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Id: biblio-1145546
Autor: Chaparro, Alejandra; Sanz, Antonio; Wolnitzky, Andrei; Realini, Ornella; Bendek, María José; Betancur, Daniel; Albers, Daniela; Beltrán, Víctor.
Título: Lymphocyte B and Th17 chemotactic cytokine levels in peri-implant crevicular fluid of patients with healthy, peri-mucositis, and peri-implantitis implants / Niveles de citoquinas quimiotácticas de linfocitos B y Th17 en el fluido crevicular periimplantario de pacientes con implantes sanos, perimucositis y periimplantitis
Fonte: J. oral res. (Impresa);S1 Preecedings:20-25, jul. 1, 2020. graf.
Idioma: en.
Resumo: Peri-implantitis is one of the leading causes of implant failure and loss, and its early diagnosis is not currently feasible due to the low sensitivity of currents methods. In the current exploratory cross-sectional study, we explored the diagnostic potential of lymphocyte B and Th17-chemotactic cytokine levels in peri-implant crevicular fluid (PICF) in 54 patients with healthy, peri-mucositis, or peri-implantitis implants. Peri-implant crevicular fluid was collected, and the levels of the molecules under study were quantified by Luminex assay. The concentrations of CCL-20 MIP-3 alpha, BAFF/BLYS, RANKL and OPG concentration in PICF were analyzed in the context of patient and clinical variables (smoking status, history of periodontitis, periodontal diagnosis, implant survival, suppuration, bleeding on probing, periodontal probing depth, clinical attachment level, mean of implant probing depth, and plaque index). Patients with peri-implantitis, appear to have an overregulation of the RANKL/BAFF-BLyS axis. This phenomenon needs to be investigated in depth in further studies with a larger sample size.

La periimplantitis es una de las principales causas de falla y pérdida del implante, y su diagnóstico temprano no es factible debido a la baja sensibilidad de los métodos actuales. En este estudio transversal exploratorio, se estudió el potencial diagnóstico de los niveles de citocinas quimiotácticas de linfocitos B y Th17 en el líquido crevicular periimplantario (LCPI) en 54 pacientes con implantes sanos, peri-mucositis o periimplantitis. Se recogió líquido crevicular periimplantario y se cuantificaron los niveles de las moléculas estudiadas mediante Luminex assay. Las concentraciones de CCL-20 MIP-3 alfa, BAFF/BLYS, RANKL y la concentración de OPG en LCPI se analizaron en el contexto de las variables clínicas y del paciente (tabaquismo, antecedentes de periodontitis, diagnóstico periodontal, supervivencia del implante, supuración, sangrado al sondaje, profundidad de sondeo periodontal, nivel de inserción clínica, media de la profundidad de sondeo del implante e índice de placa). Los pacientes con periimplantitis parecen tener una sobrerregulación del eje RANKL/BAFF-BLyS. Este fenómeno debe investigarse en profundidad en futuros estudios con un tamaño de muestra mayor.
Descritores: Implantes Dentários/efeitos adversos
Peri-Implantite/diagnóstico
-Biomarcadores
Chile
Estudos Transversais
Líquido do Sulco Gengival
Mucosite
Ligante RANK
Quimiocina CCL20
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: CL30.1 - Biblioteca


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Id: biblio-950898
Autor: Diao, Ruiying; Cai, Xueyong; Liu, Lu; Yang, Lihua; Duan, YongGang; Cai, Zhiming; Gui, Yaoting; Mou, Lisha.
Título: In vitro chemokine (C-C motif) receptor 6-dependent non-inflammatory chemotaxis during spermatogenesis
Fonte: Biol. Res;51:12, 2018. graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Guangdong Natural Science Foundation; . Shenzhen Foundation of Science and Technology; . Medical Scientific Research Foundation of Guangdong.
Resumo: BACKGROUND: Chemokine (C-C motif) receptor 6 (CCR6) is present in sperm and plays a significant role in sperm motility and chemotaxis acting in the reproductive tracts. However, the expression and functional significance of CCR6 in testis are still poorly understood, especially in the process of spermatogenesis. METHODS AND RESULTS: CCR6 was expressed in spermatogenic cell lines and its expression was shown in an age-dependent upregulation manner from puberty to adulthood in mouse testis. Immunostaining results confirmed the localization of CCR 6 in testis. Further chemotaxis assays demonstrated that spermatogenic cells GC-1 and -2 exhibited a directional movement toward CCR6-specific ligand such as CCL20 or Sertoli cells in vitro. CONCLUSIONS: The present findings indicate that CCR6 is involved in the chemotaxis of spermatogenic cells in vitro and promotes chemotaxis under non-inflammatory conditions during normal spermatogenesis.
Descritores: Espermatogênese/fisiologia
Quimiotaxia/fisiologia
Criptorquidismo/metabolismo
Quimiocina CCL20/metabolismo
Receptores CCR6/metabolismo
-Células de Sertoli
Motilidade Espermática/fisiologia
Testículo/fisiologia
Imuno-Histoquímica
Western Blotting
Imunofluorescência
Camundongos Endogâmicos C57BL
Limites: Humanos
Animais
Masculino
Camundongos
Coelhos
Responsável: CL1.1 - Biblioteca Central



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