Base de dados : LILACS
Pesquisa : D12.644.276.374.200.120.100 [Categoria DeCS]
Referências encontradas : 1 [refinar]
Mostrando: 1 .. 1   no formato [Detalhado]

página 1 de 1

  1 / 1 LILACS  
             
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-781333
Autor: Simão, Raif Restivo; Ferreira, Sueli Gomes; Kudo, Guilherme Konishi; Armstrong Junior, Roberto; Silva, Luiz Fernando Ferraz da; Sannomiya, Paulina; Breithaupt-Faloppa, Ana Cristina; Moreira, Luiz Felipe Pinho.
Título: Sex differences on solid organ histological characteristics after brain death1
Fonte: Acta cir. bras;31(4):278-285, Apr. 2016. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: PURPOSE: To investigate gender differences in the evolution of the inflammatory process in rats subjected to brain death (BD). METHODS: Adult Wistar rats were divided into three groups: female; ovariectomized female; and male rats. BD was induced using intracranial balloon inflation and confirmed by maximal pupil dilatation, apnea, absence of reflex, and drop of mean arterial pressure. Six hours after BD, histological evaluation was performed in lungs, heart, liver and kidneys, and levels of inflammatory proteins, estrogen, progesterone, and corticosterone were determined in plasma. RESULTS: In the lungs, females presented more leukocyte infiltration compared to males (p<0.01). Ovariectomized female rat lungs were more hemorrhagic compared to other groups (p<0.001). In the heart, females had higher leukocyte infiltration and tissue edema compared to males (p<0.05). In the liver and kidneys, there were no differences among groups. In female group estradiol and progesterone were sharply reduced 6 hours after BD (p<0.001) to values observed in ovariectomized females and males. Corticosterone levels were similar. CONCLUSIONS: Sex hormones influence the development of inflammation and the status of organs. The increased inflammation in lungs and heart of female rats might be associated with the acute reduction in female hormones triggered by BD.
Descritores: Morte Encefálica/patologia
Caracteres Sexuais
Rim/patologia
Fígado/patologia
Pulmão/patologia
Miocárdio/patologia
-Especificidade de Órgãos
Progesterona/sangue
Valores de Referência
Fatores de Tempo
Ovariectomia
Fatores Sexuais
Ratos Wistar
Edema/patologia
Estradiol/sangue
Quimiocina CXCL1/análise
Quimiocina CXCL2/análise
Inflamação/patologia
Limites: Animais
Masculino
Feminino
Responsável: BR1.1 - BIREME



página 1 de 1
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde