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Id: biblio-898606
Autor: Beraldo, Rebeca Antunes; Santos, André Pereira dos; Guimarães, Mariana Palma; Vassimon, Helena Siqueira; Paula, Francisco José Albuquerque de; Machado, Dalmo Roberto Lopes; Foss-Freitas, Maria Cristina; Navarro, Anderson Marliere.
Título: Redistribuição de gordura corporal e alterações no metabolismo de lipídeos e glicose em pessoas vivendo com HIV/AIDS / Body fat redistribution and changes in lipid and glucose metabolism in people living with HIV/AIDS
Fonte: Rev. bras. epidemiol;20(3):526-536, Jul.-Set. 2017. tab.
Idioma: pt.
Resumo: RESUMO: Introdução: A síndrome da lipodistrofia do HIV é caracterizada por alterações no metabolismo e na composição corporal, que aumentam o risco cardiovascular de pessoas vivendo com HIV/AIDS (PVHA) em uso da terapia antirretroviral de alta potência (TARV). Objetivo: Avaliar a prevalência de lipodistrofia e de alterações do metabolismo de lipídios e glicose em PVHA em uso da TARV. Métodos: Para avaliação antropométrica foram aferidos peso, estatura e circunferência abdominal (CA). Para avaliação da lipodistrofia foi realizado o exame físico (subjetivo) e o exame (objetivo) de absortometria com raios X de dupla energia (DEXA) por meio da razão de massa gorda (RMG). Foram também realizados exames de lipidograma e glicemia de jejum e utilizados os critérios sugeridos pelo The National Cholesterol Education Program III para classificação de alterações metabólicas. Resultados: A amostra final consistiu em 262 pacientes com idade média de 44,3 ± 10,2 anos. A lipodistrofia, de acordo com o exame físico, esteve presente em 47,7% (IC95% 41,7 - 53,8) dos pacientes, enquanto pela RMG (DEXA) sua prevalência foi de 40,8% (IC95% 33,1 - 48,5). A maioria (53,0%; IC95% 47,0 - 59,1) dos pacientes apresentou aumento de adiposidade abdominal segundo a CA. As alterações metabólicas mais presentes foram o HDL reduzido (67,6%; IC95% 61,9 - 73,2) e a hipertrigliceridemia (55,7%; IC95% 49,7 - 61,7). Conclusões: A alta prevalência de lipodistrofia e alterações do metabolismo de lipídios e glicose evidenciam a importância da intervenção precoce nesse grupo de pacientes para prevenir complicações cardiovasculares.

ABSTRACT: Introduction: The HIV lipodystrophy syndrome is characterized by changes in metabolism, and body composition that increase cardiovascular risk of people living with HIV/AIDS (PLWHA) using highly active antiretroviral therapy (HAART). Objective: To assess the prevalence of lipodystrophy and changes in lipid and glucose metabolism in PLWHA in use of HAART. Methods: For the anthropometric evaluation we measured weight, height and abdominal circumference (AC). For the lipodystrophy evaluation we conducted physical examination (subjective) and the (objective) examination of absorptiometry with X-ray dual energy (DEXA) by fat mass ratio (FMR). We also conducted lipid profile tests and fasting glucose and used the criteria suggested by The National Cholesterol Education Program III for metabolic disorders classification. Results: The final sample consisted of 262 patients with a mean age of 44.3 ± 10.2 years. Lipodystrophy, according to the physical examination, was present in 47.7% (95%CI 41.7 - 53.8) of patients, while the prevalence using FMR (DEXA) was 40.8% (95%CI 33.1 - 48.5). Most (53.0%; 95%CI 47.0 - 59.1) of the patients showed increased abdominal adiposity according to AC. The most prevalent metabolic alterations were reduced HDL (67.6%; 95%CI 61.9 - 73.2) and hypertriglyceridemia (55.7%; 95%CI 49.7 - 61.7). Conclusion: The high prevalence of lipodystrophy and changes in lipid and glucose metabolism show the importance of early intervention in this group of patients to prevent cardiovascular complications.
Descritores: Infecções por HIV/metabolismo
Infecções por HIV/tratamento farmacológico
Tecido Adiposo
Terapia Antirretroviral de Alta Atividade
Metabolismo dos Lipídeos
Glucose/metabolismo
Lipodistrofia/epidemiologia
-Infecções por HIV/complicações
Prevalência
Estudos Transversais
Síndrome de Imunodeficiência Adquirida/metabolismo
Lipodistrofia/etiologia
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-838419
Autor: Batista, Gisele Almeida; Souza, Aglécio Luiz de; Marin, Daniela Miguel; Sider, Marina; Melhado, Vaneska Carvalho; Fernandes, Arlete Maria; Alegre, Sarah Monte.
Título: Body composition, resting energy expenditure and inflammatory markers: impact in users of depot medroxyprogesterone acetate after 12 months follow-up
Fonte: Arch. endocrinol. metab. (Online);61(1):70-75, Jan.-Feb. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective The aim of this study was to evaluate for 12 months the changes of body weight using Depot Medroxyprogesterone Acetate (DMPA) and if these changes are related to inflammatory markers. Subjects and methods Twenty women of childbearing age who chose the DMPA, without previous use of this method, BMI < 30 kg/m2, and 17 women using IUD TCu 380A, participated in the study. At the baseline and after one year, changes in weight gain, body composition by the bioimpedance electric method, resting energy expenditure (REE) by the indirect calorimetry method, inflammatory markers and HOMA-IR were assessed. Results After 12 months of evaluation, we could observe a significant increase in the DMPA group in weight (3,01 kg) and BMI, while the IUD group’s only significant increase was observed in the BMI. Relative to REE there was an increase of basal metabolic rate (BMR) in both groups after one year. The sub-group DMPA that gained < 3 kg had increased significant weight, BMI and body surface (BS) with respiratory quotient (RQ) reduction, while the sub-group that gained ≥ 3 kg had a significant increase in weight, BMI, BS, fat-free mass, fat mass, BMR, Leptin, HOMA-IR and waist circumference, with RQ significantly reduced. Conclusion Our study found significant changes in weight, body composition and metabolic profile of the population studied in the first 12 months of contraceptive use. These changes mainly increased body weight, leptin levels and HOMA-IR which can contribute to the development of some chronic complications, including obesity, insulin resistance and diabetes mellitus.
Descritores: Composição Corporal/efeitos dos fármacos
Biomarcadores/sangue
Ganho de Peso/efeitos dos fármacos
Acetato de Medroxiprogesterona/farmacologia
Metabolismo Energético/efeitos dos fármacos
-Metabolismo Basal/efeitos dos fármacos
Calorimetria Indireta
Índice de Massa Corporal
Seguimentos
Interleucina-6/sangue
Fator de Necrose Tumoral alfa/sangue
Leptina/sangue
Adiponectina/sangue
Nicotinamida Fosforribosiltransferase/sangue
Glucose/análise
Insulina/sangue
Limites: Humanos
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-887618
Autor: Frankenberg, Anize Delfino von; Reis, André F; Gerchman, Fernando.
Título: Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes: a literature review
Fonte: Arch. endocrinol. metab. (Online);61(6):614-622, Dec. 2017. graf.
Idioma: en.
Projeto: Fapergs; . FIPE-HCPA; . CNPq.
Resumo: ABSTRACT Elevated hepatic glucose production, impaired insulin secretion, and insulin resistance - abnormalities of glucose metabolism typically found in subjects with obesity - are major factors underlying the pathogenesis of type 2 diabetes (DM2) and the metabolic syndrome (MS). Adiponectin is a major regulator of glucose and lipid homeostasis via its insulin-sensitizing properties, and lower levels seems to be associated with the development of DM2 and MS. The purpose of this review is to clarify the mechanisms whereby adiponectin relates to the development of DM2 and MS and the association between polymorphisms of the adiponectin gene, circulating levels of the hormone, and its relationships with DM2. In addition, the impact of dietary lipids in the circulating levels of adiponectin will be addressed. According to the literature, circulating adiponectin levels seem to decrease as the number of MS components increases. Lower adiponectin concentrations are associated with higher intra-abdominal fat content. Therefore, adiponectin could link intra-abdominal fat with insulin resistance and development of MS. Therapeutic strategies that target the MS and its components, such as lifestyle modification through physical activity and weight loss, have been shown to increase adiponectin concentrations. Possible roles of diets containing either low or high amounts of fat, or different types of fat, have been analyzed in several studies, with heterogeneous results. Supplementation with n-3 PUFA modestly increases adiponectin levels, whereas conjugated linoleic acid supplementation appears to reduce concentrations when compared with unsaturated fatty acid supplementation used as an active placebo.
Descritores: Síndrome Metabólica/etiologia
Diabetes Mellitus Tipo 2/etiologia
Adiponectina/metabolismo
Glucose/metabolismo
-Síndrome Metabólica/metabolismo
Diabetes Mellitus Tipo 2/metabolismo
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-950066
Autor: Magno, Fernanda Cristina Carvalho Mattos; Sousa, Priscila Alves Medeiros de; Rodrigues, Marcelo Paiva; Pereira, Lícia Lopes Pio; Oliveira, José Egídio Paulo de; Rosado, Eliane Lopes; Carneiro, João Régis Ivar.
Título: Long term maintenance of glucose and lipid concentrations after Roux-en-Y gastric bypass
Fonte: Arch. endocrinol. metab. (Online);62(3):346-351, May-June 2018. tab, graf.
Idioma: en.
Resumo: Abstract Objective: Roux-en-Y gastric bypass (RYGB) reduces body weight and the comorbidities associated with obesity. The aim of this study was to evaluate whether glucose and lipid profiles were maintained during a 5-year follow-up period after RYGB. Subjects and methods: Anthropometric and laboratory data from 323 patients who had undergone this operation were analyzed. Differences in laboratory variables between the baseline and 12, 24, 36, 48 and 60 months postoperatively (PO) were assessed using a one-way ANOVA test to compare the three groups. Delta significance using one-way ANOVA was performed to assess anthropometric variable in the postoperative period (p < 0.05). Results: 77 patients (24%) were included in Group 1 (G1), 101 (32%) in Group 2 (G2), and 141 (44%) in Group 3 (G3). The majority of patients, 71.7% in G1, 82.8% in G2, and 70% in G3, showed high triglycerides (TG) before surgery. A decrease in weight loss was observed in all groups followed by an increase in body weight in G2 and G3 at 36, 48 and 60 months. Laboratory results for G1, G2 and G3 showed no significant differences between groups at baseline and during the post-operative period. Conclusion: Our results suggest that weight regain after RYGB has no significant impact on the long-term evolution of the lipid profile and glycemia.
Descritores: Obesidade Mórbida/cirurgia
Glucose/análise
Lipídeos/sangue
-Obesidade Mórbida/sangue
Derivação Gástrica
Estudos Retrospectivos
Seguimentos
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: lil-457891
Autor: Alcaraz, Gloria Margarita.
Título: Solución de rehidratación oral preparada con harina de plátano. Estudio bioquímico / Oral rehydration solution prepared with plantain flour. Biochemical study
Fonte: Invest. educ. enferm;12(1):38-49, mar. 1994. tab.
Idioma: es.
Resumo: Se pretende mediante el método bioquímico estudiar una solución de rehidratación oral segura para prevenir la deshidratación o para tratarla en caso de deshidratación leve o moderada. Se seleccionó la harina de plátano por ser está la base de la alimentación para la población indígena emberá y de la población general del Choco biogeográfico. El estudio se realizó en condición de ciego y los resultados fueron en promedio por 100g de harina de plátano; glucosa 83,32g; 24g aportarían 20g de glucosa; sodio 0,05mg; potasio 1,00mg; cloruro 0,13mg. El análisis cualitativo de aminoácidos muestra que el 45,45 por ciento son neutros. La osmolaridad de la solución estandarizada: 110ml de agua, 3,5g de cloruro de sodio y 24g de harina de plátano, fue de 134mOsm/l. Esta solución ofrece desde el punto de vista bioquímico, una alternativa de suero preparada en el hogar con recursos propios de la comunidad. Es eficaz para prevenir la deshidratación o para tratar la deshidratación leve o moderada, en el caso de las comunidades geográficamente inaccesibles, a las cuales llegan difícilmente las SRO estándar.
