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Cirelli, Joni Augusto
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Id: biblio-952120
Autor: Souza, João Antonio Chaves de; Nogueira, Andressa Vilas Boas; Souza, Pedro Paulo Chaves de; Oliveira, Guilherme José Pimentel Lopes de; Medeiros, Marcell Costa de; Garlet, Gustavo Pompermaier; Cirelli, Joni Augusto; Rossa-Junior, Carlos.
Título: Suppressor of cytokine signaling 1 expression during LPS-induced inflammation and bone loss in rats
Fonte: Braz. oral res. (Online);31:e75, 2017. tab, graf.
Idioma: en.
Resumo: Abstract This study aimed to characterize the dynamics of suppressor of cytokine signaling (SOCS1) expression in a rat model of lipopolysaccharide-induced periodontitis. Wistar rats in the experimental groups were injected three times/week with LPS from Escherichia coli on the palatal aspect of the first molars, and control animals were injected with vehicle (phosphate-buffered saline). Animals were sacrificed 7, 15, and 30 days after the first injection to analyze inflammation (stereometric analysis), bone loss (macroscopic analysis), gene expression (qRT-PCR), and protein expression/activation (Western blotting). The severity of inflammation and bone loss associated with LPS-induced periodontitis increased from day 7 to day 15, and it was sustained through day 30. Significant (p < 0.05) increases in SOCS1, RANKL, OPG, and IFN-γ gene expression were observed in the experimental group versus the control group at day 15. SOCS1 protein expression and STAT1 and NF-κB activation were increased throughout the 30-day experimental period. Gingival tissues affected by experimental periodontitis express SOCS1, indicating that this protein may potentially downregulate signaling events involved in inflammatory reactions and bone loss and thus may play a relevant role in the development and progression of periodontal disease.
Descritores: Periodontite/patologia
Perda do Osso Alveolar/patologia
Proteína 1 Supressora da Sinalização de Citocina/análise
-Periodontite/etiologia
Periodontite/metabolismo
Fatores de Tempo
Imuno-Histoquímica
Distribuição Aleatória
Lipopolissacarídeos
Western Blotting
Perda do Osso Alveolar/etiologia
Perda do Osso Alveolar/metabolismo
NF-kappa B/análise
Interferon gama/análise
Ratos Wistar
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Fator de Transcrição STAT1/análise
Ligante RANK/análise
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: biblio-1285571
Autor: Araujo, Ludmilla Dela Coletta Troiano; Rodriguez-Fernández, Daniel Ernesto; Karp, Susan Grace; Marquez, Ellen de Souza; Santos, Aline Cristina dos; Hospinal-Santiani, Manuel; Boschero, Raphael Aparecido; Ramos, Eliezer Lucas Pires; Thomaz-Soccol, Vanete.
Título: Formulation and Validation of Recombinant Antigens CFP10 and ESAT6 for Tuberculosis Diagnosis
Fonte: Braz. arch. biol. technol;64(spe):e21210127, 2021. tab, graf.
Idioma: en.
Projeto: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; . Conselho Nacional de Desenvolvimento Científico e Tecnológico; . Fundação Araucária.
Resumo: Abstract The rapid and accurate diagnosis of tuberculosis (TB), especially considering limited resources, is still a challenge. Development of new methodologies and tests are needed to overcome several disadvantages of the available standard tests. We evaluated the diagnostic potential of two antigens specific for Mycobacterium tuberculosis, the CFP10 and ESAT6 recombinant proteins, and developed stable formulations thereof. Sensitivity and specificity of the delayed-type hypersensitivity (DTH) skin testing and the induction of gamma interferon production (IFN-γ) by lymphocytes, as a non-invasive test, were evaluated using the CFP10 and ESAT6 protein formulations. The recombinant proteins produced by our group presented a high DTH response and the ability to differentiate between tuberculosis infection, BCG vaccination, and the contact with non-tuberculous mycobacteria (NTM). The production of IFN-γ by stimulation with individual and combined proteins was detected in a panel of 40 individuals and showed a specificity of 100% and a sensitivity of 90% when the two proteins were used together. Lyophilized formulations were stable under all conditions, while soluble formulations were stable under freezing at -20 ºC and -80 ºC. The proposed formulations containing the ESAT6 and CFP10 recombinant antigens constitute satisfactory tools for TB testing, suitable to be developed and implemented in a large-scale trial.
Descritores: Tuberculose/diagnóstico
Interferon gama
Mycobacterium tuberculosis/isolamento & purificação
Antígenos/química
Responsável: BR1.1 - BIREME


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Id: biblio-978319
Autor: Aleem, Daniyal; Tohid, Hassaan.
Título: Pro-inflammatory Cytokines, Biomarkers, Genetics and the Immune System: A Mechanistic Approach of Depression and Psoriasis / Citocinas proinflamatorias, biomarcadores, genética y sistema inmunológico: un enfoque mecanicista de la depresión y la psoriasis
Fonte: Rev. colomb. psiquiatr;47(3):177-186, jul.-set. 2018. tab.
Idioma: en.
Resumo: ABSTRACT Objective: To highlight the inflammatory and immunological mechanisms involved in depression and psoriasis. Methods: A comprehensive literature search was performed in various databases, in total 145 studies were selected. Results: Depression and psoriasis have an association. Immune mechanisms -the actions of tumor necrosis factor-a, interleukin 1 (IL-1), IL-2, IL-10, IL-22, IL-17, interferon-7, IL-1ß, prostaglandin E2, C-reactive protein, IL-6, and IL-8 etc.-, and some genetic changes are involved. Conclusions: A possible bidirectional relationship of psoriasis and major depression exists; i.e. the depression leads to psoriasis, and psoriasis leads to depression. We recommend more studies in the future to get a deeper and better understanding about this relationship.

RESUMEN Objetivo: Poner de relieve los mecanismos inflamatorios e inmunológicos involucrados en la depresión y la psoriasis. Métodos: Se realizó en varias bases de datos una búsqueda bibliográfica completa; en total se incluyeron 145 estudios. Resultados: Hay asociación entre depresión y psoriasis y están involucrados mecanismos inmunitarios -las acciones del factor de necrosis tumoral alfa, las interleucinas (IL) 1, 2, 10, 22 y 17, el interferón gamma, la IL-1ß, la prostaglandina E2, la proteína C reactiva, la IL-6 y la IL-8, etc. - y algunos cambios genéticos. Conclusiones: Hay una posible relación bidireccional entre psoriasis y depresión, es decir, la depresión lleva a psoriasis y la psoriasis lleva a depresión. Se recomiendan más estudios en el futuro para obtener una comprensión más profunda y mejor sobre esta relación.
Descritores: Biomarcadores
Citocinas
Genética
-Proteína C
Interferon gama
Interleucina-1
Interleucina-2
Interleucina-10
Interleucina-17
Depressão
Sistema Imunitário
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Revisão
Responsável: CO78 - Asociación Colombiana de Psiquiatría


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Id: biblio-1045760
Autor: Marie, MAM; John, J; Krishnappa, L Gowda; Gopalkrishnan, S; Bindurani, SR; CS, P.
Título: Role of interleukin-6, gamma interferon and adenosine deaminase markers in management of pleural effusion patients / Papel de la interleucina-6, el interferón gamma, y la adenosina desaminasa como marcadores en el tratamiento de pacientes con derrame pleural
Fonte: West Indian med. j;62(9):803-807, Dec. 2013. tab.
Idioma: en.
Projeto: King Saud University. Deanship of Scientific Research.
Resumo: OBJECTIVE: Pleural effusion is a common diagnostic and clinical problem. Neoplasms and tuberculosis are the most frequent diagnostic causes of such effusions. Conventional laboratory methods for diagnosis of such effusion are inefficient because tubercle bacilli are rarely seen in direct examinations of pleural fluid. The present study evaluates interleukin-6 (IL-6), gamma interferon (IFN-γ) and adenosine deaminase (ADA) as diagnostic tools in pleural effusion. METHODS: Interleukin-6, IFN-γ and ADA were measured in pleural fluid from the patients, with exudative pleural effusion from tuberculous, malignant and postpneumonic origin and transudative pleural effusion ofsystemic origin in order to evaluate the diagnostic utility ofthese. RESULTS: The three markers were detectable in all effusions with significantly high levels in exudative as compared to transudative effusions. There was a statically significant difference noticed in tuberculous as compared to malignant andpostpneumonic origin and transudative pleural effusion. CONCLUSION: We concluded that IL-6, IFN-γ and ADA levels in pleural effusion are sensitive parameters to differentiate an exudate from a transudate and they can also differentiate exudates of different aetiology. Finally, the results suggest that there is a remarkable difference in production of these three markers in exudative pleural effusions as compared to transudative pleural effusions.

OBJETIVO: El derrame pleural es un problema diagnóstico y clínico común. Las neoplasias y la tuberculosis son las causas más frecuentes en los diagnósticos de tales derrames. Los métodos de laboratorio convencionales para el diagnóstico de tales derrames son ineficientes, porque los bacilos de la tuberculosis raramente se ven en los exámenes directos del líquido pleural. El presente estudio evalúa la interleucina-6, el interferón gamma (IFN-γ) y la adenosina desaminasa (ADA) como herramientas de diagnóstico en el derrame pleural. MÉTODOS: La interleucina-6, el IFN-γ, y la ADA fueron medidos en el líquido pleural de los pacientes con derrame pleural exudativo de origen tuberculoso, maligno y post-pneumónico, y el derrame pleural trasudativo de origen sistémico, con el fin de evaluar la utilidad diagnóstica de éstos. RESULTADOS: Los tres marcadores eran observables en todos los derrames, con niveles significativamente altos en los exudativos en comparación con los trasudativos. Se notó una diferencia estadísticamente significativa en los derrames de origen tuberculoso en comparación con los de origen maligno y postpneumónico, y los derrames pleurales trasudativos. CONCLUSIÓN: Llegamos a la conclusión de que los niveles de IL-6, IFN-Correspondence: Dr M Marie, College of Applied Medical Sciences, Clinical Laboratory Department, King Saud University, PO Box 10219, Riyadh 11433, Kingdom of Saudi Arabia. E-mail: drmmarie.2000@ gmail.com *Equally contributed to the manuscript YADA en el derrame pleural, son parámetros sensibles para diferenciar un derrame pleural exudado de uno trasudado, pudiendo por otra parte ayudar también a distinguir exudados de diferentes etiologías. Finalmente, los resultados sugieren que existe una diferencia notable en la forma en que se producen estos tres marcadores en los derrames efusiones pleurales exudativos en comparación con los derrames pleurales trasudativos.
Descritores: Derrame Pleural/diagnóstico
Adenosina Desaminase/análise
Interleucina-6/análise
Interferon gama/análise
Exsudatos e Transudatos/química
-Biomarcadores/análise
Limites: Humanos
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
Texto completo
Id: biblio-950711
Autor: Promphet, Porkaew; Bunarsa, Sirirat; Sutheerawattananonda, Manote; Kunthalert, Duangkamol.
Título: Immune enhancement activities of silk lutein extract from Bombyx mori cocoons
Fonte: Biol. Res;47:1-10, 2014. graf, tab.
Idioma: en.
Resumo: BACKGROUND: Declining immune function poses an important clinical challenge worldwide and supplementation with natural products that possessing immune enhancing properties is a promising approach for preventing or delaying immune function decline. Cocoons from yellow silkworms are a significant source of lutein, and this unexplored silk extract could be a viable alternative source for dietary lutein. This study assessed immunomodulatory activities of the silk lutein extract. Female BALB/c mice orally received lutein, either as silk or marigold extracts (10 or 20 mg/kg daily), or vehicle only (1% tween 80 in PBS pH 7.4) for 4 weeks. Natural killer (NK) cell activity, specific antibody production, lymphocyte subpopulations, mitogen-induced lymphocyte proliferation, and cytokine production were examined. RESULTS: Silk lutein extract increased NK cell activity, and the effect was dose-related whereas marigold lutein extract was ineffective. Silk lutein extract dose-dependently enhanced antibody production in pre-immunized mice but marigold lutein extract had no effect. Feeding with silk lutein extract increased the populations of CD3+ and CD4 + CD3 + cells. Silk lutein extract also stimulated concanavalin A- and lipopolysaccharide-induced proliferations of T and B lymphocytes, respectively. Moreover, silk lutein extract increased IL-2 and IFN-γ production while the effect of marigold lutein extract was undetectable. CONCLUSIONS: Together, silk lutein extract enhanced both innate and adaptive immune functions. This preparation may prove to be an effective supplement for strengthened immunity.
Descritores: Bombyx/imunologia
Extratos de Tecidos/imunologia
Luteína/imunologia
Seda/imunologia
Exoesqueleto/química
Fatores Imunológicos/análise
-Pupa/imunologia
Pupa/metabolismo
Bombyx/metabolismo
Extratos de Tecidos/farmacologia
Luteína/isolamento & purificação
Anticorpos Heterófilos/sangue
Extratos Vegetais/imunologia
Linfócitos B/efeitos dos fármacos
Células Matadoras Naturais/efeitos dos fármacos
Células Matadoras Naturais/imunologia
Linfócitos T/efeitos dos fármacos
Interleucina-4/análise
Interferon gama/análise
Interleucina-2/análise
Interleucina-10/análise
Tagetes/imunologia
Flores/imunologia
Seda/química
Proliferação de Células/efeitos dos fármacos
Citometria de Fluxo
Camundongos Endogâmicos BALB C
Limites: Animais
Feminino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Texto completo
Id: biblio-842845
Autor: Araujo, Zaida; Palacios, Andrea; Biomon, Rubén; Rivas-Santiago, Bruno; Serrano, Carmen Judith; Enciso-Moreno, Leonor; López-Ramos, Juan Ernesto; Wide, Albina; Jiménez, Juan Carlos; Larrea, Carlos Fernández de; Enciso-Moreno, José Antonio.
Título: Concordance between IFNγ gene +874 A/T polymorphism and interferon-γ expression in a TB-endemic indigenous setting
Fonte: Rev. Soc. Bras. Med. Trop;50(2):199-207, Mar.-Apr. 2017. tab, graf.
Idioma: en.
Resumo: Abstract INTRODUCTION: Interferon-γ (IFN-γ) plays a crucial role in resistance to mycobacterial diseases; accordingly, variants of the gene encoding this cytokine may be associated with elevated risk of contracting pulmonary tuberculosis (TB). METHODS: Blood samples were collected from 135 Warao indigenous individuals with newly diagnosed sputum culture-positive TB. Of these, 24 were diagnosed with active tuberculosis (ATB). The study comprised 111 participants, who were grouped as follows: 1) 14 tuberculin skin test (TST)-positive Warao indigenous individuals and 4 that were QuantiFERON-TB?Gold In-Tube (QFT-IT) test-positive, collectively comprising the latent TB infection group (LTBI), n = 18), and 2) healthy controls who were QFT-IT- and TST-negative, comprising the control group (CTRL, n = 93). Detection of the IFN γ gene (IFNG) +874A/T polymorphism was performed via PCR and quantification of IFNG expression via qPCR. RESULTS: Relative to indigenous and white Americans, ATB and CTRL groups had a higher frequency of the IFNG SNP (+874A): 23 (95.8%) and 108 (97.3%), respectively. Indigenous Warao individuals homozygous for the IFNG (+874) A allele exhibited 3.59-fold increased risk of developing TB (95% confidence interval, 2.60-4.96, p =0.0001). A decreased frequency of the AT genotype was observed in individuals with pulmonary TB (4.16%) and controls (0.90%). The frequency of the TT genotype was decreased among controls (1.80%); none of the patients with TB were found to have this genotype. The differences in IFNG expression between the groups, under unstimulated and stimulated conditions, were not statistically significant. CONCLUSIONS: Preliminary results demonstrate concordance between IFNG +874 A/A genotype and low expression of IFNG.
Descritores: Polimorfismo Genético/genética
Tuberculose Pulmonar/diagnóstico
Índios Sul-Americanos/estatística & dados numéricos
Interferon gama/genética
-Tuberculose Pulmonar/etnologia
Tuberculose Pulmonar/epidemiologia
Venezuela/epidemiologia
Teste Tuberculínico
Reação em Cadeia da Polimerase
Estudos Transversais
Interferon gama/metabolismo
Doenças Endêmicas
Genótipo
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Montenegro, Silvia Maria Lucena
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Id: biblio-897054
Autor: Sampaio, Aletheia Soares; Vasconcelos, Ana Lucia Ribeiro de; Morais, Clarice Neuenschwander Lins de; Diniz, George Tadeu Nunes; Figueiredo, Anna Lígia de Castro; Montenegro, Sílvia Maria Lucena.
Título: Social conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil
Fonte: Rev. Soc. Bras. Med. Trop;51(1):21-29, Jan.-Feb. 2018. tab, graf.
Idioma: en.
Projeto: Program to Support Research in Health (PAPES VI), National Council for Technological and Scientific Development, Oswaldo Cruz Foundation,.
Resumo: Abstract INTRODUCTION The functioning of the immune system during pregnancy is altered in both human immunodeficiency virus (HIV)-infected and uninfected women. Unfavorable socioeconomic conditions have been indicative of higher morbidity and mortality and worsening of the immune system. The aim of this study was to correlate social status with levels of interleukin (IL)-10 (non-inflammatory) and interferon-gamma (IFN-γ; inflammatory) cytokines. METHODS A cross-sectional study was conducted with three groups of women: 33 pregnant HIV-infected (G1); 40 non-pregnant, HIV-infected (G2); and 35 pregnant, HIV-uninfected. To measure the social status, a compound indicator called the social status index (SSI), was established using sociodemographic variables (i.e., education level, housing conditions, per capita income, and habitation and sanitary conditions). RESULTS The HIV-infected women had a higher proportion of unfavorable SSI (73% and 75% of G1 and G2, respectively). There were significantly lower IL-10 levels in the G1 group with both unfavorable and favorable SSI than in the other groups. No significant difference in IFN-γ levels was observed among groups. However, the G1 group had higher IFN-γ values among both favorable and unfavorable SSI groups. CONCLUSIONS Higher rates of unfavorable conditions, including lower education levels, IL-10 levels, and a trend for higher IFN-γ levels, were identified among HIV-infected women, pregnant and non-pregnant. These factors may interfere in health care and lead to poor outcomes during pregnancy. Therefore, we suggest that health policies could be created to specifically address these factors in this population.
Descritores: Complicações Infecciosas na Gravidez/imunologia
Infecções por HIV/imunologia
Interferon gama/sangue
Interleucina-10/sangue
-Complicações Infecciosas na Gravidez/sangue
Complicações Infecciosas na Gravidez/virologia
Condições Sociais
Fatores Socioeconômicos
Brasil
Infecções por HIV/sangue
Estudos Transversais
Interferon gama/imunologia
Interleucina-10/imunologia
Limites: Humanos
Feminino
Gravidez
Adulto
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
Texto completo
Id: biblio-1041447
Autor: Peleteiro, Thaís Silva; Oliveira, Evelin Santos; Conceição, Elisabete Lopes; Nascimento-Sampaio, Francisco; Alcântara-Neves, Neuza Maria; Mendes, Carlos Mauricio Cardeal; Bessa, Theolis Costa Barbosa.
Título: Impact of Bacille Calmette-Guérin revaccination on serum IgE levels in a randomized controlled trial
Fonte: Rev. Soc. Bras. Med. Trop;51(1):94-98, Jan.-Feb. 2018. tab, graf.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado da Bahia.
Resumo: Abstract INTRODUCTION: Bacille Calmette-Guérin (BCG) downmodulates allergen-specific IgE levels and prevents other atopic responses in experimental models but fails to protect against respiratory allergies. Human responsiveness to BCG is variable and may interfere with protection. METHODS: Multivariate models were evaluated to test the possible effect of responsiveness (assessed by IFN-γ production) to BCG revaccination on the modulation of total and allergen-specific serum IgE levels in healthy volunteers participating in a randomized controlled trial. RESULTS: Serum total or Derp-specific IgE levels did not change regardless of the increase in IFN-γ levels. CONCLUSIONS: BCG responsiveness does not affect protection against atopy.
Descritores: Imunoglobulina E/sangue
Vacina BCG/imunologia
Imunização Secundária
Interferon gama/biossíntese
-Fatores de Tempo
Imunoglobulina E/imunologia
Testes Cutâneos
Regulação para Baixo
Hipersensibilidade
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Texto completo
Id: biblio-1013318
Autor: Burbano, Yulieth Cristina Bermúdez; Paz, Angie Vanessa Caicedo; Caldon, Cristhian Camilo Rivera; Constain, Juan Sebastián Rodríguez; Gonzáles, Gloria Inés Ávila; Hernández, Julio César Klínger; Marin-Agudelo, Nancy; Dueñas-Cuellar, Rosa Amalia; Castaño, Victoria Eugenia Niño.
Título: Low frequency of regulatory B-cells and increased CD4+ and CD8+ interferon-γ-producing cells in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type
Fonte: Rev. Soc. Bras. Med. Trop;52:e20190101, 2019. tab, graf.
Idioma: en.
Resumo: Abstract INTRODUCTION: Tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1 (HTLV-I) that mainly infects CD4 T cells-for example, those of the CD4+CD25hiFOXP3+ [Treg] phenotype-where it inhibits forkhead box protein P3 (FOXP3) expression and promotes interferon-γ (IFN-γ) expression. However, the role it exerts on regulatory B cells (CD19+CD24hiCD38hi; Breg) is unknown. METHODS: The frequencies of Treg and Breg cells was evaluated and the Th1 profiles were assessed in TSP/HAM patients and healthy control subjects. RESULTS: Low percentages of Breg cells and high production of IFN-γ were observed in patients compared to those in healthy control subjects. CONCLUSIONS: The low percentage of Breg cells in patients and the increase in the frequency of Th1 cells suggest an imbalance in the control of the inflammatory response that contributes to the immunopathogenesis of TSP/HAM.
Descritores: Linfócitos T CD4-Positivos/imunologia
Paraparesia Espástica Tropical/imunologia
Interferon gama/imunologia
Linfócitos T Reguladores/imunologia
Linfócitos T CD8-Positivos/imunologia
Linfócitos B Reguladores/imunologia
-Linfócitos T CD4-Positivos/virologia
Paraparesia Espástica Tropical/virologia
Linfócitos T Reguladores/virologia
Linfócitos T CD8-Positivos/virologia
Carga Viral
Linfócitos B Reguladores/virologia
Limites: Humanos
Masculino
Feminino
Adolescente
Responsável: BR1.1 - BIREME


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Id: biblio-1239002
Autor: Machado, Paulo.
Título: Produção de citocinas por células mononucleares do sangue periférico na hanseníase / ?.
Fonte: Salvador; s.n; 1997. vii,55 p. ilus, tab, graf.
Idioma: pt.
Tese: Apresentada a Universidade Federal da Bahia. Faculdade de Medicina para obtenção do grau de Master.
Resumo: A hanseníase é uma doença espectral que apresenta grande variação no quadro clínico, diretamente relacionada com a resposta imune celular do hospedeiro dirigida contra os antígenos do Mycobacterium Leprae. Assim, no pólo tuberculóide, o quadro clínico de poucas lesões associa-se a uma baixa carga bacilar e à presença da resposta imune celular contra o bacilo de Hansen. No outro pólo da doença, a forma virchowiana, o quadro clínico de lesões disseminadas está associado a uma alta bacilífera e ausência de resposta imune celular. A produção de citocinas pelo sistema imune parece de fundamental importância na regulação da resposta imune humoral e celular, sendo por sua vez modulada por antígenos micobacterianos diversos. Portanto, as duas formas 'polares da hanseníase devem se diferenciar quanto ao perfil de produção de citocinas em resposta ao M. leprae, e difrentes antígenos micobacterianos devem modificar este perfil.
Descritores: Alergia e Imunologia
Citocinas
Hanseníase
Interferon gama
Responsável: BR191.1 - Biblioteca e Centro de Documentação Luiza Keffer
[{"text": "BR191.1", "_a": "WC335.500", "_b": "M119p"}]



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