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Id: biblio-990071
Autor: Leal, Aila Maria Cipriano; Rolim, Fabiana Gouveia; Silva, Marta Almeida; Ferreira, Josie Haydeé Lima; Vale, Glauber Campos.
Título: Effect of Sweeteners on Root Dentine Demineralization Using a Microcosm Biofilm Model / Efecto de los Edulcorantes en la Desmineralización de la Dentina Radicular Utilizando un Modelo de Biofilm Microcosmo
Fonte: Int. j. odontostomatol. (Print);13(1):93-96, mar. 2019. graf.
Idioma: en.
Resumo: ABSTRACT: The aim of the present study was to evaluate the effect of commercial sweeteners on root dentin demineralization using a microcosm biofilm model. Bovine dentin specimens with pre-determined surface hardness were randomized into six groups according to the studied sweeteners: sucralose, stevia, saccharin, aspartame. Sucrose was used as a positive control and an untreated group as a negative control. The specimens were submitted to biofilm development from one saliva donor and the cariogenic challenge occurred on subsequent five days, twice a day. At the end, the percentage of surface hardness loss (%SHL) and biomass was determined and submitted to ANOVA followed by Tukey's test. Sucrose presented the highest rate of demineralization, however, all sweeteners tested lead to a statistically higher root demineralization compared to the negative control (p <0.05). Sucrose caused greater demineralization in root dentin, however, the sweeteners were also able to induce it under this biofilm model.

RESUMEN: El objetivo del presente estudio fue evaluar el efecto de los edulcorantes comerciales en la desmineralización de la dentina radicular utilizando un modelo de biofilm microcosmo. Se asignaron al azar muestras de dentina bovina con una dureza de la superficie predeterminada de acuerdo con los edulcorantes estudiados: sucralosa, estevia, sacarina, aspartame. La sacarosa se utilizó como control positivo y un grupo no tratado como control negativo. Las muestras se enviaron al desarrollo de biopelículas de un donante de saliva y el desafío cariogénico se produjo en los siguientes cinco días, dos veces al día. Al final, se determinó el porcentaje de pérdida de dureza de la superficie (% PDS) y biomasa y se aplicó un estudio estadístico de ANOVA seguido de la prueba de Tukey. La sacarosa presentó la mayor tasa de desmineralización; sin embargo, todos los endulzantes probados condujeron a una desmineralización de la raíz estadísticamente mayor en comparación con el control negativo (p<0,05). La sacarosa causó una mayor desmineralización en la dentina de raíz, sin embargo, los edulcorantes también fueron capaces de inducirla bajo este modelo de biofilm.
Descritores: Sacarose/farmacologia
Desmineralização do Dente/microbiologia
Biofilmes/efeitos dos fármacos
Dentina/microbiologia
-Raiz Dentária/efeitos dos fármacos
Raiz Dentária/microbiologia
Brasil/epidemiologia
Cariogênicos/farmacologia
Análise Estatística
Limites: Animais
Bovinos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1056878
Autor: Siddiq, Hanan; Pentapati, Kalyana Chakravarthy; Shenoy, Revathi; Velayutham, Anupama; Acharya, Shashidhar.
Título: Evaluation of Sugar Content and Erosive Potential of the Commonly Prescribed Liquid Oral Medications
Fonte: Pesqui. bras. odontopediatria clín. integr;20:e5025, 2020. tab.
Idioma: en.
Resumo: Abstract Objective: To assess the total sugar content, endogenous pH, total soluble solids content (TSSC) and titratable acidity of the commonly prescribed long-term and short-term liquid oral medicines (LOM) for children and to compare the erosive potential with the total sugar content and total soluble solids of the LOM. Material and Methods: Twenty-three most commonly prescribed pediatric LOM were evaluated in-vitro for the cariogenic and erosive potential. Manufacturers' information on labels, endogenous pH, titratable acidity, TSSC, and the total sugar content was determined. Descriptive statistics and the Mann-Whitney U test were applied. Results: Overall, 22 LOM contained sugar. Only 3 LOM revealed the sugar content of the formulation but did not disclose the quantity (Cheston, Ventorlin and Eptoin). None of the samples revealed the sugar content as well as endogenous pH in their labels. The overall mean total sugar content was 6.92 ± 3.49 g/100ml, ranging from 3.40 ± 0.00 (corticosteroids) to 9.67 ± 0.61 (antitussive/expectorant). The mean endogenous pH for the total sample of medicines was 5.91 ± 1.51 (range of 3.5 to 10.3). Eptoin (0.013%) presented the lowest titratable acidity and Imol (1.171%) presented the highest titratable acidity with an overall mean of 0.40 ± 0.73. Omnacortil and Epilex presented the highest TSS content (19.3%), and Ventorlin presented the lowest TSS content (18.7%) with an overall mean of 18.97 ± 0.19. Over twelve medicines were identified to have the potential to cause dental erosion. No significant differences were seen in the total sugar content, total soluble solids, titratable acidity, and the endogenous pH between the short-term and long-term LOMs (p=0.145, p=0.263, p=0.067 and p=0.107), respectively. Conclusion: The pediatric LOMs showed the presence of the sugar, low endogenous pH, high titratable acidity and high total soluble solids.
Descritores: Sacarose
Erosão Dentária/diagnóstico
Criança
Cárie Dentária
Acidez
-Técnicas In Vitro/métodos
Estatísticas não Paramétricas
Concentração de Íons de Hidrogênio
Índia/epidemiologia
Tipo de Publ: Estudo de Avaliação
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos


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Id: biblio-1101301
Autor: Nuraini, Prawati; Pradopo, Seno; Pronorahardjo, Amirah Saraswati.
Título: Sucrose and Xylitol-Induced Streptococcus mutans Biofilm Adherence
Fonte: Pesqui. bras. odontopediatria clín. integr;20:e4823, 2020. tab.
Idioma: en.
Projeto: Ministry of Research, Technology, and Higher Education.
Resumo: Abstract Objective: To study the adherence of Streptococcus mutans biofilm after induction with sucrose and xylitol. Material and Methods: Laboratory experimental study incorporating posttest-only control group design. S. mutans biofilm was generated for 24 hours at a temperature of 37°C using BHIB with 5% sucrose and BHIB with 1% xylitol. An adherence assay was conducted in accordance with the method applied previously. The quantity of adhered bacteria was measured by means of a spectrophotometer at 570 nm. The data were presented as mean and standard deviation. Results: A biofilm induced with sucrose has a higher adherence level (0.9294 ± 0.0431) compared with one induced with xylitol (0.5095 ± 0.0392). Sucrose induces adherence levels by increasing glucan binding protein and glucosyltransferase of the bacteria, whereas xylitol will inhibit the glycolysis process of the bacteria. Conclusion: The adherence of sucrose-induced S. mutans biofilm is higher than that of xylitol-induced S. mutans biofilm.
Descritores: Streptococcus mutans/imunologia
Sacarose/farmacologia
Xilitol
Placa Dentária/prevenção & controle
-Interpretação Estatística de Dados
Indonésia
Tipo de Publ: Estudo Comparativo
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos


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Id: biblio-950717
Autor: Gundogdu, Muttalip; Ozrenk, Koray; Ercisli, Sezai; Kan, Tuncay; Kodad, Ossama; Hegedus, Attila.
Título: Organic acids, sugars, vitamin C content and some pomological characteristics of eleven hawthorn species (Crataegus spp) from Turkey
Fonte: Biol. Res;47:1-5, 2014. tab.
Idioma: en.
Resumo: BACKGROUND: The Hawthorn (Crateagus sp.) mostly occurs around the temperate region of the world with a high number of species, producing a fruit with numerous beneficial effects for human health. The aim of the study was to determine organic acid and sugar contents in the fruit of a number of hawthorn species grown in Erzincan province of Turkey. RESULTS: Citric acid was the predominant organic acid in all hawthorn species and C. pseudoheterophylla had the highest citric acid content (23.688 g/100 g). There were not statistically significant differences among hawthorn species (except C. atrosanguinea Pojark) in terms of fumaric acid content. C. pontica C.Koch had a higher content of vitamin C (9.418 mg/100 g) compared to other species. Fructose was the predominant sugar component in all species and C. monogyna subsp. monogyna Joiq had the highest fructose content (18.378 g/100 g). CONCLUSIONS: The high fruit quality of the studied species indicates the importance of this fruit in human nutrition as a natural source. The study revealed that there were differences in terms of fruit characteristics among hawthorn species and thus better quality hawthorn genotypes can be selected within the species. Hence, this study is considered to be a valuable reference for forthcoming studies. The high fruit quality of the studied species indicates the importance of this fruit in human nutrition as a natural source.
