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Pesquisa : D12.644 [Categoria DeCS]
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Id: biblio-1346435
Autor: Santos, Ariane Teixeira dos; Cruz, Gabriela Silva; Baptista, Gandhi Rádis.
Título: Anti-inflammatory activities of arthropod peptides: a systematic review
Fonte: J. venom. anim. toxins incl. trop. dis;27:e20200152, 2021. tab, graf.
Idioma: en.
Resumo: Peptides obtained from different animal species have gained importance recently due to research that aims to develop biopharmaceuticals with therapeutic potential. In this sense, arthropod venoms have drawn attention, not only because of their toxicity but mainly for the search for molecules with various bioactivities, including anti-inflammatory activity. The purpose of the present study is to gather data available in the literature on new peptides derived from arthropod species with anti-inflammatory potential. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Studies on peptides from arthropods that display anti-inflammatory activity were retrieved from PubMed, Scopus, Web of Science, and Google Scholar databases. The bibliographic research started in 2020 and searched papers without a limit on the publication date. The articles were analyzed using a search string containing the following terms: "Peptides" and "Anti-inflammatory", in combinations such as "Ant", "Bee", "Wasp", "Crab", "Shrimp", "Scorpion", "Spider", "Tick" and "Centipedes". Besides, a search was carried out in the databases with the terms: "Peptides", "Antitumor", or "Anticancer", and "Arthropods". Articles that met the inclusion and exclusion criteria totalized 171, and these served for data extraction. Additionally, the present review included anti-inflammatory peptides with anticancer properties. Peptides with confirmed anti-inflammatory activity were from insects (ants, bees, and wasps), crustaceans (shrimp and crabs), arachnids (scorpions, spiders, and ticks), and centipedes. These arthropod peptides act mainly by decreasing pro-inflammatory cytokines as analyzed in vitro and in vivo. Some showed significant antineoplastic activity, working in essential cellular pathways against malignant neoplasms.(AU)
Descritores: Peptídeos
Venenos de Artrópodes
Artrópodes
Produtos Biológicos
Anti-Inflamatórios/análise
-Citocinas
Literatura
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


  2 / 394 LILACS  
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Id: biblio-1346436
Autor: Nie, Xuekui; He, Qiyi; Zhou, Bin; Huang, Dachun; Chen, Junbo; Chen, Qianzi; Yang, Shuqing; Yu, Xiaodong.
Título: Exploring the five-paced viper (Deinagkistrodon acutus) venom proteome by integrating a combinatorial peptide ligand library approach with shotgun LC-MS/MS
Fonte: J. venom. anim. toxins incl. trop. dis;27:e20200196, 2021. tab, graf, ilus.
Idioma: en.
Projeto: Chongqing Normal University Fund.
Resumo: Snake venoms are complex mixtures of toxic proteins or peptides encoded by various gene families that function synergistically to incapacitate prey. In the present study, in order to unravel the proteomic repertoire of Deinagkistrodon acutus venom, some trace abundance components were analyzed. Methods Shotgun proteomic approach combined with shotgun nano-LC-ESI-MS/MS were employed to characterize the medically important D. acutus venom, after collected samples were enriched with the combinatorial peptide ligand library (CPLL). Results This avenue helped us find some trace components, undetected before, in D. acutus venom. The results indicated that D. acutus venom comprised 84 distinct proteins from 10 toxin families and 12 other proteins. These results are more than twice the number of venom components obtained from previous studies, which were only 29 distinct proteins obtained through RP-HPLC for the venom of the same species. The present results indicated that in D. acutus venom, the most abundant components (66.9%) included metalloproteinases, serine proteinases, and C-type lectin proteins; the medium abundant components (13%) comprised phospholipases A2 (PLA2) and 5'-nucleotidases and nucleases; whereas least abundant components (6%) were aminopeptidases, L-amino acid oxidases (LAAO), neurotoxins and disintegrins; and the trace components. The last were undetected before the use of conventional shotgun proteomics combined with shotgun nano-LC-ESI-MS/MS, such as cysteine-rich secretory proteins Da-CRPa, phospholipases B-like 1, phospholipases B (PLB), nerve growth factors (NGF), glutaminyl-peptide cyclortransferases (QC), and vascular non-inflammatory molecules 2 (VNN2). Conclusion These findings demonstrated that the CPLL enrichment method worked well in finding the trace toxin proteins in D. acutus venom, in contrast with the previous venomic characterization of D. acutus by conventional LC-MS/MS. In conclusion, this approach combined with the CPLL enrichment was effective for allowing us to explore the hidden D. acutus venomic profile and extended the list of potential venom toxins.(AU)
Descritores: Oxirredutases
Peptídeos
Venenos de Víboras
Proteoma
Neurotoxinas
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


  3 / 394 LILACS  
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Id: lil-635677
Autor: Gómez, Alberto.
Título: De monos y humanos: la búsqueda de una estrategia de vacunación antipalúdica basada en péptidos sintéticos / From Apes to Humans: search for an antipaludian inoculation strategy based on synthetic peptides
Fonte: Infectio;15(2):75-83, abr.-jun. 2011.
Idioma: es.
Resumo: El trabajo del grupo de investigación de la Fundación Instituto de Inmunología de Colombia (FIDIC), liderado por el doctor Manuel Elkin Patarroyo, se ha centrado principalmente en el estudio de la interacción microbio-huésped a nivel molecular. Sus resultados se pueden consultar en detalle en más de 250 publicaciones científicas disponibles en PubMed (2). Entre éstas, se destaca el reporte publicado en 1987 en la revista Nature, sobre la molécula sintética SPf66 que fue postulada como precursora de una eventual vacuna antipalúdica, en la medida en que generó protección total en 40 % del modelo animal experimental, Aotus trivirgatus.

The work of the research group of the Colombian Immunology Institute Foundation (FIDIC), led by Dr. Manuel Elkin Patarroyo, has focused mainly on the study of the microbe-host interaction at the molecular level. Its results can be consulted in detail in more than 250 scientific publications available in PubMed (2). Among these, the report published in 1987 in the journal Nature stands out, on the synthetic molecule SPf66, which was postulated as a precursor of an eventual antimalarial vaccine, insofar as it generated total protection in 40% of the experimental animal model, Aotus trivirgatus.
Descritores: Peptídeos
-Vacinas
Vacinas Sintéticas
Vacinação
Haplorrinos
Relatório de Pesquisa
Malária
Limites: Humanos
Animais
Tipo de Publ: Editorial
Responsável: CO359.1 - ACIN - Asociación Colombiana de Infectologia


  4 / 394 LILACS  
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Id: biblio-951744
Autor: Li, Shan; Wang, Xiaoman; Zhang, Jielei; Li, Jingyi; Liu, Xiaogang; Ma, Yuanyuan; Han, Chao; Zhang, Lixia; Zheng, Lili.
Título: Exenatide ameliorates hepatic steatosis and attenuates fat mass and FTO gene expression through PI3K signaling pathway in nonalcoholic fatty liver disease
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(8):e7299, 2018. graf.
Idioma: en.
Resumo: Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist antidiabetic drug, has the capacity to overcome insulin resistance and attenuate hepatic steatosis but the specific underlying mechanism is unclear. This study was designed to investigate the underlying molecular mechanisms of exenatide therapy on NAFLD. We used in vivo and in vitro techniques to investigate the protective effects of exenatide on fatty liver via fat mass and obesity associated gene (FTO) in a high-fat (HF) diet-induced NAFLD animal model and related cell culture model. Exenatide significantly decreased body weight, serum glucose, insulin, insulin resistance, serum free fatty acid, triglyceride, total cholesterol, low-density lipoprotein, aspartate aminotransferase, and alanine aminotransferase levels in HF-induced obese rabbits. Histological analysis showed that exenatide significantly reversed HF-induced lipid accumulation and inflammatory changes accompanied by decreased FTO mRNA and protein expression, which were abrogated by PI3K inhibitor LY294002. This study indicated that pharmacological interventions with GLP-1 may represent a promising therapeutic strategy for NAFLD.
Descritores: Peptídeos/farmacologia
Peçonhas/farmacologia
Substâncias Protetoras/farmacologia
Fígado Gorduroso/metabolismo
Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico
Dioxigenase FTO Dependente de alfa-Cetoglutarato/efeitos dos fármacos
-Glicemia/análise
Peso Corporal/efeitos dos fármacos
Técnicas In Vitro
Regulação da Expressão Gênica/efeitos dos fármacos
Morfolinas/metabolismo
Cromonas/metabolismo
Modelos Animais de Doenças
Ingestão de Alimentos/efeitos dos fármacos
Inibidores Enzimáticos/metabolismo
Fígado Gorduroso/patologia
Dieta Hiperlipídica
Dioxigenase FTO Dependente de alfa-Cetoglutarato/genética
Exenatida
Insulina/sangue
Malondialdeído/análise
Obesidade/metabolismo
Limites: Animais
Masculino
Coelhos
Responsável: BR1.1 - BIREME


  5 / 394 LILACS  
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Id: biblio-975875
Autor: Pelá, Vinícius Taioqui; Cassiano, Luiza Paula Silva; Departmento de Ciências BiológicasVentura, Talita Mendes da Silva; Departmento de Ciências BiológicasSouza-e-Silva, Cintia Maria de; Departmento de Ciências BiológicasGironda, Carlos Condarco; Departmento de Ciências BiológicasRios, Daniela; Departmento de Ciências BiológicasBuzalaf, Marília Afonso Rabelo.
Título: Proteomic analysis of the acquired enamel pellicle formed on human and bovine tooth: a study using the Bauru in situ pellicle model (BISPM)
Fonte: J. appl. oral sci;27:e20180113, 2019. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Abstract The acquired enamel pellicle (AEP) is an organic film, bacteria-free, formed in vivo as a result of the selective adsorption of salivary proteins and glycoproteins to the solid surfaces exposed to the oral environment. Objective: This study aimed to compare the proteomic profile of AEP formed in situ on human and bovine enamel using a new intraoral device (Bauru in situ pellicle model - BISPM). Material and Methods: One hundred and eight samples of human and bovine enamel were prepared (4×4 mm). Nine subjects with good oral conditions wore a removable jaw appliance (BISPM) with 6 slabs of each substrate randomly allocated. The AEP was formed during the morning, for 120 minutes, and collected with an electrode filter paper soaked in 3% citric acid. This procedure was conducted in triplicate and the pellicle collected was processed for analysis by LC-ESI-MS/MS. The obtained mass spectrometry MS/MS spectra were searched against human protein database (SWISS-PROT). Results: The use of BISPM allowed the collection of enough proteins amount for proper analysis. A total of 51 proteins were found in the AEP collected from the substrates. Among them, 15 were common to both groups, 14 were exclusive of the bovine enamel, and 22 were exclusive of the human enamel. Proteins typically found in the AEP were identified, such as Histatin-1, Ig alpha-1, Ig alpha 2, Lysozyme C, Statherin and Submaxillary gland androgen-regulated protein 3B. Proteins not previously described in the AEP, such as metabolism, cell signaling, cell adhesion, cell division, transport, protein synthesis and degradation were also identified. Conclusion: These results demonstrate that the proteins typically found in the AEP appeared in both groups, regardless the substrate. The BISPM revealed to be a good device to be used in studies involving proteomic analysis of the AEP.
Descritores: Proteínas/análise
Película Dentária/química
-Peptídeos/análise
Valores de Referência
Saliva/química
Espectrometria de Massas
Fatores de Tempo
Proteômica
Limites: Humanos
Animais
Bovinos
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


  6 / 394 LILACS  
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Id: biblio-1134797
Autor: Tulumbaci, Fatih; Gungormus, Mustafa.
Título: In vitro remineralization of primary teeth with a mineralization-promoting peptide containing dental varnish
Fonte: J. appl. oral sci;28:e20200259, 2020. graf.
Idioma: en.
Projeto: Ankara Yildirim Beyazit University.
Resumo: Abstract Mineralization-promoting peptides are attractive candidates for new remineralization systems. In previous studies, peptides have been applied as aqueous solutions, which is not a clinically relevant form. Objective This study aims to investigate the efficiency of a mineralization-promoting peptide, applied in varnish, on remineralizing artificial caries on primary teeth. Methodology 55 primary molars were collected. Specimens were immersed in a demineralizing solution for 7 days and then, divided into 7 groups: Baseline: No-remineralization, Placebo: Blank colophony, F: Colophony 5% fluoride, P: Colophony 10% peptide, P+F: Colophony 5% fluoride and 10% peptide, Embrace: Embrace™ varnish, Durashield: Durashield™ varnish. A mixture of 35% w/v colophony varnishes were prepared in ethanol and applied accordingly. Specimens were immersed in a remineralization solution for 4 weeks and it was evaluated using PLM and SEM. Lesion depth reduction was examined by one-way ANOVA. Results There was no significant difference in mean lesion depths between baseline (147.04 ± 10.18 µm) and placebo groups (139.73 ± 14.92 µm), between F (120.95 ± 12.23 µm) and Durashield (113.47 ± 14.36 µm) groups and between P (81.79 ± 23.15 µm) and Embrace (90.26 ± 17.72 µm) groups. Lesion depth for the P+F group (66.95±10.59 µm) was significantly higher compared to all other groups. All groups contained samples with subsurface demineralized regions. Number of subsurface demineralized regions were higher in fluoride-containing groups. Conclusions We conclude that the mineralization-promoting peptide (MPP3) is effective in this in vitro study and the peptide shows benefits over fluoride as it yields less subsurface demineralized regions.
Descritores: Remineralização Dentária
Cárie Dentária
-Pintura
Peptídeos
Dente Decíduo
Cariostáticos
Fluoretos Tópicos
Limites: Humanos
Criança
Responsável: BR1.1 - BIREME


  7 / 394 LILACS  
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Id: biblio-1143142
Autor: Toraman, Ayse; Arabaci, Taner; Aytekin, Zeliha; Albayrak, Mevlüt; Bayir, Yasin.
Título: Effects of vitamin C local application on ligature-induced periodontitis in diabetic rats
Fonte: J. appl. oral sci;28:e20200444, 2020. tab, graf.
Idioma: en.
Resumo: Abstract Objective: This study evaluated the effects of local vitamin C treatment on tissue advanced glycation end products (AGE), interleukin (IL)-6, 8-hydroxy-2-deoxyguanosine (8-OHdG), and matrix metalloproteinases (MMP)-8 in tissues; serum C-terminal telopeptide fragments (CTX); and alveolar bone loss (ABL) in rats. Methodology: 35 male Sprague Dawley rats were divided equally into five groups: 1) control (C), 2) experimental periodontitis (P), 3) experimental diabetes (D), 4) experimental diabetes and experimental periodontitis (D + P), and 5) experimental diabetes-experimental periodontitis-locally applied vitamin C (D + P + LvitC). Diabetes was induced in rats with alloxan monohydrate, after which periodontitis was induced by ligature placement in the right mandibular first molar teeth for 11 days. In the treatment group, vitamin C was administered locally three times with two-days interval after ligature removal. The animals were sacrificed, and the samples were analyzed histometrically and immunohistochemically. Results: CTX, 8-OHdG, and AGE values significantly decreased in the treatment group compared to the D + P group. IL-6 and MMP-8 values decreased in the treatment group compared to the D + P group, but this is not significant. ABL was significantly reduced by the local delivery of vitamin C. Conclusion: This study reveals that vitamin C treatment may be beneficial to reduce serum CTX and gingival MMP-8 levels, oxidative stress, inflammation, and AGE accumulation in periodontal tissue. Vitamin C may be an immunomodulator and antioxidant locally applied in the treatment of periodontitis to reduce the adverse effects of diabetes in periodontal tissues.
Descritores: Periodontite/tratamento farmacológico
Ácido Ascórbico/administração & dosagem
Perda do Osso Alveolar
Diabetes Mellitus Experimental/complicações
Diabetes Mellitus Experimental/tratamento farmacológico
-Peptídeos
Interleucina-6
Ratos Sprague-Dawley
Produtos Finais de Glicação Avançada
Estresse Oxidativo
Metaloproteinase 8 da Matriz
Colágeno Tipo I
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


  8 / 394 LILACS  
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Id: biblio-1180740
Autor: Chen, Qizuan; Yang, Pengfan; Lin, Qiao; Pei, Jiasheng; Jia, Yanzeng; Zhong, Zhonghui; Wang, Shousen.
Título: Effects of scorpion venom heat-resistant peptide on the hippocampal neurons of kainic acid-induced epileptic rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;54(5):e10717, 2021. tab, graf.
Idioma: en.
Projeto: General Program of Logistics Science Foundation of PLA.
Resumo: Scorpion venom is a Chinese medicine for epilepsy treatment, but the underlying mechanism is not clear. Scorpion venom heat-resistant peptide (SVHRP), a peptide isolated from the venom of Buthus martensii Karsch, has an anti-epileptic effect by reducing seizure behavior according to a modified Racine scale. The present study aimed to investigate the molecular mechanism of SVHRP on temporal lobe epilepsy. The hippocampus and hippocampal neurons from kainic acid-induced epileptic rats were treated with SVHRP at different doses and duration. Quantitative RT-PCR and immunoblotting were used to detect the expression level of brain-derived neurotrophic factor (BDNF), neuropeptide Y (NPY), cAMP-response element binding protein (CREB), stromal interaction molecule (STIM), and calcium release-activated calcium channel protein 1 (ORAI1). In the hippocampal tissues and primary hippocampal neuron cultures, SVHRP treatment resulted in increased mRNA and protein levels of BDNF and NPY under the epileptic condition. The upregulation of BDNF and NPY expression was positively correlated with the dose level and treatment duration of SVHRP in hippocampal tissues from kainic acid-induced epileptic rats. On the other hand, no significant changes in the levels of CREB, STIM, or ORAI1 were observed. SVHRP may exhibit an anti-epileptic effect by upregulating the expression of BDNF and NPY in the epileptic hippocampus.
Descritores: Venenos de Escorpião/toxicidade
Epilepsia/induzido quimicamente
Epilepsia/tratamento farmacológico
-Peptídeos
Fator Neurotrófico Derivado do Encéfalo/metabolismo
Temperatura Alta
Hipocampo/metabolismo
Ácido Caínico/toxicidade
Neurônios
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


  9 / 394 LILACS  
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Id: biblio-1285668
Autor: Graziani, D; Ribeiro, J V V; Cruz, V S; Gomes, R M; Araújo, E G; Santos Júnior, A C M; Tomaz, H C M; Castro, C H; Fontes, W; Batista, K A; Fernandes, K F; Xavier, C H.
Título: Oxidonitrergic and antioxidant effects of a low molecular weight peptide fraction from hardened bean (Phaseolus vulgaris) on endothelium
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;54(6):e10423, 2021. tab, graf.
Idioma: en.
Projeto: CNPq.
Resumo: About 3000 tons of beans are not used in human food due to hardening. Several studies on bean-derived bioactive peptides have shown potential to treat some diseases, including those relying on oxidative dysfunctions. We assessed the effects of peptides extracted from hardened bean Phaseolus vulgaris (PV) on reactive oxygen species (ROS) and nitric oxide (NO) production, cytotoxic and cytoprotective effects in endothelial cells, and oxidonitrergic-dependent vasodilating effects. Extract was composed by peptide fraction <3 kDa (PV3) from hardened common bean residue. PV3 sequences were obtained and analyzed with bioinformatics. Human umbilical vein endothelial cells were treated with 10, 20, 30, and 250 µg/mL PV3. Oxidative stress was provoked by 3% H2O2. Cytotoxicity and cytoprotective effects were evaluated by MTT assay, whereas, ROS and NO were quantified using DHE and DAF-FM fluorescent probes by confocal microscopy. NO- and endothelium-dependent vasodilating effects of PV3 were assessed in isolated aortic rings. We found 35 peptides with an average mass of 1.14 kDa. There were no cell deaths with 10 and 20 μg/mL PV3. PV3 at 30 μg/mL increased cell viability, while cytotoxicity was observed only with 250 μg/mL PV3. PV3 at 10 μg/mL was able to protect cells from oxidative stress. PV3 also increased NO release without causing cell death. It also reduced relative ROS production induced by H2O2. PV3 vasodilating effects relied on endothelium-dependent NO release. PV3 obtained from low-commercial-value bean displays little cytotoxicity and exerts antioxidant effects, whereas it increases endothelial NO release.
Descritores: Phaseolus
-Peptídeos/farmacologia
Endotélio
Peróxido de Hidrogênio
Peso Molecular
Antioxidantes/farmacologia
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-1292419
Autor: Jiang, Ruijiao; Zhang, Pengfei; Wu, Xulong; Wang, Yin; Rehman, Tayyab; Yao, Xueping; Luo, Yan; Yang, Zexiao.
Título: Expression of antimicrobial peptide Cecropin P1 in Saccharomyces cerevisiae and its antibacterial and antiviral activity in vitro
Fonte: Electron. j. biotechnol;50:16-22, Mar. 2021. ilus, tab.
Idioma: en.
Projeto: Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System.
Resumo: BACKGROUND: Cecropin P1, acting as an antimicrobial, has a broad-spectrum antibacterial activity with some antiviral and antifungal properties. It is a promising natural alternative to antibiotics which is originally isolated from the pig intestinal parasitic nematode Ascaris suum. Many studies have shown that Cecropin P1 is helpful for the prevention or treatment of clinical diseases. Therefore, it is very necessary to establish a safe, nontoxic, and efficient expression method of Cecropin P1. RESULTS: The results indicated that the recombinant protein was about 5.5 kDa showed by Tricine­SDS­ PAGE and Western blot. And Cecropin P1 was efficiently secreted and expressed after 12 h of induction, with an increasing yield over the course of the induction. Its maximum concentration was 7.83 mg/L after concentration and purification. In addition, in vitro experiments demonstrated that Cecropin P1 not only exerted a strong inhibitory effect on Escherichia coli, Salmonella sp., Shigella sp., and Pasteurella sp., but also displayed an antiviral activity against PRRSV NADC30-Like strain. CONCLUSIONS: Collectively, the strategy of expressing Cecropin P1 in Saccharomyces cerevisiae is harmless, efficient, and safe for cells. In addition, the expressed Cecropin P1 has antiviral and antibacterial properties concurrently.
Descritores: Peptídeos/farmacologia
Saccharomyces cerevisiae/efeitos dos fármacos
Antibacterianos/farmacologia
-Antivirais/farmacologia
Peptídeos/química
Técnicas In Vitro
Proteínas Recombinantes
Testes de Sensibilidade Microbiana
Western Blotting
Responsável: CL1.1 - Biblioteca Central



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