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Id: lil-761962
Autor: Palomino, Diana Carolina Torres; Marti, Luciana Cavalheiro.
Título: Chemokines and immunity / Quimiocinas e imunidade
Fonte: Einstein (Säo Paulo);13(3):469-473, July-Sep. 2015. tab.
Idioma: en.
Projeto: FAPESP.
Resumo: Chemokines are a large family of small cytokines and generally have low molecular weight ranging from 7 to 15kDa. Chemokines and their receptors are able to control the migration and residence of all immune cells. Some chemokines are considered pro-inflammatory, and their release can be induced during an immune response at a site of infection, while others are considered homeostatic and are involved in controlling of cells migration during tissue development or maintenance. The physiologic importance of this family of mediators is resulting from their specificity − members of the chemokine family induce recruitment of well-defined leukocyte subsets. There are two major chemokine sub-families based upon cysteine residues position: CXC and CC. As a general rule, members of the CXC chemokines are chemotactic for neutrophils, and CC chemokines are chemotactic for monocytes and sub-set of lymphocytes, although there are some exceptions. This review discusses the potential role of chemokines in inflammation focusing on the two best-characterized chemokines: monocyte chemoattractant protein-1, a CC chemokine, and interleukin-8, a member of the CXC chemokine sub-family.

Quimiocinas são uma grande família de pequenas citocinas e seu peso molecular varia de 7 a 15kDa. As quimiocinas e seus receptores são capazes de controlar a migração e a residência de células imunes. Algumas quimiocinas são consideradas pró-inflamatórias e podem ser induzidas durante a resposta imune no sítio de infecção, enquanto outras são consideradas homeostáticas e estão envolvidas no controle da migração celular durante o desenvolvimento ou a manutenção dos tecidos. A importância fisiológica dessa família de mediadores é resultado de sua especificidade − os membros da família de quimiocinas induzem ao recrutamento de subtipos bem definidos de leucócitos. Existem duas grandes subfamílias de quimiocinas baseadas na posição dos resíduos de cisteínas: CXC e CC. Como regra geral, membros da família de quimiocinas CXC são quimiotáticos de neutrófilos, e as quimiocinas CC são quimiotáticos de monócitos e subtipos de linfócitos, apesar de existirem algumas exceções. Esta revisão discute o potencial papel das quimiocinas na inflamação focando nas duas quimiocinas mais bem caracterizadas: a proteína quimioatraente de monócitos-1, uma quimiocina CC, e a interleucina 8, uma quimiocina membro da subfamília CXC.
Descritores: Quimiocinas/imunologia
-Fragmentos de Peptídeos/imunologia
Doença Aguda
Interleucina-8/imunologia
Quimiocina CCL2/imunologia
Inflamação/imunologia
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: lil-787548
Autor: KNOB, Carollinie Dias; SILVA, Milena; GASPAROTO, Thaís Helena; OLIVEIRA, Carine Ervolino; AMÔR, Nádia Ghinelli; ARAKAWA, Nilton Syogo; COSTA, Fernando Batista; CAMPANELLI, Ana Paula.
Título: Effects of budlein A on human neutrophils and lymphocytes
Fonte: J. appl. oral sci;24(3):271-277graf.
Idioma: en.
Projeto: São Paulo Research Foundation; . São Paulo Research Foundation; . São Paulo Research Foundation.
Resumo: ABSTRACT Sesquiterpene lactones (SLs) are the active constituents of a variety of medicinal plants used in traditional medicine for the treatment of inflammatory diseases and other ailments. Objective In this study, we evaluated whether budlein A modulates the activation of innate and adaptive immune cells such as neutrophils and lymphocytes. Material and Methods Our research group has investigated several plant species and several compounds have been isolated, identified, and their medical potential evaluated. Budlein A is a SL isolated from the species Aldama buddlejiformis and A. robusta (Asteraceae) and shows anti-inflammatory and anti-nociceptive activities. Advances in understanding how plant-derived substances modulate the activation of innate and adaptive immune cells have led to the development of new therapies for human diseases. Results Budlein A inhibited MPO activity, IL-6, CXCL8, IL-10, and IL-12 production and induces neutrophil apoptosis. In contrast, budlein A inhibited lymphocyte proliferation and IL-2, IL-10, TGF-β, and IFN-γ production, but it did not lead to cell death. Conclusions Collectively, our results indicate that budlein A shows distinct immunomodulatory effects on immune cells.
Descritores: Sesquiterpenos/farmacologia
Linfócitos T/efeitos dos fármacos
Lactonas/farmacologia
Anti-Inflamatórios/farmacologia
Neutrófilos/efeitos dos fármacos
-Ensaio de Imunoadsorção Enzimática
Fatores de Crescimento Transformadores/análise
Fatores de Crescimento Transformadores/efeitos dos fármacos
Células Cultivadas
Reprodutibilidade dos Testes
Análise de Variância
Interleucina-8/análise
Interleucina-8/efeitos dos fármacos
Interleucinas/análise
Apoptose/efeitos dos fármacos
Peroxidase/análise
Peroxidase/efeitos dos fármacos
Asteraceae/química
Proliferação Celular/efeitos dos fármacos
Citometria de Fluxo
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-777353
Autor: Mendi, Ayşegül; Köse, Sevil; Uçkan, Duygu; Akca, Gülçin; Yilmaz, Derviş; Aral, Levent; Gültekin, Sibel Elif; Eroğlu, Tamer; Kiliç, Emine; Uçkan, Sina.
Título: Lactobacillus rhamnosus could inhibit Porphyromonas gingivalis derived CXCL8 attenuation
Fonte: J. appl. oral sci;24(1):67-75, Jan.-Feb. 2016. tab, graf.
Idioma: en.
Projeto: TUBITAK; . TUBITAK; . TUBITAK.
Resumo: ABSTRACT An increasing body of evidence suggests that the use of probiotic bacteria is a promising intervention approach for the treatment of inflammatory diseases with a polymicrobial etiology. P. gingivalis has been noted to have a different way of interacting with the innate immune response of the host compared to other pathogenic bacteria, which is a recognized feature that inhibits CXCL8 expression. Objective The aim of the study was to determine if P. gingivalis infection modulates the inflammatory response of gingival stromal stem cells (G-MSSCs), including the release of CXCL8, and the expression of TLRs and if immunomodulatory L. rhamnosus ATCC9595 could prevent CXCL8 inhibition in experimental inflammation. Material and Methods G-MSSCs were pretreated with L. rhamnosus ATCC9595 and then stimulated with P. gingivalis ATCC33277. CXCL8 and IL-10 levels were investigated with ELISA and the TLR-4 and 2 were determined through flow cytometer analysis. Results CXCL8 was suppressed by P. gingivalis and L. rhamnosus ATCC9595, whereas incubation with both strains did not abolish CXCL8. L. rhamnosus ATCC9595 scaled down the expression of TLR4 and induced TLR2 expression when exposed to P. gingivalis stimulation (p<0.01). Conclusions These findings provide evidence that L. rhamnosus ATCC9595 can modulate the inflammatory signals and could introduce P. gingivalis to immune systems by inducing CXCL8 secretion.
Descritores: Interleucina-8/análise
Porphyromonas gingivalis/imunologia
Probióticos/farmacologia
Lactobacillus rhamnosus/fisiologia
Células Mesenquimais Estromais/microbiologia
-Periodontite/microbiologia
Aderência Bacteriana/imunologia
Ensaio de Imunoadsorção Enzimática
Células Cultivadas
Interleucina-8/imunologia
Interferon gama/análise
Interferon gama/imunologia
Interleucina-10
Estatísticas não Paramétricas
Receptor 4 Toll-Like/análise
Receptor 4 Toll-Like/imunologia
Citometria de Fluxo
Imunidade Inata
Limites: Seres Humanos
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-787423
Autor: Utiyama, Daniela Mitiyo Odagiri; Yoshida, Carolina Tieko; Goto, Danielle Miyuki; de Santana Carvalho, Tômas; de Paula Santos, Ubiratan; Koczulla, Andreas Rembert; Saldiva, Paulo Hilário Nascimento; Nakagawa, Naomi Kondo.
Título: The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation
Fonte: Clinics;71(6):344-350tab, graf.
Idioma: en.
Projeto: Fundação de Amparo è Pesquisa do Estado de São Paulo.
