: CL334.1 - Biblioteca UBO


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Id: biblio-974418
Autor: Ciftci, Osman; Duman, Ahmet Sefa; Turkmen, Nese Basak; Taslidere, Asli.
Título: Beta-glucan prevents toxic effects of 2, 3, 7, 8-TCDD in terms of oxidative and histopathological damage in heart tissue of rats
Fonte: Braz. J. Pharm. Sci. (Online);54(3):e17674, 2018. graf.
Idioma: en.
Resumo: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant which causes severe toxic effects. Despite there is some suggestion concerning with TCDD induced cardiotoxicity such as formation of free radicals, the main mechanism has not been entirely explained. Beta-glucan is known as strong antioxidant matter and can scavenge free radicals. Therefore this study aimed to investigate the protective effects of beta-glucan against TCDD induced cardiotoxicity in rats. In this study, 2-3 months of age and 190-250 g in weight 32 rats were randomly divided into four equal groups (n=8 for each group). Group 1 was control; Group 2 was TCDD group (2 µg/kg/week); group 3 was the beta-glucan group(50 mg/kg/day), and group 4 was TCDD and beta-glucan treatment group. The heart samples were taken from rats after 21 days treatment. The results were shown that Despite TCDD exposure visibly caused to increase (p ≤ 0.001) in TBARS levels, It caused a visible decline in the levels of GSH, CAT, GSH-Px, and SOD. However Beta glucan significantly increased GSH, CAT, GSH-Px, SOD levels and decreased generation of TBARS. Additionally, our histopathological observations were in agreement with the biochemical results. In conclusion, Beta-glucan treatment exhibited protective activity on TCDD induced cardiotoxicity
Descritores: beta-Glucanas/análise
beta-Glucanas/efeitos adversos
Dibenzodioxinas Policloradas/toxicidade
-Cardiotoxicidade/classificação
Limites: Animais
Feminino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-895529
Autor: Porsani, Mariana Y. H; Paludetti, Monique; Orlando, Débora R; Peconick, Ana P; Costa, Rafael C; Oliveira, Luiz E. D; Zangeronimo, Márcio G; Sousa, Raimundo V.
Título: Protective effect of ß-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C) / Efeito protetor do ß-glucano e glutamina em lesões intestinais e imunológicas induzidas por ciratabina (Ara-C) em camundongos
Fonte: Pesqui. vet. bras = Braz. j. vet. res;37(9):977-983, Sept. 2017. ilus.
Idioma: en.
Resumo: Recently, glutamine and ß-glucan have been demonstrated to play an important role in modulation of the immune system and in promoting intestinal health benefits. The aim of this study was to investigate the effect of this intervention on inflammatory responses and intestinal health in mice orally pretreated with soluble Saccharomyces cerevisiae derived 1,3/1,6-ß-glucan (80mg/kg) with or without glutamine (150mg/kg) and then challenged with cytarabine (Ara-C) (15mg/kg). Improvements in villi and crypts were not observed in the ß-glucan group. The intestinal morphometry in the glutamine group showed the best results. ß-glucan in combination with glutamine presented the highest values of IL-1ß and IL-10 and lowest values for leukocytes and INF-γ. Based on these results, combined ß-glucan and glutamine pretreatment reduced intestinal inflammation and improved the immune response after Ara-C challenge.(AU)

