Base de dados : LILACS
Pesquisa : D12.644.276.374.200.110.250 [Categoria DeCS]
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Costa, Paulo Inácio da
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Id: lil-415686
Autor: Mikawa, Angela Yumico; Malavazi, Iran; Tagliavini, Sandra Antonia; Abrão, Emiliana P; Costa, Paulo Inácio da.
Título: The beta-chemokines MIP-1alpha and RANTES and lipoprotein metabolism in HIV-infected brazilian patients
Fonte: Braz. j. infect. dis;9(4):315-323, Aug. 2005. tab, graf.
Idioma: en.
Resumo: HIV patients are predisposed to the development of hypertriglyceridemia and hypercholesterolemia as a result of both viral infection and HIV infection therapy, especially the protease inhibitors. Chemokines and cytokines are present at sites of inflammation and can influence the nature of the inflammatory response in atherosclerosis. We investigated the correlation between biochemical variables and beta-chemokines (MIP-1alpha and RANTES) and the apolipoprotein E genotype in HIV-infected individuals. The apolipoproteins were measured by nephelometry. Triglycerides and total cholesterol were determined by standard enzymatic procedures. The beta-chemokines were detected by ELISA. The genetic category of CCR5 and apolipoprotein E were determined by PCR amplification and restriction enzymes. Immunological and virological profiles were assessed by TCD4+ and TCD8+ lymphocyte counts and viral load quantification. Positive correlations were found between apo E and CD8+ (p = 0.035), apo E and viral load (p = 0.018), MIP-1alpha and triglycerides (p = 0.039) and MIP-1a and VLDL (p = 0.040). Negative correlations were found between viral load and CD4+ (p = 0.05) and RANTES and CD4+ (p = 0.029). The beta-chemokine levels may influence lipid metabolism in HIV-infected individuals.
Descritores: Apolipoproteínas E/sangue
Quimiocina CCL5
Infecções por HIV/sangue
Lipoproteínas/sangue
Proteínas Inflamatórias de Macrófagos
-Apolipoproteínas E/genética
Apolipoproteínas E/metabolismo
Biomarcadores/sangue
CDABBREVIATIONS AS TOPIC-CDABDOMINAL NEOPLASMS RATIO
Quimiocina CCL5
Ensaio de Imunoadsorção Enzimática
Genótipo
Infecções por HIV/metabolismo
Lipoproteínas/metabolismo
Proteínas Inflamatórias de Macrófagos
Nefelometria e Turbidimetria
Reação em Cadeia da Polimerase
/sangue
RECEPTORS, CCRABDOMEN/sangue
Carga Viral
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-326254
Autor: Mikawa, A. Y; Tagliavini, S. A; Costa, P. I.
Título: CCR5 genotype and plasma ß-chemokine concentration of Brazilian HIV-infected individuals
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;35(11):1333-1337, Nov. 2002. tab.
Idioma: en.
Conferência: Apresentado em: Annual Meeting of the Federação de Sociedades de Biologia Experimental, 16, Apresentado em: Congress of Pharmaceutical Sciences, 3, Caxambu, 29 Aug. -1 Sept. 2001.
Resumo: The 32-bp deletion in the HIV-1 co-receptor CCR5 confers a high degree of resistance to HIV-1 infection in homozygous individuals for the deleted allele and partial protection against HIV-1 during disease progression in heterozygotes. Natural ligands for CCR5, MIP-1alpha, MIP-1ß and RANTES, have been shown to inhibit HIV replication in CD4+ T cells. In the present study, we examined the CCR5 genotype by PCR and the plasma levels of RANTES and MIP-1alpha by ELISA among blood donors (N = 26) and among HIV-1-infected individuals (N = 129). The control group consisted of healthy adult volunteers and HIV-1-infected subjects were an asymptomatic and heterogeneous group of individuals with regard to immunologic and virologic markers of HIV-1 disease. The frequency of the CCR5 mutant allele (delta32ccr5) in this population was 0.032; however, no delta32ccr5 homozygote was detected. These results could be related to the intense ethnic admixture of the Brazilian population. There was no correlation between circulating ß-chemokines (MIP-1alpha, RANTES) and viral load in HIV-infected individuals. RANTES concentrations in plasma samples from HIV+ patients carrying the homozygous CCR5 allele (CCR5/CCR5) (28.23 ng/ml) were higher than in the control samples (16.07 ng/ml; P<0.05); however, this HIV+ patient group (mean 26.23 pg/ml) had significantly lower concentrations of MIP-1alpha than those observed in control samples (mean 31.20 pg/ml; P<0.05). Both HIV-1-infected and uninfected individuals heterozygous for the delta32ccr5 allele had significantly lower concentrations of circulating RANTES (mean 16.07 and 6.11 ng/ml, respectively) than CCR5/CCR5 individuals (mean 28.23 and 16.07 ng/ml, respectively; P<0.05). These findings suggest that the CCR5 allele and ß-chemokine production may affect the immunopathogenesis of HIV-1
Descritores: Quimiocina CCL5
Infecções por HIV
HIV-1
Proteínas Inflamatórias de Macrófagos
Receptores CCR5
-Alelos
Estudos de Casos e Controles
Linfócitos T CD4-Positivos
Linfócitos T CD8-Positivos
Quimiocina CCL5
Ensaio de Imunoadsorção Enzimática
Genótipo
Infecções por HIV
Proteínas Inflamatórias de Macrófagos
Reação em Cadeia da Polimerase
RNA Viral
Carga Viral
Limites: Humanos
Adulto
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-202023
Autor: Lacy, P; Moqbel, R.
Título: Eokines: synthesis, storage and release from human eosinophils
Fonte: Mem. Inst. Oswaldo Cruz;92(supl.2):125-33, Dec. 1997. ilus, tab.
Idioma: en.
Conferência: Apresentado em: New perspectives in eosinophils, Rio de Janeiro, 1996.
Resumo: Eosinophils are prominent inflammatory cells in asthma and other allergic disorders, as well as in helminthic parasite infections. Recently, eosinophils have been reported to synthesize and store a range of regulatory proteins within their secretory granules (eokines). Eokines comprise a group of cytokines, chemokines, and growth factors which are elaborated by eosinophils. These proteins, and the messages which encode them, appear to be identical to those produced by lymphocytes and other tissues. Interestingly, immunoreactivity to many of these eokines has been found to co-localize to the eosinophil's secretory granules. In this review, we have discussed the repertoire of 18 eokines so far identified in eosinophils, and focused on four of these, namely, interleukin-2 (IL-2), IL-4, granulocyte/macrophage colony-stimulating factor (GM-CSF), and RANTES. These four eokines co-localize to the crystalloid granules in eosinophils, as shown in studies using subcellular fractionation and immunogold labeling in electron microscopy. During stimulation by physiological triggers, for example, with serum-coated particles, eosinophils release these mediators into the surrounding supernatant. In addition, eokines are likely to be synthesized within eosinophils rather than taken up by endocytosis, as show in detection of mRNA for each of these proteins using in situ hybridization, RT-PCR, and in the case of RANTES, in situ RT-PCR. Eokines synthesis and release from eosinophils challenges the commonly held notion that these cells act downstream of key elements in immune system, and indicate that they may instead belong to the afferent arm of immunity.
Descritores: Citocinas/imunologia
Eosinófilos
-Quimiocina CCL5
Quimiocinas/imunologia
Substâncias de Crescimento
Interleucina-2
Interleucina-4
Responsável: BR15.1 - Biblioteca de Ciências Biomédicas



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