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Pesquisa : D09.947.875.359.250 [Categoria DeCS]
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Id: biblio-1026812
Autor: Sulieman, Ashraf K; Putra, Meilana Dharma; Abasaeed, Ahmed E; Gaily, Mohamed H; Al-Zahrani, Saeed M; Zeinelabdeen, Mohamed A.
Título: Kinetic modeling of the simultaneous production of ethanol and fructose by Saccharomyces cerevisiae
Fonte: Electron. j. biotechnol;34:1-8, july. 2018. tab, graf.
Idioma: en.
Resumo: Background: Ethanol and fructose are two important industrial products that enjoy many uses. In this contribution, their production via selective fermentation of date extract using Saccharomyces cerevisiae was studied. Scaling up the process for possible commercialization was investigated in three fermentors with working volume ratio of 1:40:400. Results: Higher ethanol concentration was obtained in the larger fermentor due to conversion of fructose. Fructose yields in the 0.5-L, 7.5-L and 80-L fermentors were 99, 92 and 90%, respectively. Good fitting was obtained with the modified Monod kinetics; however, a better fit of cell mass was obtained with the modified Ghose­Tyagi model which accounts for ethanol inhibition. Conclusions: The modified Gompertz model was expanded to facilitate prediction of products' formation and fructose fractions in all three fermentors. Such expansion will be beneficial in industrial applications.
Descritores: Saccharomyces cerevisiae/metabolismo
Etanol/síntese química
Frutose/biossíntese
-Leveduras
Cinética
Reatores Biológicos
Fermentação
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1253024
Autor: Canwei, Shu; Xiaoyun, Hu; Ahmed, Nauman; Shiqi, Wang; Erxun, Zhou; Meide, Liao.
Título: Fructosan form Paenibacillus kribbensis PS04 enhance disease resistance against Rhizoctonia solani and tobacco mosaic virus
Fonte: Electron. j. biotechnol;47:43-50, sept. 2020. tab, graf.
Idioma: en.
Projeto: National Key R&D Program fromthe Ministry of Science of China; . Science and Technology Plan Project of Guangzhou, China.
Resumo: BACKGROUND: Rice sheath blight (caused by Rhizoctonia solani) and tobacco mosaic virus are very important plant diseases, causing a huge loss in global crop production. Paenibacillus kribbensis PS04 is a broad-spectrum biocontrol agent, used for controlling these diseases. Previously, extracellular polysaccharides (EPS) from P. kribbensis PS04 had been purified and their structure was inferred to be fructosan. This study aimed to evaluate the effects of exogenous EPS treatment on plant­pathogen interactions. RESULTS: Plant defense genes such as phenylalanine ammonia-lyase, catalase, chitinase, allene oxide synthase, and PR1a proteins were significantly induced by exogenous EPS treatment. Moreover, subsequent challenge of EPSpretreated plants with the pathogens (R. solani or tobacco mosaic virus) resulted in higher expression of defenseassociated genes. Increased activities of defense-associated enzymes, total phenols, and flavonoids were also observed in EPS pretreated plants. The contents of malondialdehyde in plants, which act as indicator of lipid peroxidation, were reduced by EPS treatment. CONCLUSIONS: This study comprehensively showed that EPS produced from P. kribbensis PS04 enhances disease resistance in plants by the activation of defense-associated genes as well as through the enhancement of activities of defense-related enzymes.
Descritores: Doenças das Plantas/imunologia
Rhizoctonia/patogenicidade
Vírus do Mosaico do Tabaco/patogenicidade
Paenibacillus/imunologia
-Doenças das Plantas/microbiologia
Polissacarídeos Bacterianos
Controle Biológico de Vetores
Interações Hospedeiro-Patógeno
Paenibacillus/genética
Resistência à Doença/genética
Reação em Cadeia da Polimerase em Tempo Real
Frutose/análogos & derivados
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1254708
Autor: Putra, Meilana Dharma; Abasaeed, Ahmed E; Al-Zahrani, Saeed M.
Título: Prospective production of fructose and single cell protein from date palm waste
Fonte: Electron. j. biotechnol;48:46-52, nov. 2020. graf, tab.
Idioma: en.
Projeto: King Saud University.