Recentemente, glutamina e ß-glucano têm demonstrado desempenhar um papel importante na modulação do sistema imune e na promoção de benefícios para a saúde intestinal. O objetivo deste estudo foi investigar o efeito dessa intervenção sobre as respostas inflamatórias e saúde intestinal de camundongos pré- tratados por via oral com 1,3/1,6-ß-glucano (80mg/kg) derivado de Saccharomyces cerevisiae com ou sem glutamina (150mg/kg) e posteriormente desafiados com citarabina (Ara-C) (15mg/kg). Melhoras em vilosidades e criptas não foram observadas no grupo de tratamento com ß-glucano. A morfometria intestinal no grupo de tratamento com glutamina apresentou os melhores resultados. O grupo em que foi utilizado ß-glucano em combinação com glutamina apresentou os maiores valores de IL-1ß e IL -10 e valores mais baixos para os leucócitos e INF-γ. Com base nestes resultados, o pré-tratamento de ß-glucano combinado com glutamina reduziu a inflamação intestinal e melhorou a resposta imune após o desafio com Ara-C.(AU)
Descritores: Citarabina
beta-Glucanas/uso terapêutico
Glutamina/uso terapêutico
Sistema Imunitário/efeitos dos fármacos
Mucosa Intestinal
Limites: Animais
Masculino
Camundongos
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: lil-734789
Autor: Pizarro C, Sebastián; Ronco M, Ana María; Gotteland R, Martín.
Título: ß-glucanos: ¿qué tipos existen y cuáles son sus beneficios en la salud? / ß-glucans: what types exist and what are their health benefits?
Fonte: Rev. chil. nutr;41(4):439-446, dic. 2014. ilus.
Idioma: es.
Resumo: ß-glucans are glucose polymers (polysaccharides) of high molecular weight naturally present in the cell wall of various living organisms such as bacteria, yeasts, fungus and plants (mainly cereals like barley and oat). ß-glucans are GRAS and are currently used as texturing agents by the food industry. Furthermore, scientific evidence suggest that, depending on their physicochemical structure and source, their intake would be associated with health promoting effect such as the decrease of plasma cholesterol and the improvement of the glycemic index of the ß-glucan-containing foodstuffs. Accordingly, a health claim related with the intake of cereal ß-glucans and plasma cholesterol improvement has been accepted by the FDA in U.S.A. and by the EFSA in the E.U. For this reason, ß-glucans are increasingly used in the world for the development of functional foods. However, the effect of yeast ß-glucans on immune system stimulation is still discussed.

Los ß-glucanos son polímeros de glucosa (polisacáridos) de elevado peso molecular que se encuentran en forma natural en la pared celular de diversos organismos vivos como bacterias, levaduras, hongos y plantas (cereales como avena y cebada). Los ß-glucanos son inocuos y actualmente son utilizados por las empresas de alimentos como agentes texturizantes. Además, antecedentes científicos sugieren que, dependiendo de su estructura fisicoquímica y de su origen, su consumo se asociaría a efectos beneficiosos para la salud del ser humano como la disminución de la concentración plasmática de colesterol total y la reducción del índice glicémico de los alimentos que lo incluyen. Un mensaje de salud sobre consumo de ß-glucanos de cereales y disminución del colesterol ha sido aceptado tanto por la FDA de EE.UU. como por la EFSA de la U.E. Por esta razón los ß-glucanos están siendo utilizados cada vez más para el desarrollo de alimentos funcionales en varios países del mundo. Sin embargo, el efecto de los ß-glucanos de levadura sobre la estimulación de la respuesta inmune aún está en discusión.
Descritores: Glicemia
Indústria Alimentícia
Colesterol
Saúde
beta-Glucanas
Alimentos
-Impactos na Saúde
Limites: Seres Humanos
Tipo de Publ: Artigo Clássico
Responsável: CL334.1 - Biblioteca UBO


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Id: biblio-994930
Autor: Vasquez Mejia, Sandra Milena; De Francisco, Alicia; Manique Barreto, Pedro Luiz; Mattioni, Bruna; Zibetti, André Wüst; Molognoni, Luciano; Daguer, Heitor.
Título: Physicochemical comparison of commercial VS. extracted ß-glucans and structural characterization after enzymatic purification / Comparación fisicoquímica entre ß-glucanos comerciales y extraídos, y caracterización estructural después de purificación enzimática
Fonte: Vitae (Medellín);25(1):26-36, 2018. Ilustraciones.
Idioma: en.
Resumo: Background: ß-glucans (1-3: 1-4) are soluble fibers applied to foods due to their technological properties (water binding capacity, viscosity, emulsification and stabilization) and their beneficial effects on health. The functional properties of ß-glucans can be lost during the extraction and purification processes. The high viscosity of ß-glucans is related to a high molecular weight and its physiological properties in the intestine. Therefore, to characterize the fiber after its extraction and purification is fundamental to understand its possible applications in foods. Objectives: characterize ß-glucans extracted (EßG) and compare them with three commercial ß-glucans (CßG-A, CßG-B and CßG-C) to identify its possible applications in foods and to evaluate if enzymatic purification affects molecular and structurally the ß-glucans. Methods: barley ß-glucans were extracted (EßG), characterized by chemical analyzes, rheological behavior, and color, and compared to three commercial ß-glucans samples. Then, the extract was purified and its structural and molecular characteristics were calculated. Results: EßG contained 64.38 ± 3.54% of ß-glucans, high starch contamination (12.70 ± 1.73%), high content of calcium (8894 mg/kg), pseudoplastic behavior, and dark color (L* = 52.77 ± 0.7). All commercial samples showed low starch contamination, lighter color, and Newtonian behavior. After purification starch and protein contamination decreased (0.85 ± 0.46% and 5.50 ± 0.12% respectively), increased the content of ßG (69.45 ± 0.81%) and increased brightness (L* = 92.60 ± 1.70). Purified ß-glucans (PßG) showed a molar weight of 690 ± 1.6 kDa and species with degree polymerization 3 (DP3) to 11 (DP11) were identified on the structure. Conclusions: EßG extracts before the purification presented a high viscosity and contamination. The enzymatic purification process was effective and allowed to maintain a high molar mass of PßG and its distinctive molecular structures (species with DP3 and DP4). The commercial samples CßG-A and CßG-B showed a low content of ß-glucans. Finally, CßG-C presented the best physicochemical and rheological properties for its subsequent application in food.

Antecedentes: los ß-glucanos (1-3: 1-4) son fibras solubles aplicadas a los alimentos debido a sus propiedades tecnológicas (capacidad de retención de agua, viscosidad, emulsificación y estabilización) y a sus efectos beneficiosos en la salud. Las propiedades funcionales de los ß-glucanos pueden perderse durante los procesos de extracción y purificación. La alta viscosidad de los ß-glucanos está relacionada con un alto peso molecular y con sus propiedades fisiológicas en el intestino. Por lo tanto, caracterizar la fibra después de su extracción y purificación es fundamental para comprender sus posibles aplicaciones en alimentos. Objetivos: caracterizar ß-glucanos extraídos (EßG) y compararlos con tres marcas comerciales (CßG-A, CßG-B y CßG-C) para identificar su futura aplicación en alimentos y evaluar si la purificación enzimática afecta molecular y estructuralmente los ß-glucanos. Métodos: se extrajeron ß-glucanos de cebada (EßG), caracterizados por análisis químicos, comportamiento reológico y color, y se compararon con tres muestras comerciales. Posteriormente, el extracto (EßG) se purificó y se identificaron sus características estructurales y su peso molecular. Resultados: EßG contenía 64.38 ± 3.54% de ß-glucanos, alta contaminación con almidón (12.70 ± 1.73%), alto contenido de calcio (8894 mg / kg), comportamiento pseudoplástico y color oscuro (L* = 52.77 ± 0.7). Todas las muestras comerciales mostraron una baja contaminación con almidón, color más claro y comportamiento newtoniano. Después de la purificación de EßG, la contaminación con almidón y proteína disminuyó (0.85 ± 0.46% y 5.50 ± 0.12%, respectivamente), aumentó el contenido de ßG (69.45 ± 0.81%) y aumentó su luminosidad (L* = 92.60 ± 1.70). Los ß-glucanos purificados (PßG) mostraron un peso molar de 690 ± 1,6 kDa y se identificaron en la estructura especies con grado de polimerización desde 3 (GP3) hasta 11 (GP11). Conclusiones: los EßG antes de la purificación presentaron alta viscosidad y contaminación. El proceso de purificación enzimática fue efectivo y permitió mantener una alta masa molar de la fibra y sus estructuras moleculares características (especies con GP3 y GP4). Las muestras comerciales CßG-A y CßG-B mostraron un bajo contenido de ß-glucanos. Finalmente, la CßG-C presentó las mejores propiedades fisicoquímicas y reológicas para su posterior aplicación en alimentos.
Descritores: beta-Glucanas
-Viscosidade
Fibras na Dieta
Alimentos Integrais
Peso Molecular
Limites: Seres Humanos
Tipo de Publ: Artigo Clássico
Responsável: CO56.3 - Biblioteca