Descritores: Potássio
Sódio
Farinha
Glucose
Concentração Osmolar
Grupos Étnicos
Responsável: CO103.1 - Biblioteca


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Id: biblio-908201
Autor: Melo, Gleicia Martins de; Cardoso, Maria Vera Lúcia Moreira Leitão.
Título: Dor em recém-nascidos pré-termo submetidos à intervenção música e glicose 25 / Pain in preterm newborns submitted to music and 25 glucose intervention
Fonte: Rev. RENE;18(1):3-10, jan-fev. 2017. ilus, tab.
Idioma: en; pt.
Resumo: Comparar resposta de dor de recém-nascidos pré-termo submetidos à punção arterial que receberam intervenção musical com os que receberam intervenção de glicose 25%. Métodos: ensaio clínico randomizado,duplo cego, amostra de 48 vídeos de prematuros dos grupos, Experimental (música, n=26), ouviu música por 10 minutos e; Controle (glicose 25%, n=22), recebeu glicose 25% dois minutos antes da punção. A dorfoi avaliada pela Neonatal Facial Coding System nos momentos: Basal, Tratamento, Doloroso, Recuperação1 e Recuperação 2. Resultados: houve semelhanças entre grupos nos momentos Basal, Recuperação 1 e 2.Constatou-se diferença estatisticamente significante no momento Tratamento (p=0,014), Doloroso (p=0,029)para grupo Controle. Conclusão: glicose 25% diferiu da música ao se comparar a resposta de dor nos momentos Tratamento e Doloroso. Registro Brasileiro de Ensaio Clínico: UTN: U1111-1123-4821.

Objective: to compare the pain response of preterm newborns submitted to arterial puncture who receivedmusical intervention with those who received 25% glucose intervention. Methods: randomized, double-blindclinical trial; the sample consisted of 48 videos of preterm infants of the experimental group (music, n= 6),who listened to music for 10 minutes, and the control group (25% glucose, n=22), who received 25% glucosetwo minutes before puncture. The pain was evaluated by the Neonatal Facial Coding System at moments:Baseline, Treatment, Painful, Recovery 1 and Recovery 2. Results: there were similarities between groups atthe moments Baseline, Recovery 1 and 2. A statistically significant difference was observed at the momentTreatment (p=0.014), Painful (p=0.029) for the control group. Conclusion: 25% glucose differed from musicwhen comparing the pain response in the Treatment and Painful moments. Brazilian Registry of Clinical Trials:UTN: U1111-1123-4821.
Descritores: Glucose
Recém-Nascido
Terapia Intensiva Neonatal
Música
Enfermagem Neonatal
Dor
Limites: Humanos
Recém-Nascido
Responsável: BR6.1 - BCS - Biblioteca de Ciências da Saúde


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Zajdenverg, Lenita
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Registro de Ensaios Clínicos
Id: biblio-1019349
Autor: Souto, Débora Lopes; Lima, Érika dos Santos; Dantas, Joana Rodrigues; Zajdenverg, Lenita; Rodacki, Melanie; Rosado, Eliane Lopes.
Título: Postprandial metabolic effects of fructose and glucose in type 1 diabetes patients: a pilot randomized crossover clinical trial
Fonte: Arch. endocrinol. metab. (Online);63(4):376-384, July-Aug. 2019. tab.
Idioma: en.
Reg. de E.C: https://clinicaltrials.gov/ct2/show/NCT01713023
Resumo: ABSTRACT Objective To test the influence of oral fructose and glucose dose-response solutions in blood glucose (BG), glucagon, triglycerides, uricaemia, and malondialdehyde in postprandial states in type 1 diabetes mellitus (T1DM) patients. Subjects and methods The study had a simple-blind, randomized, two-way crossover design in which T1DM patients were selected to receive fructose and glucose solutions (75g of sugars dissolved in 200 mL of mineral-water) in two separate study days, with 2-7 weeks washout period. In each day, blood samples were drawn after 8h fasting and at 180 min postprandial to obtain glucose, glucagon, triglycerides, uric acid, lactate, and malondialdehyde levels. Results Sixteen T1DM patients (seven men) were evaluated, with a mean age of 25.19 ± 8.8 years, a mean duration of disease of 14.88 ± 4.73 years, and glycated hemoglobin of 8.13 ± 1.84%. Fructose resulted in lower postprandial BG levels than glucose (4.4 ± 5.5 mmol/L; and 12.9 ± 4.1 mmol/L, respectively; p < 0.01). Uric acid levels increased after fructose (26.1 ± 49.9 µmol/L; p < 0.01) and reduced after glucose (-13.6 ± 9.5 µmol/L; p < 0.01). The malondialdehyde increased after fructose (1.4 ± 1.6 µmol/L; p < 0.01) and did not change after glucose solution (-0.2 ± 1.6 µmol/L; p = 0.40). Other variables did not change. Conclusions Fructose and glucose had similar sweetness, flavor and aftertaste characteristics and did not change triglycerides, lactate or glucagon levels. Although fructose resulted in lower postprandial BG than glucose, it increased uric acid and malondialdehyde levels in T1DM patients. Therefore it should be used with caution. ClinicalTrials.gov registration: NCT01713023.
Descritores: Edulcorantes/metabolismo
Período Pós-Prandial/efeitos dos fármacos
Diabetes Mellitus Tipo 1/metabolismo
Frutose/metabolismo
Glucose/metabolismo
-Triglicerídeos/sangue
Glicemia/análise
Glicemia/efeitos dos fármacos
Estudos Cross-Over
Relação Dose-Resposta a Droga
Tolerância a Medicamentos
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: biblio-1055018
Autor: Garmes, Heraldo Mendes; Castillo, Alejandro Rosell.
Título: Insulin signaling in the whole spectrum of GH deficiency
Fonte: Arch. endocrinol. metab. (Online);63(6):582-591, Nov.-Dec. 2019. tab.
Idioma: en.
Resumo: ABSTRACT GH is one of the insulin counterregulatory hormones which acts in the opposite way to insulin, increasing the glucose production by the liver and kidneys and decreasing glucose uptake from peripheral tissues, thus being a hyperglycemic hormone. When in excess, as in acromegaly, it induces glucose intolerance and diabetes. As expected, patients with GH deficiency (GHD) have hypoglycemia, especially in early childhood, but as GH is also a lipolytic hormone, these patients are becoming obese with higher percentages of body fat. Although obesity in general is directly related to insulin resistance, in patients with GH secretion disorders this relationship may be altered. In acromegaly there is a decrease in fat mass with worsening insulin sensitivity and mice with isolated GHD are characterized by greater insulin sensitivity despite excess fat mass. In humans with GHD, body composition shows increased body fat and decreased free fat mass, but the results regarding insulin sensitivity are still controversial in these patients. These discrepant results regarding insulin sensitivity in patients with GHD suggest the existence of other variables influencing these results. In the present review, we will try to follow the path of the different researches conducted on this subject, both in animal and human models, with the goal of understanding the current knowledge of insulin sensitivity across the spectrum of GHD. Arch Endocrinol Metab. 2019;63(6):582-91
Descritores: Resistência à Insulina/fisiologia
Transdução de Sinais/fisiologia
Hormônio do Crescimento Humano/deficiência
Hormônio do Crescimento Humano/fisiologia
Glucose/fisiologia
-Glucose/metabolismo
Limites: Humanos
Animais
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-1088773
Autor: Cardoso, Nathália Sigilló; Ribeiro, Victor Barbosa; Dutra, Sabrina Graziani Veloso; Ferriani, Rui Alberto; Gastaldi, Ada Clarice; Araújo, João Eduardo de; Souza, Hugo Celso Dutra de.
Título: Polycystic ovary syndrome associated with increased adiposity interferes with serum levels of TNF-alpha and IL-6 differently from leptin and adiponectin
Fonte: Arch. endocrinol. metab. (Online);64(1):4-10, Jan.-Feb. 2020. tab.
Idioma: en.
Projeto: Fapesp.
Resumo: ABSTRACT Objective The aim of this study was to investigate polycystic ovary syndrome (PCOS) and to explore the relationship between body fat percentage and metabolic markers. Subjects and methods Sedentary women were assigned to PCOS (N = 60) and CONTROL (N = 60) groups. Each group was subdivided into three subgroups according to body fat percentage (22-27%, 27-32% and 32-37%). The protocol consisted of assessments of glucose, insulin, androgens, follicle stimulating hormone (FSH), luteinizing hormone (LH), 17-hydroxyprogesterone (17-OHP), leptin, adiponectin, tumor necrosis factor (TNF-α) and interleukin-6 (IL-6). Results The PCOS subgroups showed higher concentrations of androgens, LH and 17-OHP. Leptin showed direct relationship with increased body fat percentage, whereas adiponectin showed the inverse effect. However, both were unaffected by PCOS. TNF-α and IL-6 were higher in PCOS women and showed a direct relationship with increased body fat percentage. Glucose showed direct relationship with body fat percentage, whereas insulin presented higher values in PCOS women and direct relationship with increased body fat percentage. Conclusions Our findings indicate that PCOS and body fat percentage directly influence concentrations of insulin, TNF-α and IL-6, whereas leptin and adiponectin are influenced only by the increase in body fat percentage in these women. Arch Endocrinol Metab. 2020;64(1):4-10
Descritores: Biomarcadores/sangue
Tecido Adiposo/anatomia & histologia
Doenças Metabólicas/sangue
-Resistência à Insulina
Hormônio Luteinizante/sangue
Índice de Massa Corporal
Estudos de Casos e Controles
Interleucina-6/sangue
Fator de Necrose Tumoral alfa/sangue
17-alfa-Hidroxiprogesterona/sangue
Leptina/sangue
Adiponectina/sangue
Hormônio Foliculoestimulante/sangue
Glucose/análise
Androgênios/sangue
Insulina/sangue
Limites: Humanos
Feminino
Adolescente
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-886648
Autor: FOGLIARINI, CARINE O; GARLET, QUELEN I; PARODI, THAYLISE V; BECKER, ALEXSSANDRO G; GARCIA, LUCIANO O; HEINZMANN, BERTA M; PEREIRA, ANA MARIA S; BALDISSEROTTO, BERNARDO.
Título: Anesthesia of Epinephelus marginatus with essential oil of Aloysia polystachya: an approach on blood parameters
Fonte: An. acad. bras. ciênc;89(1,supl):445-456, May. 2017. tab, graf.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul/Programa de Apoio a Núcleos de Excelência; . Conselho Nacional de Desenvolvimento Científico e Tecnológico.
Resumo: ABSTRACT This study investigated the anesthetic potential of the essential oil (EO) of Aloysia polystachya in juveniles of dusky grouper (Epinephelus marginatus). Fish were exposed to different concentrations of EO of A. polystachya to evaluate time of induction and recovery from anesthesia. In the second experiment, fish were divided into four groups: control, ethanol and 50 or 300 µL L−1 EO of A. polystachya, and each group was submitted to induction for 3.5 min and recovery for 5 or 10 min. The blood gases and glucose levels showed alterations as a function of the recovery times, but Na+ and K+ levels did not show any alteration. In conclusion, the EO from leaves of A. polystachya is an effective anesthetic for dusky grouper, because anesthesia was reached within the recommended time at EO concentrations of 300 and 400 µL L−1. However, most evaluated blood parameters showed compensatory responses due to EO exposure.
Descritores: Peixes-Gato/sangue
Óleos Vegetais/farmacologia
Óleos Voláteis/farmacologia
Biomarcadores/sangue
Verbenaceae/química
Anestésicos/farmacologia
-Bicarbonatos/sangue
Hemoglobinas/análise
Folhas de Planta/química
Gases/sangue
Glucose/análise
Hematócrito
Concentração de Íons de Hidrogênio
Metais Alcalinos/sangue
Limites: Animais
Responsável: BR1.1 - BIREME



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