Resumo: BACKGROUND: Fructose and single cell protein are important products for the food market. Abundant amounts of low-grade dates worldwide are annually wasted. In this study, highly concentrated fructose syrups and single cell protein were obtained through selective fermentation of date extracts by Saccharomyces cerevisiae. RESULTS: The effect of air flow (0.1, 0.5, 0.75, 1, 1.25 and 1.5 vvm) and pH (4.5, 4.8, 5, 5.3 and 5.6) was investigated. Higher air flow led to lower fructose yield. The optimum cell mass production of 10 g/L was achieved at air flow of 1.25 vvm with the fructose yield of 91%. Similar cell mass production was obtained in the range pH of 5.0­5.6, while less cell mass was obtained at pH less than 5. Controlling the pH at 4.5, 5.0 and 5.3 failed to improve the production of cell mass which were 5.6, 5.9 and 5.4 g/L respectively; however, better fructose yield was obtained. CONCLUSIONS: Extension of the modified Gompertz enabled excellent predictions of the cell mass, fructose production and fructose fraction. The proposed model was also successfully validated against data from literatures. Thus, the model will be useful for wide application of biological processes.
Descritores: Saccharomyces cerevisiae/fisiologia
Phoeniceae
Frutose/biossíntese
-Aerobiose
Conceitos Matemáticos
Fermentação
Resíduos de Alimentos
Concentração de Íons de Hidrogênio
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Uruguai
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Id: biblio-1144758
Autor: Gugliucci, Alejandro; Rodríguez-Mortera, Reyna.
Título: Fructosa, un factor clave modificable en la patogenia del síndrome metabólico, la esteatosis hepática y la obesidad / Fructose, a modifiable key factor in the pathogenic basis of metabolic syndrome, NAFLD and obesity / Frutose, um fator chave modificável na patogênese da síndrome metabólica, esteatose hepática e obesidade
Fonte: Rev. méd. Urug;36(4):204-233, dic. 2020. graf.
Idioma: es.
Resumo: Resumen: En esta revisión se resume el rol específico que el exceso de consumo de fructosa más allá de sus calorías puede tener en el desarrollo del síndrome metabólico, la esteatosis hepática no alcohólica y su asociación con la obesidad. Se desglosan los efectos de la fructosa (en comparación con la glucosa) en la esteatosis hepática, lo que genera la insulino-resistencia y la hipertrigliceridemia. Por su metabolismo hepático mayoritario y la falta de regulación, los flujos altos de fructosa consumen ATP generando ácido úrico, producen metabolitos tóxicos, como ceramidas y metilglioxal, y activan la síntesis de lípidos. Además, se analizan los efectos en el tejido adiposo, la activación del cortisol y las hormonas involucradas en el control de la saciedad, todas las cuales se ven afectadas por el consumo de fructosa. La insulino-resistencia hepática inicial se complica con insulino-resistencia sistémica, que genera leptino-resistencia y un ciclo de hiperfagia. Estos resultados subrayan la necesidad de intervenciones clínicas y educativas dentro de la población para regular o reducir el consumo de fructosa, especialmente en niños y adolescentes, sus principales consumidores.

Summary: This review summarizes the specific role that excess fructose consumption (beyond its calories) may have in the development of MetS, NAFLD and its association with obesity. The effects of fructose (compared to glucose) on hepatic steatosis are discussed as well as their consequence: insulin resistance and hypertriglyceridemia. Unlike glucose, more than 80% ingested fructose stays in the liver, and due to lack of fine metabolic regulation, high fructose flows consume ATP generating uric acid, produce toxic metabolites such as ceramides and methylglyoxal and activate lipid synthesis. In addition, the study analyzes the effects of fructose on adipose tissue, cortisol activation and hormones involved in satiety control, all of which are affected by fructose consumption. The initial hepatic insulin resistance is complicated by systemic insulin resistance, which generates leptin resistance and a hyperphagia cycle. These results underscore the need for clinical and educational interventions within the population to regulate / reduce fructose consumption, especially in children and adolescents, their main consumers.

Resumo: No momento vivemos uma pandemia causada pelo vírus SARS-CoV-2, COVID-19, sendo o mais recomendado ficar em casa para reduzir o contágio e que este seja reduzido ao mínimo possível. No século 21, a tecnologia está mais presente do que nunca e faz parte do nosso dia a dia. Tendo em vista que há significativo abuso da mesma, principalmente por adolescentes, na nossa perspectiva que promove o movimento e a redução do comportamento sedentário, propomos o uso de videogames ativos em substituição aos videogames convencionais. Para isso, fizemos uma revisão dos principais benefícios que estas podem trazer, tanto para a população mais jovem como para os idosos. Esta última faixa etária é uma das mais afetadas pela pandemia e, portanto, há uma forte recomendação para que fiquem em casa. No entanto, é recomendável usá-lo com responsabilidade e não investir tempo excessivo que possa causar danos.
Descritores: Resistência à Insulina
Síndrome Metabólica
Frutose
Responsável: UY6.1 - Biblioteca


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Texto completo SciELO Chile
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Id: biblio-950717
Autor: Gundogdu, Muttalip; Ozrenk, Koray; Ercisli, Sezai; Kan, Tuncay; Kodad, Ossama; Hegedus, Attila.
Título: Organic acids, sugars, vitamin C content and some pomological characteristics of eleven hawthorn species (Crataegus spp) from Turkey
Fonte: Biol. Res;47:1-5, 2014. tab.
Idioma: en.
Resumo: BACKGROUND: The Hawthorn (Crateagus sp.) mostly occurs around the temperate region of the world with a high number of species, producing a fruit with numerous beneficial effects for human health. The aim of the study was to determine organic acid and sugar contents in the fruit of a number of hawthorn species grown in Erzincan province of Turkey. RESULTS: Citric acid was the predominant organic acid in all hawthorn species and C. pseudoheterophylla had the highest citric acid content (23.688 g/100 g). There were not statistically significant differences among hawthorn species (except C. atrosanguinea Pojark) in terms of fumaric acid content. C. pontica C.Koch had a higher content of vitamin C (9.418 mg/100 g) compared to other species. Fructose was the predominant sugar component in all species and C. monogyna subsp. monogyna Joiq had the highest fructose content (18.378 g/100 g). CONCLUSIONS: The high fruit quality of the studied species indicates the importance of this fruit in human nutrition as a natural source. The study revealed that there were differences in terms of fruit characteristics among hawthorn species and thus better quality hawthorn genotypes can be selected within the species. Hence, this study is considered to be a valuable reference for forthcoming studies. The high fruit quality of the studied species indicates the importance of this fruit in human nutrition as a natural source.
Descritores: Ácido Ascórbico/análise
Ácido Cítrico/análise
Crataegus/química
Frutose/análise
Frutas/química
Valor Nutritivo
-Sacarose/análise
Turquia
Carboidratos da Dieta/análise
Extratos Vegetais/análise
Produtos Agrícolas/química
Ácidos Dicarboxílicos/análise
Glucose/análise
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1016141
Autor: Gutt, Susana Ruth; Venczel, Analía Verónica.
Título: Beneficios de la terapia psicológica y farmacológica en adultos con trastorno por atracón / Benefits of psychological and pharmacological therapy in adults with binge eating disorder
Fonte: Evid. actual. práct. ambul;21(3):76-77, oct. 2018. ilus..
Idioma: es.
Descritores: Transtorno da Compulsão Alimentar/terapia
-Terapia Cognitivo-Comportamental
Antidepressivos de Segunda Geração/efeitos adversos
Antidepressivos de Segunda Geração/uso terapêutico
Fármacos Antiobesidade/efeitos adversos
Fármacos Antiobesidade/uso terapêutico
Transtorno da Compulsão Alimentar/psicologia
Transtorno da Compulsão Alimentar/tratamento farmacológico
Dimesilato de Lisdexanfetamina/efeitos adversos
Dimesilato de Lisdexanfetamina/uso terapêutico
Topiramato
Frutose/análogos & derivados
Frutose/efeitos adversos
Frutose/uso terapêutico
Estimulantes do Sistema Nervoso Central/efeitos adversos
Estimulantes do Sistema Nervoso Central/uso terapêutico
Limites: Humanos
Adulto
Tipo de Publ: Comentário
Responsável: AR2.1 - Biblioteca Central


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Texto completo SciELO Chile
Texto completo
Id: biblio-950817
Autor: Hernández-Salinas, Romina; Decap, Valerie; Leguina, Alberto; Cáceres, Patricio; Perez, Druso; Urquiaga, Ines; Iturriaga, Rodrigo; Velarde, Victoria.
Título: Antioxidant and anti hyperglycemic role of wine grape powder in rats fed with a high fructose diet
Fonte: Biol. Res;48:1-9, 2015. graf, tab.