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Id: biblio-877772
Autor: Naranjo Quimbiulco, Luis David; Castillo Altamirano, Crista María.
Título: Desarrollo y evaluación de una infusión de té rojo (Camellia sinensis) con mora (Rubus ulmifolius) enriquecido con ß-glucanos para el control de glicemia en personas diabéticas / Development and evaluation of an infusion of red tea (Camellia sinensis) with blackberry (Rubus ulmifolius) enriched with ß-glucans for the control of glycemia in diabetic people.
Fonte: Tegucigalpa; s.n; 2017. 38 p. graf, tab.
Idioma: es.
Tese: Apresentada a Escuela Agrícola Panamericana para obtenção do grau de Especialista.
Resumo: La diabetes es una enfermedad crónica degenerativa, exponencialmente creciente, y generando altos costos para los sistemas de salud a nivel mundial. Un alto porcentaje de la población utiliza medicina tradicional como extractos de plantas para satisfacer sus necesidades de atención primaria de salud. El objetivo del estudio fue desarrollar y evaluar una infusión de té rojo con moras enriquecido con ß-glucanos para el control de glicemia en personas diabéticas de la aldea de Jicarito. Se utilizó un DCA con un arreglo factorial 2 × 2 × 2, evaluando dos concentraciones de té rojo con mora (50/50 y 75/25), dos temperaturas (75 y 95 °C) y dos tiempos (2 y 5 minutos), seleccionando el tratamiento con mayor contenido de polifenoles totales (P2T2t2). El mejor tratamiento se evaluó en una muestra de 30 diabéticos, a los cuáles se realizaron medidas antropométricas (peso, talla, circunferencia de cintura-cadera y presión arterial), medidas bioquímicas (glucosa y colesterol) y se analizó la ingesta alimentaria a través de recordatorio de 24 horas. Los resultados demostraron reducción de Índice de Masa Corporal (IMC) en edades de 44- 65 años, en niveles de glucosa en edades de 45-65 y > 65 años, en niveles de colesterol total en edades de 45-65 años y no existió reducción en presión arterial ni en el Índice de Cintura- Cadera (ICC) para ambos sexos. Se determinó una mayor ingesta alimentaria de hidratos de carbono y grasas en la población de diabéticos. Para evaluar modificaciones en medidas antropométricas y bioquímicas se necesita de al menos tres meses de consumo del té.
Descritores: beta-Glucanas
Glicemia/efeitos dos fármacos
Camellia sinensis
Rubus
-Coleta de Dados
Diabetes Mellitus/terapia
Plantas Medicinais
Limites: Seres Humanos
Masculino
Feminino
Responsável: BR1.1 - BIREME


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Id: biblio-870751
Autor: Batista, Marjorie Vieira.
Título: Aspergilose invasiva em pacientes imunodeprimidos: comparação entre as provas de galactomanana, 1,3 betaD-glucana, dados tomográficos e desfecho clínico / Performance of galactomannan and 1,3 beta-glucan enzyme assays in the serum and bronchoalveolar lavage and comparison with computer tomography scan for the diagnosis of invasive aspergillosis in immunocompromised hosts.
Fonte: São Paulo; s.n; 2015. [130] p. ilus, tab, graf.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Faculdade de Medicina para obtenção do grau de Doutor.
Resumo: A aspergilose invasiva (AI) é a infecção por fungos filamentosos mais comum em pacientes imunodeprimidos, especialmente em transplantes de células tronco hematopoiético e neoplasias hematológicas. Objetivo: Geral: Estabelecer a comparação entre a dosagem de Galactomanana (GM), 1,3betaD-glucana (BDG) e dados tomográficos no diagnóstico da AI bem como seu papel no desfecho clínico. Específicos: 1. Verificar a sensibilidade e especificidade dos ensaios de Galactomanana e de 1,3betaD-glucana no soro e lavado broncoalveolar. 2. Comparar os resultados da galatomanana e 1,3betaD-glucana com os dados de imagem em pacientes com suspeita de AI. 3. Verificar a relação entre a evolução dos níveis de GM e desfecho clínico (óbito e sobrevida). Casuística, Materiais e Métodos: Realizou-se um estudo tipo coorte prospectiva, incluindo 398 sujeitos das diversas enfermarias de pacientes imunodeprimidos do HCFMUSP, sendo incluídos dois grupos de pacientes: 202(51%) AI e 198(49%) controles. Resultados: Dos casos, 18 (8,8%) tinham aspergilose provada, 28 (13,7%) provável e 158 possível (77,5%), de acordo a classificação de 2002 EORTC/MSG (European Organization for Research and Treatment of Cancer / Mycoses Study Group). Os sujeitos submetidos ao TCTH eram 42,7%, com neoplasias hematológicas 37%, TOS 9% e outras doenças 11,3%. Os fatores de risco associados ao desenvolvimento da AI foram neutropenia, monocitopenia, uso de corticóide, presença de doença pelo citomegalovírus e rejeição ou doença do enxerto contra o hospedeiro. O fator de risco associado à evolução para o óbito foi a presença de AI. Foram observados bons desempenhos para a GM tanto no soro como no LBA com LR menores que os registrados na literatura. O melhor desempenho da GM no soro para aspergilose+provável ocorreu com LR de 0,35 com sensibilidade-S, especificidade-E, valor preditivo positivo- VPP), valor preditivo negativo-VPN) e área sob a curva-ASC de 54,4%, 73,4%, 50,8%, 76,2% e 0,64, sendo os valores superiores...

Invasive aspergillosis (IA) has become the leading infectious cause of death in immunocompromised hosts, particularly in subjects under SCTH and hematologic neoplasias. Objectives: General: To compare the performance of GM and BG tests in serum and bronchoalveolar lavage fluid (BAL) and computer tomography (CT) scans in the diagnosis of IA in immunocompromised hosts as well as their role in the patient outcome. Specific: 1. To analyse the sensitivity and specificity of Galactomannan and 1,3 betaD-glucan assays in the serum and bronchoalveolar lavage. 2. To compare the results of Galactomannan and 1,3betaD-glucan assays with CT scans in patients with invasive aspergilosis. 3. To analyse the relationship between the evolution of galactomannan levels and clinical outcome (death or survival). Patients, Materials and Methods: From December 2008 to March 2013, a prospective cohort of 398 patients from several wards of immunocompromised patients of Hospital das Clínicas, Faculdade de Medicina, University of São Paulo was included classified in two groups of patients: 202 (51%) with invasive aspergillosis (IA) and 198 (49%) control patients. Results: Considering 202 cases, 18(8.8%) were subjects with proven, 28(13.7%) with probable aspergillosis and 156(77.5%), with possible aspergillosis, according to 2002 EORTC/MSG (European Organization for Research and Treatment of Cancer/Mycoses Study Group) criteria. The most common underlying disease were: HSCT (42.7%), hematologic malignancy (37%), SOT (9%), or other diseases (11.3%). The main risk factors associated with IA were neutropenia, monocytopenia, patients under corticosterois, presence of CMV disease, and rejection or graft versus host disease. The risk factor associated with death was the presence of invasive aspergillosis. Good performances for serum and BAL GM were registered with lower cutoffs in the present workin relationship to those found in the literature. The best cutoff for proven + probable...
Descritores: Aspergilose Pulmonar Invasiva/microbiologia
beta-Glucanas
Neutropenia Febril
Galactanos/administração & dosagem
Transplante de Células-Tronco Hematopoéticas
Hospedeiro Imunocomprometido
Testes Imunológicos
Micoses/microbiologia
Tomografia Computadorizada por Raios X
Transplante
Limites: Seres Humanos
Tipo de Publ: Estudo Comparativo
Responsável: BR66.1 - Divisão de Biblioteca e Documentação
BR66.1



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