Base de dados : LILACS
Pesquisa : D12.644.276.374.200.120.050 [Categoria DeCS]
Referências encontradas : 3 [refinar]
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Texto completo SciELO Brasil
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Id: lil-781333
Autor: Simão, Raif Restivo; Ferreira, Sueli Gomes; Kudo, Guilherme Konishi; Armstrong Junior, Roberto; Silva, Luiz Fernando Ferraz da; Sannomiya, Paulina; Breithaupt-Faloppa, Ana Cristina; Moreira, Luiz Felipe Pinho.
Título: Sex differences on solid organ histological characteristics after brain death1
Fonte: Acta cir. bras;31(4):278-285, Apr. 2016. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: PURPOSE: To investigate gender differences in the evolution of the inflammatory process in rats subjected to brain death (BD). METHODS: Adult Wistar rats were divided into three groups: female; ovariectomized female; and male rats. BD was induced using intracranial balloon inflation and confirmed by maximal pupil dilatation, apnea, absence of reflex, and drop of mean arterial pressure. Six hours after BD, histological evaluation was performed in lungs, heart, liver and kidneys, and levels of inflammatory proteins, estrogen, progesterone, and corticosterone were determined in plasma. RESULTS: In the lungs, females presented more leukocyte infiltration compared to males (p<0.01). Ovariectomized female rat lungs were more hemorrhagic compared to other groups (p<0.001). In the heart, females had higher leukocyte infiltration and tissue edema compared to males (p<0.05). In the liver and kidneys, there were no differences among groups. In female group estradiol and progesterone were sharply reduced 6 hours after BD (p<0.001) to values observed in ovariectomized females and males. Corticosterone levels were similar. CONCLUSIONS: Sex hormones influence the development of inflammation and the status of organs. The increased inflammation in lungs and heart of female rats might be associated with the acute reduction in female hormones triggered by BD.
Descritores: Morte Encefálica/patologia
Caracteres Sexuais
Rim/patologia
Fígado/patologia
Pulmão/patologia
Miocárdio/patologia
-Especificidade de Órgãos
Progesterona/sangue
Valores de Referência
Fatores de Tempo
Ovariectomia
Fatores Sexuais
Ratos Wistar
Edema/patologia
Estradiol/sangue
Quimiocina CXCL1/análise
Quimiocina CXCL2/análise
Inflamação/patologia
Limites: Animais
Masculino
Feminino
Responsável: BR1.1 - BIREME


  2 / 3 LILACS  
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Rasslan, Samir
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Id: lil-771855
Autor: Pinheiro, Daniel Faria de Campos; Fontes, Belchor; Shimazaki, John Kioshi; Heimbecker, Ana Maria Cattani; Jacysyn, Jacqueline de Fátima; Rasslan, Samir; Montero, Edna Frasson de Souza; Utiyama, Edivaldo Massazo.
Título: Ischemic preconditioning modifies mortality and inflammatory response
Fonte: Acta cir. bras;31(1):1-7, Jan. 2016. graf.
Idioma: en.
Resumo: PURPOSE: To evaluate the effect of ischemic preconditioning on mortality, inflammatory mediators and oxidative stress after intestinal ischemia and reperfusion. METHODS: Male Wistar rats were allocated according to the period of ischemia with or without ischemic preconditioning which consist on clamping the superior mesenteric artery for 10 minutes followed by reperfusion for 10 minutes before the sustained ischemia period. Mortality was assessed in Phase 1 study, and the CINC-1, CINC-2 and MDA levels in the lungs were analyzed in Phase 2. RESULTS: Mortality was lower in the ischemic preconditioning group subjected to 90 minutes of ischemia compared to the group without ischemic preconditioning (I-90: 50% and IPC-90: 15%, p=0.018), and it was lower in the ischemic preconditioning group as a whole compared to the groups without ischemic preconditioning (IPC-14% and I=30%, p=0.006). Lower levels of MDA, CINC-1, and CINC-2 were observed in the animals that were subjected to ischemic preconditioning compared to the animals that were not (MDA: I-45=1.23 nmol/mg protein, and IPC-45=0.62 nmol/mg protein, p=0.0333; CINC-1: I-45=0.82 ng/mL and IPC-45=0.67 ng/mL, p=0.041; CINC-2: I-45=0.52 ng/mL and IPC-45=0.35 ng/mL, p=0.032). CONCLUSION: Ischemic preconditioning reduces mortality, inflammatory process and oxidative stress in rats subjected to intestinal ischemia and reperfusion.
Descritores: Mediadores da Inflamação/metabolismo
Precondicionamento Isquêmico/mortalidade
Isquemia Mesentérica/metabolismo
Estresse Oxidativo/imunologia
Traumatismo por Reperfusão/mortalidade
-Quimiocina CXCL1/análise
Quimiocinas CXC/análise
Ensaio de Imunoadsorção Enzimática
Pulmão/metabolismo
Pulmão/fisiopatologia
Malondialdeído/análise
Artérias Mesentéricas/metabolismo
Isquemia Mesentérica/mortalidade
Ratos Wistar
Estatísticas não Paramétricas
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Younes, Riad N
Rasslan, Samir
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Id: lil-539837
Autor: Souza, Yglesio Moyses de; Fontes, Belchor; Martins, Joilson O; Sannomiya, Paulina; Brito, Glacus S; Younes, Riad N; Rasslan, Samir.
Título: Evaluation of the effects of ozone therapy in the treatment of intra-abdominal infection in rats
Fonte: Clinics;65(2):195-202, 2010. ilus.
Idioma: en.
Resumo: INTRODUCTION: The antibacterial effect of ozone (O3) has been described in the extant literature, but the role of O3 therapy in the treatment of certain types of infection remains controversial. OBJECTIVES: To evaluate the effect of intraperitoneal (i.p.) O3 application in a cecal ligation/puncture rat model on interleukins (IL-6, IL-10) and cytokine-induced neutrophil chemoattractant (CINC)-1 serum levels, acute lung injury and survival rates. METHODS: Four animal groups were used for the study: a) the SHAM group underwent laparotomy; b) the cecal ligation/puncture group underwent cecal ligation/puncture procedures; and c) the CLP+O2 and CLP+O3 groups underwent CLP+ corresponding gas mixture infusions (i.p.) throughout the observation period. IL-6, CINC-1 and IL-10 concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Acute lung injury was evaluated with the Evans blue dye lung leakage method and by lung histology. P<0.05 was considered significant. RESULTS: CINC-1 was at the lowest level in the SHAM group and was lower for the CLP+O3 group vs. the CLP+O2 group and the cecal ligation/puncture group. IL-10 was lower for the SHAM group vs. the other three groups, which were similar compared to each other. IL-6 was lower for the SHAM group vs. all other groups, was lower for the CLP+O3 or CLP+O2 group vs. the cecal ligation/puncture group, and was similar for the CLP+O3 group vs. the CLP+O2 group. The lung histology score was lower for the SHAM group vs. the other groups. The Evans blue dye result was lower for the CLP+O3 group vs. the CLP+O2 group and the cecal ligation/puncture group but similar to that of the SHAM group. The survival rate for the CLP+O3 group was lower than for the SHAM group and similar to that for the other 2 groups (CLP and CLP+O2). CONCLUSION: Ozone therapy modulated the inflammatory response and acute lung injury in the cecal ligation/puncture infection model in rats, although there was no ...
Descritores: Quimiocina CXCL1/sangue
/sangue
INTERLEUKIN-ABDOMEN, ACUTE/sangue
/sangue
INTERLEUKIN-ABDUCENS NERVE/sangue
Ozônio/uso terapêutico
Peritonite/tratamento farmacológico
Sepse/tratamento farmacológico
-Ceco/cirurgia
Modelos Animais de Doenças
Ensaio de Imunoadsorção Enzimática
Ligadura
Punções
Peritonite/sangue
Ratos Wistar
Sepse/sangue
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME



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