Resumo: OBJECTIVE: The aim of the present study was to assess nasal mucociliary clearance, mucus properties and inflammation in smokers and subjects enrolled in a Smoking Cessation Program (referred to as quitters). METHOD: A total of 33 subjects with a median (IQR) smoking history of 34 (20-58) pack years were examined for nasal mucociliary clearance using a saccharine transit test, mucus properties using contact angle and sneeze clearability tests, and quantification of inflammatory and epithelial cells, IL-6 and IL-8 concentrations in nasal lavage fluid. Twenty quitters (mean age: 51 years, 9 male) were assessed at baseline, 1 month, 3 months and 12 months after smoking cessation, and 13 smokers (mean age: 52 years, 6 male) were assessed at baseline and after 12 months. Clinicaltrials.gov: NCT02136550. RESULTS: Smokers and quitters showed similar demographic characteristics and morbidities. At baseline, all subjects showed impaired nasal mucociliary clearance (mean 17.6 min), although 63% and 85% of the quitters demonstrated significant nasal mucociliary clearance improvement at 1 month and 12 months, respectively. At 12 months, quitters also showed mucus sneeze clearability improvement (∼26%), an increased number of macrophages (2-fold) and no changes in mucus contact angle or cytokine concentrations. CONCLUSION: This study showed that smoking cessation induced early improvements in nasal mucociliary clearance independent of mucus properties and inflammation. Changes in mucus properties were observed after only 12 months of smoking cessation.
Descritores: Fumar/efeitos adversos
Abandono do Hábito de Fumar
Muco/química
-Fatores de Tempo
Monóxido de Carbono/análise
Fumar/metabolismo
Contagem de Células
Depuração Mucociliar
Estudos Longitudinais
Interleucina-8/metabolismo
Interleucina-6/metabolismo
Líquido da Lavagem Nasal/química
Cotinina/análise
Inflamação/patologia
Mucosa Nasal/patologia
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-1008594
Autor: García, Apolinaria; Navarro, Karen; Sanhueza, Enrique; Pineda, Susana; Pastene, Edgar; Quezada, Manuel; Henríquez, Karem; Karlyshev, Andrey; Villena, Julio; González, Carlos.
Título: Characterization of Lactobacillus fermentum UCO-979C, a probiotic strain with a potent anti-Helicobacter pylori activity
Fonte: Electron. j. biotechnol;25:75-83, ene. 2017. tab, graf, ilus.
Idioma: en.
Projeto: INNOVA CHILE; . INNOVA BIO.
Resumo: Background: Helicobacter pylori is considered as the main risk factor in the development of gastric cancer. In the present study, we performed a detailed characterization of the probiotic properties and the anti-H. pylori activity of a previously isolated lactobacillus strain ­ Lactobacillus fermentum UCO-979C ­ obtained from human gut. Results: The strain tolerated pH 3.0; grew in the presence of 2% bile salts; produced lactic acid and hydrogen peroxide; aggregated in saline solution; showed high hydrophobicity; showed high adherence to glass; Caco-2 and gastric adenocarcinoma human cells (AGS) cells; showed an efficient colonization in Mongolian Gerbils; and potently inhibited the growth and urease activity of H. pylori strains. L. fermentum UCO-979C significantly inhibited H. pylori-induced IL-8 production in AGS cells and reduced the viability of H. pylori. With regard to innocuousness, the strain UCO-979C was susceptible to several antibiotics and did not produce histamine or beta-haemolysis in blood agar containing red blood cells from various origins. Conclusion: The results demonstrated that L. fermentum UCO-979C is a very good candidate as a probiotic for the protection of humans against H. pylori infections.
Descritores: Helicobacter pylori/efeitos dos fármacos
Infecções por Helicobacter/prevenção & controle
Probióticos/farmacologia
Lactobacillus fermentum/fisiologia
Antibacterianos/farmacologia
-Neoplasias Gástricas/prevenção & controle
Urease/antagonistas & inibidores
Interleucina-8/antagonistas & inibidores
Gerbillinae
Modelos Animais de Doenças
Interações Hidrofóbicas e Hidrofílicas
Limites: Seres Humanos
Animais
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-890678
Autor: Carvalho, Marcus VH; Marchi, Evaldo; Fruchi, Andre J; Dias, Bruno VB; Pinto, Clovis L; dos Santos, Geovane R; Acencio, Milena MP.
Título: Local and systemic effects of fibrin and cyanoacrylate adhesives on lung lesions in rabbits
Fonte: Clinics;72(10):624-628, Oct. 2017. tab, graf.
Idioma: en.
Projeto: Medical College of Jundiai.
Resumo: OBJECTIVES: Tissue adhesives can be used to prevent pulmonary air leaks, which frequently occur after lung interventions. The objective of this study is to evaluate local and systemic effects of fibrin and cyanoacrylate tissue adhesives on lung lesions in rabbits. METHODS: Eighteen rabbits were submitted to videothoracoscopy + lung incision alone (control) or videothoracoscopy + lung incision + local application of fibrin or cyanoacrylate adhesive. Blood samples were collected and assessed for leukocyte, neutrophil and lymphocyte counts and interleukin-8 levels preoperatively and at 48 hours and 28 days post-operatively. After 28 days, the animals were euthanized for gross examination of the lung surface, and lung fragments were excised for histopathological analysis. RESULTS: Fibrin and cyanoacrylate produced similar adhesion scores of the lung to the parietal pleura. Microscopic analysis revealed uniform low-cellular tissue infiltration in the fibrin group and an intense tissue reaction characterized by dense inflammatory infiltration of granulocytes, giant cells and necrosis in the cyanoacrylate group. No changes were detected in the leukocyte, neutrophil or lymphocyte count at any time-point, while the interleukin-8 levels were increased in the fibrin and cyanoacrylate groups after 48 hours compared with the pre-operative control levels (p<0.01). CONCLUSION: Both adhesive agents promoted normal tissue healing, with a more pronounced local inflammatory reaction observed for cyanoacrylate. Among the serum markers of inflammation, only the interleukin-8 levels changed post-operatively, increasing after 48 hours and decreasing after 28 days to levels similar to those of the control group in both the fibrin and cyanoacrylate groups.
Descritores: Adesivos Teciduais/uso terapêutico
Adesivo Tecidual de Fibrina/uso terapêutico
Cianoacrilatos/uso terapêutico
Lesão Pulmonar/tratamento farmacológico
-Valores de Referência
Toracoscopia/métodos
Fatores de Tempo
Ensaio de Imunoadsorção Enzimática
Distribuição Aleatória
Reprodutibilidade dos Testes
Interleucina-8/sangue
Resultado do Tratamento
Hemodinâmica
Contagem de Leucócitos
Pulmão/efeitos dos fármacos
Pulmão/patologia
Limites: Animais
Masculino
Coelhos
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-889055
Autor: Ribeiro, VGC; Mendonça, VA; Souza, ALC; Fonseca, SF; Camargos, ACR; Lage, VKS; Neves, CDC; Santos, JM; Teixeira, LAC; Vieira, ELM; Teixeira Junior, AL; Mezêncio, B; Fernandes, JSC; Leite, HR; Poortmans, JR; Lacerda, ACR.
Título: Inflammatory biomarkers responses after acute whole body vibration in fibromyalgia
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(4):e6775, 2018. tab, graf.
Idioma: en.
Projeto: FAPEMIG; . CNPq.
Resumo: The aims of this study were 1) to characterize the intensity of the vibration stimulation in women diagnosed with fibromyalgia (FM) compared to a control group of healthy women (HW) matched by age and anthropometric parameters, and 2) to investigate the effect of a single session of whole body vibration (WBV) on inflammatory responses. Levels of adipokines, soluble tumor necrosis factor receptors (sTNFr1, sTNFr2), and brain-derived neurotrophic factor (BDNF) were determined by enzyme-linked immunosorbent assay. Oxygen consumption (VO2) was estimated by a portable gas analysis system, heart rate (HR) was measured using a HR monitor, and perceived exertion (RPE) was evaluated using the Borg scale of perceived exertion. Acutely mild WBV increased VO2 and HR similarly in both groups. There was an interaction (disease vs vibration) in RPE (P=0.0078), showing a higher RPE in FM compared to HW at rest, which further increased in FM after acute WBV, whereas it remained unchanged in HW. In addition, there was an interaction (disease vs vibration) in plasma levels of adiponectin (P=0.0001), sTNFR1 (P=0.000001), sTNFR2 (P=0.0052), leptin (P=0.0007), resistin (P=0.0166), and BDNF (P=0.0179). In conclusion, a single acute session of mild and short WBV can improve the inflammatory status in patients with FM, reaching values close to those of matched HW at their basal status. The neuroendocrine mechanism seems to be an exercise-induced modulation towards greater adaptation to stress response in these patients.
Descritores: Vibração
Exercício
Fibromialgia/sangue
Fibromialgia/terapia
Mediadores da Inflamação/sangue
-Consumo de Oxigênio/fisiologia
Ensaio de Imunoadsorção Enzimática
Biomarcadores/sangue
Estudos de Casos e Controles
Interleucina-8/sangue
Receptores do Fator de Necrose Tumoral/sangue
Fator Neurotrófico Derivado do Encéfalo/sangue
Leptina/sangue
Resistina/sangue
Adipocinas/sangue
Frequência Cardíaca/fisiologia
Inflamação/sangue
Inflamação/terapia
Limites: Seres Humanos
Feminino
Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-994945
Autor: Barahona Correa, Julián Esteban; Franco Cortés, Manuel Antonio; Uribe, Juana Ángel; Rodríguez Camacho, Luz Stella.
Título: Comparison of Plasma Cytokine Levels before and after Treatment with Rituximab in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus-Associated Polyautoimmunity / Comparación de citocinas plasmáticas antes y después del tratamiento con rituximab en pacientes con artritis reumatoide y lupus eritematoso sistémico asociado a poliautoinmunidad
Fonte: Univ. med;59(3), 2018. ilus, tab.
Idioma: en.
Resumo: Introducción: La coexistencia de más de una enfermedad autoinmune (EAI) en un paciente se conoce como poliautoinmunidad (PAI) y se observa en el 35% de los pacientes con EAI. La eliminación de linfocitos B usando rituximab (RTX) controla la actividad de diferentes EAI. En el lupus eritematoso sistémico (LES) y en PAI no es clara la producción de citocinas por los linfocitos B. Métodos: Estudio exploratorio. Se obtuvo plasma de 11 pacientes con artritis reumatoide (AR) y poliautoinmunidad asociada a LES (PAILES) antes y después de rituximab (i. e., 6 meses). Como controles se utilizaron ocho individuos sanos. Las citocinas se midieron por ELISA (IFN-a, TGF-pl) o Cytometnc Bead Array (TNF-a, IL-ip, IL-ó, IL-8, IL-10, IL-12p7O). Resultados: Previo a RTX, IL-ó se encontró elevada únicamente en AR, mientras que IL-8 lo estuvo en AR y en PAILES, comparados con controles. Después de RTX se encontró una disminución significativa de IL-ó en AR y de IL-8 en PAILES. Las concentraciones de otras citocinas medidas fueron similares (IFN-a, TGF-B1) o se encontraron por debajo de límite de detección (TNF-a, IL-1[3, IL-10, IL-12p7O), tanto en pacientes como en controles. Conclusión: Los datos resaltan la importancia de la secreción de citocinas por los linfocitos B y sugieren un rol diferencial en cada patología. El incremento de IL-8 previo a RTX en ambos grupos y la reducción después de la terapia en PAILES respaldan el potencial de la IL-8 como objetivo terapéutico. La heterogeneidad de la población de pacientes con PAI reafirma la importancia de la selección de subgrupos específicos en estudios futuros.

Introduction: Coexistence of more than one autoimmune disease (AD) in a single patient is known as polyautoimmunity, and may be seen in up to 35% of patients with ADs. The elimination of B-cells using Rituximab (RTX) improves clinical status in different ADs. The role of cytokine production by B-cells is unclear in systemic lupus erythematosus (SLE) and polyautoimmunity. Methods: As an exploratory study, plasma from 11 patients with either rheumatoid arthritis (RA) or SLE-associated polyautoimmunity was assessed prior and 6 months after therapy with RTX. Eight healthy individuáis were used as Controls. Cytokine levels were measured using ELISA (IFN-a and TGF-61) or Cytometric Bead Array (TNF-a, IL-1
Descritores: Artrite Reumatoide/classificação
Citocinas
Interleucina-8/classificação
-Rituximab
Lúpus Eritematoso Sistêmico
Responsável: CO185.1 - Biblioteca Alfonso Borrero Cabal, S. J.


  9 / 27 LILACS  
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Id: biblio-839499
Autor: ALIKHANI, Milad; GHALAIANI, Parichehr; ASKARIYAN, Elham; KHUNSARAKI, Zahra Ahmadi; TAVANGAR, Atefeh; NADERI, Aliasghar.
Título: Association between the clinical severity of oral lichen planus and anti-TPO level in thyroid patients
Fonte: Braz. oral res. (Online);31:e10, 2017. tab.
Idioma: en.
Resumo: Abstract This study considered a possible relationship between the severity of oral lichen planus (OLP), serum anti-TPO autoantibodies (TPOAb) titer and thyroid disease in OLP patients. Forty-six OLP patients with positive TPOAb results (> 35 IU/ml) who had also been diagnosed with thyroid disease were included in the study group. The control group consisted of 46OLP patients with no thyroid disease. The study and control groups (92) were divided to two subgroups of erosive OLP (EOLP) and non-erosive OLP (NEOLP). Serum TPOAb levels and IL-8 (to measure OLP severity) were evaluated using the independent t-test, chi-square and conditional logistic regression analysis (α = 0.05). A significant positive correlation was found between serum IL-8 and TPOAb levels in the study group (r = 0.783; p = 0.001). The positive blood levels of TPOAb were significantly associated with an increased risk of EOLP (OR = 4.02 at 95%CI; 1.21–13.4; p = 0.023). It is possible to used positive serum TPOAb levels in patients with OLP as in indicator of possible undetected thyroid disorders in those patients. Because erosive OLP has been associated with TPOAb in thyroid patients, it may be useful to determine TPOAb levels of such patients to diagnose a possible undetected thyroid disorders and follow-up for malignancy.
Descritores: Autoanticorpos/sangue
Iodeto Peroxidase/imunologia
Líquen Plano Bucal/imunologia
Doenças da Glândula Tireoide/imunologia
-Biomarcadores/sangue
Estudos de Casos e Controles
Interleucina-8/sangue
Iodeto Peroxidase/sangue
Valores de Referência
Índice de Gravidade de Doença
Estatísticas não Paramétricas
Doenças da Glândula Tireoide/fisiopatologia
Glândula Tireoide/fisiopatologia
Limites: Seres Humanos
Masculino
Feminino
Adolescente
Adulto
Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-829247
Autor: Lima Júnior, Sérgio Ferreira de; Tavares, Mayara Mansur Fernandes; Macedo, Jamilly Lopes de; Oliveira, Renata Santos de; Heráclio, Sandra de Andrade; Maia, Maria de Mascena Diniz; Souza, Paulo Roberto Eleutério de; Moura, Ronald; Crovella, Sergio.
Título: Influence of IL-6, IL-8, and TGF-β 1 gene polymorphisms on the risk of human papillomavirus-infection in women from Pernambuco, Brazil
Fonte: Mem. Inst. Oswaldo Cruz;111(11):663-669, Nov. 2016. tab.
Idioma: en.
Resumo: Human papillomavirus (HPV) infections are strongly associated with the development of cervical intraepithelial neoplasias and invasive cervical cancer. Polymorphisms in cytokine-encoding genes and behavioural cofactors could play an important role in protecting an individual against viral infections and cancer. Here, we investigated whether IL-6 -174 G>C, IL-8 +396 G>T, and TGF-β1 +869 G>C and +915 G>C polymorphisms were associated with susceptibility to HPV infection in women from north-east (Pernambuco) Brazil. We analysed 108 healthy uninfected women (HC) and 108 HPV-positive women with cervical lesions. Genetic polymorphisms were assessed using Sanger sequencing and polymerase chain reaction-restriction fragment length polymorphism. Comparison of the distribution of the genotypic and allelic frequencies of the IL-18 +396 T>G polymorphism between HPV infected woman an uninfected controls showed that the GG genotype and G allele were both more frequent in the HC group, and were associated with protection from HPV infection (p = 0.0015; OR = 0.29 CI95% = 0.13-0.61; p = 0.0005; OR = 0.45 CI95% 0.29-0.7, respectively). Individuals from the control group could have previously had HPV infection that was spontaneously eliminated; however, it was undetectable at the time of sample collection. Based on our findings, we hypothesize that the IL-8 +396 G>T polymorphism could interfere with susceptibility to HPV infection, by modulating the ability of immune system to fight the virus.
Descritores: Neoplasia Intraepitelial Cervical/genética
Interleucina-6/genética
Interleucina-8/genética
Infecções por Papillomavirus/genética
Polimorfismo de Nucleotídeo Único
Fator de Crescimento Transformador beta1/genética
Neoplasias do Colo do Útero/genética
-Alelos
Sequência de Bases
Brasil
Neoplasia Intraepitelial Cervical/virologia
Estudos Transversais
DNA Viral/análise
Frequência do Gene
Predisposição Genética para Doença
Infecções por Papillomavirus/virologia
Reação em Cadeia da Polimerase
Neoplasias do Colo do Útero/virologia
Limites: Seres Humanos
Feminino
Adolescente
Adulto
Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde