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Id: biblio-989293
Autor: Yasar, Hamiyet Yilmaz; Demirpence, Mustafa; Colak, Ayfer; Yurdakul, Leman; Zeytinli, Merve; Turkon, Hakan; Ekinci, Ferhat; Günaslan, Aybike; Yasar, Erdem.
Título: Serum irisin and apelin levels and markers of atherosclerosis in patients with subclinical hypothyroidism
Fonte: Arch. endocrinol. metab. (Online);63(1):16-21, Jan.-Feb. 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective: In this study, we aimed to evaluate serum irisin and apelin levels in patients with subclinical hypothyroidism (SCH) when they were subclinical hypothyroid and become euthyroid after levothyroxine therapy and association of these adipokines with markers of atherosclerosis such as serum homocysteine levels and carotid intima-media thickness (IMT). Subjects and methods: The study included 160 patients with newly diagnosed subclinical hypothyroidism due to Hashimoto's thyroiditis and 86 euthyroid healty subjects. Serum glucose and lipid profile, insulin, HOMA, TSH, free T3, free T4, anti-thyroperoxidase and anti-thyroglobulin antibodies, homocysteine, apelin and irisin levels were measured in all study subjects. Thyroid and carotid ultrasound examinations were performed. The subclinical hypothyroid group was reevaluated after 12-weeks of levothyroxine therapy when they became euthyroid. Results: Clinical characteristics of the patient and control group were similar. Glucose, insulin and HOMA levels, lipid parameters and free T3 were similar between the two groups.. Serum homocystein was higher and apelin was lower in patients with SCH, but irisin levels were similar between the two groups. While thyroid volume was lower, carotid IMT was significantly greater in patients with SCH (pCarotidIMT:0,01). After 12-weeks of levothyroxine therapy, all the studied parameters remained unchanged except, serum freeT4, TSH, homocystein and apelin. While homocystein decreased (p: 0,001), apelin increased significantly (p = 0,049). In multivariate analysis, low apelin levels significantly contributed to carotid IMT (p = 0,041). Conclusions: Apelin-APJ system may play a role in vascular and cardiac dysfunction in patients with SCH and treatment of this condition may improve the risk of cardiovascular disease.
Descritores: Fibronectinas/sangue
Aterosclerose/etiologia
Doença de Hashimoto/complicações
Apelina/sangue
Hipotireoidismo/complicações
-Testes de Função Tireóidea
Tiroxina/uso terapêutico
Biomarcadores/sangue
Estudos de Casos e Controles
Estudos Prospectivos
Aterosclerose/diagnóstico
Aterosclerose/sangue
Doença de Hashimoto/tratamento farmacológico
Doença de Hashimoto/sangue
Espessura Intima-Media Carotídea
Hipotireoidismo/tratamento farmacológico
Hipotireoidismo/sangue
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME



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