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Id: lil-791328
Autor: Palacio, Juan David; Guzman, Sandra; Vargas, Cristian; Díaz-Zuluaga, Ana María; López-Jaramillo, Carlos.
Título: Comparación de biomarcadores inflamatorios en pacientes con trastorno afectivo bipolar tipo I y sujetos controles / Comparison of Inflammatory Biomarkers Between Bipolar Disorder I Patients and Control Subjects
Fonte: Rev. colomb. psiquiatr;45(1):8-13, ene.-mar. 2016. tab.
Idioma: es.
Resumo: Introducción: En el trastorno afectivo bipolar tipo I (TABI) se han descrito cambios inflamatorios en los diferentes episodios afectivos y en la etapa de eutimia, propuestos como posibles marcadores periféricos del trastorno, razón por la cual son necesarios estudios con adecuados criterios de inclusión para explorar esta hipótesis. Objetivo: Cuantificar y comparar las concentraciones séricas de interleucinas (IL) y factor de necrosis tumoral (TNF) en pacientes con TABI y en sujetos controles, incluyendo un análisis de comparación según el estado afectivo. Métodos: Estudio transversal sobre 41 pacientes con TABI y 11 controles, en los que se determinaron concentraciones de IL-1B, IL-RA, IL-2, IL-4, IL-6, IL-7, IL-8, IL-10, IL-12 y TNF durante las fases de eutimia, depresión y manía, y se compararon con los de los sujetos controles. Resultados y conclusiones: El subgrupo de pacientes en manía tenía menor escolaridad y mayor número de hospitalizaciones, y el subgrupo de pacientes en depresión mostró mayor número de episodios depresivos a lo largo de la vida. No se encontraron diferencias estadísticamente significativas entre las concentraciones de IL y TNF de sujetos con TABI y sujetos controles ni entre los diferentes subgrupos de TABI (eutimia, depresión y manía). Es necesario aumentar la muestra en estudios posteriores con el fin de mejorar el poder estadístico y explorar la hipótesis infamatoria del trastorno bipolar.

Introduction: Inflammatory changes have been described in different affective episodes, as well as in the euthymic phase of Bipolar I Disease. These changes have been proposed as possible peripheral markers of the disease. For this reason well-designed studies are needed to explore this hypothesis. Objective: Quantify and compare the serum levels of interleukins (IL) and tumour necrosis factor (TNF) in bipolar I patients and healthy subjects, including the comparison between the affective episodes of the disease. Methods: Cross-sectional study including 41 bipolar I patients and 11 healthy control subjects. Serum levels of IL-1B, IL-RA, IL-2, IL-4, IL-6, IL-7, IL-8, IL-10, IL-12, and TNF were measured during the euthymic, depressive, and manic phases and were compared with the serum levels of the healthy subjects. Conclusions: Manic phase patients had low education and high number of hospitalisations. Depressive phase patients showed high number of depressive episodes throughout life. No statistically significant differences were found in IL and TNF levels between bipolar I patients and healthy controls, or between the bipolar I subgroups (euthymic, manic and depressive states). An increase in the size of the sample is necessary in future studies, in order to enhance the statistical value of the results, and explore the inflammatory hypothesis of the bipolar disease.
Descritores: Transtorno Bipolar
Biomarcadores
Interleucinas
-Estudos Transversais
Depressão
Previsões
Métodos
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: CO78 - Asociación Colombiana de Psiquiatría


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Id: biblio-1255187
Autor: Instituto Nacional de Enfermedades Neoplásicas.
Título: Dosaje de interleucina-6 (IL-6) para monitoreo de pacientes con COVID-19 / Interleukin-6 (IL-6) dosing for monitoring patients with COVID-19.
Fonte: Lima; INEN; sept. 2020.
Idioma: es.
Descritores: Interleucinas/análise
Vírus da SARS/isolamento & purificação
COVID-19/diagnóstico
-Avaliação da Tecnologia Biomédica
Avaliação em Saúde
Limites: Humanos
Tipo de Publ: Revisão
Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-961467
Autor: Brahm, Javier; Urzúa, Alvaro; Poniachik, Jaime; Cáceres, Dante D; Carreño, Laura; Venegas, Mauricio.
Título: El polimorfismo rs12979860 C> T en el gen Interferón lambda 4 no está asociado a riesgo de fibrosis hepática en pacientes chilenos con hepatitis crónica por virus C / Interferon Lambda 4 RS12979860 C> T polymorphism is not associated with liver fibrosis in patients with hepatitis C
Fonte: Rev. méd. Chile;146(7):823-829, jul. 2018. tab.
Idioma: es.
Projeto: OAIC.
Resumo: Background. Host genetic predispositions may be important determinants of liver fibrosis in patients with chronic hepatitis C (CHC). The association between Interferon-L 4 (IFNL4) rs12979860 C>T polymorphism and risk of liver fibrosis in CHC is contradictory. Aim: To evaluate the impact of IFNL4 rs12979860 polymorphism on the risk of fibrosis in patients with CHC. Material and Methods: One hundred fifty patients with CHC aged 50 ± 11 years (89 females) were genotyped for IFNL4 rs12979860 using real time PCR. Fibrosis present in liver biopsies was assessed using the METAVIR score, comparing patients with either no fibrosis, mild fibrosis, or intermediate fibrosis (F0+F1+F2, n = 96), with patients with severe fibrosis or cirrhosis (F3+F4, n = 54). Results: In F0-F2 patients the distribution of rs12979860 genotypes was 22 CC, 57 CT and 17 TT, whereas in patients F3-F4 the distribution was 10, 29 and 15, respectively. No association between IFNL4 rs12979860 genotype and risk of fibrosis was observed in uni or multivariate analyses. Conclusions: IFNL4 rs12979860 C>T polymorphism is not associated with risk of liver fibrosis in this group of patients with CHC.
Descritores: Interleucinas/genética
Hepatite C Crônica/genética
Cirrose Hepática/genética
-Antivirais/uso terapêutico
Chile
Estudos Retrospectivos
Fatores de Risco
Interferons/uso terapêutico
Hepatite C Crônica/tratamento farmacológico
Hepatite C Crônica/sangue
Polimorfismo de Nucleotídeo Único
Genótipo
Cirrose Hepática/sangue
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-991637
Autor: Amorim, Juleimar Soares Coelho de; Torres, Karen Cecília Lima; Teixeira-Carvalho, Andréa; Martins-Filho, Olindo Assis; Lima-Costa, Maria Fernanda; Peixoto, Sérgio Viana.
Título: Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging / Marcadores inflamatórios e ocorrência de quedas: coorte de idosos de Bambuí
Fonte: Rev. saúde pública (Online);53:35, jan. 2019. tab.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de Minas Gerais.
Resumo: ABSTRACT OBJECTIVE Analyze whether inflammatory markers are associated with falls among older adults living in Bambuí. METHODS Study that analyzed baseline data from a Bambuí Cohort Study of Aging, involving 1,250 participants. Data about falls were collected from previous 12 months, classified as single or multiple occurrence and severity (participant seeking health services). Information about sociodemographic characteristics, health behaviors and health condition was also collected and used as confounding factors. The exposures of interest included interleukins (IL-1β, IL-6, IL-8, IL-10, IL-12), tumor necrosis factor (TNF), ultra-sensitive C-reactive protein (us-CRP) and chemokines (CXCL9, CCL5, CCL10, MCP1). Data were processed through logistic regression, obtaining odds ratio and 95% confidence interval (95%CI). RESULTS The prevalence of falls was 27.1%; 40.1% of the older adults reported multiple falls and 33.3% sought health services. After adjustments, the following elevated levels were associated with falls: us-CRP (OR = 1.46, 95%CI 1.04-2.03), CCL5 (OR = 1.38, 95%CI 1.01-1.90) and CXCL9 (OR = 1.43, 95%CI 1.02-2.02). An association was observed between the number of elevated markers and the occurrence of falls: two (OR = 1.47, 95%CI 1.02-2.12) and three (OR = 2.08, 95%CI 1.12-3.87) elevated biomarkers indicated fall probability of 32.0% and 39.4%, respectively. CONCLUSIONS Elevated levels of us-CRP, CCL5 and CXCL9, which were associated with falls, may contribute to a proper understanding of the mechanism associated with the occurrence of falls among older people.

RESUMO OBJETIVO Analisar se marcadores inflamatórios estão associados a quedas em idosos vivendo na comunidade. MÉTODOS Estudo da coorte de idosos de Bambuí, envolvendo 1.250 participantes da linha de base do projeto. Foram coletadas informações sobre quedas nos últimos 12 meses, classificadas quanto à ocorrência (única ou múltipla) e gravidade (procura por serviços de saúde). O inquérito também continha informações a respeito das características sociodemográficas, comportamentais e condições de saúde, as quais foram utilizadas como fatores de confusão. As exposições pesquisadas incluíram: interleucinas (IL-1β, IL-6, IL-8, IL-10 e IL-12), fator de necrose tumoral (TNF), proteína C reativa ultrassensível (PCRus) e quimiocinas (CXCL9, CCL5, CCL10 e MCP1). O tratamento dos dados foi realizado por meio de regressão logística, obtendo-se odds ratio e intervalo de 95% de confiança (IC95%). RESULTADOS A prevalência de queda foi 27,1%; 40,1% dos idosos relataram quedas múltiplas e 33,3% procuraram serviços de saúde. Após ajustes, permaneceram associados às quedas os níveis elevados de PCRus (OR = 1,46; IC95% 1,04-2,03), CCL5 (OR = 1,38; IC95% 1,01-1,90) e CXCL9 (OR = 1,43; IC95% 1,02-2,02). Houve associação entre o número de marcadores elevados e a ocorrência de quedas: dois (OR = 1,47; IC95% 1,02-2,12) e três (OR = 2,08; IC95% 1,12-3,87) biomarcadores aumentados predisseram probabilidades de quedas iguais a 32,0% e 39,4%, respectivamente. CONCLUSÕES Os níveis elevados de PCRus, CCL5 e CXCL9, que estiveram associados a quedas, podem contribuir para o adequado entendimento do mecanismo associado à ocorrência desse evento em idosos.
Descritores: Acidentes por Quedas
Envelhecimento
Interleucinas/sangue
Fator de Necrose Tumoral alfa/sangue
Quimiocinas/sangue
-Brasil
Biomarcadores/sangue
Índice de Massa Corporal
Reação em Cadeia da Polimerase
Estado Nutricional
Estudos Prospectivos
Fatores de Risco
Escolaridade
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-1045847
Autor: Qiu, ZL; Wang, ZJ; Huang, JK; Dou, HH; Zhen, CM; Cheng, F.
Título: The Effect of Thymosin Alpha 1 on Severe Acute Pancreatitis in Rats / Estudios sobre el efecto de la timosina alfa 1 sobre la pancreatitis aguda grave en ratas
Fonte: West Indian med. j;67(3):238-242, July-Sept. 2018. tab.
Idioma: en.
Projeto: Natural Science Foundation of Anhui Province Educational Committee; . Natural Science Foundation of Bengbu Medical College.
Resumo: ABSTRACT Objective: To observe the effect of thymosin alpha l (Tα1) on severe acute pancreatitis (SAP) in rats. Methods: Twenty-four adult male Sprague-Dawley rats were randomly divided into three groups (eight in each group): control group (Group A), SAP group (Group B) and Tα1 treatment group (Group C). Animal models of SAP were made by retrograde injection of 5% sodium taurocholate into the biliopancreatic duct. Rats in Group C were treated with Tα1 (6 mg/kg) via intraperitoneal administration prior to SAP modelling. Eight rats in each group were sacrificed at 12 hours, respectively, after modelling. The serum levels of amylase, tumour necrosis factor-α (TNF-α), interleukin-lβ (IL-lβ and interleukin-6 (IL-6) were detected in each group. The pathological scores of the tissue in the pancreas head were observed by light microscopy. Results: The levels of serum amylase of Group B were 6378 ± 538 U/L, which were significantly higher than those (4587 ± 478 U/L) of Group C (p < 0.05). The levels of serum TNF-α of Group B were 360.32 ± 28.67 pg/mL, which were higher than those (269.99 ± 26.11 pg/mL) of Group C (p < 0.05). The levels of serum IL-lβ of Group B were 435.93 ± 36.00 pg/mL, which were higher than those (312.42 ± 17.89 pg/mL) of Group C (p < 0.05). The levels of serum IL-6 of Group B were 433.90 ± 28.36 pg/mL, which were higher than those (289.98 ± 23.00 pg/mL) of Group C (p < 0.05). The pancreatic pathological scores of Group B were 13.34 ± 2.19, which were higher than those (6.39 ± 1.86) of Group C (p < 0.05). Conclusion: Thymosin alpha 1 could decrease proinflammatory cytokines and reduce pancreas injury and had a protective effect in rats with SAP. This provides a new strategy for the clinical treatment of SAP.

RESUMEN Objetivo: Observar el efecto de la timosina alfa l (Tα1) sobre la pancreatitis aguda grave (PAG) en ratas. Métodos: Veinticuatro ratas Sprague-Dawley adultas machos fueron divididas aleatoriamente en tres grupos (ocho en cada grupo): grupo de control (grupo A), grupo de PAG (grupo B) y grupo de tratamiento con Tα1 (grupo C). Los modelos animales de PAG fueron creados mediante inyección retrógrada de taurocolato de sodio al 5% en el conducto biliopancreático. Las ratas del grupo C se trataron con Tα1 (6 mg/kg) via administración intraperitoneal antes del modelado de PAG. Las ocho ratas en cada grupo fueron sacrificadas a las 12 horas, respectivamente, después del modelado. Los niveles séricos de amilasa, factor-α de necrosis tumoral (TNF-α), interleucina-β (Il-β) e interleucina-6 (IL-6) fueron detectados en cada grupo. Las puntuaciones patológicas del tejido en la cabeza del páncreas fueron observadas mediante microscopía de luz. Resultados: Los niveles de amilasa sérica del grupo B fueron 6378 ± 538 U/L, y resultaron significativamente más altos (p < 0.05) que los niveles 4587 ± 478 U/L del grupo C. Los niveles séricos de TNF-α del grupo B fueron 360.32 ± 28.67 pg/mL, y resultaron ser más altos (p < 0.05) que los 269.99 ± 26.11 pg/mL del grupo C. Los niveles séricos de Il-β del grupo B fueron 435.93 ± 36.00 pg/mL, y fueron más altos (p < 0.05) que los 312.42 ± 17.89 pg/mL) del grupo C. Los niveles de suero IL-6 del grupo B fueron 433.90 ± 28.36 pg/mL, y resultaron ser más altos (p < 0.05) que los 289.98 ± 23.00 pg/mL del grupo C. Las puntuaciones patológicas pancreáticas del grupo B fueron 13.34 ± 2.19, y resultaron ser más altas (p < 0.05) que las puntuaciones 6.39 ± 1.86 del grupo C. Conclusión: La timosina alfa pudo disminuir las citoquinas proinflamatorias y reducir la lesión del páncreas, y tuvo un efecto protector en las ratas con PAG. Esto ofrece una nueva estrategia para el tratamiento clínico de PAG.
Descritores: Pancreatite/tratamento farmacológico
Biomarcadores/sangue
Adjuvantes Imunológicos/administração & dosagem
Timalfasina/administração & dosagem
-Índice de Gravidade de Doença
Doença Aguda
Interleucinas/sangue
Fator de Necrose Tumoral alfa/sangue
Ratos Sprague-Dawley
Modelos Animais de Doenças
Amilases/sangue
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-952810
Autor: Forgiarini, Soraia Genebra Ibrahim; Rosa, Darlan Pase da; Forgiarini, Luiz Felipe; Teixeira, Cassiano; Andrade, Cristiano Feijó; Forgiarini Junior, Luiz Alberto; Felix, Elaine Aparecida; Friedman, Gilberto.
Título: Evaluation of systemic inflammation in patients being weaned from mechanical ventilation
Fonte: Clinics;73:e256, 2018. tab, graf.
Idioma: en.
Resumo: OBJECTIVES: The aim of this study was to evaluate systemic inflammatory factors and their relation to success or failure in a spontaneous ventilation test. METHODS: This cross-sectional study included a sample of 54 adult patients. Demographic data and clinical parameters were collected, and blood samples were collected in the first minute of the spontaneous ventilation test to evaluate interleukin (IL)-1β, IL-6, IL-8, and IL-10, tumour necrosis factor alpha (TNFα) and C-reactive protein. RESULTS: Patients who experienced extubation failure presented a lower rapid shallow breathing index than those who passed, and these patients also showed a significant increase in C-reactive protein 48 hours after extubation. We observed, moreover, that each unit increase in inflammatory factors led to a higher risk of spontaneous ventilation test failure, with a risk of 2.27 (1.001 - 4.60, p=0.049) for TNFα, 2.23 (1.06 - 6.54, p=0.037) for IL-6, 2.66 (1.06 - 6.70, p=0.037) for IL-8 and 2.08 (1.01 - 4.31, p=0.04) for IL-10, and the rapid shallow breathing index was correlated with IL-1 (r=-0.51, p=0.04). CONCLUSIONS: C-reactive protein is increased in patients who fail the spontaneous ventilation test, and increased ILs are associated with a greater prevalence of failure in this process; the rapid shallow breathing index may not be effective in patients who present systemic inflammation.
Descritores: Desmame do Respirador
Inflamação/sangue
-Testes de Função Respiratória
Estresse Fisiológico/fisiologia
Proteína C-Reativa/análise
Estudos Transversais
Estudos Prospectivos
Interleucinas/sangue
Fator de Necrose Tumoral alfa/sangue
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-792643
Autor: Braulio, Renato; Sanches, Marcelo Dias; Teixeira Junior, Antonio Lúcio; Costa, Paulo Henrique Nogueira; Moreira, Maria da Consolação Vieira; Rocha, Monaliza Angela; Andrade, Silvio Amadeu de; Gelape, Cláudio Léo.
Título: Associated clinical and laboratory markers of donor on allograft function after heart transplant
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);31(2):89-97, Mar.-Apr. 2016. tab, graf.
Idioma: en.
Resumo: Abstract Introduction: Primary graft dysfunction is a major cause of mortality after heart transplantation. Objective: To evaluate correlations between donor-related clinical/biochemical markers and the occurrence of primary graft dysfunction/clinical outcomes of recipients within 30 days of transplant. Methods: The prospective study involved 43 donor/recipient pairs. Data collected from donors included demographic and echocardiographic information, noradrenaline administration rates and concentrations of soluble tumor necrosis factor receptors (sTNFR1 and sTNFR2), interleukins (IL-6 and IL-10), monocyte chemoattractant protein-1, C-reactive protein and cardiac troponin I. Data collected from recipients included operating, cardiopulmonary bypass, intensive care unit and hospitalization times, inotrope administration and left/right ventricular function through echocardiography. Results: Recipients who developed moderate/severe left ventricular dysfunction had received organs from significantly older donors (P =0.020). Recipients from donors who required moderate/high doses of noradrenaline (>0.23 µg/kg/min) around harvesting time exhibited lower post-transplant ventricular ejection fractions (P =0.002) and required longer CPB times (P =0.039). Significantly higher concentrations of sTNFR1 (P =0.014) and sTNFR2 (P =0.030) in donors were associated with reduced intensive care unit times (≤5 days) in recipients, while higher donor IL-6 (P =0.029) and IL-10 (P =0.037) levels were correlated with reduced hospitalization times (≤25 days) in recipients. Recipients who required moderate/high levels of noradrenaline for weaning off cardiopulmonary bypass were associated with lower donor concentrations of sTNFR2 (P =0.028) and IL-6 (P =0.001). Conclusion: High levels of sTNFR1, sTNFR2, IL-6 and IL-10 in donors were associated with enhanced evolution in recipients. Allografts from older donors, or from those treated with noradrenaline doses >0.23 µg/kg/min, were more frequently affected by primary graft dysfunction within 30 days of surgery.
Descritores: Doadores de Tecidos
Norepinefrina/administração & dosagem
Transplante de Coração/normas
Disfunção Primária do Enxerto/sangue
-Período Pós-Operatório
Biomarcadores/sangue
Norepinefrina/efeitos adversos
Estudos Prospectivos
Fatores Etários
Transplante de Coração/mortalidade
Interleucinas/análise
Receptores do Fator de Necrose Tumoral/análise
Seleção do Doador/normas
Disfunção Primária do Enxerto/etiologia
Aloenxertos/fisiopatologia
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-897004
Autor: Avanzi, Valéria Miranda; Vicente, Bianca Arão; Beloto, Nayara Carvalho Polido; Gomes-da-Silva, Monica Maria; Ribeiro, Clea Elisa Lopes; Tuon, Felipe Francisco; Vidal, Luine Rosele Renaud; Nogueira, Meri Bordignon; Raboni, Sonia Mara.
Título: Profile of HIV subtypes in HIV/HBV- and HIV/HCV-coinfected patients in Southern Brazil
Fonte: Rev. Soc. Bras. Med. Trop;50(4):470-477, July-Aug. 2017. tab, graf.
Idioma: en.
Projeto: Conselho Nacional de Desenvolvimento Científico e Tecnológico.
Resumo: Abstract INTRODUCTION: HIV and viral hepatitis infections are major causes of chronic disease worldwide and have some similarities with regard to routes of transmission, epidemiology, front barriers faced during access of treatment, and strategies for a global public health response. The objective was to describe the HIV-1 subtypes, viral tropism and single-nucleotide polymorphisms (SNPs) of interleukin 28B (IL28B) from a case series of HIV/viral hepatitis coinfected patients from southern Brazil. METHODS: Clinical and epidemiological data were evaluated by a review of medical records. Periodic blood draws were taken to determine the viral and host characteristics. RESULTS: This study included 38 patients with HIV/HBV or HIV/HCV coinfection; the median age was 49 years. Thirty-seven (97.4%) were on antiretroviral therapy, 32 (84.2%) had an undetectable viral load, a median CD4+ T-cell count of 452 cells/mm3. HIV-1 subtyping showed 47.4 and 31.6% of patients with subtypes C and B, respectively. Analysis of viral co-receptor usage showed a predominance of the R5 variant (64.7%), with no significant difference between the subtypes. Twenty patients with HIV/HCV coinfection were eligible to receive HCV therapy with pegylated-interferon-alpha plus ribavirin, and 10/20 (50%) of them achieved sustained virological response. SNPs of IL28B were evaluated in 93.3% of patients with HIV/HCV coinfection, and 17 (60.7%) presented the CC genotype. CONCLUSIONS: In the present case series, a higher frequency of HIV subtype C was found in coinfected patients. However such findings need to be prospectively evaluated with the inclusion of data from regional multicenter analyses.
Descritores: Variação Genética
Infecções por HIV/virologia
Interleucinas/genética
Hepatite C Crônica/complicações
Polimorfismo de Nucleotídeo Único
Hepatite B/complicações
-Infecções por HIV/complicações
Estudos Transversais
Interferons
Tropismo Viral
Coinfecção/virologia
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Responsável: BR1.1 - BIREME


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Id: biblio-1137330
Autor: Dasturian, Farzaneh; Naderi, Nadereh; Farshidfar, Gholamreza; Montazerghaem, Hossein; Khayatian, Mahmood; Chegeni, Sara Aghakhani; Rahimzadeh, Mahsa.
Título: The relationship between serum concentration of interleukin-35 and foxp3 polymorphism in patients undergoing coronary artery bypass graft surgery
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);35(5):697-705, Sept.-Oct. 2020. tab, graf.
Idioma: en.
Resumo: Abstract Objective: To investigate the association between interleukin-35 (IL-35) levels and single nucleotide polymorphisms (rs3761548, rs3761547) of the FoxP3 gene in coronary artery bypass grafting (CABG) patients. Methods: We conducted a prospective study including 140 patients, who were scheduled for elective isolated on-pump CABG with cardiopulmonary bypass (CPB) from January 2017 to September 2018 in the Jorjani heart center. Blood samples were collected before and 12 hours after the operation. Serum levels of IL-35 were measured by enzyme-linked immunosorbent assay and the pattern of genetic variations was assessed using single specific primer-polymerase chain reaction. Results: The serum concentrations of IL-35 after surgery were significantly higher than pre-surgery levels (18.4±8.3 vs. 9.89±3.2, respectively, P=0.002). There was no significant association between genotype frequencies of rs3761548 and rs3761547 and elevated IL-35 levels (P>0.05). There were significant associations between IL-35 levels and preoperative variables, including age (r=-0.34, P=0.047) and body mass index (r=-0.41, P=0.045), and intraoperative variables, including CPB time (r=0.4, P=0.02) and mean arterial pressure (r=-0.38, P=0.046), in carriers of the rs3761548 AA genotype. Conclusion: Serum IL-35 concentrations were significantly increased in CPB patients, which may contribute to the post-CPB compensatory anti-inflammatory response syndrome. IL-35 increased levels were not influenced by FoxP3 promoter polymorphisms (rs3761548, rs3761547).
Descritores: Ponte Cardiopulmonar
Ponte de Artéria Coronária
Interleucinas/sangue
Fatores de Transcrição Forkhead/sangue
-Estudos Prospectivos
Interleucinas/genética
Polimorfismo de Nucleotídeo Único
Fatores de Transcrição Forkhead/genética
Limites: Humanos
Masculino
Feminino
Responsável: BR1.1 - BIREME


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Id: biblio-1242345
Autor: Palacios, Ronald.
Título: Mechanism of T Cell Activation: Role and Functional Relationship of HLA-DR Antigens and Interleukins.
Fonte: s.l; s.n; 1982. 110 p. tab.
Idioma: en.
Descritores: Antígenos HLA/farmacologia
Antígenos HLA/genética
Antígenos HLA/imunologia
Antígenos HLA/química
Interleucinas/farmacologia
Interleucinas/imunologia
Interleucinas/química
Linfócitos T/citologia
Linfócitos T/fisiologia
Linfócitos T/imunologia
Linfócitos T/química
Limites: Humanos
Tipo de Publ: Estudo Comparativo
Artigo Clássico
Responsável: BR191.1 - Biblioteca e Centro de Documentação Luiza Keffer
[{"text": "Br191.1", "_a": "01427/S"}]



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