Base de dados : LILACS
Pesquisa : D10.251 [Categoria DeCS]
Referências encontradas : 711 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 72 ir para página                         

  1 / 711 LILACS  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-1055394
Autor: Postgraduate Program in Health and Development in the Midwestern RegionAydos, Leonardo Recena; Postgraduate Program in Health and Development in the Midwestern RegionAmaral, Luane Aparecida do; Souza, Gabriel Henrique Oliveira de; Postgraduate Program in ChemistryCavalheiro, Leandro Fontoura; Vargas, Márcio Olívio Figueiredo; Postgraduate Program in Pharmaceutical SciencesRafacho, Bruna Paola Murino; Postgraduate Program in ChemistryNazário, Carlos Eduardo Domingues; Program in Health and Development in the Midwestern RegionOliveira, Rodrigo Juliano; Postgraduate Program in Health and Development in the Midwestern RegionMacedo, Maria Ligia Rodrigues; Postgraduate Program in Health and Development in the Midwestern RegionSantos, Elisvânia Freitas dos.
Título: Tucum-do-Pantanal (Bactris setosa Mart): Physicochemical Characterization of Almonds, Press Cake and Crude Oil
Fonte: Braz. arch. biol. technol;62:e19180420, 2019. tab, graf.
Idioma: en.
Projeto: CAPES.
Resumo: Abstract Brazil has high diversity of native fruits with high nutritional and biochemical value. Bactris setosa Mart. (tucum-do-Pantanal) stands out by its oil-rich almond. This study aimed to determine the physicochemical characteristics of tucum-do-Pantanal almond and its by-products: press cake and crude oil. The almond of tucum-do-Pantanal had total weight of 0.81g, lager diameter 10.87mm, small diameter 8.21mm, height 12.50, weight of almond 0.38g, weight of endocarp 0.25g. In relation to the chemical analysis, the cake had higher ash, protein and carbohydrate contents than the almond. On the other hand, the content of moisture, lipids and calories were higher in the almond. The press cake showed 636.80 g kg-1 of total fiber. The fatty acids that predominated in tucum-do-Pantanal oil were lauric (58.48), myristic (12.59) and oleic (10.15%) acids. The oil of tucum-do-Pantanal had an acid index of 3.01 KOH / g, peroxide index of 4.84 meq / kg, saponification index of 140.91 mg KOH / oil g, iodine index of 3.72 gI2 / 100 g, refractive index of 1.46, density of 0.92 g / mL, water content of 493.11 ppm and oxidation stability of 32.01 h. The results suggest that tucum-do-Pantanal almond as an important source of oil, calories and fibers, with potential use in the food industry.
Descritores: Arecaceae/química
Ácidos Graxos/análise
-Brasil
Análise de Alimentos/instrumentação
Responsável: BR1.1 - BIREME


  2 / 711 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: biblio-1022822
Autor: Salas-Navarrete, Caheri; Hernández-Chávez, Georgina; Flores, Noemí; Martínez, Luz María; Martinez, Alfredo; Bolívar, Francisco; Barona-Gomez, Francisco; Gosset, Guillermo.
Título: Increasing pinosylvin production in Escherichia coli by reducing the expression level of the gene fabI-encoded enoyl-acyl carrier protein reductase
Fonte: Electron. j. biotechnol;33:11-16, May. 2018. ilus, tab, graf.
Idioma: en.
Projeto: Consejo Nacional de Ciencia y Tecnología, México.
Resumo: Background: The plant secondary metabolite pinosylvin is a polyphenol from the stilbene family, which have positive effects on human health. Biotechnological production is an attractive alternative for obtaining this stilbene. In Escherichia coli, malonyl-CoA is the precursor for both stilbene and fatty acid syntheses. In this study, with the aim of increasing pinosylvin production, we evaluated a novel approach that is based on reducing the expression of the gene fabI, which encodes the enzyme enoyl-acyl carrier protein reductase that is involved in fatty acid synthesis. Results: A recombineering method was employed to eliminate the chromosomal -35 promoter sequence and the upstream region of the gene fabI in E. coli strain W3110. Analysis, employing RT-qPCR, showed that such modification caused a 60% reduction in the fabI transcript level in the mutant strain W3110Δ-35fabI::Cm compared to the wild type W3110. Synthetic genes encoding a mutant version of 4-coumaroyl-CoA ligase from Streptomyces coelicolor A3 with improved catalytic activity employing cinnamic acid as substrate and a stilbene synthase from Vitis vinifera were cloned to generate the plasmid pTrc-Sc4CL(M)-VvSTS. The production performance of strains W3110Δ-35fabI::Cm/pTrc-Sc4CL(M)-VvSTS and W3110/pTrc-Sc4CL(M)- VvSTS was determined in shake flask cultures with Luria-Bertani medium supplemented with 10 g/L glycerol and 3 mM cinnamic acid. Under these conditions, the strain W3110Δ-35fabI::Cm/pTrc-Sc4CL(M)-VvSTS produced 52.67 mg/L pinosylvin, a level 1.5-fold higher than that observed with W3110/pTrc-Sc4CL(M)-VvSTS. Conclusion: A reduction in the transcript level of fabI caused by the elimination of the -35 and upstream promoter sequences is a successful strategy to improve pinosylvin production in E. coli.
Descritores: Estilbenos/metabolismo
Escherichia coli/metabolismo
Enoil-(Proteína de Transporte de Acila) Redutase (NADH)/genética
-Produtos Biológicos
Coenzima A Ligases
Ácidos Graxos
Engenharia Metabólica
Responsável: CL1.1 - Biblioteca Central


  3 / 711 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Chile
Zambiazi, Rui Carlos
Texto completo
Id: biblio-1138590
Autor: Castro, Larissa Sá Britto; Oliveira Pacheco, Denise; Radünz, Marjana; Helbig, Elizabete; Arocha Gularte, Márcia; Zambiazi, Rui Carlos; Lameiro Rodrigues, Kelly; Valente Gandra, Tatiane Kuka; Avila Gandra, Eliezer.
Título: Physicochemical characterization and microbiological analysis of Oligosarcus robustus raw fish meat and development a fish hamburger / Caracterización físico-química y análisis microbiológico de la carne cruda de pescado Oligosarcus robustus y desarrollo de una hamburguesa de pescado
Fonte: Rev. chil. nutr;47(4):561-567, ago. 2020. tab.
Idioma: en.
Resumo: ABSTRACT This study aimed to evaluate the microbiological, physicochemical and fatty acid profile of the of "Tambica" (Oligosarcus robustus) raw fish meat and develop and characterize a fish burger. The fish burger was subjected to a sensory analysis. The raw fish meat showed a high content of moisture (82.3%) and minerals (3.1%), a low content of fat (1.5%) and a considerable protein content (13.1%). The raw fish showed a high count of positive coagulase Staphylococcus. Tambica lipid fraction was composed of 41.9% unsaturated and 58.2% saturated fatty acids. Palmitic acid and oleic acid were the major fatty acids in the raw meat fish. The fish burger was well accepted by sensory analysis.

RESUMEN Este estudio tuvo como objetivo evaluar el perfil microbiológico, fisicoquímico y de ácidos grasos de la carne de pescado cruda "Tambica" (Oligosarcus robustus); y desarrollar y caracterizar una hamburguesa de pescado. La hamburguesa de pescado fue sometida a análisis sensorial. La carne de pescado cruda mostró un alto contenido de humedad (82,3%) y minerales (3,1%), bajo contenido de grasa (1,5%) y un contenido de proteína considerable (13,1%). El pescado crudo mostró un recuento alto de Staphylococcus coagulasa positivo. La fracción lipídica de Tambica estaba compuesta por un 41,9% de ácidos grasos insaturados y 58,2% de ácidos grasos saturados. El ácido palmítico y el ácido oleico fueron los principales ácidos grasos en el pescado de carne cruda. La hamburguesa de pescado fue bien aceptada por el análisis sensorial.
Descritores: Ácidos Graxos
Proteínas de Carne
Carne
-Staphylococcus
Técnicas Microbiológicas
Produtos Pesqueiros
Limites: Animais
Tipo de Publ: Artigo Clássico
Responsável: CL334.1 - Biblioteca UBO


  4 / 711 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Chile
Texto completo
Id: biblio-1138591
Autor: Gómez Ramírez, Briana Davahiva; Sepúlveda Valencia, José Uriel; Alzate Arbelaez, Andrés Felipe; Herrera, Jorge Mario; Rojano, Benjamín Alberto.
Título: Evaluación oxidativa, microbiológica, sensorial y perfil de ácidos grasos de un yogur con ácido docosahexaenoico (DHA) extraído de aceite de microalgas / Oxidative, sensory and fatty acid profile evaluation of a yogurt with docosahexaenoic acid (DHA) extracted from microalgae oil
Fonte: Rev. chil. nutr;47(4):568-579, ago. 2020. tab, graf.
Idioma: es.
Resumo: RESUMEN Las necesidades de ácido docosahexaenoico (DHA), se incrementan en la mujer gestante para el desarrollo visual y neurológico del feto y el lactante. En este trabajo, se desarrolló y se evaluó un yogur adicionado con aceite de microalgas, que contribuyera a la recomendación dietaria de DHA en mujeres gestantes y lactantes. Se diseñaron tres formulaciones de yogur con 0,075; 0,125 y 0,175% de aceite de microalga y se compararon con una muestra control. Se evaluaron propiedades fisicoquímicas, sensoriales, microbiológicas, perfil de ácidos grasos, potencial antioxidante (ABTS, fenoles totales) y peroxidación lipídica (sustancias reactivas al ácido tiobarbitúrico [TBARS]). Los yogures adicionados con el aceite de microalga cubrieron en 30, 45 y 63% las recomendaciones de DHA para mujeres gestantes y lactantes por porción (200 mL). Se observó estabilidad del ácido graso, excepto en la muestra de mayor adición del aceite. La muestra con adición de 0,125% de aceite de microalga fue la de mejor calificación por el panel sensorial. Todas las muestras cumplieron con el estándar microbiológico y fisicoquímico para un yogur entero adicionado con dulce. Se observó potencial antioxidante promisorio en el yogur, capaz de proteger el DHA. Se concluye que las bebidas lácteas como el yogur son matrices adecuadas para la adición de aceite de microalga con la finalidad de aumentar el DHA en la dieta, especialmente en etapas en que las necesidades de este componente son más altas, como en periodo de gestación y lactancia.

ABSTRACT The needs for docosahexaenoic acid (DHA) are increased during pregnancy for the visual and neurological development of the fetus and the breastfed infant. In this study, a yogurt with microalgae oil added to contribute to the dietary recommendation of DHA in pregnant and breastfeeding women was developed and evaluated. Three yogurt formulations were designed with 0.075; 0.125 and 0.175 microalgae oil percentage and compared with a control sample. Fatty acid profile, antioxidant potential (ABTS, total phenols), lipid peroxidation (thiobarbitrical acid reactive substances [TBARS]), physicochemical, sensory, and microbiological properties were evaluated. Yogurts with microalgae oil added covered 30, 45 and 63% of DHA recommendations for pregnant and breastfeeding women per portion (200 mL). Fat acid stability was observed, except in the one with the greatest oil addition. The sample with 0.125% of microalgae oil added was rated the highest by the sensory panel. All samples met the microbiological and physicochemical standard for a whole yogurt added with sugar. Promising antioxidant potential capable of protecting DHA was observed in the yogurt. We conclude that dairy drinks such as yogurt are suitable matrices for adding microalgae oil in order to increase DHA in the diet, especially in stages where the needs of this component are higher as is the case during pregnancy and lactation periods.
Descritores: Aleitamento Materno
Gravidez
Feto
-Fenóis
Ácidos Graxos
Microalgas
Antioxidantes
Limites: Feminino
Gravidez
Lactente
Tipo de Publ: Artigo Clássico
Responsável: CL334.1 - Biblioteca UBO


  5 / 711 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Cuba
Texto completo
Texto completo
Id: biblio-1251752
Autor: Cuartas, Silvina; Pérez Torre, María.
Título: Metabolismo e importancia de los ácidos grasos poliinsaturados en la gestación y lactancia / Metabolism and importance of polyunsaturated fatty acids in pregnancy and lactation
Fonte: Rev. cuba. pediatr;93(1):e1194, ene.-mar. 2021. fig.
Idioma: es.
Resumo: Introducción: Los ácidos grasos polinsaturados de cadena larga son esenciales en la nutrición del feto y del recién nacido. Objetivo: Examinar la importancia de los ácidos grasos poliinsaturados durante el embarazo y la lactancia, para destacar los requerimientos, las recomendaciones y fuentes alimentarias. Métodos: Se realizó una revisión sistemática de la literatura internacional de los últimos 15 años en bases de datos, en español y en inglés. Se utilizaron las siguientes palabras clave: embarazo, lactancia, ácidos grasos poliinsaturados, omega 3/6, fuentes y requerimientos. Se identificaron los aspectos más relevantes y controversiales. Resultados: El ácido araquidónico y docosahexaenoico influyen sobre el perfil lipídico, la sensibilidad a la insulina, la proliferación y diferenciación de los preadipocitos. Sus concentraciones durante la gestación resultan uno de los principales factores responsables de la programación fetal, que son las adaptaciones metabólicas que condicionan la evolución de la salud futura. Concentraciones óptimas de ácidos grasos omega 3 y 6 son vitales para el desarrollo neurológico del feto y del recién nacido. La funcionalidad de la placenta puede afectar la adiposidad y los niveles fetales de nutrientes clave, como los ácidos grasos poliinsaturados de cadena larga. Conclusiones: La dieta es uno de los principales factores ambientales durante la gestación. La lactancia materna es la mejor alternativa nutricional durante el primer año de vida, por eso es fundamental promocionarla. Es importante ofrecer una asistencia adecuada y generar estrategias que estimulen el consumo de ácidos omega-3 como una herramienta de prevención a largo plazo(AU)

Introduction: Long-chain polyunsaturated fatty acids are essential in the nutrition of the fetus and newborns. Objective: Examine the importance of polyunsaturated fatty acids during pregnancy and lactation to highlight food requirements, recommendations and sources. Methods: A systematic review of the international literature of the last 15 years was carried out in databases, in Spanish and English, using the following keywords: pregnancy, lactation, polyunsaturated fatty acids, omega 3/6, sources and requirements. The most relevant and controversial aspects were identified. Results: Arachydonic and docosahexaenoic acid influence lipid profile, insulin sensitivity, proliferation and differentiation of preadipocytes. Their levels during gestation are one of the main factors responsible for fetal programming that are metabolic adaptations conditioning the evolution of future health. Optimal levels of omega-3 and 6 fatty acids are vital for the neurological development of the fetus and newborn. Placenta´s functionality can affect adiposity and fetal levels of key nutrients, such as long-chain polyunsaturated fatty acids. Conclusions: Diet is one of the main environmental factors during gestation. Breastfeeding is the best nutritional alternative during the first year of life, which is why it is essential to promote it. It is important to provide adequate assistance and generate strategies that stimulate the consumption of omega-3 acids as a long-term prevention tool(AU)
Descritores: Adiposidade
Ciências da Nutrição
Ácidos Graxos
Ácidos Graxos Insaturados
Alimentos
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CU1.1 - Biblioteca Médica Nacional


  6 / 711 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Chile
Texto completo
Id: biblio-990037
Autor: Snehunsu, Adhikari; Nayak, Satheesha B; Kandwal, Mamta; Piyali, Adhikari; Adiga, Murali; Sahoo, Pabitra; Medabala, T; Raghavenra-Rao, K; Joseph, Alex.
Título: 1-triacontanol cerotate isolated from Marsilea quadrifolia Linn. safeguards hippocampal CA3 neurons and augments special memory deficit in chronic epileptic rats / Cerotato de 1-triacontanol aislado de Marsilea quadrifolia Linn. protege las neuronas CA3 del hipocampo y mejora el déficit de memoria especial en ratas epilépticas crónicas
Fonte: Int. j. morphol;37(1):265-272, 2019. graf.
Idioma: en.
Resumo: SUMMARY: Currently many people with epilepsy do not have seizure control even with the best available medications. Moreover various antiepileptics have adverse cognitive impact with other side effect. Thus, need for new antiepileptic drugs still remains challenge. However, many of the natural components have antiepileptic action and this fact remains scientifically unexplored. This study was designed to check the behavioral and neuro-pathological outcome of 1-Triacontanol cerotate (1TAC), isolated from Marsilea quadrifolia Linn. (MQ) on chronic Pentylenetetrazol (PTZ) kindling model of epilepsy in rats. Two-month-old adult male Wistar rats (n=60) were randomly divided into six groups; Group I (Cage Control), II (Vehicle Control), III (Positive Control), IV (Standard drug treated), V (1TAC: 40 mg/kg) & VI (1TAC: 80 mg/kg). To induce kindling a 35 mg/kg dose of PTZ was injected i.p. in every 48 hrs for 30 days in Group III to VI. Spatial memory performance was tested using Morris water maze, following which brains were further processed for histopathological investigations. Interestingly, 1TAC was able to minimize the loss of pyramidal cells in hippocampal CA3 region. These cellular changes were behaviorally responded as improved special learning and memory, a better spatial navigation and object place configuration. The current study strongly implicates that 1TAC from MQ has potent neuroprotective role and augments special memory deficit in chronic epileptic rats. The isolated component which attenuates spatial memory performance could be beneficial outcome to retain cognitive blunting in chronic epilepsy.

RESUMEN: Actualmente, muchas personas con epilepsia no cuentan con un control adecuado de las convulsiones, incluso con los mejores medicamentos disponibles. Además, varios antiepilépticos tienen un impacto cognitivo adverso además de efectos secundarios. Por lo tanto, la necesidad de nuevos fármacos antiepilépticos sigue siendo un desafío. Sin embargo, muchos de los componentes naturales tienen acción antiepiléptica y este hecho permanece científicamente inexplorado. Este estudio se diseñó para verificar el resultado conductual y neuro-patológico del cerotato de 1-triacontanol (1TAC), aislado de Marsilea quadrifolia Linn. (MQ) en el modelo de epilepsia en ratas del pentilenetetrazol (PTZ) crónico (PTZ). Ratas Wistar adultas de dos meses de edad (n = 60) se dividieron aleatoriamente en seis grupos; Grupo I (Control de jaula), II (Control de vehículo), III (Control positivo), IV (Medicamento estándar de tratamiento), V (1TAC: 40 mg / kg) y VI (1TAC: 80 mg / kg). Para inducir la inflamación se inyectó una dosis de 35 mg / kg de PTZ i.p. en cada 48 horas durante 30 días en los grupos III a VI. El rendimiento de la memoria espacial se probó utilizando el laberinto de agua de Morris, después de lo cual se procesaron los cerebros para investigaciones histopatológicas. Curiosamente, 1TAC pudo minimizar la pérdida de células piramidales en la región CA3 del hipocampo. Estos cambios celulares respondieron de manera conductual como una mejora del aprendizaje especial y la memoria, una mejor navegación espacial y la configuración del lugar del objeto. El estudio actual implica fuertemente que 1TAC de MQ tiene un potente papel neuroprotector y mejora el déficit de memoria especial en ratas epilépticas crónicas. El componente aislado que atenúa el rendimiento de la memoria espacial podría ser un resultado beneficioso para retener la reducción cognitiva en la epilepsia crónica.
Descritores: Marsileaceae/química
Epilepsia/tratamento farmacológico
Álcoois Graxos/administração & dosagem
Região CA3 Hipocampal/efeitos dos fármacos
Memória Espacial/efeitos dos fármacos
-Pentilenotetrazol/efeitos adversos
Doença Crônica
Ratos Wistar
Células Piramidais
Epilepsia/induzido quimicamente
Ácidos Graxos
Álcoois Graxos/isolamento & purificação
Teste do Labirinto Aquático de Morris
Hipocampo/efeitos dos fármacos
Limites: Animais
Masculino
Ratos
Responsável: CL1.1 - Biblioteca Central


  7 / 711 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: biblio-1045777
Autor: Henry, FJ.
Título: Revisiting plant fats and health in the Caribbean
Fonte: West Indian med. j;63(1):1-1, Jan. 2014.
Idioma: en.
Descritores: Cocos/química
Persea/química
Blighia/química
Ácidos Graxos/análise
Comportamento Alimentar
Valor Nutritivo
-Região do Caribe
Limites: Humanos
Tipo de Publ: Editorial
Responsável: BR1.1 - BIREME


  8 / 711 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: biblio-1045779
Autor: Goldson, A; Bremmer, D; Nelson, K; Minott, DA.
Título: Fat profile of Jamaican ackees, oleic acid content and possible health implications / Perfil de grasas del seso vegetal jamaicano, contenido de ácido oleico, y posibles implicaciones para la salud
Fonte: West Indian med. j;63(1):9-12, Jan. 2014. tab.
Idioma: en.
Resumo: OBJECTIVE: To re-investigate the composition of ackee oil and unequivocally determine its principal fatty acid components. METHODS: Oil was extracted from the edible portion of ackees harvested in three different studies (I - III) by several analysts; studies I and II utilized composite samples from several trees while study III consisted of ackees from seven separate trees. The oils were either saponified and methylated or trans-methylated and the fatty acid methyl ester content analysed by gas chromatography-mass spectrometry (GC-MS). Relative fatty acid composition was quantified based on chromatographic peak areas while fatty acids were identified by mass spectrometry. The degree of unsaturation of the ackee oils was characterized by determination of the iodine value. RESULTS: Gas chromatography-mass spectrometry data from the three studies were assessed. Relative fatty acid composition for the ackee oils was consistent across the three studies. The major fatty acid components were oleic acid (55.44%), palmitic acid (25.57%) and stearic acid (12.59%); linoleic acid was present in minor to undetectable amounts. An iodine value of 49 was determined which is consistent with the high oleic acid content of the ackee oil. CONCLUSION: The ackee samples analysed were rich in the monounsaturated fatty acid (MUFA) oleic acid.Consideration should be given to potential protective health effects of diets which include ackee.

OBJETIVO: Re-investigar la composición del aceite del seso vegetal (ackee) y determinar de manera inequívoca sus componentes principales de ácidos grasos. MÉTODOS: Se extrajo el aceite de la porción comestible de sesos vegetales de la Blighia sapida (ackee), cosechados como parte de tres estudios diferentes (I - III) por varios analistas. Los estudios I y II utilizaron muestras combinadas de varios árboles de Blighia sapida, en tanto que el estudio III estuvo formado por muestras de siete árboles de Blighia sapida por separado. Los aceites fueron saponificados y metilados o transmetilados, y el contenido de éster metílico de ácidos grasos fue analizado mediante técnicas de cromatografía de gases y espectrometría de masas (GC-MS). La composición relativa de ácidos grasos se cuantificó sobre la base de las áreas cromatográficas pico, mientras que los ácidos grasos se identificaron mediante espectrometría de masas. El grado de insaturación de los aceites de seso vegetal fue caracterizado mediante la determinación del valor de yodo. RESULTADOS: Se evaluaron los datos de la cromatografía de gases acoplada con espectrometría de masas de los tres estudios. La composición relativa de ácido grasos de los aceites de seso vegetal, fue constante a través de los tres estudios. Los componentes principales del ácido graso fueron el ácido oleico (55.44%), el ácido palmítico (25.57%), y el ácido esteárico (12.59%). El ácido linoleico estuvo presente en cantidades que fluctuaron de menores a indetectables. Se determinó un valor de yodo de 49, el cual está en correspondencia con el alto contenido de ácido oleico en el seso vegetal. CONCLUSIÓN: Las muestras analizadas de sesos vegetales de la Blighia sapida (ackee) eran ricas en ácidos grasos monoinsaturados (MUFA por sus siglas en inglés) y ácidos oleicos. Debe prestarse atención a los posibles efectos protectores de la salud de dietas que incluyen sesos vegetales.
Descritores: Óleos Vegetais/química
Blighia/química
Ácidos Graxos/análise
-Espectrometria de Massas
Ácido Palmítico/análise
Ácido Oleico/análise
Jamaica
Cromatografia Gasosa-Espectrometria de Massas
Responsável: BR1.1 - BIREME


  9 / 711 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-1019889
Autor: Fattahi, Amir; Latifi, Zeinab; Darabi, Masoud; Salmassi, Ali; Farzadi, Laya; Shaaker, Maghsood; Mehdizadeh, Amir; Ghasemnejad, Tohid; Roshangar, Leila; Nouri, Mohammad.
Título: Mating with seminal vesicle-excised male can affect the uterus phospholipid fatty-acids composition during implantation in an experimental mouse model
Fonte: Int. braz. j. urol;45(4):825-833, July-Aug. 2019. tab, graf.
Idioma: en.
Projeto: Tabriz University of Medical Sciences.
Resumo: ABSTRACT Purpose No comprehensive information is available about uterus fatty acid (FA) change during implantation period and possible effects of the seminal vesicle secretion on it. Materials and Methods In this study, we evaluated FA composition of uterus phospholipids during the implantation period in intact and seminal vesicle-excised (SVX) mated female mice. Forty NMRI female mice were divided into control (mated with intact male) and seminal vesicle excised (SVX)-mated (mated with SVX-male) groups. The phospholipid fatty acids composition was monitored during the first five days of pregnancy using gas chromatography and also implantation rate was evaluated on fifth day of pregnancy. Results We found that levels of linoleic acid (LNA) and arachidonic acid (ARA) showed a decreasing trend from the first to the third day of pregnancy and then started to increase on the fourth day and peaked on the fifth day. In contrast, the level of saturated FA (SFA) increased on the second and third day of pregnancy compared to the first (p<0.05) and then decreased on the fourth and fifth. We also found that the seminal vesicle secretion could affect the levels of LNA, ARA, SFA, and PUFA in uterine phospholipids especially on second and third day. Moreover, there was a positive correlation between ARA level and implantation rate in control but not SVX-mated groups. Conclusions It can be concluded that several uterus FA that have important roles in early pregnancy could be affected by seminal vesicle secretion.
Descritores: Implantação do Embrião/fisiologia
Glândulas Seminais/metabolismo
Útero/química
Modelos Animais
Ácidos Graxos/química
-Tamanho do Órgão/fisiologia
Valores de Referência
Fatores de Tempo
Gravidez/metabolismo
Distribuição Aleatória
Ácidos Graxos/análise
Camundongos
Limites: Animais
Masculino
Feminino
Responsável: BR1.1 - BIREME


  10 / 711 LILACS  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
Id: biblio-1248278
Autor: Marchetti, Desirèe; Coelho, Daniella; Coitinho, Adriana; Guzzo, Edson; Padilha, Rafael; Rosa, Gabriel; Vargas, Carmen.
Título: Increased levels of hexacosanoic acid in the brain of Winstar rats: a behavioral study
Fonte: Clin. biomed. res;40(3):161-166, 2020. graf.
Idioma: en.
Resumo: Introduction: X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal metabolic disorder associated with mutations in the ATP-binding cassette sub-family D member1 (ABCD1) gene. Practically all male patients with X-ALD develop adrenocortical insufficiency during childhood and progressive myelopathy and peripheral neuropathy in adulthood. However, some male patients develop a fatal cerebral demyelinating disease named cerebral adrenoleukodystrophy. Although the exact mechanisms underlying brain damage in X-ALD are still poorly elucidated, it is known that hexacosanoic acid (C26:0) accumulation represents a hallmark in the pathogenesis of this disease. In this study, we examined whether an overload of C26:0 injected in Wistar rats was capable of causing behavioral changes in these animals. Methods: Egg lecithin in ethanol was dried under a nitrogen stream and mixed with C26:0 methyl ester. Male Wistar rats at 2-3 weeks of age were obtained from Universidade Federal do Rio Grande do Sul (UFRGS), divided into 8 groups, and submitted to an open field test. We then analyzed line crossings (locomotion and exploration), rearing (orienting and investigatory responses), grooming (anxiety manifestation), and latency to move for each animal. Results: Animals subjected to C26:0 administration presented fewer crossings and rearing episodes and a higher latency to move 45 minutes after C26:0 injection. The present work yields experimental evidence that C26:0, the main accumulated metabolite in X-ALD, can cause behavioral alterations in rats such as the impairment of locomotion and exploratory capabilities, as well as a reduction in orienting and investigatory responses. Conclusion: Although our results are preliminary, they are extremely important for future studies that investigate C26:0 accumulation and locomotor impairment in patients with X-ALD. (AU)
Descritores: Comportamento
Ratos Wistar
-Adrenoleucodistrofia
Cérebro/efeitos dos fármacos
Ácidos Graxos
Atividade Motora/efeitos dos fármacos
Limites: Animais
Ratos
Responsável: BR18.1 - Biblioteca FAMED/HCPA



página 1 de 72 ir para página                         
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde