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Id: lil-605219
Autor: Echagüe, Gloria; Sosa, Liliana; Stanley, Jenny; Pistilli, Norma; Funes, Patricia; Ramírez, Alejandrina; Zenteno, Jorge; Díaz, Valentina; Ruíz, Irene; Zárate, Javier.
Título: Niveles séricos de apolipoproteínas A-I y B en niños escolares de escuelas rurales / Serum levels of apolipoprotein A-I and B in rural school children
Fonte: Pediatr. (Asunción);38(2):118-122, ago. 2011. tab.
Idioma: es.
Resumo: Los biomarcadores de riesgo aterogénico están presentes desdeetapas tempranas de la vida, uno de ellos son las apolipoproteínas. Estas juegan un papel fundamental en eldesarrollo de aterosclerosis según resultados de numerosos estudios epidemiológicos. El objetivo del trabajo fue evaluar los niveles de apolipoproteínas (apo) A-I y B y el coeficiente apo B/ apo A-1 en niños dislipidémicos. Se realizó un estudioobservacional, descriptivo, de corte transversal con muestreo no probabilístico. En una población de 132 niños, de ambos sexos, entre 4 a 13 años de edad, pertenecientes a 4 escuelas rurales de diferentes localidades del Paraguay, se encontraron 38 niños hipercolesterolémicos en quienes además se evaluaron los niveles de apolipoproteínas A-I y B. Se obtuvo consentimiento informado de los padres. El colesterol total fue medido por elmétodo enzimático automatizado y las apolipoproteínas A-I y B por el método inmunoturbidimétrico. Las concentraciones medias de apo A-I y B fueron de 159,89 ± 28,63 mg/dl y 99,79 ± 20,86 mg/dl respectivamente, la concentración media de colesterol fue de 192 ± 22,31. La media del cociente apo B/apo A-I fue de 0,64. Se detectaron niveles moderados a altos de apo B, en un considerable número de niños (63,5 %), y una correlación positiva entre las apolipoproteínas B y el colesterol, un 10, 53 % de los niños presentaron riesgo aterogénico alto deacuerdo al cociente apo B/apo A-I.

Biomarkers for atherogenic risk are present early in life, one such biomarker are the apolipoproteins. Apolipoproteins play a key role in the development of atherosclerosis according to results of numerous epidemiological studies. Our objective was to assess the levels of apolipoprotein (apo) A1 and B and the apo B/A-1 ratio in dyslipidemic children. We performed an observational, descriptive, cross-sectional study with nonprobabilistic sampling. In a population of 132 children aged 4 to13 years of both sexes from 4 rural schools in different parts of Paraguay, levels of apolipoproteins A-1 and B were assessed in 38 who were found to be hypercholesterolemic. Informedconsent was obtained from parents. Total cholesterol was measured by the automated enzymatic method andapolipoproteins A1 and B by the immunoturbidimetric method. Mean concentration was 159.89 ±28.63 mg/dl for apo A-1 and 99.79 ±20.86 mg/dl for apo B, while the mean cholesterol concentration was 192 ±22.31. The mean ratio of apo B/A1 was 0.64. We detected moderate to high levels of apo B in a considerable number of children (63.5%), and a positive correlation between apolipoprotein B and cholesterol. Some10.53% of children demonstrated high atherogenic risk as shown by the apo B/A1 ratio found.
Descritores: Apolipoproteína A-I
Hipobetalipoproteinemia Familiar por Apolipoproteína B
Pré-Escolar
Limites: Seres Humanos
Responsável: PY30.1 - Biblioteca


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Id: biblio-1038427
Autor: Cura-Esquivel, Idalia; Cordero-Pérez, Paula; Torres-González, Liliana; Muñoz-Espinosa, Linda E.
Título: Marcadores de fase aguda en niños y adolescentes obesos con trastornos metabólicos / Acute phase markers in obese children and adolescents with metabolic disorders
Fonte: Arch. argent. pediatr;116(4):275-279, ago. 2018. graf, tab.
Idioma: en; es.
Resumo: Introducción. La obesidad es un problema de salud pública mundial y la enfermedad crónica no transmisible más frecuente. Se asocia con la elevación de proteínas inflamatorias de fase aguda y citocinas proinflamatorias. Objetivo. Evaluar los niveles de proteínas de fase aguda en niños y adolescentes obesos con esteatosis hepática y síndrome agudo metabólico. Metodología. Se incluyeron 45 niños con índice de masa corporal ≥ percentil 95, de edades entre 5,0 y 15,5 años. Se determinaron reactantes de fase aguda: proteína C reactiva, haptoglobina, a-2 macroglobulina y apolipoproteína A-1, y se realizó una ecografía para evaluar la esteatosis hepática. Resultados. Todos los pacientes mostraron una elevación de proteína C reactiva. Los pacientes con síndrome metabólico también tuvieron un incremento en la apolipoproteína A-1 y la haptoglobina. Los pacientes con esteatosis hepática tuvieron un aumento significativo en la a-2 macroglobulina además de la protenína C reactiva.

Introduction. Obesity is a worldwide public health problem and the most common non-communicable chronic disease. It is associated with an increase in inflammatory acute phase proteins and proinflammatory cytokines. Objective. To assess the levels of acute phase proteins in obese children and adolescents with hepatic steatosis and metabolic syndrome. Methodology. Forty-five children with a body mass index ≥ 95th percentile aged 5.0-15.5 years were included. The following acute phase reactants were determined: C-reactive protein, haptoglobin, alpha-2-macroglobulin, and apolipoprotein A-1; besides, an ultrasound was done to assess hepatic steatosis. Results. C-reactive protein levels increased in all patients. Patients with metabolic syndrome also had high levels of apolipoprotein A-1 and haptoglobin. Patients with hepatic steatosis had a significant increase in alpha-2-macroglobulin in addition to high C-reactive protein.
Descritores: alfa-Macroglobulinas
Proteína C-Reativa
Haptoglobinas
Apolipoproteína A-I
Obesidade
Limites: Seres Humanos
Criança
Adolescente
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: lil-762908
Autor: Song, Y.R.; Wu, B.; Yang, Y.T.; Chen, J.; Zhang, L.J.; Zhang, Z.W.; Shi, H.Y.; Huang, C.L.; Pan, J.X.; Xie, P..
Título: Specific alterations in plasma proteins during depressed, manic, and euthymic states of bipolar disorder
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;48(11):973-982, Nov. 2015. tab, graf.
Idioma: en.
Projeto: National Key Scientific Program of China.
Resumo: Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2% of the general population of different European countries. Unfortunately, there is no objective laboratory-based test to aid BD diagnosis or monitor its progression, and little is known about the molecular basis of BD. Here, we performed a comparative proteomic study to identify differentially expressed plasma proteins in various BD mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched healthy control subjects were recruited. Seven high-abundance proteins were immunodepleted in plasma samples from the 4 experimental groups, which were then subjected to proteome-wide expression profiling by two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem mass spectrometry. Proteomic results were validated by immunoblotting and bioinformatically analyzed using MetaCore. From a total of 32 proteins identified with 1.5-fold changes in expression compared with healthy controls, 16 proteins were perturbed in BD independent of mood state, while 16 proteins were specifically associated with particular BD mood states. Two mood-independent differential proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be associated with early perturbations in lipid metabolism. Moreover, down-regulation of one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be associated with early perturbations in lipid metabolism that are independent of mood state, while CA-1 may be involved in the pathophysiology of depressive episodes.
Descritores: Apolipoproteína A-I/sangue
Apolipoproteínas/sangue
Transtorno Bipolar/sangue
Anidrase Carbônica I/sangue
Transtornos do Metabolismo dos Lipídeos/metabolismo
Lipoproteínas HDL/sangue
Proteômica
-Transtorno Bipolar/complicações
Transtorno Bipolar/diagnóstico
Bases de Dados de Proteínas
Diagnóstico Diferencial
Progressão da Doença
Regulação para Baixo
Transtorno Depressivo Maior/diagnóstico
Eletroforese em Gel Bidimensional
Immunoblotting
Imunoprecipitação
Transtornos do Metabolismo dos Lipídeos/complicações
Espectrometria de Massas/métodos
Limites: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-706544
Autor: Contreras-Duarte, Susana; Varas, Pablo; Awad, Fernanda; Busso, Dolores; Rigotti, Attilio.
Título: Papel protector de las lipoproteínas de alta densidad en sepsis: aspectos básicos e implicancias clínicas / Protective role of high density lipoproteins in sepsis: basic issues and clinical implications
Fonte: Rev. chil. infectol;31(1):34-43, feb. 2014. ilus.
Idioma: es.
Resumo: High density lipoproteins (HDL) are responsible of reverse cholesterol transport and play an important antiatherogenic role. In recent years, several studies suggest that HDL have additional functions, including a possible anti-inflammatory activity in infectious conditions. Furthermore, available evidence indicates that the presence of lipopolysaccharide (LPS) within the circulation during infectious states induced by gram-negative bacteria may be involved in the decrease in HDL cholesterol levels and changes in lipoprotein composition, which have been associated with a higher mortality due to sepsis in animal models and in humans. In this article, we review this subject and also discuss possible mechanisms that explain the positive impact achieved by native HDL, reconstituted HDL, or HDL apolipoprotein peptides on the inflammatory response and mortality in models of endotoxemia. In this regard, it has been proposed that one of the mechanisms by which HDL protect against sepsis may be mediated by its binding ability and/or neutralizing capacity on LPS, avoiding an excessive response of the immune system. Thus, increasing blood levels of HDL and/or parenteral HDL administration may represent a new anti-inflammatory tool for managing septic states in humans.

Las lipoproteínas de alta densidad (HDL) son responsables del transporte reverso de colesterol y ejercen un importante papel anti-aterogénico. En los últimos años, diversos estudios indican que las HDL también tendrían otras funciones críticas, incluyendo una posible actividad anti-inflamatoria durante estados infecciosos. Además, la evidencia disponible sugiere que la presencia de lipopolisacárido (LPS) en la circulación durante estados infecciosos inducidos por bacterias gramnegativas podría estar involucrado en la disminución del colesterol HDL y los cambios en composición de esta clase lipoproteínas, lo cual se asociaría con una mayor tasa de mortalidad por sepsis en modelos animales y en humanos. En este trabajo, se revisan los antecedentes mencionados y además se discuten posibles mecanismos que explican la disminución de la respuesta inflamatoria y de la mortalidad que se logran en modelos de endotoxemia tratados con HDL o preparaciones similares. En este sentido, se ha propuesto que uno de los mecanismos protectores de las HDL estaría mediado por su capacidad de unión y/o neutralización del LPS, evitando una respuesta exacerbada del sistema inmune. De esta manera, el aumento de los niveles sanguíneos de HDL y/o su administración parenteral podrían constituir nuevas herramientas anti-inflamatorias para el manejo de estados sépticos en humanos.
Descritores: Aterosclerose/prevenção & controle
Endotoxemia/imunologia
Lipoproteínas HDL/fisiologia
Estresse Oxidativo/fisiologia
Sepse/imunologia
-Anti-Inflamatórios/farmacologia
Apolipoproteína A-I/análise
Colesterol/sangue
Modelos Animais de Doenças
Endotoxemia/sangue
Mediadores da Inflamação/metabolismo
Inflamação/sangue
Inflamação/imunologia
Lipopolissacarídeos/sangue
Lipoproteínas HDL/sangue
Lipoproteínas HDL/efeitos dos fármacos
Sepse/sangue
Trombose/sangue
Limites: Animais
Seres Humanos
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: lil-703417
Autor: Nieto, Olga A.; García, Diana M.; Jiménez, Jorge A.; Landázuri, Patricia.
Título: Efecto del ejercicio en subpoblaciones de lipoproteínas de alta densidad y en la presión arterial / Effect of exercise on high density lipoprotein subpopulations and blood pressure
Fonte: Rev. salud pública;15(1):12-22, ene.-feb. 2013. ilus.
Idioma: es.
Resumo: Objetivo Determinar la relación del ejercicio con los niveles séricos de la apoA-I y las subpoblaciones de HDL2 y HDL3, en personas hipertensas de la Ciudad de Armenia - Quindío. Métodos La intervención fueron dos meses de ejercicio. La presión arterial se tomó con las recomendaciones del Ministerio de Salud de Colombia. Las subpoblaciones de HDL se midieron con el método del precipitado ionico y la apoA-I se midió con la técnica de nefelometría de bindig site. Resultados Los datos se analizaron con estadística descriptiva e inferencial. Se captaron 160 pacientes de los cuales 125 permanecieron hasta el final del proyecto, es decir, hubo un 78,12 % de permanencia; el 28 % hicieron ejercicio. El análisis mostró una reducción altamente significativa de la tensión arterial sistólica y diastólica mayor en las personas que hicieron que en las que no hicieron ejercicio. Las cifras de HDL estaban por debajo de lo normal antes del ejercicio aumentaron significativamente con el ejercicio pero aún se mantuvieron por debajo de los valores de referencia, las HDL2 aumentaron significativamente, mientras las HDL3 descendieroncon niveles normales de apoA-I. Conclusiones Este trabajo muestra que el ejercicio aumenta las HDL totales, pero lo más importante es que modifica la subpoblaciones de HDL en una relación que favorece aquellas que parecen tener propiedades ateroprotectivas. Y la evidencia de la interrelación entre factores protectores, aporta nuevos argumentos para las acciones en salud pública, frente al riesgo cardiovascular y la hipertensión Arterial.

Objetive Determine the relationship of exercise with serum levels of apoA-I and HDL2 and HDL3, subpopulations in hypertensive individuals from the city of Armenia - Quindío. Methods The interventions were two months of exercise. Blood pressure was taken with the recommendations of the Ministry of Health of Colombia. HDL subpopulations were measured with the method of precipitate ionicand the apoA-I was measured using nephelometry of Bindig site. Results Descriptive and inferential statistics were used for data analysis. A total of 160 patients of whom 125 remained until the end of the project were gathered, that is, there was a 78.12 % retention, 28 % did the exercise. The analysis showed a highly significant reduction of systolic and diastolic blood pressure, higher in people who did exercise. The HDL were below normal before exercise, significantly increased with exercise but still remained below the reference values, the HDL2 increased significantly, while HDL3 decreased with normal levels of apoA-I. Conclusion This study shows that exercise increases the total HDL, but the most important is that exercise modified the HDL subpopulations in a relationship that favors those which seem to have ateroprotective properties. The evidence of the interrelationship between protective factors provides new arguments for public health actions against the cardiovascular risk and hypertension.
Descritores: Apolipoproteína A-I/sangue
Pressão Sanguínea
Exercício/fisiologia
/sangue
LIPOPROTEINS, HDLABATTOIRS/sangue
/sangue
LIPOPROTEINS, HDLTEMEFOS/sangue
Limites: Feminino
Seres Humanos
Masculino
Meia-Idade
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CO332 - Facultad de Medicina


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Id: lil-674194
Autor: Morais, Charles Augusto dos Santos; Oliveira, Samuel Henrique Vieira; Lima, Luciana Moreira.
Título: Índices Lipídicos Tetravalente (LTI) e Pentavalente (LPI) em indivíduos saudáveis / Lipid Tetrad Index (LTI) and Lipid Pentad Index (LPI) in healthy subjects
Fonte: Arq. bras. cardiol;100(4):322-327, abr. 2013. graf, tab.
Idioma: pt.
Resumo: FUNDAMENTO: A prevalência das doenças cardiovasculares (DCV) tem aumentado nos últimos anos. A literatura revela que cerca de 35% dos eventos ateroscleróticos ocorrem na ausência dos fatores de risco clássicos, requerendo uma avaliação individual minuciosa para melhor caracterizar o risco. Os índices lipídicos tetravalente (LTI) e pentavalente (LPI) constituem uma nova e eficiente forma de avaliação do perfil lipídico e do risco para DCV. OBJETIVO: O presente estudo avaliou o LTI e o LPI em estudantes de graduação, estabelecendo estes índices em indivíduos saudáveis e correlacionando-os com o perfil lipídico tradicional. MÉTODOS: Participaram do estudo 110 estudantes, 48 (44%) do sexo masculino e 62 (56%) do sexo feminino, com média de idade de 20,9 ± 1,7 anos. Apolipoproteína-AI, apolipoproteína B, colesterol total, lipoproteína (a), triglicérides, HDL e LDL foram analisados usando-se métodos diagnósticos específicos. LTI e LPI foram calculados por meio das equações LTI = [colesterol total x triglicérides x lipoproteína (a) / HDL] e LPI = [colesterol total x triglicérides x lipoproteína (a) x apolipoproteína B / apolipoproteína A-I], respectivamente. RESULTADOS: Os valores de LTI e de LPI foram significativamente maiores nas mulheres quando comparados aos dos homens. Para os outros parâmetros, houve diferenças significativas entre os gêneros apenas para colesterol total, HDL e apolipoproteína A-I. Houve correlações positivas e significativas entre LDL e LTI e entre LDL e LPI. CONCLUSÃO: Os achados indicam que LTI e LPI estavam associados com LDL, um parâmetro não utilizado para calcular os índices lipídicos e amplamente usado na prática clínica para investigação do risco cardiovascular.

BACKGROUND: The prevalence of cardiovascular disease (CVD) has increased steadily in recent years. Literature data show that about 35% of atherosclerotic events occur in the absence of classic risk factors, requiring a broader assessment of the individual to better characterize the risk. Lipid Tetrad Index (LTI) and Lipid Pentad Index (LPI) constitute a new and efficient evaluation of the lipid profile and CVD risk. OBJECTIVE: This study assessed LTI and LPI in undergraduate students, seeking to establish the parameters of these indices in healthy subjects and correlate them with the conventional lipid profile. METHODS: The study included 110 students, 48 (44%) males and 62 (56%) females, mean age 20.9 ± 1.7. Apolipoprotein-AI, apolipoprotein B, total cholesterol, lipoprotein(a), triglycerides, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were assessed, using specific diagnostic methods. LTI and LPI indices were calculated using the equations LTI = [total cholesterol x triglycerides x lipoprotein(a) / HDL] and LPI = [total cholesterol x triglycerides x lipoprotein(a) x apolipoprotein B/apolipoprotein-AI], respectively. RESULTS: LTI and LPI values were significantly higher in females compared to males. As for the other parameters, there were significant differences between males and females only regarding total cholesterol, HDL and apolipoprotein-AI. There were significant and positive correlations between LDL and LTI and between LDL and LPI. CONCLUSIONS: Findings indicate that both LTI and LPI were associated with LDL, a parameter not used to calculate lipid indices and widely used in clinical practice for cardiovascular risk assessment.
Descritores: Apolipoproteína A-I/sangue
Apolipoproteínas B/sangue
Doenças Cardiovasculares/diagnóstico
Colesterol/sangue
Lipoproteína(a)/sangue
Estudantes/estatística & dados numéricos
Triglicerídeos/sangue
-Biomarcadores/sangue
Fatores de Risco
Estatísticas não Paramétricas
Limites: Feminino
Seres Humanos
Masculino
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-633797
Autor: González, Ana Inés; Brites, Fernando; Elbert, Alicia; Gómez-Rosso, Leonardo; Berg, Gabriela; Wikinski, Regina; Schreier, Laura.
Título: Relación entre paraoxonasa, otros componentes de HDL y estado inflamatorio en hemodiálisis / Relation between paraoxonase activity, other HDL components and inflammatory conditions in hemodialyzed patients
Fonte: Medicina (B.Aires);70(6):508-512, dic. 2010. graf, tab.
Idioma: es.
Projeto: Universidad de Buenos Aires; . Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT). PICT 195.
Resumo: La enfermedad renal crónica (ERC) se asocia estrechamente con un estado pro-inflamatorio, aumento de lipoproteínas ricas en triglicéridos y disminución de HDL. La HDL contiene enzimas antioxidantes asociadas como la paraoxonasa (PON), cuya actividad en ERC se encuentra disminuida. Nuestro objetivo fue evaluar la relación entre la actividad de PON, apoA1, colesterol(col)-HDL y Proteína C reactiva-altamente sensible (PCR-as) como marcador de inflamación en pacientes en hemodiálisis. Se estudiaron n = 42 pacientes; edad, mediana (rango) = 50 (25-67) años; sexo M/F = 22/20; antigüedad de hemodiálisis = 4.4 ± 0.5 años; índice de masa corporal (IMC) = 23 ± 0.5 kg/m². Se obtuvo una muestra de sangre después de 12 h de ayuno y se determinaron los parámetros clásicos del perfil lipídico, se midieron los valores de apoproteínas A1 y B, PON a través de su actividad arilesterasa y PCR-as, la cual permitió dividir a los pacientes con PCR-as ≤ 1 (bajo riesgo, rango: 0.1 a 1.0 mg/l) y > 1 mg/l (moderado y alto riesgo, 1.1 a 10.7 mg/l). Los niveles de triglicéridos, col-LDL y apoB no fueron diferentes entre los grupos. Los pacientes con PCR-as > 1 presentaron menor col-HDL (40 ± 2 mg/dl) y apoA1 (118 ± 4 mg/dl) que los pacientes con PCR-as ≤ 1 (50 ± 4 y 133 ± 5, respectivamente); p < 0.05. La PON fue menor en PCR-as > 1: 90.5 ± 24.0 μmol/ml.min que en PCR-as ≤ 1: 105.2 ± 18.0. Consecuentemente, se obtuvieron correlaciones inversas entre apoA1 y PCR-as, r = -0.381 p = 0.013 y entre PON y PCR-as, r = -0.32, p = 0.042. Además, el aumento de PCR-as correlacionó positivamente con el IMC, r = 0.318, p = 0.042. La disminución de col-HDL, apoA1 y PON en los individuos con mayor estado inflamatorio explicaría, en parte, el aumento de riesgo cardiovascular de estos pacientes, dado los efectos antiinflamatorios de la apoA1 y antioxidantes de la PON.

Advanced Chronic Renal Disease (CKD) is closely associated with a pro-inflammatory condition, with an increase in triglyceride-rich lipoproteins and decrease in HDL level. HDL contains antioxidant enzymes such as paraoxonase (PON), whose activity is diminished in CKD. The aim of our study was to evaluate the relationship between PON activity with HDL cholesterol, apo A1 and hs-CRP levels, which are known to be inflammatory markers in hemodialyzed patients. Forty-two patients were studied; age, median (range) = 50 (25-67) years old, gender M/F = 22/20, duration of hemodialysis = 4.4 ± 0.5 years, BMI: 23 ± 0.5 kg/m². After a 12 h fast, a blood sample was obtained and classic components of lipid profile were determined, as well as apoproteins A1 and B, PON by means of its arylsterase activity and hs-CRP levels. On the basis of the latter, patients were divided into two groups: hs-CRP ≤ 1 (low risk, range: 0.1 to 1.0 mg/l) and >1 mg/l (moderate and high risk, 1.1 to 10.7 mg/l). No difference was found in triglycerides, LDL cholesterol and apo B in the groups. Patients with hs-CRP > 1 showed lower HDL cholesterol (40 ± 2 mg/dl) and apo A1 (118 ± 4 mg/dl) than patients with hs-CRP ≤ 1 (50 ± 4 and 133 ± 5, respectively); p < 0.05. PON was lower in hs-CRP > 1 = 90.5 ± 24.0 μmol/ml.min than in hs-CRP ≤ 1 = 105.2 ± 18.0. Consequently, inverse correlations were obtained between apo A1 and hs-CRP, r = -0.381, p = 0.013 and between PON and hs-CRP, r = -0.32, p = 0.042. Furthermore, increase in hs-CRP correlated positively with BMI r = 0.318, p = 0.042. Since apo A1 has an anti-inflammatory role and PON an antioxidant activity, the decrease in HDL and its components, cholesterol, apo A1 and PON, in subjects with higher chronic inflammatory condition might explain, in part, the increased cardiovascular risk in these patients.
Descritores: Apolipoproteína A-I/sangue
Arildialquilfosfatase/sangue
Proteína C-Reativa/análise
HDL-Colesterol/sangue
Inflamação/sangue
Diálise Renal
-Índice de Massa Corporal
Biomarcadores/sangue
Valores de Referência
Limites: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas


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Id: lil-589979
Autor: Song, Yong Yan; Gong, Ren Rong; Zhang, Zhen; Li, Yuan Hao; Xiao, Li Ying; Zhou, Xue Dong; Fang, Ding Zhi.
Título: A high-carbohydrate diet enhances the adverse effect of the S2 allele of APOC3 SstI polymorphism on the TG/HDL-C ratio only in young Chinese females
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;44(6):524-530, June 2011. tab.
Idioma: en.
Resumo: Both genetic background and diet have profound effects on plasma lipid profiles. We hypothesized that a high-carbohydrate (high-CHO) diet may affect the ratios of serum lipids and apolipoproteins (apo) differently in subjects with different genotypes of the SstI polymorphism in the apoCIII gene (APOC3). Fifty-six healthy university students (27 males and 29 females, 22.89 ± 1.80 years) were given a washout diet of 54 percent carbohydrate for 7 days, followed by a high-CHO diet of 70 percent carbohydrate for 6 days without total energy restriction. Serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apoB100, apoAI, and the APOC3 SstI polymorphism were analyzed. The ratios of serum lipids and apoB100/apoAI were calculated. At baseline, the TG/HDL-C ratio was significantly higher in females, but not in males, with the S2 allele. The differences in the TG/HDL-C ratio between genotypes remained the same after the washout and the high-CHO diet in females. When compared with those before the high-CHO diet, the TC/HDL-C (male S2 carriers: 3.13 ± 1.00 vs 2.36 ± 0.65, P = 0.000; male subjects with the S1S1 genotype: 2.97 ± 0.74 vs 2.09 ± 0.55, P = 0.000; female S2 carriers: 2.68 ± 0.36 vs 2.24 ± 0.37, P = 0.004; female subjects with the S1S1 genotype: 2.69 ± 0.41 vs 2.09 ± 0.31, P = 0.000) and LDL-C/HDL-C (male S2 carriers: 1.44 ± 0.71 vs 1.06 ± 0.26, P = 0.012; male subjects with the S1S1 genotype: 1.35 ± 0.61 vs 1.01 ± 0.29, P = 0.005; female S2 carriers: 1.18 ± 0.33 vs 1.00 ± 0.18, P = 0.049; female subjects with the S1S1 genotype: 1.18 ± 0.35 vs 1.04 ± 0.19, P = 0.026) ratios were significantly decreased after the high-CHO diet regardless of gender and of genotype of the APOC3 SstI polymorphism. However, in female S2 carriers, the TG/HDL-C (1.38 ± 0.46 vs 1.63 ± 0.70, P = 0.039) ratio was significantly increased after the high-CHO diet. In conclusion, the high-CHO diet has favorable effects on the TC/HDL-C and LDL-C/HDL-C ratios regardless of gender and of genotype of the APOC3 SstI polymorphism. Somehow, it enhanced the adverse effect of the S2 allele on the TG/HDL-C ratio only in females.
Descritores: Apolipoproteína C-III/genética
HDL-Colesterol/sangue
Carboidratos da Dieta/efeitos adversos
Polimorfismo Genético
Triglicerídeos/sangue
-Alelos
Grupo com Ancestrais do Continente Asiático
Apolipoproteína A-I/sangue
Apolipoproteína A-I/genética
/sangue
APOLIPOPROTEIN B-ACETOLACTATE SYNTHASE/sangue
/genética
APOLIPOPROTEIN B-ACETOLACTATE SYNTHASE/genética
Apolipoproteína C-III/sangue
HDL-Colesterol/genética
LDL-Colesterol/sangue
LDL-Colesterol/genética
Colesterol/sangue
Colesterol/genética
Carboidratos da Dieta/administração & dosagem
Genótipo
Técnicas de Genotipagem
Heterozigoto
Fatores Sexuais
Limites: Feminino
Seres Humanos
Masculino
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-586976
Autor: Souza, Juliana Ascenção de.
Título: Heterogeneidade e mecanismos moleculares da atividade anti-apoptótica das subfrações de HDL em células endoteliais humanas / Heterogeneity and molecular mechanisms of anti-apoptotic activity of high-density lipoprotein (HDL) subfractions on endothelial cells.
Fonte: São Paulo; s.n; 2007. [148] p. ilus, tab, graf.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Faculdade de Medicina para obtenção do grau de Doutor.
Resumo: Introdução: A lipoproteína de baixa densidade (LDL) e suas formas oxidadas (LDLox) possuem múltiplas propriedades aterogênicas, atuando na deposição de colesterol, indução e manutenção da inflamação, disfunção endotelial, surgimento de células espumosas na parede arterial e conseqüente formação da placa de ateroma. Adicionalmente, LDLox induz apoptose de células endoteliais humanas (HMEC). A lipoproteína de alta densidade (HDL) possui inúmeras atividades antiaterogênicas, incluindo ações antioxidante, anti-inflamatória e anti-trombótica. A HDL é capaz de proteger as HMEC contra apoptose. As subfrações de HDL (sHDL) são heterogêneas em sua composição físico-química e atividades biológicas. A atividade antioxidante das sHDL aumenta com a densidade (HDL2b100% - anexina V) e 3b (43% e 67%, respectivamente) de indivíduos normolipidêmicos apresentaram atividade anti-apoptótica mais potente do que as subfrações HDL2a (29% e 28%; p<0,01 vs. HDL3c, respectivamente) e 2b (25% e 62%; p<0,001 vs. HDL3c, respectivamente). Todas sHDL reduziram geração de espécies reativas de oxigênio (ROS) induzida pela LDLox, sendo a HDL3c (54%) mais potente do que HDL2b (21%; p<0.05 vs. HDL3c). Houve correlação positiva entre as atividades anti-apoptótica e antioxidante intracelular com conteúdo de apoA-I e esfingosina 1-fosfato (E1F) das sHDL, senda HDL3b e 3c ricas em E1F. A atividade anti-apoptótica da E1F e das sHDL parece depender da interação com as células endoteliais via apoA-I e seu receptor SR-BI. Finalmente, as HDL3c (n=5) isoladas de pacientes com SMet possuem conteúdo significativamente menor de apoA-I e reduzida atividade anti-apoptótica (60%, p<0,01), quando comparada aos controles normolipidêmicos (n=5). Houve tendência à diminuição da proteção contra a geração de ROS (SMet, n=10). Conclusão: As subfrações HDL3c protegem de forma potente as células endoteliais humanas contra toxicidade e apoptose induzidas pela LDLox, assim como contra geração de ROS...

Background: Low density lipoprotein (LDL) and its oxidized forms (oxLDL) have several atherogenic properties, including cholesterol deposition, inflammation, endothelial dysfunction and foam cell formation on the arterial wall, leading to atherosclerotic plaque development. In addition, oxLDL induces human endothelial cell apoptosis (HMEC). High-density lipoprotein (HDL) has number of antiatherogenic activities, as antioxidative, anti-inflammatory and anti-thrombotic actions. HDL displays anti-apoptotic activity and is able to protect endothelial cells against oxLDL-induced apoptosis. HDL subfractions (sHDL) are highly heterogeneous in their physical and chemical composition and biological functions. Antioxidative activity of HDL subfractions increases with increment in density, HDL2b100% in annexin V biding) and 3b subfractions (43% and 67%, respectively) were more potent against oxLDL-induced toxicity and apoptosis as compared to HDL2a (29% and 28%; p<0.01 vs. HDL3c, respectively) and 2b subfractions (25% and 62%; p<0.001 vs. HDL3c, respectively). All HDL subfractions attenuated of reactive oxygen species (ROS) generation in HMEC induced by oxLDL. Again, HDL3c (54% inhibition) were more potent as compared to HDL2b (21%; p<0.05 vs. HDL3c). The anti-apoptotic and intracellular antioxidative activities of HDL3 were positively correlated with apoA-I and sphingosine 1-phosphate (S1P) content of sHDL and, possibly, depend on their cellular interaction through apoA-I and its SR-BI receptor. The sHDL3c isolated from MetS patients (n=5) possess reduced content of apoA-I and less potent anti-apoptotic activity (-60%, p<0.01) than controls (n=5). Conclusion: Normolipidemic small dense HDL3 provide potent protection of human endothelial cells from oxLDL-induced apoptosis; this anti-apoptotic activity is reduced in the MetS.
Descritores: Apolipoproteína A-I
Apoptose
Dislipidemias
Células Endoteliais
Lipoproteínas HDL
Síndrome Metabólica
Esfingosina
Limites: Seres Humanos
Masculino
Responsável: BR66.1 - Divisão de Biblioteca e Documentação
BR66.1; W4.DB8, S715h, FM-2, 2007


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Souza, Dorotéia Rossi Silva
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Id: lil-586495
Autor: Zanella, Aline Margioti; Nakazone, Marcelo Arruda; Pinhel, Marcela Augusta Souza; Souza, Dorotéia Rossi Silva.
Título: Lipid profile, apolipoprotein A-I and oxidative stress in professional footballers, sedentary individuals, and their relatives / Perfil lipídico, apolipoproteína A-I e estresse oxidativo em jogadores de futebol profissionais, indivíduos sedentários e seus familiares
Fonte: Arq. bras. endocrinol. metab;55(2):121-126, mar. 2011. tab.
Idioma: en.
Resumo: OBJECTIVE: To evaluate whether lipid profile (LP), apolipoprotein A-1 (apo A-I) and malondialdehyde (MDA) have any relationship with physical exercise by comparing the groups of footballers (FG) with sedentary individuals (CG) and their relatives (RFG and RCG). SUBJECTS AND METHODS: Twenty individuals from FG and CG, 60 from RFG, and 57 from RCG were studied. RESULTS: FG showed lower levels of total cholesterol (119.5 ± 37.9 mg/dL), LDL-cholesterol fraction (53.6 ± 30.3), apo A-I (116.7 ± 11.9), and higher level of HDL-cholesterol fraction (HDLc) (49.7 ± 8.5) compared to RFG (148.3 ± 36.9, P = 0.02; 82.4 ± 37.7, P < 0.01; 124.6 ± 10.2, P = 0.03; and 42.7 ± 7.7, P < 0.01; respectively). Moreover, FG had reduced levels of MDA (101.0 ± 77.0 ng/mL) compared to CG (290.0 ± 341.0, P = 0.03) and RFG (209.9 ± 197.5, P = 0.04). CONCLUSIONS: These results suggest an association between physical exercise and lower levels of MDA in FG. Physical activity seems to promote beneficial effects on the LP regardless of the genetic influence considering HDLc levels.

OBJETIVO: Avaliar se perfil lipídico (PL), apolipoproteína A-1 (apo A-I) e malondialdeído (MDA) têm relação com atividade física comparando os grupos: jogadores de futebol (FG) com indivíduos sedentários (CG) e seus familiares. SUJEITOS E MÉTODOS: Foram avaliados 20 indivíduos de FG e CG, além de 60 familiares de FG (RFG) e 57 de CG (RCG). RESULTADOS: FG mostrou menores níveis (média ± DP [mg/dL]) de colesterol total (119.5 ± 37.9), LDL colesterol (53.6 ± 30.3), e apo A-I (116.7 ± 11.9), e maiores níveis de HDL colesterol (HDLc) (49.7 ± 8.5) comparado ao RFG (148.3 ± 36.9, P = 0.02; 82.4 ± 37.7, P < 0.01; 124.6 ± 10.2, P = 0.03; e 42.7 ± 7.7, P < 0.01; respectivamente). Além disso, o FG mostrou níveis reduzidos de MDA (101.0 ± 77.0 [ng/mL]) comparado a CG (290.0 ± 341.0, P = 0.03) e RFG (209.9 ± 197.5, P = 0.04). CONCLUSÕES: Esses resultados sugerem que existe uma associação entre atividade física e níveis reduzidos de MDA em FG. O exercício físico parece promover efeitos benéficos no PL independente da influência genética considerando os níveis de HDLc.
Descritores: Apolipoproteína A-I/sangue
Lipídeos/sangue
Malondialdeído/sangue
Estresse Oxidativo/fisiologia
Resistência Física/fisiologia
Estilo de Vida Sedentário
Futebol/fisiologia
-Estudos de Casos e Controles
Teste de Esforço/métodos
Família
Limites: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME



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