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Id: |
lil-695956
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Autor: |
Brasileiro, José Lacerda; Inoye, Celso Maschaschi; Aydos, Ricardo Dutra; Silva, Iandara Schettert; Falcão, Gustavo Ribeiro; Marks, Guido; Pereira, Daniel Martins. |
Título: |
Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1 |
Fonte: |
Acta cir. bras;28(11):767-773, Nov. 2013. ilus, tab.
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Idioma: |
en.
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Resumo: |
PURPOSE: To investigate the small intestinal tissue alterations in rats submitted to ischemia and tissue reperfusion using pentoxyfilline or prostaglandin E1. METHODS: Thirty five Wistar rats were used, distributed into group control (A) n=10 were submitted to intestinal ischemia and reperfusion during 60 minutes and no one drug have been utilized. In the group pentoxyfilline (B) n=10 have been utilized during tissue ischemia and reperfusion as well as prostaglandin E1 (C) n=10, but separately. In the group sham (D) n=5, the animals were submitted to surgical. After euthanasia of the animals, a segment of the small intestine was cut, stained by hematoxilin-eosin and histological analysis according to Chiu criteria. RESULTS: Histological results showed that using pentoxyflline or prostaglandin E1 the results during tissue reperfusion were better, since the levels of criteria from Chiu that predominated were level 2 and 3, indicating less tissue damage in comparison to the control group (group A) that showed levels 4 and 5, what means more severe histological tissue alterations. CONCLUSION: Use of pentoxyfilline or prostaglandin E1 promoted a beneficial effect during intestinal reperfusion, demonstrated by less severe histological lesions in the small intestine mucosa of rats submitted to ischemia and tissue reperfusion when helped by the drugs.
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Descritores: |
Alprostadil/farmacologia Intestino Delgado/irrigação sanguínea Isquemia/tratamento farmacológico Pentoxifilina/farmacologia Traumatismo por Reperfusão/tratamento farmacológico Vasodilatadores/farmacologia
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-Modelos Animais de Doenças Mucosa Intestinal/irrigação sanguínea Mucosa Intestinal/patologia Intestino Delgado/patologia Ratos Wistar Reprodutibilidade dos Testes Fatores de Tempo
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Limites: |
Animais Masculino Ratos
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Responsável: |
BR1.1 - BIREME
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