Base de dados : LILACS
Pesquisa : D12.125.067.625.349 [Categoria DeCS]
Referências encontradas : 135 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 14 ir para página                         

  1 / 135 LILACS  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: lil-478282
Autor: Lima, Rafael Rodrigues; Costa, Ana Maria Rabelo; Souza, Renata Duarte de; Gomes-Leal, Walace.
Título: Degeneração neuronal secundária e excitotoxicidade / Secondary neurodegeneration and excitotoxicity
Fonte: Rev. para. med = Rev. Para. Med. (Impr.);21(1):27-31, jan.-mar. 2007.
Idioma: pt.
Resumo: Objetivo: caracterizar os principais eventos correlatos entre degeneração neuronal secundária e excitotoxicidade em doenças neurodegenerativas. Método: revisão de literatura através de pesquisa bibliográfica na base de dados PUBMED/MEDLINE. Considerações Finais: o dano tecidual proveniente de lesões isquêmicas ou traumáticas no sistema nervoso central não se restringe somente à lesão primária propriamente dita, mas também, e em grande intensidade do processo de degeneração neuronal secundária desencadeada, seja pela resposta inflamatória ou através de cascatas destrutivas ativadas durante a excitotoxicidade mediada por glutamato. O melhor entendimento molecular desse processo toma-se necessário para um bloqueio seletivo desses eventos patológicos, minimizando os efeitos colaterais, o que permitirá a elaboração de abordagens terapêuticas neuroprotetoras eficazes.

Objective: Review the main experimental evidences for a role of excitotoxic events on the pathophysiology neurodegenerative diseases. Methods: Literature review through bibliographical search in the databases PUBMED/MEDLINE. Final considerations: The tis sue damage occurring following ischemic and/or traumatic injuries in the central system nervous is not due the primary pathological events, but also, and more importantly, to the second neurodegeneration involving excitotoxicity, inflammation, oxidative stress, apoptosis. The understanding of t molecular mechanisms of these events is necessary for the more effective development of neuroprotectiveneuroregenerative therapies for CNS diseases.
Descritores: Degeneração Neural
Doenças Neurodegenerativas
Revisão
Ácido Glutâmico
-Morte Celular
Responsável: BR3.1 - Biblioteca Central


  2 / 135 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Chile
Texto completo
Id: biblio-950769
Autor: Matias, Carlos M; Dionísio, Jose C; Saggau, Peter; Quinta-Ferreira, Maria Emilia.
Título: Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers
Fonte: Biol. Res;47:1-6, 2014. ilus, graf.
Idioma: en.
Projeto: CNC; . MCTES. FCT; . FEDER. COMPETE.
Resumo: BACKGROUND: The hippocampal CA3 area contains large amounts of vesicular zinc in the mossy fiber terminals which is released during synaptic activity, depending on presynaptic calcium. Another characteristic of these synapses is the presynaptic localization of high concentrations of group II metabotropic glutamate receptors, specifically activated by DCG-IV. Previous work has shown that DCG-IV affects only mossy fiber-evoked responses but not the signals from associational-commissural afferents, blocking mossy fiber synaptic transmission. Since zinc is released from mossy fibers even for single stimuli and it is generally assumed to be co-released with glutamate, the aim of the work was to investigate the effect of DCG-IV on mossy fiber zinc signals. RESULTS: Studies were performed using the membrane-permeant fluorescent zinc probe TSQ, and indicate that DCG-IV almost completely abolishes mossy fiber zinc changes as it does with synaptic transmission. CONCLUSIONS: Zinc signaling is regulated by the activation of type II metabotropic receptors, as it has been previously shown for glutamate, further supporting the corelease of glutamate and zinc from mossy fibers.
Descritores: Zinco/metabolismo
Receptores de Glutamato Metabotrópico/metabolismo
Fibras Musgosas Hipocampais/efeitos dos fármacos
Ciclopropanos/farmacologia
Glicina/análogos & derivados
Anticonvulsivantes/farmacologia
-Vesículas Sinápticas/efeitos dos fármacos
Vesículas Sinápticas/metabolismo
Transdução de Sinais/efeitos dos fármacos
Ratos Wistar
Terminações Pré-Sinápticas/efeitos dos fármacos
Terminações Pré-Sinápticas/metabolismo
Transmissão Sináptica/efeitos dos fármacos
6-Ciano-7-nitroquinoxalina-2,3-diona/farmacologia
Estatísticas não Paramétricas
Ácido Glutâmico/metabolismo
Antagonistas de Aminoácidos Excitatórios/farmacologia
Fibras Musgosas Hipocampais/metabolismo
Glicina/farmacologia
Hipocampo/efeitos dos fármacos
Limites: Animais
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


  3 / 135 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Chile
Texto completo
Id: biblio-950819
Autor: Koriauli, S; Natsvlishvili, N; Barbakadze, T; Mikeladze, D.
Título: Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons
Fonte: Biol. Res;48:1-5, 2015. graf.
Idioma: en.
Resumo: BACKGROUND: In the central nervous system, interleukin-10 (IL-10) provides trophic and survival effects directly on neurons, modulates neurite plasticity, and has a pivotal importance in the neuronal regeneration in neurodegenerative and neuroinflammatory conditions. This cytokine is primarily produced by glial cells and has beneficial effects on the neuronal viability. However, the mechanisms of IL-10-elicited neuroprotection are not clear. RESULTS: Membrane preparations, isolated from wild-type (Wt) and IL-10 knockout (KO) mice brain were used in this study. It has been shown that compared to wild-type mice, in IL-10 KO mice brain, the amount of immunoglobulin binding protein (BiP) is greatly increased, whereas the content of sigma receptor-1 (SigR1) is not changed significantly. Co-immunoprecipitation experiments have shown that the association of SigR1 with small GTPase Rac1 (Ras-related C3 botulinum toxin substrate 1), NR2B subunit of NMDA-receptor (NMDAR) and inositol-3-phosphate receptor (IP3R) is higher in the IL-10 KO mice brain than in the Wt mice brain. Besides, we have found that either glutamate or sigma ligands, separately or together, do not change glutamate-induced NADPH-oxidase (NOX) activity in Wt-type mice brain membrane preparations, whereas in IL-10 KO mice high concentration of glutamate markedly increases the NOX-dependent production of reactive oxygen species (ROS). Glutamate-dependent ROS production was decreased to the normal levels by the action of sigma-agonists. CONCLUSIONS: It has been concluded that IL-10 deprivation, at least in part, can lead to the induction of ER-stress, which causes BiP expression and SigR1 redistribution between components of endoplasmic reticulum (ER) and plasma membrane. Moreover, IL-10 deficiency can change the specific organization of NMDAR, increasing the surface expression of SigR1-sensitive NR2B-containing NMDAR. In these conditions, glutamate-dependent ROS production is greatly increased leading to the initiation of apoptosis. In this circumstances, sigma-ligands could play a preventive role against NMDA receptor-mediated excitotoxicity.
Descritores: Encéfalo/metabolismo
Interleucina-10/genética
Receptores sigma/metabolismo
Ácido Glutâmico/metabolismo
NADPH Oxidases/metabolismo
-Membrana Celular/metabolismo
Receptores sigma/classificação
Receptores sigma/agonistas
Espécies Reativas de Oxigênio/análise
Espécies Reativas de Oxigênio/metabolismo
Receptores de N-Metil-D-Aspartato/classificação
Receptores de N-Metil-D-Aspartato/metabolismo
Proteínas rac1 de Ligação ao GTP/metabolismo
Imunoprecipitação
Retículo Endoplasmático/metabolismo
Receptores de Inositol 1,4,5-Trifosfato/metabolismo
Técnicas de Silenciamento de Genes
Proteínas de Choque Térmico/metabolismo
Camundongos Endogâmicos C57BL
Neurônios/metabolismo
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


  4 / 135 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Chile
Texto completo
Id: biblio-1131882
Autor: Wang, Zhifu; Huang, Sheng; Yu, Xiangmei; Li, Long; Yang, Minguang; Liang, Shengxiang; Liu, Weilin; Tao, Jing.
Título: Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain
Fonte: Biol. Res;53:36, 2020. tab, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Fujian Natural Science Foundation of China.
Resumo: BACKGROUND: To investigate the thalamic neurotransmitters and functional connections in the development of chronic constriction injury (CCI)-induced neuropathic pain. METHODS: The paw withdrawal threshold was measured by mechanical stimulation the right hind paw with the von frey hair in the rats of CCI-induced neuropathic pain. The N-acetylaspartate (NAA) and Glutamate (Glu) in thalamus were detected by magnetic resonance spectrum (MRS) process. The thalamic functional connectivity with other brain regions was scanned by functional magnetic resonance image (fMRI). RESULTS: The paw withdrawal threshold of the ipsilateral side showed a noticeable decline during the pathological process. Increased concentrations of Glu and decreased levels of NAA in the thalamus were significantly correlated with mechanical allodynia in the neuropathic pain states. The thalamic regional homogeneity (ReHo) decreased during the process of neuropathic pain. The functional connectivity among the thalamus with the insula and somatosensory cortex were significantly increased at different time points (7, 14, 21 days) after CCI surgery. CONCLUSION: Our study suggests that dynamic changes in thalamic NAA and Glu levels contribute to the thalamic functional connection hyper-excitation during CCI-induced neuropathic pain. Enhanced thalamus-insula functional connection might have a significant effect on the occurrence of neuropathic pain.
Descritores: Tálamo/metabolismo
Ferimentos e Lesões/fisiopatologia
Neurotransmissores/metabolismo
Neuralgia
-Tálamo/fisiopatologia
Ácido Aspártico/análogos & derivados
Ácido Aspártico/metabolismo
Ácido Glutâmico/metabolismo
Constrição
Hiperalgesia
Limites: Animais
Ratos
Responsável: CL1.1 - Biblioteca Central


  5 / 135 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-796839
Autor: Souza, Paulo Victor Sgobbi de; Pinto, Wladimir Bocca Vieira de Rezende; Rezende Filho, Flávio Moura; Oliveira, Acary Souza Bulle.
Título: Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis / Muito além do neurônio motor: o papel das células da glia na esclerose lateral amiotrófica
Fonte: Arq. neuropsiquiatr;74(10):849-854, Oct. 2016. graf.
Idioma: en.
Resumo: ABSTRACT Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not restricted to the unique functions of the alpha motor neurons but which actually involve diverse functions of glial cell interaction. This review aims to expose some of the leading roles of glial cells in the physiological mechanisms of neuron-glial cell interactions and the mechanisms related to motor neuron survival linked to glial cell functions.

RESUMO A doença do neurônio motor constitui um dos principais grupos de doenças neurodegenerativas, representadas principalmente pela esclerose lateral amiotrófica. Apesar dos amplos dados genéticos e bioquímicos em relação aos seus mecanismos fisiopatológicos, a doença do neurônio motor se desenvolve sob uma complexa rede de mecanismos não restritos às funções particulares dos neurônios motores alfa, mas, na verdade, envolvendo diversas funções interativas das células da glia. Esta revisão tem como objetivo expor alguns dos principais papéis das células da glia nos mecanismos fisiológicos de interações neurônio-glia e os mecanismos relacionados à sobrevivência do neurônio motor ligados a funções das células da glia.
Descritores: Neuroglia/fisiologia
Esclerose Amiotrófica Lateral/fisiopatologia
Esclerose Amiotrófica Lateral/patologia
Neurônios Motores/fisiologia
-Neuroglia/química
Ácido Glutâmico/fisiologia
Ilustração Médica
Neurônios Motores/química
Fatores de Crescimento Neural/fisiologia
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


  6 / 135 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Chile
Texto completo
Id: biblio-950883
Autor: González, Luis F; Henríquez-Belmar, Francisca; Delgado-Acevedo, Claudia; Cisternas-Olmedo, Marisol; Arriagada, Gloria; Sotomayor-Zárate, Ramón; Murphy, Dennis L; Moya, Pablo R.
Título: Neurochemical and behavioral characterization of neuronal glutamate transporter EAAT3 heterozygous mice
Fonte: Biol. Res;50:29, 2017. tab, graf.
Idioma: en.
Projeto: FONDECYT; . Millennium Nucleus; . FONDECYT.
Resumo: BACKGROUND: Obsessive-compulsive disorder (OCD) is a severe neuropsychiatric condition affecting 1-3% of the worldwide population. OCD has a strong genetic component, and the SLC1A1 gene that encodes neuronal glutamate transporter EAAT3 is a strong candidate for this disorder. To evaluate the impact of reduced EAAT3 expression in vivo, we studied male EAAT3 heterozygous and wild-type littermate mice using a battery of behavioral paradigms relevant to anxiety (open field test, elevated plus maze) and compulsivity (marble burying), as well as locomotor activity induced by amphetamine. Using high-performance liquid chromatography, we also determined tissue neurotransmitter levels in cortex, striatum and thalamus-brain areas that are relevant to OCD. RESULTS: Compared to wild-type littermates, EAAT3 heterozygous male mice have unaltered baseline anxiety-like, compulsive-like behavior and locomotor activity. Administration of acute amphetamine (5 mg/kg intraperitoneally) increased locomotion with no differences across genotypes. Tissue levels of glutamate, GABA, dopamine and serotonin did not vary between EAAT3 heterozygous and wild-type mice. CONCLUSIONS: Our results indicate that reduced EAAT3 expression does not impact neurotransmitter content in the corticostriatal circuit nor alter anxiety or compulsive-like behaviors.
Descritores: Ácido Glutâmico/metabolismo
Transportador 3 de Aminoácido Excitatório/metabolismo
Transtorno Obsessivo-Compulsivo/metabolismo
-Ácido Glutâmico/genética
Modelos Animais de Doenças
Transportador 3 de Aminoácido Excitatório/genética
Genótipo
Heterozigoto
Transtorno Obsessivo-Compulsivo/genética
Limites: Animais
Masculino
Camundongos
Responsável: CL1.1 - Biblioteca Central


  7 / 135 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Chile
Texto completo
Id: biblio-950905
Autor: Lin, Ruhui; Li, Long; Zhang, Yingzheng; Huang, Sheng; Chen, Shangjie; Shi, Jiao; Zhuo, Peiyuan; Jin, Hao; Li, Zuanfang; Liu, Weilin; Wang, Zhifu; Chen, Lidian; Tao, Jing.
Título: Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice
Fonte: Biol. Res;51:21, 2018. graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Fujian Rehabilitation Technology of Collaborative Innovation Center; . Fujian Rehabilitation Technology of Collaborative Innovation Center; . Fujian Rehabilitation Technology of Collaborative Innovation Center; . Fujian Natural Science Foundation of China; . Fujian University of Traditional Chinese Medicine.
Resumo: OBJECTIVE: To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. Methods N -Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot. RESULTS: EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice. CONCLUSION: These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice.
Descritores: Eletroacupuntura/métodos
Ácido Aspártico/análogos & derivados
Ácido Glutâmico/metabolismo
Hipocampo/química
Aprendizagem/fisiologia
Memória/fisiologia
-Proteínas Tirosina Quinases/análise
Imageamento por Ressonância Magnética
Glicoproteínas de Membrana/análise
Camundongos Transgênicos
Espectroscopia de Ressonância Magnética
Distribuição Aleatória
Western Blotting
Ácido Aspártico/metabolismo
Aprendizagem em Labirinto
Fator Neurotrófico Derivado do Encéfalo
Modelos Animais
Teste de Esforço
Hipocampo/diagnóstico por imagem
Inositol/análise
Limites: Animais
Masculino
Camundongos
Responsável: CL1.1 - Biblioteca Central


  8 / 135 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-886818
Autor: RODRIGUES, THIAGO A D; ARRUDA, EDUARDO J DE; FERNANDES, MAGDA F; CARVALHO, CLAUDIO T DE; LIMA, ALESSANDRA R; CABRINI, ISAÍAS.
Título: Copper II - polar amino acid complexes: toxicity to bacteria and larvae of Aedes aegypti
Fonte: An. acad. bras. ciênc;89(3,supl):2273-2280, 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Control strategies using insecticides are sometimes ineffective due to the resistance of the insect vectors.In this scenario new products must be proposed for the control of insect vectors.The complexes L-aspartate Cu (II) and L-glutamate-Cu (II) complexes were synthesized and characterized by elemental analysis, visible ultraviolet, infrared spectroscopy and potentiometric titration. The toxicity of these complexes was analyzed in Aedes aegypti (Diptera: Culicidae) larvae and Gram-negative and Gram-positive bacteria. The interaction between the ligands and the amino acid balance and the distribution of the species as a function of pH were discussed. The lethal concentration median (LC50) for Ae. aegypti larvae were: L-glutamic acid-Cu (II) - 53.401 mg L-1 and L-aspartate-Cu (II) - 108.647 mg L-1. The minimum inhibitory concentration (MIC) required for Staphylococcus aureus and Escherichia coli was: L-glutamate-Cu (II) 500-2000 mg L-1 and L-aspartate-Cu (II) 1000-2000 mg L-1. The concentrations demonstrated toxicity that evidence the potential of the complexes as bactericide and insecticide. Metal complexes formed by amino acids and transition metals are advantageous because of low environmental toxicity, biodegradability and low production cost.
Descritores: Staphylococcus aureus/efeitos dos fármacos
Ácido Aspártico/química
Ácido Glutâmico/química
Cobre/química
Aedes/efeitos dos fármacos
Escherichia coli/efeitos dos fármacos
-Testes de Toxicidade
Larva/efeitos dos fármacos
Dose Letal Mediana
Limites: Animais
Responsável: BR1.1 - BIREME


  9 / 135 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: lil-645919
Autor: Alvarado, Patricia.
Título: Unami, quinto sabor básico: la importancia del glutamato monosódico en la dieta / Unami, fifth basic taste: the importance of monosodium glutamate in the diet
Fonte: ReNut;2(4):178-179, abr.-jun. 2008.
Idioma: es.
Descritores: Aromatizantes
Glutamato de Sódio
Ácido Glutâmico
Responsável: PE1.1 - Oficina Universitária de Biblioteca


  10 / 135 LILACS  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
Id: lil-722014
Autor: Muñoz Jáuregui, Ana Mar¡a; Castañeda Castañeda, Benjamín; Inocente Camones, Miguel Úngel; Encina Zelada, Christian; Mishti Llecllish, Oscar Julián; Quispe Fuentes, Glorinda.
Título: Contenido de glutamato, aspartato y glicinato en diversos preparados de la comida peruana / Content of glutamate, aspartate and glycinate in different preparations of Peruvian food
Fonte: Horiz. méd. (Impresa);13(4):15-20, oct.-dic. 2013. ilus, tab, graf.
Idioma: es.
Resumo: Objetivo: Evaluar la concentración de glutamato, aspartato y glicinato en alimentos elaborados en Lima, Perú. Material y Métodos: Se analizó el contenido de glutamato, aspartato y glicinato, aminoácidos no esenciales presentes en diez comidas peruanas: lomo saltado, arroz con pollo, arroz chaufa, rocoto relleno, seco de carne, ceviche de caballa, escabeche de pollo, tallar¡n saltado de carne, causa de conserva de pescado, ají de pollo. Se realizó el análisis del contenido de aminoácidos en cada una de los preparados por cromatografía líquida HPLC según Quattrocchi y Laba por el método de derivatización pre-columna. Resultados: Se encontró mayor contenido de glutamato: 2463 mg/100g en tallarín saltado de carne. El aspartato y glicinato fueron más abundantes en ceviche de caballa con 1707,95 mg/100g y 893,73 mg/100g respectivamente. Conclusiones: En las comidas analizadas se halló mayor contenido de glutámico lo cual se relaciona al buen sabor y aceptabilidad de las comidas elaboradas en Lima, PerúAU)

Objective: to evaluate the concentration of glutamate, aspartite and glycinate in foods made in Lima, Peru. Material and Methods: The present study analyzed the content of non-essential amino acids glutamate, aspartite and glycinate, present in ten Peruvian foods. Those selected were “lomo saltado, arroz con pollo, arroz chaufa, rocoto relleno, seco de carne, ceviche de caballa, escabeche de pollo, tallar¡n saltado de carne, causa de conserva de pescado, aj¡ de pollo”. The analysis of the content of amino acids on the ten Peruvian Creole food was done by liquid chromatography HPLC according to Quattrocchi and Laba by pre-columna derivatization method. Results: Highest content of glutamate was found in “tallarin saltado de carne”: 2463 mg / 100g. Aspartite and glycinate were more abundant in ceviche with 1707,95 mg / 100g and 893,73 mg / 100g respectively. Conclusions: in the analyzed meals we found high content of glutamate which relates to the good taste and acceptability of meals prepared in Lima, Peru
Descritores: Refeições
Culinária
Glicina
Ácido D-Aspártico
Ácido Glutâmico
Responsável: PE1.1 - Oficina Universitária de Biblioteca



página 1 de 14 ir para página                         
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde