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Id: biblio-1283597
Autor: Velázquez-Hernández, María Elena; Ochoa-Zarzosa, Alejandra; López-Meza, Joel E.
Título: Defensin c-thionin from Capsicum chinense improves butyrate cytotoxicity on human colon adenocarcinoma cell line Caco-2
Fonte: Electron. j. biotechnol;52:76-84, July. 2021. graf, ilus.
Idioma: en.
Projeto: CONACyT; . CIC14.5 to JELM; ICGEB.
Resumo: BACKGROUND: Butyrate is a histone deacetylase inhibitor that induces apoptosis and inhibits cell proliferation of colorectal cancer cells. To improve its anticancer activity, butyrate has been evaluated mixed with drugs and different molecules. Plant antimicrobial peptides are attractive anticancer alternative molecules because they show selective cytotoxic activity against different cancer cell lines. In this work, we explore if the plant defensin c-thionin (Capsicum chinense) can improve butyrate activity on Caco-2 cell line and we also determined the mechanism of death activated. RESULTS: The combined treatment of c-thionin (3.5 mM) and butyrate (50 mM) showed higher cytotoxicity on Caco-2 cells with respect to single treatments. Also, the combined treatment reduced cell proliferation and exhibited a higher rate of apoptosis than single treatments. Combined treatment induced caspases 8 and 9 activation to an extent comparable with that of butyrate while c-thionin did not activate caspases. Additionally, reactive oxygen species generation preceded the onset of apoptosis, and superoxide anion production was higher in cells treated with the combined treatment. CONCLUSIONS: The c-thionin from Habanero chili pepper improved the butyrate cytotoxicity on Caco-2 cells. This effect occurred through apoptosis induction associated with reactive oxygen species production. Therefore, the combination of butyrate with cytotoxic antimicrobial peptides could be an attractive strategy for cancer therapy.
Descritores: Butiratos
Capsicum/química
Adenocarcinoma
Neoplasias do Colo
-Ciclo Celular
Espécies Reativas de Oxigênio
Apoptose
Células CACO-2
Defensinas
Tioninas
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


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Id: lil-748438
Autor: Carmona, Andrés; Laurentin, Alexander.
Título: Bengoa y Jaffé: el grupo de bioquímica y nutrición de la facultad de ciencias, universidad central de venezuela / Bengoa and Jaffé: the biochemistry and nutrition group of the faculty of science, central university of venezuela
Fonte: An. venez. nutr;27(1):214-217, jun. 2014.
Idioma: es.
Descritores: Educação Alimentar e Nutricional
Tioninas/análise
Tecnologia de Alimentos
Fabaceae
-Faculdades de Medicina
Ensino
Bioquímica
Laboratórios
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Congresso
Responsável: VE557.1 - Biblioteca Fundación Bengoa



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