Descritores: Ácido Ascórbico/análise
Ácido Cítrico/análise
Crataegus/química
Frutose/análise
Frutas/química
Valor Nutritivo
-Sacarose/análise
Turquia
Carboidratos da Dieta/análise
Extratos Vegetais/análise
Produtos Agrícolas/química
Ácidos Dicarboxílicos/análise
Glucose/análise
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950827
Autor: Alkhateeb, Suliman A; Alkhateeb, Abdullatif A; Solliman, Mohei EL-Din.
Título: In vitro response of date palm (Phoenix dactylifera L) to K/Na ratio under saline conditions
Fonte: Biol. Res;48:1-9, 2015. ilus, graf, tab.
Idioma: en.
Projeto: King Faisal University.
Resumo: BACKGROUND: Salinity is a serious factor limiting the productivity of agricultural plants. One of the potential problems for plants growing under saline conditions is the inability to up take enough K+. The addition of K+ may considerably improve the salt tolerance of plants grown under salinity. It is assumed that increasing the K+ supply at the root zone can ameliorate the reduction in growth imposed by high salinity. The present study aims to determine whether an increase in the K/Na ratio in the external media would enhance the growth of date palm seedlings under in vitro saline conditions. METHODS: Date palm plants were grown at four concentrations of Na + K/Cl (mol/m³) with three different K/Na ratios. The 12 salt treatments were added to modified MS medium. The modified MS medium was further supplemented with sucrose at 30 g/l. RESULTS: Growth decreased substantially with increasing salinity. Growth expressed as shoot and root weight, enhanced significantly with certain K/Na ratios, and higher weight was maintained in the presence of equal K and Na. It is the leaf length, leaf thickness and root thickness that had significant contribution on total dry weight. Na+ contents in leaf and root increased significantly increased with increasing salinity but substantial decreases in Na+ contents were observed in the leaf and root with certain K/Na ratios. This could be attributed to the presence of a high K+ concentration in the media. The internal Na+ concentration was higher in the roots in all treatments, which might indicate a mechanism excluding Na+ from the leaves and its retention in the roots. K/Na ratios up to one significantly increased the leaf and root K+ concentration, and it was most pronounced in leaves. The K+ contents in leaf and root was not proportional to the K+ increase in the media, showing a high affinity for K+ uptake at lower external K+ concentrations, but this mechanism continues to operate even with high external Na+ concentrations. CONCLUSION: Increasing K/Na ratios in the growing media of date plam significantly reduced the absorption of Na+ less than 200 mM and also balance ions compartmentalization.
Descritores: Potássio/metabolismo
Sódio/metabolismo
Produtos Agrícolas
Salinidade
Phoeniceae/fisiologia
-Sacarose/farmacologia
Técnicas In Vitro
Compartimento Celular/fisiologia
Brotos de Planta/metabolismo
Raízes de Plantas/metabolismo
Folhas de Planta/metabolismo
Phoeniceae/crescimento & desenvolvimento
Absorção Fisico-Química
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1127720
Autor: Vázquez Hernández, María Cristina; Guevara González, Ramón Gerardo; Aguirre Becerra, Humberto; Mariana Alvarado, Aurora; Romero Zepeda, Hilda.
Título: Consumo actual de edulcorantes naturales (beneficios y problemática): Stevia / Current consumption of natural sweeteners (benefits and problems): Stevia
Fonte: Rev. medica electron;39(5):1153-1159, set.-oct. 2017.
Idioma: es.
Resumo: La estevia [Stevia rebaudiana (Bertoni)] es un arbusto de tipo perenne de la familia de las Asteraceas que crece en áreas tropicales y subtropicales de Suramérica. Hoy en día, su cultivo se ha extendido a otras regiones del mundo, incluyendo Canadá y algunas partes de Asia, Europa y México, donde sus hojas se han utilizado tradicionalmente como edulcorante natural durante cientos de años. En la actualidad, el uso potencial y las implicaciones prácticas de la estevia como un edulcorante se muestran en una serie de alimentos procesados, ya que contiene glucósidos de esteviol como ingrediente activo, que puede ser bajo o no calórico, y hasta 100-300 veces más dulce que la sacarosa. Además, las hojas secas de estevia contienen también minerales, vitaminas, compuestos fenólicos, flavonoides y otros compuestos antioxidantes, con propiedades antimicrobianas y antioxidantes. Stevia acumula hasta un 30 % de los glucósidos de esteviol (SGs por su sigla en inglés) del peso seco de las hojas. El esteviósido y el rebaudiósido A son las principales SGs. Desde diciembre de 2011, los SGs (E 960) se han autorizado como aditivo alimentario y edulcorante en Estados Unidos. Su uso en diversas categorías de alimentos está regulado como por ejemplo en suplementos alimenticios y alimentos dietéticos para propósitos médicos especiales y control de peso. Sin embargo, la información ofrecida al consumidor es engañosa y dista de ser confiable. Este artículo ofrece al público interesado, datos que deben de ser evaluados al comprar productos adicionados con estevia (AU).

Stevia [Stevia rebaudiana (Bertoni)] is a perennial shrub belonging to the Asteraceae family that grows in tropical and subtropical areas of South America. Today its cultivation has spread to other regions of the world, including Canada and some parts of Asia, Europe and México, where its leaves have been used traditionally as a natural sweetener for hundreds of years. Nowadays, the potential use and practical implications of Stevia as a sweetener are shown in a number of processed foods, because it contains steviol-glycosides, which are low- or non-caloric ingredients, up to 100­300 times sweeter than sucrose. In addition, dry Stevia leaves also contain minerals, vitamins, phenolic compounds, flavonoids and other antioxidant compounds, with antimicrobial and antioxidant properties. Stevia accumulates up to 30% of diterpenoid steviol glycosides (SGs) of the leaf dry weight. Stevioside and rebaudioside A are the major SGs. Since December 2011, SGs (E 960) have been permitted for use as food additive and a sweetener in the United States. Its use in various food categories is regulated, e.g. food supplements and dietary foods for special medical purposes and weight control. However, the information offered to the consumers is misleading and far from reliable. This article offers the interested public, data that should be evaluated when buying products added with Stevia (AU).
Descritores: Stevia/classificação
Glucosídeos/administração & dosagem
-Sacarose/administração & dosagem
Edulcorantes/administração & dosagem
Comentário
Obesidade/complicações
Obesidade/prevenção & controle
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Comentário
Responsável: CU424.1 - Centro Provincial de Información de Ciencias Médicas


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Id: lil-465322
Autor: Zamora Castro, Susana; Flamana Franco, Maria J; Rivero Acosta, Yolaisy.
Título: Experiencia en la cura de úlceras por presión con sacarosa / Experience in the cure of decubitus ulcer with sacarose
Fonte: Rev. cuba. enferm;22(3), jul.-sept. 2006. ilus, tab.
Idioma: es.
Resumo: Las úlceras por presión son provocadas por la disminución del riego sanguíneo en los pacientes que permanecen encamados durante mucho tiempo. Un método muy eficaz para la cura de estas lesiones es el empleo de la sacarosa, por sus propiedades antisépticas, antibacteriana, bacteriostáticas, antiinflamatorias y cicatrizantes que posee. Por tal motivo se realizó un estudio descriptivo, prospectivo a 50 pacientes que presentaron esta complicación, en el Hospital Saturnino Lora, con el objetivo de demostrar los beneficios obtenidos con la aplicación de este método de cura en un período de cuatro años. Predominaron los pacientes con lesiones fases III y IV, con 22 (44 por ciento) y 20 casos (40 por ciento) respectivamente. Luego de iniciar el tratamiento el olor característico de ese tipo de lesión, se eliminó a las 24 h y el enrojecimiento desapareció gradualmente en todas las fases; mientras que el tejido de granulación en la fase III y IV apareció al cabo de los 7 días en todos los pacientes. Se constató que en el 90 por ciento (45 casos) fue eficaz el tratamiento con sacarosa y en un 10 por ciento (5 casos) fue aceptable(AU)

Decubitus ulcers are caused by the reduction of the blood flow in those patients that stay in bed for a long time. An efficient method for curing these lesions is the use of sacarose due to its antiseptic, antibacterial, bacteriostatic, antiinflammatory and cicatrizing properties. Taking this into account, a descriptive and prospective study was conducted among 50 patients with this complication at "Sarturnino Lora" Hospital in order to show the benefits obtained with the application of this curative method in a period of 4 years. Patients with stage III and IV lesions predominated, with 22 (44 percent) and 20 cases (40 percent), respectively. After initiating the treatment, the characteristic smell of this type of lesion was eliminated at 24 hours and redness gradually dissapeared in all stages; whereas the granulation tissue in stage III and IV appeared at 7 days in every patient. It was proved that the treatment with sacarose was efficient in 90 percent (45 cases), and acceptable in 10 percent (5 cases)(AU)
Descritores: Sacarose/uso terapêutico
Lesão por Pressão/terapia
Cuidados de Enfermagem/métodos
-Epidemiologia Descritiva
Estudos Prospectivos
Limites: Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-1130602
Autor: Méndez Gaspar, Valeria; Sánchez Meza, Karmina; López Alcaraz, Fátima; Palacios Fonseca, Alin Jael; del Toro Equihua, Mario; Montero Cruz, Sergio Adrián; Hummel, Janet; Cerna Cortés, Jorge Francisco; Cerna Cortés, Joel.
Título: Reducción de la ingesta de alimento balanceado por consumo de agua endulzada con sacarosa en ratas Wistar / Reduction of balanced food intake by consumption of water sweetened with sucrose in Wistar rats
Fonte: Acta bioquím. clín. latinoam;54(3):279-284, set. 2020. tab.
Idioma: es.
Resumo: El azúcar de mesa, que se obtiene de la caña de azúcar, es el edulcorante más utilizado en la elaboración de los alimentos. El azúcar es importante en la obtención de energía, es necesario para la síntesis de ácidos grasos, de ácidos nucleicos, evita el estrés oxidativo y el desarrollo de anemia. Puede ocasionar caries, diabetes, obesidad, arteriosclerosis y otras patologías. En el presente trabajo se valoró el efecto que tiene la ingesta crónica de agua endulzada con sacarosa al 30% sobre el consumo de alimento balanceado, el perfil lipídico, la concentración de glucosa sérica, y sobre algunos marcadores del estado nutricional como el peso y las proteínas séricas totales, en machos de ratas Wistar. El agua endulzada con sacarosa al 30% se administró a un grupo de 9 ratas Wistar durante 3 meses y se tomó como grupo control a un grupo de 9 ratas que bebieron agua natural. El consumo de alimentos por ambos grupos, así como los marcadores de química sanguínea se analizaron al final del tratamiento. Los niveles de glucosa, lípidos y proteínas séricas totales se midieron mediante espectroscopía. Los resultados mostraron que el consumo de agua endulzada con sacarosa al 30% redujo en más de un 90% el consumo de alimento balanceado; sin embargo, no afectó el perfil lipídico ni el nivel de glucosa en sangre, así como tampoco el nivel de proteínas séricas totales. El consumo de agua endulzada con sacarosa podría provocar desnutrición a largo plazo ya que ocasiona una reducción en la ingesta de alimento rico en nutrientes.

Sugar, obtained from sugarcane, is the most commonly used sweetener in food processing. Sugar is an important food for energy generation and it is necessary for the synthesis of fatty acids and nucleic acids. It prevents oxidative stress and anemia development. However, its consumption can cause dental caries, diabetes, obesity, arteriosclerosis and other pathologies. In the present work, the effect of chronic intake of water sweetened with 30% sucrose on balanced food consumption, lipid profile, serum glucose concentration, as well as some markers of nutritional status such as weight and total serum proteins was assessed in male Wistar rats. The water sweetened with 30% sucrose was administered to a group of 9 Wistar rats for 3 months, having 9 rats as a control group that drank natural water. Food consumption between both groups as well as blood chemistry markers were analyzed at the end of the treatment. Glucose, lipid levels as well as total serum proteins were measured by spectroscopy. The results showed that the consumption of water sweetened with 30% sucrose reduced the consumption of balanced food by more than 90%, however, it did not affect the lipid profile, the level of glucose in the blood or the level of total serum proteins concentration. Consumption of sucrose-sweetened water could lead to long-term malnutrition by reducing the intake of nutrient-rich food.

O açúcar comum, obtido a partir da cana de açúcar, é o adoçante mais utilizado na elaboração dos alimentos. O açúcar é importante para a geração de energia; necessário para a síntese de ácidos graxos e de ácidos nucleicos. Previne o estresse oxidativo e o desenvolvimento de anemia. No entanto, seu consumo pode causar cárie dentária, diabetes, obesidade, arteriosclerose e outras patologias. No presente trabalho, foi avaliado o efeito da ingestão crônica de água adoçada com sacarose a 30% sobre o consumo de alimentos ricos em nutrientes, perfil lipídico, concentração sérica de glicose e alguns marcadores do estado nutricional, como o peso. e as proteínas séricas totais em ratos Wistar machos. A água adoçada com sacarose a 30% foi administrada a um grupo de 9 ratos Wistar por 3 meses, tendo como grupo controle um grupo de 9 ratos que beberam água natural. O consumo de alimentos entre os dois grupos e os marcadores de química sanguínea foram analisados no final do tratamento. Os níveis de glicose, lipídios e proteínas séricas totais foram medidos por espectroscopia. Os resultados mostraram que o consumo de água adoçada com sacarose a 30% reduziu em mais de 90% o consumo de alimentos ricos em nutrientes, no entanto, não afetou o perfil lipídico, o nível de glicose em sangue nem o nível de proteínas séricas totais. O consumo de água adoçada com sacarose poderia levar à desnutrição no longo prazo, visto que produz uma redução na ingestão de alimentos ricos em nutrientes.
Descritores: Arteriosclerose
Análise Espectral
Sangue
Ácidos Nucleicos
Ingestão de Alimentos
Ratos Wistar
Sacarose na Dieta
Saccharum
Controle
Ácidos Graxos
Anemia
-Sacarose
Terapêutica
Água
Afeto
Cárie Dentária
Desnutrição
Crescimento e Desenvolvimento
Diabetes Mellitus
Açúcares
Alimentos
Manipulação de Alimentos
Limites: Humanos
Animais
Masculino
Feminino
Tipo de Publ: Relatos de Casos
Artigo Clássico
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco


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Id: biblio-1051517
Autor: Moreira, Lucas Roberto; Marcellino, Marcia Clélia Leite; Bertozzo, Thainá Valente; Angelo, Jonatas Medeiros de Almeida.
Título: Avaliação comportamental pelo teste de preferência a sacarose em camundongos suíços machos tratados com extrato de Tribulus terrestris L / Behavioral evaluation by sucrose preference test in male swan mice treated with extract of Tribulus terrestris L
Fonte: Rev. Salusvita (Online);38(3):655-664, 2019.
Idioma: pt.
Resumo: Introdução: O déficit de hormônios sexuais associa-se à depressão e, neste contexto, buscam-se plantas medicinais, como o Tribulus terrestris L. (TT). Objetivo: Investigar o efeito do declínio de testosterona, da suplementação com o propionato de testosterona e o TT no comportamento de animais. Métodos: O procedimento utilizou 40 camundongos suíços machos divididos em 4 grupos. Os grupos denominados controle e castrado receberam veículo aquoso durante o experimento. O grupo testosterona recebeu 20mg/kg do fármaco e o grupo TT recebeu 10 mg/kg do extrato das flores da planta. O comportamento foi avaliado pelo teste de preferência a sacarose. Ao fim do experimento o sangue coletado para dosagem de testosterona livre. Resultados e Discussão: O processo cirúrgico como um todo e o uso do anestésico quetamina evidenciaram suposto efeito ansiogênico. Conclusão: A alteração hormonal causada pela castração, além do estresse da cirurgia e da complexa farmacologia do anestésico, possui a capacidade de alterar o comportamento dos animais.

Introduction: Sexual hormone deficiency is associated with depression, and in this context, medicinal plants such as Tribulus terrestris L. (TT) are sought. Objective: To investigate the effect of testosterone decline, supplementation with testosterone propionate and TT on animal behavior. Methods: The procedure used 40 male Swiss mice divided into 4 groups. The groups called control and castrated received an aqueous vehicle during the experiment. The testosterone group received 20 mg / kg of the drug and the Tribulus group received 10 mg / kg of the plant extract. The behavior was evaluated by the sucrose preference test. At the end of the experiment the blood collected for free testosterone dosage. Results and Discussion: The surgical process as a whole and the use of the anesthetic ketamine evidenced an anxiogenic effect. Conclusion: The hormonal alteration caused by castration, besides the stress of surgery and the complex pharmacology of the anesthetic, has the capacity to alter the behavior of the animals.
Descritores: Ações Químicas e Utilizações
-Sacarose
Testosterona
Limites: Camundongos
Tipo de Publ: Estudo Comparativo
Responsável: BR36.1 - Biblioteca


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Id: biblio-1090766
Autor: AYOUB, Hadeel M; GREGORY, Richard L; TANG, Qing; LIPPERT, Frank.
Título: Influence of salivary conditioning and sucrose concentration on biofilm-mediated enamel demineralization
Fonte: J. appl. oral sci;28:e20190501, 2020. tab.
Idioma: en.
Resumo: Abstract The acquired pellicle formation is the first step in dental biofilm formation. It distinguishes dental biofilms from other biofilm types. Objective To explore the influence of salivary pellicle formation before biofilm formation on enamel demineralization. Methodology Saliva collection was approved by Indiana University IRB. Three donors provided wax-stimulated saliva as the microcosm bacterial inoculum source. Acquired pellicle was formed on bovine enamel samples. Two groups (0.5% and 1% sucrose-supplemented growth media) with three subgroups (surface conditioning using filtered/pasteurized saliva; filtered saliva; and deionized water (DIW)) were included (n=9/subgroup). Biofilm was then allowed to grow for 48 h using Brain Heart Infusion media supplemented with 5 g/l yeast extract, 1 mM CaCl2.2H2O, 5% vitamin K and hemin (v/v), and sucrose. Enamel samples were analyzed for Vickers surface microhardness change (VHNchange), and transverse microradiography measuring lesion depth (L) and mineral loss (∆Z). Data were analyzed using two-way ANOVA. Results The two-way interaction of sucrose concentration × surface conditioning was not significant for VHNchange (p=0.872), ∆Z (p=0.662) or L (p=0.436). Surface conditioning affected VHNchange (p=0.0079), while sucrose concentration impacted ∆Z (p<0.0001) and L (p<0.0001). Surface conditioning with filtered/pasteurized saliva resulted in the lowest VHNchange values for both sucrose concentrations. The differences between filtered/pasteurized subgroups and the two other surface conditionings were significant (filtered saliva p=0.006; DIW p=0.0075). Growing the biofilm in 1% sucrose resulted in lesions with higher ∆Z and L values when compared with 0.5% sucrose. The differences in ∆Z and L between sucrose concentration subgroups was significant, regardless of surface conditioning (both p<0.0001). Conclusion Within the study limitations, surface conditioning using human saliva does not influence biofilm-mediated enamel caries lesion formation as measured by transverse microradiography, while differences were observed using surface microhardness, indicating a complex interaction between pellicle proteins and biofilm-mediated demineralization of the enamel surface.
Descritores: Saliva/química
Sacarose/química
Desmineralização do Dente/microbiologia
Biofilmes/crescimento & desenvolvimento
Esmalte Dentário/microbiologia
-Valores de Referência
Saliva/microbiologia
Sacarose/análise
Propriedades de Superfície
Microrradiografia/métodos
Esmalte Dentário/química
Película Dentária/microbiologia
Pasteurização
Dureza
Limites: Animais
Bovinos
Responsável: BR28.1 - Serviço de Biblioteca e Documentação Professor Doutor Antônio Gabriel Atta



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