Idioma: en.
Projeto: CONICYT. Fondef; . PUC.
Resumo: BACKGROUND: Metabolic syndrome is a growing worldwide health problem. We evaluated the effects of wine grape powder (WGP), rich in antioxidants and fiber, in a rat model of metabolic syndrome induced by a high fructose diet. We tested whether WGP supplementation may prevent glucose intolerance and decrease oxidative stress in rats fed with a high fructose diet. METHODS: Male Sprague-Dawley rats weighing 180 g were divided into four groups according to their feeding protocols. Rats were fed with control diet (C), control plus 20 % WGP (C + WGP), 50 % high fructose (HF) or 50 % fructose plus 20 % WGP (HF + WGP) for 16 weeks. Blood glucose, insulin and triglycerides, weight, and arterial blood pressure were measured. Homeostasis model assessment (HOMA) index was calculated using insulin and glucose values. A glucose tolerance test was performed 2 days before the end of the experiment. As an index of oxidative stress, thio-barbituric acid reactive substances (TBARS) level was measured in plasma and kidney, and superoxide dismutase was measured in the kidney. RESULTS: Thiobarbituric acid reactive substances in plasma and renal tissue were significantly higher when compared to the control group. In addition, the area under the curve of the glucose tolerance test was higher in HF fed animals. Furthermore, fasting blood glucose, plasma insulin levels, and the HOMA index, were also increased. WGP supplementation prevented these alterations in rats fed with the HF diet. We did not find any significant difference in body weight or systolic blood pressure in any of the groups. CONCLUSIONS: Our results show that WGP supplementation prevented hyperglycemia, insulin resistance and reduced oxidative stress in rats fed with HF diet. We propose that WGP may be used as a supplement in human food as well.
Descritores: Vinho
Intolerância à Glucose/prevenção & controle
Estresse Oxidativo/efeitos dos fármacos
Vitis/química
Síndrome Metabólica/prevenção & controle
Hiperglicemia/prevenção & controle
Fitoterapia/métodos
-Pós/uso terapêutico
Superóxido Dismutase/análise
Tiobarbitúricos/análise
Triglicerídeos/análise
Glicemia/análise
Resistência à Insulina
Ratos Sprague-Dawley
Síndrome Metabólica/induzido quimicamente
Modelos Animais de Doenças
Pressão Arterial
Frutose/administração & dosagem
Teste de Tolerância a Glucose
Insulina/sangue
Rim/metabolismo
Antioxidantes/farmacologia
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
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Id: biblio-889287
Autor: Salmito, Márcio Cavalcante; Duarte, Juliana Antoniolli; Morganti, Lígia Oliveira Golçalves; Brandão, Priscila Valéria Caus; Nakao, Bruno Higa; Villa, Thais Rodrigues; Ganança, Fernando Freitas.
Título: Prophylactic treatment of vestibular migraine / Tratamento profilático da migrânea vestibular
Fonte: Braz. j. otorhinolaryngol. (Impr.);83(4):404-410, July-Aug. 2017. tab.
Idioma: en.
Resumo: Abstract Introduction: Vestibular migraine (VM) is now accepted as a common cause of episodic vertigo. Treatment of VM involves two situations: the vestibular symptom attacks and the period between attacks. For the latter, some prophylaxis methods can be used. The current recommendation is to use the same prophylactic drugs used for migraines, including β-blockers, antidepressants and anticonvulsants. The recent diagnostic definition of vestibular migraine makes the number of studies on its treatment scarce. Objective: To evaluate the efficacy of prophylactic treatment used in patients from a VM outpatient clinic. Methods: Review of medical records from patients with VM according to the criteria of the Bárány Society/International Headache Society of 2012 criteria. The drugs used in the treatment and treatment response obtained through the visual analog scale (VAS) for dizziness and headache were assessed. The pre and post-treatment VAS scores were compared (the improvement was evaluated together and individually, per drug used). Associations with clinical subgroups of patients were also assessed. Results: Of the 88 assessed records, 47 were eligible. We included patients that met the diagnostic criteria for VM and excluded those whose medical records were illegible and those of patients with other disorders causing dizziness and/or headache that did not meet the 2012 criteria for VM. 80.9% of the patients showed improvement with prophylaxis (p < 0.001). Amitriptyline, Flunarizine, Propranolol and Topiramate improved vestibular symptoms (p < 0.001) and headache (p < 0.015). The four drugs were effective in a statistically significant manner. There was a positive statistical association between the time of vestibular symptoms and clinical improvement. There was no additional benefit in hypertensive patients who used antihypertensive drugs as prophylaxis or depressed patients who used antidepressants in relation to other prophylactic drugs. Drug association did not show statistically significant results in relation to the use of a single drug. Conclusions: Prophylactic medications used to treat VM improve the symptoms of this disease, but there is no statistically significant difference between the responses of prophylactic drugs. The time of vestibular symptom seems to increase the benefit with prophylactic treatment.

Resumo Introdução: A migrânea vestibular (MV) é aceita atualmente como uma causa comum de vertigem episódica. O tratamento da MV envolve duas situações: as crises de sintomas vestibulares e o período intercrise. Para esse último, pode-se usar algum método de profilaxia. A recomendação atual é que se usem os mesmos medicamentos profiláticos usados para a enxaqueca, o que inclui os β-bloqueadores, antidepressivos e anticonvulsivantes. A recente definição diagnóstica da migrânea vestibular torna escasso o número de estudos sobre seu tratamento. Objetivo: Avaliar a eficácia do tratamento profilático usado em pacientes em um ambulatório de MV. Método: Revisão de prontuários de pacientes com MV pelos critérios da Bárány Society/International Headeache Society de 2012. Foram pesquisados os medicamentos usados e resposta ao tratamento obtida através da escala visual analógica (EVA) para tontura e cefaleia. Foram comparados os escores da EVA pré e pós-tratamento (a melhoria foi avaliada em conjunto e individualmente por droga usada). Também foram pesquisadas relações com subgrupos clínicos dos pacientes. Resultados: De 88 prontuários estudados, 47 foram elegíveis. Incluíram-se os pacientes que preenchiam os critérios diagnósticos para MV, foram excluídos os prontuários ilegíveis e aqueles de pacientes com outro distúrbio causador de tontura e/ou cefaleia que não preenchiam critérios de 2012 para MV. Apresentaram melhoria com a profilaxia 80,9% dos pacientes (p < 0,001). Amitriptilina, flunarizina, propranolol e topiramato apresentaram melhoria para sintomas vestibulares (p < 0,001) e para cefaleia (p < 0,015). Os quatro medicamentos foram eficazes de forma estatisticamente significante. Houve relação estatística positiva entre tempo de sintoma vestibular e melhoria clínica. Não houve benefício adicional para hipertensos que usaram anti-hipertensivos como profilaxia ou para os deprimidos que usaram antidepressivos em relação ao uso dos outros profiláticos. A associação de medicamentos não mostrou resultados estatisticamente significantes do uso de um medicamento isolado. Conclusões: Os medicamentos profiláticos usados para MV melhoram os sintomas dessa doença, porém não há diferença estatisticamente significante entre as respostas dos medicamentos profiláticos. O tempo de sintoma vestibular parece aumentar a melhoria obtida com o tratamento profilático.
Descritores: Propranolol/uso terapêutico
Flunarizina/uso terapêutico
Doenças Vestibulares/prevenção & controle
Frutose/análogos & derivados
Amitriptilina/uso terapêutico
Transtornos de Enxaqueca/prevenção & controle
-Estudos Retrospectivos
Estudos Longitudinais
Resultado do Tratamento
Topiramato
Frutose/uso terapêutico
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Tipo de Publ: Estudo Observacional
Responsável: BR1.1 - BIREME


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Id: biblio-1053491
Autor: Tian, Kangming; Wang, Jun; Zhang, Zhimeng; Cheng, Lei; Jin, Peng; Singh, Suren; Prior, Bernard A; Wang, Zheng-Xiang.
Título: Enzymatic preparation of fructooligosaccharides-rich burdock syrup with enhanced antioxidative properties
Fonte: Electron. j. biotechnol;40:71-77, July. 2019. tab, graf, ilus.
Idioma: en.
Projeto: Intergovernmental International Scientific and Technological Innovation Cooperation program; . Raising Program of Innovation Team for Tianjin Colleges and Universities, Tianjin, China.
Resumo: Background: Burdock (Arctium lappa L.) is a fructan-rich plant with prebiotic potential. The aim of this study was to develop an efficient enzymatic route to prepare fructooligosaccharides (FOS)-rich and highly antioxidative syrup using burdock root as a raw material. Results: Endo-inulinase significantly improved the yield of FOS 2.4-fold while tannase pretreatment further increased the yield of FOS 2.8-fold. Other enzymes, including endo-polygalacturonase, endo-glucanase and endo-xylanase, were able to increase the yield of total soluble sugar by 11.1% (w/w). By this process, a new enzymatic process for burdock syrup was developed and the yield of burdock syrup increased by 25% (w/w), whereas with FOS, total soluble sugars, total soluble protein and total soluble polyphenols were enhanced to 28.8%, 53.3%, 8.9% and 3.3% (w/w), respectively. Additionally, the scavenging abilities of DPPH and hydroxyl radicals, and total antioxidant capacity of the syrup were increased by 23.7%, 51.8% and 35.4%, respectively. Conclusions: Our results could be applied to the development of efficient extraction of valuable products from agricultural materials using enzyme-mediated methods.
Descritores: Oligossacarídeos/química
Raízes de Plantas/química
Frutose/química
Glicosídeo Hidrolases/metabolismo
Antioxidantes/química
-Oligossacarídeos/metabolismo
Poligalacturonase/metabolismo
Hidrolases de Éster Carboxílico/metabolismo
Cromatografia Líquida de Alta Pressão
Radical Hidroxila
Arctium
Alimento Funcional
Polifenóis
Frutose/metabolismo
Antioxidantes/metabolismo
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
Zajdenverg, Lenita
Texto completo
Registro de Ensaios Clínicos
Id: biblio-1019349
Autor: Souto, Débora Lopes; Lima, Érika dos Santos; Dantas, Joana Rodrigues; Zajdenverg, Lenita; Rodacki, Melanie; Rosado, Eliane Lopes.
Título: Postprandial metabolic effects of fructose and glucose in type 1 diabetes patients: a pilot randomized crossover clinical trial
Fonte: Arch. endocrinol. metab. (Online);63(4):376-384, July-Aug. 2019. tab.
Idioma: en.
Reg. de E.C: https://clinicaltrials.gov/ct2/show/NCT01713023
Resumo: ABSTRACT Objective To test the influence of oral fructose and glucose dose-response solutions in blood glucose (BG), glucagon, triglycerides, uricaemia, and malondialdehyde in postprandial states in type 1 diabetes mellitus (T1DM) patients. Subjects and methods The study had a simple-blind, randomized, two-way crossover design in which T1DM patients were selected to receive fructose and glucose solutions (75g of sugars dissolved in 200 mL of mineral-water) in two separate study days, with 2-7 weeks washout period. In each day, blood samples were drawn after 8h fasting and at 180 min postprandial to obtain glucose, glucagon, triglycerides, uric acid, lactate, and malondialdehyde levels. Results Sixteen T1DM patients (seven men) were evaluated, with a mean age of 25.19 ± 8.8 years, a mean duration of disease of 14.88 ± 4.73 years, and glycated hemoglobin of 8.13 ± 1.84%. Fructose resulted in lower postprandial BG levels than glucose (4.4 ± 5.5 mmol/L; and 12.9 ± 4.1 mmol/L, respectively; p < 0.01). Uric acid levels increased after fructose (26.1 ± 49.9 µmol/L; p < 0.01) and reduced after glucose (-13.6 ± 9.5 µmol/L; p < 0.01). The malondialdehyde increased after fructose (1.4 ± 1.6 µmol/L; p < 0.01) and did not change after glucose solution (-0.2 ± 1.6 µmol/L; p = 0.40). Other variables did not change. Conclusions Fructose and glucose had similar sweetness, flavor and aftertaste characteristics and did not change triglycerides, lactate or glucagon levels. Although fructose resulted in lower postprandial BG than glucose, it increased uric acid and malondialdehyde levels in T1DM patients. Therefore it should be used with caution. ClinicalTrials.gov registration: NCT01713023.
Descritores: Edulcorantes/metabolismo
Período Pós-Prandial/efeitos dos fármacos
Diabetes Mellitus Tipo 1/metabolismo
Frutose/metabolismo
Glucose/metabolismo
-Triglicerídeos/sangue
Glicemia/análise
Glicemia/efeitos dos fármacos
Estudos Cross-Over
Relação Dose-Resposta a Droga
Tolerância a Medicamentos
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde