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Id: biblio-1285330
Autor: Smiderle, Carla Alessandra; Coral, Gabriela Perdomo; De Carli, Luiz Alberto; Mattos, Angelo Alves de; Mattos, Angelo Zambam de; Tovo, Cristiane Valle.
Título: Avaliação do desempenho do índice triglicerídeo-glicose no diagnóstico e estadiamento da DHGNA em pacientes obesos / Performace of triglyceride-glucose index on diagnosis and staging of nafld in obese patients
Fonte: Arq. gastroenterol;58(2):139-144, Apr.-June 2021. tab, graf.
Idioma: en.
Resumo: ABSTRACT BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease in the world, and its prevalence is increasing alongside obesity. In United States, NAFLD is already the second leading cause of liver transplantation. The spectrum of the disease ranges from simple steatosis, which has a benign course, to steatohepatitis, which may progress to cirrhosis and its complications. The rising of noninvasive methods for diagnosing and staging non-alcoholic steatohepatitis (NASH) and fibrosis decreases the need of liver biopsy, as well as the costs and the occurrence of complications related to it. OBJECTIVE: To analyze the performance of the triglyceride-glucose index to evaluate steatosis, NASH and liver fibrosis in obese patients with NAFLD. METHODS: This is a retrospective cross-sectional study. Every medical record of patients who were candidates for bariatric surgery at a leading hospital in Southern Brazil were analyzed. The triglyceride-glucose index (TyG Index), a method composed only of two simple laboratory tests (serum triglycerides and fasting glucose levels), was performed prior to surgery. The TyG Index performance regarding the anatomopathological findings was evaluated, and the AUROC curve was calculated to evaluate the best cut-off point for diagnosing steatosis, non-alcoholic steatohepatitis and liver fibrosis grade. Also, the NAFLD fibrosis Score (NFS) was evaluated. RESULTS: A total of 423 patients were evaluated. The TyG Index with a cut-off point of 8.76 excluded significant simple steatosis (grade 2-3) in obese patients, with 67.6% sensitivity, 65.1% specificity, 46.3% positive predictive value (PPV), 81.8% negative predictive value (NPV), 65.8% accuracy and 0.66 AUROC (P=0.005). In the evaluation of NASH, the TyG Index with a cut-off point of 8.82 excluded significant NASH (grade 2-3) with 57.3% sensitivity, 58.6% specificity, 33.7% PPV, 78.8% NPV, 58.2% accuracy and 0.58 AUROC (P=0.022). When evaluating liver fibrosis, the TyG Index with a cut-off point of 8.91 showed a sensitivity of 61.8%, a specificity of 62.5%, a PPV of 13.8 and a NPV of 94.4% for exclusion of advanced fibrosis (F3-4), with a 62.4% accuracy and 0.69 AUROC (P<0.001). When analyzing the performance of NFS in the diagnosis of advanced fibrosis, the cut-off point <-1.455 excluded advanced fibrosis with sensitivity of 59.4%, specificity of 51%, PPV of 11%, NPV of 92.4% and accuracy of 51.7%. However, the cut-off point of 0.676 to diagnose advanced fibrosis presented sensitivity of 21.9%, specificity of 83%, PPV of 11.7%, NPV of 91.2% and 77.3% accuracy. The AUROC was 0.54 (P=0.480). CONCLUSION: TyG Index did not perform well in the diagnosis of significant steatosis and NASH. However, it was able to exclude advanced fibrosis in obese patients who are candidates for bariatric surgery.

RESUMO CONTEXTO: A doença hepática gordurosa não-alcoólica (DHGNA) é a doença hepática mais prevalente no mundo. Nos Estados Unidos, a DHGNA já é a segunda causa de transplante hepático. O espectro da doença abrange desde a esteatose simples, que apresenta curso benigno, até esteato-hepatite não-alcoólica (EHNA), que pode progredir para cirrose e suas complicações. O desenvolvimento de métodos não invasivos para o diagnóstico e estadiamento da EHNA e da fibrose hepática visa diminuir a necessidade de biópsia hepática, um procedimento invasivo e não raro associado a complicações. OBJETIVO: Analisar o desempenho do índice triglicerídeo-glicose (TyG Index) para o diagnóstico e estadiamento da DHGNA em pacientes obesos. MÉTODOS: Este é um estudo transversal retrospectivo. Foram analisados todos os prontuários de pacientes candidatos a cirurgia bariátrica em um hospital de referência do Sul do Brasil e calculado o TyG Index, um escore composto por dois exames laboratoriais (triglicerídeos e glicose de jejum), realizados previamente à cirurgia. O desempenho do TyG Index em relação aos achados anatomopatológicos hepáticos foi avaliado, e calculada a curva ROC para avaliação de esteatose simples, EHNA e fibrose hepática. O NAFLD Fibrosis Score (NFS) também foi avaliado. RESULTADOS: Foram avaliados 423 pacientes. O melhor ponto de corte do TyG Index para a exclusão de esteatose simples significativa (grau 2-3) foi de 8,76, com sensibilidade 67,6%, especificidade 65,1%, valor preditivo positivo (VPP) 46,3%, valor preditivo negativo (VPN) 81,8%, acurácia 65,8% e AUROC 0,66 (P=0,005). Na avaliação de EHNA significativa (grau 2-3), o melhor ponto de corte foi de 8,82 com sensibilidade 57,3%, especificidade 58,6%, VPP 33,7%, VPN 78,8%, acurácia 58,8% e AUROC 0,58 (P=0,022). Em relação à fibrose avançada (grau 3-4), o melhor ponto de corte do TyG Index foi de 8,91 com sensibilidade 61,8%, especificidade 62,5%, VPP 13,8%, VPN 94,4%, acurácia 62,4% e AUROC 0,69 (P<0,001). Ao analisarmos o desempenho do NFS no diagnóstico de fibrose avançada, o ponto de corte de <-1,455 excluiu fibrose avançada com sensibilidade 59,4%, especificidade 51%, VPP 11%, VPN 92,4% e acurácia 51,7%. Entretanto, o ponto de corte de 0,676 para fibrose avançada apresentou sensibilidade de 21,9%, especificidade 83%, VPP 11,7%, VPN 91,2% e acurácia 77,3%. A AUROC foi de 0,54 (P=0,480). CONCLUSÃO: O TyG Index não apresentou bom desempenho para o diagnóstico e estadiamento da esteatose simples e da EHNA. Entretanto, foi capaz de excluir fibrose avançada em pacientes obesos candidatos a cirurgia bariátrica.
Descritores: Hepatopatia Gordurosa não Alcoólica/complicações
Hepatopatia Gordurosa não Alcoólica/patologia
-Triglicerídeos
Biópsia
Estudos Transversais
Estudos Retrospectivos
Glucose
Fígado/patologia
Cirrose Hepática/patologia
Obesidade
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-951527
Autor: Azuma, Mariane Maffei; Gomes-Filho, João Eduardo; Cardoso, Carolina de Barros Morais; Pipa, Camila Barbosa; Clinic and Surgery and Animal ReproductionNarciso, Luis Gustavo; Clinic and Surgery and Animal ReproductionBomfim, Suely Regina Mogami; Jacinto, Rogério de Castilho; Cintra, Luciano Tavares Angelo.
Título: Omega 3 fatty acids reduce the triglyceride levels in rats with apical periodontitis
Fonte: Braz. dent. j;29(2):173-178, Mar.-Apr. 2018. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Abstract The aim of this study was to evaluate the influence of the prophylactic and therapeutic supplementation with omega 3 polyunsaturated fatty acids (w-3 PUFAs) on the lipid profile and periapical bone resorption in rats with apical periodontitis. Forty male rats were divided into groups: control rats (C), rats treated with w-3 PUFAs (C+O), rats with pulp exposure-induced apical periodontitis (AP), and rats with AP treated with w-3 PUFAs (AP+O). The administration of w-3 PUFAs was carried out orally once a day for 15 days before pulp exposure and, subsequently, for an additional 30 days after pulp exposure. AP was induced by exposing pulpal tissues to the oral environment. The samples were collected after 30 days. Triglycerides and cholesterol levels were enzymatically measured using the Trinder method. The jaws were collected and submitted for histological analysis. Two-way analysis of variance and Kruskal-Wallis tests were used for statistical analysis, and the significance was set at p<0.05. The triglyceride levels of the AP group were significantly higher than those of the C, C+O and AP+O groups (p<0.05). However, the difference in the cholesterol levels among the groups was not significant (p>0.05). Rats with AP showed larger areas of bone resorption as well as higher inflammatory intensity compared with rats with AP supplemented with w-3 PUFAs. It may be concluded that the presence of multiple AP foci increased the triglyceride levels. In addition, omega 3 supplementation might reduce these levels in rats with AP, as well as the bone resorption areas of periapical tissues.

Resumo O objetivo deste estudo foi avaliar a influência da suplementação profilática e terapêutica com os ácidos graxos ômega-3 no perfil lipídico e na reabsorção óssea, em ratos com periodontite apical. Quarenta ratos machos foram divididos em grupos: ratos controle (C), ratos tratados com ácidos graxos ômega-3 (C+O), ratos com periodontite apical induzida por meio de exposição pulpar (PA), ratos com PA tratados com ácidos graxos ômega-3 (PA+O). A administração do ômega-3 foi realizada oralmente, uma vez ao dia durante 15 antes da exposição pulpar e, subsequentemente, por mais 30 dias depois da exposição pulpar. A PA foi induzida por meio da exposição do tecido pulpar ao ambiente oral. Após 30 dias, os ratos foram mortos e os níveis de triglicérides e colesterol foram mensurados pelo método enzimático de Trinder. As mandíbulas foram coletadas e submetidas à análise histológica. Análise de variância de dois fatores e teste de Kruskal-Wallis foram utilizados para análise estatística, e o nível de significância foi de p < 0,05. Os níveis de triglicérides do grupo PA foram significativamente maiores que dos grupos C, C+O e PA+O (p<0,05). Entretanto, não houve diferença significativa nos níveis de colesterol entre os grupos (p>0,05). Ratos com PA apresentaram maior área de reabsorção óssea bem como maior intensidade no infiltrado inflamatório comparados aos ratos com PA suplementados com ômega-3. Pode-se concluir que a presença de múltiplos focos de PA aumentou os níveis de triglicérides. Além disso, a suplementação com ômega-3 pode reduzir estes níveis em ratos com PA, bem como a área de reabsorção óssea dos tecidos periapicais.
Descritores: Periodontite Periapical/sangue
Triglicerídeos/sangue
Reabsorção Óssea/prevenção & controle
Hipertrigliceridemia/tratamento farmacológico
Ácidos Graxos Ômega-3/uso terapêutico
Suplementos Nutricionais
-Periodontite Periapical/patologia
Colesterol/sangue
Ratos Wistar
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: biblio-951693
Autor: Wang, H H; Wang, Q F.
Título: Low vaspin levels are related to endothelial dysfunction in patients with ankylosing spondylitis
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;49(7):e5231, 2016. tab, graf.
Idioma: en.
Resumo: Vaspin is a novel adipocytokine associated with glucose tolerance and chronic inflammation. Some studies reveal that vaspin may be involved in cardiovascular diseases. Our objective was to investigate the relationship between serum vaspin levels and endothelial function in patients with ankylosing spondylitis. One hundred and twenty patients with newly diagnosed ankylosing spondylitis and 100 healthy subjects were studied. Serum vaspin levels were measured with enzyme-linked immunosorbent assay. High resolution ultrasound was used to measure brachial artery diameter at rest, after reactive hyperemia (flow-mediated dilation, FMD) and after sublingual glyceryltrinitrate. Serum vaspin level in patients was 1.92±1.03 ng/mL, which was significantly lower than that in healthy subjects (2.88±0.81 ng/mL). By dividing the distribution of serum vaspin levels into quartiles, FMD levels increased gradually with the increase of serum vaspin levels in patients (P<0.01). Univariate analysis showed a correlation between vaspin and FMD (r=0.73, P=0.003), low-density lipoprotein cholesterol (r=-0.45, P=0.033), high-density lipoprotein cholesterol (r=0.63, P=0.025), fasting blood glucose (r=-0.79, P=0.006), triglycerides (TG) (r=-0.68, P=0.036), systolic blood pressure (r=-0.35, P=0.021), C-reactive protein (r=-0.67, P=0.011), homeostatic model assessment of insulin resistance (HOMA-IR) (r=-0.77, P=0.023) and erythrocyte sedimentation rate (r=-0.88, P=0.039) in patients. Multivariate analysis indicated that serum vaspin levels were independently associated with FMD, HOMA-IR and TG in patients. Our study found that serum vaspin levels were decreased in patients with ankylosing spondylitis and were associated with FMD levels. Vaspin may serve as an independent marker for detecting early stage atherosclerosis in patients with ankylosing spondylitis.
Descritores: Espondilite Anquilosante/fisiopatologia
Espondilite Anquilosante/sangue
Endotélio Vascular/fisiopatologia
Serpinas/sangue
-Valores de Referência
Triglicerídeos/sangue
Glicemia/análise
Artéria Braquial/patologia
Artéria Braquial/diagnóstico por imagem
Resistência à Insulina
Biomarcadores/sangue
Estudos de Casos e Controles
Modelos Lineares
Colesterol/sangue
Fatores de Risco
Análise de Variância
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-1151409
Autor: Sales, Narryman Jordana Ferrão; Morais, Cristiano Gonçalves; Blandes, Antonia Irisley da Silva; Takanashi, Silvania Yukiko Lins; Simplício, Irinéia de Oliveira Bacelar; Saatkamp, Cassiano Júnior; Gouvea-e-Silva, Luiz Fernando.
Título: Indicadores de saúde em usuários de uma unidade básica de saúde da cidade de Santarém, Pará, Brasil / Health indicators in users of a basic health unit in the city of Santarém, Pará, Brazil
Fonte: Arq. ciências saúde UNIPAR;25(1):43-51, jan-abr. 2021.
Idioma: pt.
Resumo: Introdução: Usuários do sistema de saúde com doenças crônicas não transmissíveis devem estar em acompanhamento constante para evitar complicações em seu estado de saúde. Objetivo: Analisar os indicadores laboratoriais de saúde em usuários de uma Unidade Básica de Saúde com e sem o diagnóstico para a diabetes e hipertensão. Métodos: A amostra foi de 231 usuários de uma unidade básica de saúde da cidade de Santarém-PA, maiores de idade, que foram agrupados em pacientes com DM/HAS (DM/HAS; n=144), e sem o diagnóstico para DM/HAS (AUS; n=87). As coletas envolveram informações socioeconômicas, clínicas e laboratoriais. Os dados foram tratados com estatística descritiva e inferencial, adotando-se p<0.05. Resultados: Tanto no DM/HAS como no AUS predominou o sexo feminino, estado civil casado, com vínculo empregatício, cor de pele parda, com 4-7 anos de estudo, renda de 1-2 salários, não tabagistas, não etilista e faixa etária de 38-77 anos. A HAS foi a doença mais presente de forma geral, bem como por sexo. Identificou-se no DM/HAS valores menores para a taxa de filtração glomerular (TFG) e maiores valores para a glicemia, triglicerídeos, colesterol total, LDL-c e não HDL-c. Conclusão: De acordo com a proposta desenvolvida, destaca-se que os usuários com DM/HAS apresentam associação positiva para valores alterados de glicemia, colesterol total, não HDL-c, triglicerídeos, TFG e para a presença da síndrome metabólica e risco cardiovascular moderado/alto.

Introduction: Users of the health system with chronic non-communicable diseases must be constantly monitored to avoid complications in their health status. Objective: Analyze laboratory health indicators in users of a Basic Health Unit with and without a diagnosis for diabetes and hypertension. Methods: The sample consisted of 231 users of a basic health unit in the city of Santarém-PA, all of them of age, grouped into patients with DM/SAH (DM/SAH; n=144), and without the diagnosis for DM/SAH (ABS; n=87). The collections involved socioeconomic, clinical, and laboratory information. The data were treated with descriptive and inferential statistics, adopting p <0.05. Results: In both DM/SAH and ABS groups, there was a predominance of female individuals, married status, employed, brown skin color, with 4-7 years of study, income of 1-2 salaries, non-smokers, non-alcoholic drinkers, and aged between 38-77 years. SAH was the most common disease in general, as well as when analyzing by gender. Lower values for the glomerular filtration rate (GFR) were identified in the DM/SAH and higher values for the glycemia, triglycerides, total cholesterol, LDL-c, and non-HDL-c. Conclusion: According to the proposal of this paper, it is noteworthy that users with DM/SAH have a positive association for altered values of blood glucose, total cholesterol, non-HDL-c, triglycerides, GFR, and for the presence of metabolic syndrome and moderate/high cardiovascular risk.
Descritores: Avaliação em Saúde/estatística & dados numéricos
Centros de Saúde
Indicadores Básicos de Saúde
-Tabagismo/complicações
Triglicerídeos/sangue
Glicemia
Consumo de Bebidas Alcoólicas/efeitos adversos
Doenças Cardiovasculares/diagnóstico
Colesterol/sangue
Doença Crônica/enfermagem
Síndrome Metabólica/diagnóstico
Diabetes Mellitus/diagnóstico
Doenças não Transmissíveis/prevenção & controle
Taxa de Filtração Glomerular
Hipertensão/diagnóstico
HDL-Colesterol
LDL-Colesterol/sangue
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Tipo de Publ: Estudo Observacional
Responsável: BR513.1 - Biblioteca Central


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Id: biblio-951762
Autor: Zaid, M; Hasnain, S.
Título: Plasma lipid abnormalities in Pakistani population: trends, associated factors, and clinical implications
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(9):e7239, 2018. tab, graf.
Idioma: en.
Resumo: Previous studies have reported increased prevalence of coronary heart disease (CHD) in Indians and South Asian settlers in North America. This increased burden of CHD among South Asians is mainly caused by dyslipidemia. To the best of our knowledge, none of the previous works has studied the patterns and prevalence of dyslipidemia in the Pakistani population. The present work aimed to study the plasma lipid trends and abnormalities in a population-based sample of urban and rural Pakistanis. The study included 238 participants (108 males,130 females). Plasma lipid profiles of the participants were determined using standard protocols. We observed that 63% of the study population displayed irregularities in at least one major lipid-fraction including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), or triglycerides (TG). The most common form of isolated-dyslipidemia was low HDL-C (17.3%) followed by high TG (11.2%). Several overlaps between high TC, LDL-C, TG and low HDL-C were also noted. Gender, urbanization, and occupational class were all observed to have an impact on lipid profiles. Briefly, male, urban, and blue-collar participants displayed higher prevalence of dyslipidemia compared to female, rural, and white-collar participants, respectively. In comparison to normal subjects, dyslipidemic subjects displayed significantly higher values for different anthropometric variables including body mass index (BMI), body fat percentage, and waist circumference. The present work provides a comprehensive estimation of the prevalence of dyslipidemia and CHD risk in the Pakistani population. This information will be helpful for better healthcare planning and resource allocation in Pakistan.
Descritores: Doença das Coronárias/etiologia
Dislipidemias/epidemiologia
Lipídeos/sangue
-Paquistão/etnologia
População Rural
Triglicerídeos/sangue
Estudos de Casos e Controles
Antropometria
Colesterol/sangue
Prevalência
Estudos Transversais
Fatores de Risco
Distribuição por Sexo
Doença das Coronárias/sangue
Dislipidemias/complicações
Dislipidemias/sangue
HDL-Colesterol/sangue
LDL-Colesterol/sangue
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-974270
Autor: Antunes, M M; de Almeida-Souza, C B; Godoy, G; Crisma, A R; Masi, L N; Curi, R; Bazotte, R B.
Título: Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;52(1):e8150, 2019. tab, graf.
Idioma: en.
Projeto: FAPESP; . CAPES, and Guggenheim Foundation.
Resumo: High caloric intake promotes chronic inflammation, insulin resistance, and chronic diseases such as type-2 diabetes, which may be prevented by food restriction (FR). The effect of FR on expression of pro-inflammatory and anti-inflammatory genes in adipose tissue, liver, muscle, and brain was compared. Male Swiss mice were submitted to FR (FR group) or had free access to food (control group) during 56 days. The liver, gastrocnemius muscle, brain, and epididymal white adipose tissue (WAT) were collected for analysis of gene expressions. FR attenuated inflammation in the liver, brain, and gastrocnemius muscle but did not markedly change inflammatory gene expression in epididymal WAT. We concluded that adipose tissue was less responsive to FR in terms of gene expression of pro-inflammatory and anti-inflammatory genes.
Descritores: Encéfalo/metabolismo
Tecido Adiposo/metabolismo
Músculo Esquelético/metabolismo
Dieta Hiperlipídica
Fígado/metabolismo
-Triglicerídeos/sangue
Glicemia/análise
Expressão Gênica
Colesterol/sangue
Limites: Animais
Masculino
Coelhos
Responsável: BR1.1 - BIREME


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Id: biblio-1011613
Autor: Milan-Mattos, J C; Anibal, F F; Perseguini, N M; Minatel, V; Rehder-Santos, P; Castro, C A; Vasilceac, F A; Mattiello, S M; Faccioli, L H; Catai, A M.
Título: Effects of natural aging and gender on pro-inflammatory markers
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;52(9):e8392, 2019. tab, graf.
Idioma: en.
Projeto: FAPESP; . CNPq; . CAPES.
Resumo: The term inflammaging is now widely used to designate the inflammatory process of natural aging. During this process, cytokine balance is altered, presumably due to the loss of homeostasis, thus contributing to a greater predisposition to disease and exacerbation of chronic diseases. The aim of the study was to analyze the relationship between pro-inflammatory markers and age in the natural aging process of healthy individuals. One hundred and ten subjects were divided into 5 groups according to age (22 subjects/group). Interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) were quantified using the ELISA method. High-sensitivity C-reactive protein (hsCRP) was analyzed by turbidimetry according to laboratory procedures. The main findings of this study were: a positive correlation between hsCRP and IL-6 as a function of age (110 subjects); women showed stronger correlations; the 51-60 age group had the highest values for hsCRP and IL-6; women presented higher values for hsCRP in the 51-60 age group and higher values for IL-6 in the 61-70 age group; and men showed higher values in the 51-60 age group for hsCRP and IL-6. In conclusion, the natural aging process increased IL-6 and hsCRP levels, which is consistent with the inflammaging theory; however, women presented stronger correlations compared to men (IL-6 and hsCRP) and the 51-60 age range seems to be a key point for these increases. These findings are important because they indicate that early preventive measures may minimize the increase in these inflammatory markers in natural human aging.
Descritores: Envelhecimento/fisiologia
Imunossenescência/fisiologia
Inflamação/sangue
-Consumo de Oxigênio/fisiologia
Triglicerídeos/sangue
Proteína C-Reativa/análise
Biomarcadores/análise
Fatores Sexuais
Colesterol/sangue
Fatores Etários
Interleucina-6/sangue
Fator de Necrose Tumoral alfa/sangue
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1089350
Autor: Teixeira-Coelho, F; Santos, D F C; Santos, G A; Sousa, T F; Moreira, S R; Souza, M V C; Wanner, S P.
Título: Ingestion of a moderate dose of alcohol enhances physical exercise-induced changes in blood lactate concentration
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;53(4):e9200, 2020. tab, graf.
Idioma: en.
Resumo: The consumption of alcoholic beverages influences carbohydrate and lipid metabolism, although it is not yet clear whether metabolism during physical exercise at different intensities is also affected. This was the objective of the present study. Eight young and healthy volunteers performed a treadmill test to identify the running speed corresponding to a lactate concentration of 4 mM (S4mM). At least 48 h later, they were subjected to two experimental trials (non-alcohol or alcohol) in which they performed two 1-km running sessions at the following intensities: 1) S4mM; 2) 15% above S4mM. In both trials, blood lactate, triglycerides, and glucose concentrations were measured before and after exercise. The acute alcohol intake increased triglycerides, but not lactate concentration under resting conditions. Interestingly, alcohol intake enhanced the exercise-induced increase in lactate concentration at the two intensities: S4mM (non-alcohol: 4.2±0.3 mM vs alcohol: 4.8±0.9 mM; P=0.003) and 15% above S4mM trial (P=0.004). When volunteers ingested alcohol, triglycerides concentration remained increased after treadmill running (e.g., at S4mM - at rest; non-alcohol: 0.2±0.5 mM vs alcohol: 1.3±1.3 mM; P=0.048). In contrast, glucose concentration was not modified by either alcohol intake, exercise, or their combination. We concluded that an acute alcohol intake changed lactate and lipid metabolism without affecting blood glucose concentration. In addition, the increase in lactate concentration caused by alcohol was specifically observed when individuals exercised, whereas augmented triglycerides concentration was already observed before exercise and was sustained thereafter.
Descritores: Resistência Física/efeitos dos fármacos
Glicemia/metabolismo
Consumo de Bebidas Alcoólicas/sangue
Ácido Láctico/sangue
Etanol/metabolismo
Bebidas Alcoólicas/análise
-Resistência Física/fisiologia
Triglicerídeos/sangue
Glicemia/análise
Teste de Esforço
Desempenho Atlético/fisiologia
Limites: Humanos
Masculino
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


  9 / 1052 LILACS  
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Id: biblio-961449
Autor: Cano-Montoya, Johnattan; Ramírez-Campillo, Rodrigo; Sade Calles, Farid; Izquierdo, Mikel; Fritz Silva, Nicole; Ateaga San Martín, Ricardo; Álvarez, Cristian.
Título: Ejercicio físico en pacientes con diabetes e hipertensión: prevalencia de respondedores y no respondedores para mejorar factores de riesgo cardiometabólicos / Effects of a six weeks exercise training program for type 2 diabetes mellitus and hypertensive patients
Fonte: Rev. méd. Chile;146(6):693-701, jun. 2018. tab, graf.
Idioma: es.
Resumo: Background: There is a wide interindividual variability in the response to a period of exercise training. The science have reported that a minimum of participants could be non-responders for improving different health-related outcomes after training. Aim: To compare the effects of a 6-weeks exercise program on body composition, cardiovascular and metabolic outcomes patients with type 2 diabetes and hypertension. Material and Methods: Data from 23 trained subjects were used in a secondary analysis of the response to exercise. Of these, 14 were considered adherent to training and nine as non-adherent. Body mass, height, waist circumference, four skinfolds and their sum, blood pressure and plasma triglyceride levels were assessed before and after the training period. Results: Among adherent participants, significant reductions were observed in the sum of four skinfolds (30 ± 7 to 27 ± 6 mm, p ≤ 0.05), systolic blood pressure (133 ± 18 to 127 ± 20 mmHg; p ≤ 0.05) and plasma triglycerides (125 ± 58 to 102 ± 34 mg/dL; p ≤ 0.05). No changes were observed in weight or diastolic blood pressure. Among non-adherent participants, no changes of measured parameters were observed. Among adherent participants, 57% were considered as non-responders for waist circumference, 7% for the sum of skinfold thickness, 50% for systolic blood pressure, 64% for diastolic blood pressure and 57% for plasma triglycerides. Conclusions: Participants with a good adherence to a 6-weeks exercise training program experienced overall improvement in body composition, blood pressure and plasma triglycerides. The prevalence of non-responders varied considerably among measured outcomes.
Descritores: Diabetes Mellitus Tipo 2/metabolismo
Diabetes Mellitus Tipo 2/prevenção & controle
Terapia por Exercício/métodos
Treinamento Intervalado de Alta Intensidade/métodos
Hipertensão/metabolismo
Hipertensão/prevenção & controle
-Fatores de Tempo
Triglicerídeos/sangue
Pressão Sanguínea/fisiologia
Composição Corporal/fisiologia
Antropometria
Reprodutibilidade dos Testes
Fatores de Risco
Cooperação do Paciente
Resultado do Tratamento
Estatísticas não Paramétricas
Limites: Humanos
Masculino
Feminino
Responsável: CL1.1 - Biblioteca Central


  10 / 1052 LILACS  
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Id: biblio-978746
Autor: SAPUNAR, JORGE; AGUILAR-FARÍAS, NICOLÁS; NAVARRO, JUAN; ARANEDA, GUSTAVO; CHANDÍA-POBLETE, DAMIAN; MANRÍQUEZ, VÍCTOR; BRITO, ROBERTO; CERDA, ÁLVARO.
Título: Alta prevalencia de dislipidemias y riesgo aterogénico en una población infanto-juvenil / High prevalence of dyslipidemia and high atherogenic index of plasma in children and adolescents
Fonte: Rev. méd. Chile;146(10):1112-1122, dic. 2018. tab, graf.
Idioma: es.
Projeto: Universidad de La Frontera; . Sociedad Chilena de Endocrinología Diabetes; . FONDECYT.
Resumo: Background: Dyslipidemias in childhood increase the risk of cardiovascular events in adult life. Aim: To evaluate the prevalence of dyslipidemia and risk of atherogenicity based in the atherogenic index of plasma (AIP) in a sample of school children and adolescents. Material and Methods: Cross-sectional study of 208 children aged 10.4 ± 1.0 years (107 women). Demographic data were obtained, and a clinical evaluation was conducted, including pubertal development according to Tanner and anthropometric parameters. A fasting blood sample was obtained to measure total cholesterol (CT), HDL cholesterol (cHDL) and triglycerides (TG), glucose and insulin. LDL cholesterol (cLDL), Non-HDL cholesterol and the indices CT/cHDL, cLDL/cHDL and AIP (log[TG/cHDL]) were calculated. Risk categories according to AIP for the pediatric population were also determined (low: AIP < 0.11, intermediate: AIP 0.11-0.21, high: AIP > 0.21). Results: Thirty eight percent of participants had dyslipidemia, without differences by gender and pubertal development. The frequency of dyslipidemia was significantly higher in children with obesity (54%, p < 0.01) and a waist circumference over percentile 90 (61%; p < 0.01). The later conditions had also higher CT/cHDL, cLDL/cHDL and AIP. According to AIP, 54% of children had a high atherogenicity risk along with alterations in anthropometric parameters and insulin resistance. All anthropometric and insulin resistance parameters were significantly correlated with the AIP. Conclusions: There is a high prevalence of dyslipidemia in the studied population, which is associated with an increased cardiometabolic risk. The indices of atherogenicity and particularly AIP are correlated with nutritional status, abdominal obesity and parameters of insulin resistance.
Descritores: Triglicerídeos/sangue
Colesterol/sangue
Dislipidemias/sangue
Dislipidemias/epidemiologia
-Valores de Referência
Fatores Socioeconômicos
Glicemia/análise
Resistência à Insulina
Doenças Cardiovasculares/etiologia
Modelos Logísticos
Chile/epidemiologia
Fatores Sexuais
Antropometria
Estado Nutricional
Prevalência
Estudos Transversais
Fatores de Risco
Análise de Variância
Distribuição por Sexo
Estatísticas não Paramétricas
Medição de Risco
Aterosclerose/sangue
Dislipidemias/complicações
Obesidade Abdominal/sangue
Limites: Humanos
Masculino
Feminino
Criança
Responsável: CL1.1 - Biblioteca Central



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