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Belone, Andrea de Faria Fernandes
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Id: biblio-976233
Autor: Camargo, Rodrigo Mendes de; Silva, Weber Laurentino da; Medeiros, Priscila; Belone, Andrea de Faria Fernandes; Latini, Ana Carla Pereira.
Título: Polymorphisms in the TGFB1 and IL2RA genes are associated with clinical forms of leprosy in Brazilian population
Fonte: Mem. Inst. Oswaldo Cruz;113(12):e180274, 2018. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: BACKGROUND Leprosy is a chronic infectious disease caused by Mycobacterium leprae, and compromises the skin and peripheral nerves. This disease has been classified as multibacillary (MB) or paucibacillary (PB) depending on the host immune response. Genetic epidemiology studies in leprosy have shown the influence of human genetic components on the disease outcomes. OBJECTIVES We conducted an association study for IL2RA and TGFB1 genes with clinical forms of leprosy based on two case-control samples. These genes encode important molecules for the immunosuppressive activity of Treg cells and present differential expressions according to the clinical forms of leprosy. Furthermore, IL2RA is a positional candidate gene because it is located near the 10p13 chromosome region, presenting a linkage peak for PB leprosy. METHODS A total of 885 leprosy cases were included in the study; 406 cases from Rondonópolis County (start population), a hyperendemic region for leprosy in Brazil, and 479 cases from São Paulo state (replication population), which has lower epidemiological indexes for the disease. We tested 11 polymorphisms in the IL2RA gene and the missense variant rs1800470 in the TGFB1 gene. FINDINGS The AA genotype of rs2386841 in IL2RA was associated with the PB form in the start population. The AA genotype of rs1800470 in TGFB1 was associated with the MB form in the start population, and this association was confirmed for the replication population. MAIN CONCLUSIONS We demonstrated, for the first time, an association data with the PB form for a gene located on chromosome 10. In addition, we reported the association of TGFB1 gene with the MB form. Our results place these genes as candidates for validation and replication studies in leprosy polarisation.
Descritores: Características da População
Fator de Crescimento Transformador beta
Interleucina-2
Hanseníase/genética
-Polimorfismo Genético/genética
Brasil
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-973496
Autor: Azevedo, Ítalo Medeiros; Araújo-Filho, Irami; Teixeira, Marianny Maiara Antas; Moreira, Marília Daniela Ferreira de Carvalho; Medeiros, Aldo Cunha.
Título: Wound healing of diabetic rats treated with Moringa oleifera extract
Fonte: Acta cir. bras;33(9):799-805, Sept. 2018. tab.
Idioma: en.
Projeto: CNPq.
Resumo: Abstract Purpose: To evaluate if Moringa oleifera leaf aqueous extract (ME) influences the healing of skin wounds of diabetic rats. Methods: Wistar rats were used (6 rats/group). Group 1 received normal saline (NS) v.o. Group 2 received moringa extract (100mg/kg v.o) for 3 weeks. Groups 3 and 4: Streptozotocin (STZ) induced diabetes. Group 3 received NS; Group 4 received aqueous ME (100mg/kg) v.o.The wounds of groups 1 and 3 rats were topically treated with NS; wounds of groups 2 and 4 treated with 200µL of 10% ME. After anesthesia, all rats had skin square excision wounds 1.5cm2. Wound percent contractions were measured. On 10th day, blood glucose and serum cytokines were measured. Histometry of wounds was studied using ImagePro6.0 software. Results: Glycemia was significantly reduced in ME treated rats. These rats had higher percent contraction of the wounds on 2nd, 5th and 10th days, then controls (p<0.05). Diabetic rats treated with NS had TNF-α, IL-1β and IL-6 expression higher than in rats receiving ME. The histopathological score of ME treated diabetic rats (198±13.7) was significantly higher than treatment with NS (145±10.5). Conclusion: ME extract positively influenced healing of wounds in diabetic rats after systemic and topical treatment.
Descritores: Cicatrização/efeitos dos fármacos
Extratos Vegetais/farmacologia
Moringa oleifera/química
-Administração Tópica
Interleucina-6/sangue
Interleucina-2/sangue
Fator de Necrose Tumoral alfa/sangue
Ratos Wistar
Estreptozocina
Diabetes Mellitus Experimental
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


  3 / 110 LILACS  
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Id: lil-219994
Autor: Cabello, Agueda; Picagua, Estela; Echauri, Mirian; Cabral, Blasia.
Título: proliferación linfocitaria inducida por PPD y producción de IL-2 en pacientes con tuberculosis / Lymphocytes proliferation induced by PPD and IL-2 production in patients with tuberculosis.
Fonte: Asunción; EFACIM-EDUNA; oct. 1997. 13-20 p.
Idioma: es.
Resumo: El objetivo del presente estudio es evaluar la respuesta proliferativa inducida por PPD, PHA y la producción de IL-2 en pacientes con tuberculosis pulmonar activa. Se utilizaron células mononucleares de los pacientes, que fueron estimuladas con fitohemaglutinina (PHA), tuberculina (PPD) por 72 horas para estudiar la proliferación celular utilizando un método colorimétrico (MTT). En la misma forma fueron tratadas células mononucleares de adultos normales como control. Además, con el objeto de evaluar la acción de IL-2 en la proliferación celular, se adicionó IL-2 a los cultivos con PHA. Por otra parte, se extrajo sobrenadantes de los cultivos con PHA y PPD a las 24 horas para el dosaje de IL-2 por el método de ELISA. De un total de 12 pacientes con tuberculosis pulmonar activa se observó que en el 20 por ciento de los pacientes estudiados la proliferación celular inducida por PHA esta disminuida en relación a los controles normales. Con la adición de IL-2 a los cultivos con PHA no se observó un aumento en la proliferación. Con respecto a la PPD se obtuvo una respuesta menor que a la obtenida con PHA. En cuanto a la producción de IL-2 solo en el 25 por ciento de los pacientes se observaron niveles superiores de IL-2 comparados a la de los controles
Descritores: Fito-Hemaglutininas
Tuberculose/diagnóstico
Tuberculose/enfermagem
Tuberculose/imunologia
Interleucina-2/envenenamento
Interleucina-2/imunologia
Responsável: PY2.1 - Centro de Documentación
PY3.1 SR 616.9363 An78a 1995


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Id: lil-219986
Autor: Picaguá, Estela; Cabello, Agueda; Elías, Estela.
Título: Proliferación celular inducida por PHA y producción de IL-2 en recién nacido / Cellular proliferation induced by PHA and IL-2 production in newborns.
Fonte: Asunción; EDUNA; 1995. 157-62 p.
Idioma: es.
Descritores: Interleucina-2/imunologia
Interleucina-2/sangue
Recém-Nascido/imunologia
Responsável: PY2.1 - Centro de Documentación
PY3.1 SR 616.9363 An78a 1994


  5 / 110 LILACS  
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Id: lil-623640
Autor: Barral, Aldina; Barral-Neto, M; Braga, Silvane; Badaro, R; Carvalho, E. M.
Título: Serum-mediated immunossuppression in american visceral leishmaniasis
Fonte: Mem. Inst. Oswaldo Cruz;83(supl.1):514-516, Nov. 1988.
Idioma: en.
Conferência: Apresentado em: Annual Meeting on Basic Research in Chagas's disease, 15, Apresentado em: Meeting of the Brazilian Society of Protozoology4, Caxambu, 7-10 Nov. 1988.
Descritores: Leucócitos Mononucleares/metabolismo
Leishmaniose Visceral/imunologia
Leishmaniose Visceral/sangue
-Interleucina-2/biossíntese
Tolerância Imunológica
Limites: Humanos
Responsável: BR1.1 - BIREME


  6 / 110 LILACS  
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Id: lil-623589
Autor: Tarleton, Rick L.
Título: Regulation of lymphokine production in experimental and human chagas' disease
Fonte: Mem. Inst. Oswaldo Cruz;83(supl.1):268-271, Nov. 1988. tab.
Idioma: en.
Conferência: Apresentado em: Annual Meeting on Basic Research in Chagas's disease, 15, Apresentado em: Meeting of the Brazilian Society of Protozoology4, Caxambu, 7-10 Nov. 1988.
Descritores: Interleucina-2/biossíntese
Doença de Chagas/metabolismo
-Baço/citologia
Baço/metabolismo
Camundongos Endogâmicos C57BL
Limites: Animais
Cobaias
Camundongos
Responsável: BR1.1 - BIREME


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Id: lil-623706
Autor: Zwingenberger, Kai; Jansen-Rosseck, Rolf; Cardoso, Alberto Eduardo Cox; Siqueira, José Geraldo Vergetti de; Feldmeier, Hermann.
Título: Altered lymphocyte proliferation and cytokine release in hepatosplenic Schistosomiais mansoni in Brazil
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):273-276, 1987. tab.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Descritores: Esquistossomose mansoni/complicações
Interleucina-2/metabolismo
Hepatomegalia/etnologia
-Ativação Linfocitária
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: lil-623762
Autor: Robb, Richard J.
Título: Structure-function relationships for the interleukin 2 receptor system
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.2):39-43, 1987. tab, ilus, graf.
Idioma: en.
Conferência: Apresentado em: International Symposium on Immunomodulators: Biology and Therapeutic Applications, Rio de Janeiro, Apr. 26-30, 1987.
Resumo: Receptors for interleukin 2 (IL-2) esit in at least three forms which differ in their subunit compositio, their affinity for ligand and their ability to mediate a cellular reponse. Type I receptors occur following cellular acitivation and consist of the 55,000 m. w. glycoprotein Tac. These receptors bind IL-2 with a low affinity, do not internalize ligand and have not been definitively associated with any response. Type II receptors, on the other hand, conssit of one or more glycoproteins of 70,000 m. w. which have been termed "beta ([beta]) chains." They bind IL-2 with an intermediate affinity and rapidly internalize the ligand. [Beta] proteins mediate many cellular IL-2-dependent reponses, including the short-term activation of natural killer cells and the induction of Tac protein expression. Type III receptors consist of a ternary complex of the Tac protein, the [beta] chain(s) and IL-2. They are characterized by a paricularly high affinity for ligand association. Type III receptors also internalize ligand and mediate IL-2-dependent responses at low factor concentrations. The identification of two independent IL-2-binding molecules, Tac and [beta], thus provides the elusive molecular explanation for the differences in IL-2 receptor affinity and suggests the potential for selective therapeutic manipulation of IL-2 reponses.
Descritores: Receptores de Interleucina-2/sangue
Interleucina-2/análise
Interleucina-2/uso terapêutico
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-888956
Autor: Li, L; Zou, C; Zhou, Z; Yu, X.
Título: Effects of herbal medicine Sijunzi decoction on rabbits after relieving intestinal obstruction
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(11):e6331, 2017. tab, graf.
Idioma: en.
Resumo: Intestinal obstruction leads to blockage of the movement of intestinal contents. After relieving the obstruction, patients might still suffer with compromised immune function and nutritional deficiency. This study aimed to evaluate the effects of Sijunzi decoction on restoring the immune function and nutritional status after relieving the obstruction. Experimental rabbits (2.5±0.2 kg) were randomly divided into normal control group, 2-day intestinal obstruction group, 2-day natural recovery group, 4-day natural recovery group, 2-day treated group, and 4-day treated group. Sijunzi decoction was given twice a day to the treated groups. The concentration of markers was analyzed to evaluate the immune function and nutritional status. The concentration of interleukin-2, immunoglobulins and complement components of the treated groups were significantly higher than the natural recovery group (P<0.05). The levels of CD4+ and CD4+/CD8+ increased then decreased in the treated groups. The levels of tumor necrosis factor-α and CD8+ were significantly lower than the natural recovery group. The level of total protein in the treated groups also increased then decreased after relieving the obstruction. The levels of albumin, prealbumin and insulin-like growth factor-1 were significantly higher in the treated groups than in the natural recovery group (P<0.05). Transferrin level in the treated groups was significantly higher than the obstruction group (P<0.05). Sijunzi decoction can lessen the inflammatory response and improve the nutrition absorption after relieving the obstruction.
Descritores: Medicamentos de Ervas Chinesas/uso terapêutico
Sistema Imunitário/efeitos dos fármacos
Obstrução Intestinal/imunologia
Estado Nutricional/efeitos dos fármacos
Fitoterapia/métodos
-Linfócitos T CD4-Positivos/citologia
Linfócitos T CD8-Positivos/citologia
Interleucina-2/análise
Obstrução Intestinal/reabilitação
Contagem de Linfócitos
Distribuição Aleatória
Recuperação de Função Fisiológica/efeitos dos fármacos
Reprodutibilidade dos Testes
Albumina Sérica/análise
Transferrinas/sangue
Fator de Necrose Tumoral alfa/análise
Limites: Animais
Coelhos
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Texto completo SciELO Cuba
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Id: lil-451088
Autor: González Rincón, Maczy; Ruiz Medina, Ana; Arteaga de Vizcaíno, Melvis; Díaz Araujo, Felipe; Weir Medina, Jesús.
Título: Niveles de interleucina-2 y su receptor soluble en pacientes operados y transfundidos / Interleukin-2 levels and its soluble receptor in operated on and transfused patients
Fonte: Rev. cuba. cir;45(2), abr.-jun. 2006. graf.
Idioma: es.
Resumo: Se realizó un estudio aleatorio para determinar los niveles de interleucina-2 (IL-2) y su receptor soluble (RsIL-2) en pacientes operados y transfundidos, antes de la cirugía, en el hemoderivado y 24 h después de la transfusión y para relacionar los niveles de IL-2 y RsIL-2 con cada período. Mediante inmunoensayo enzimático se determinaron los niveles de de IL-2 y RsIL-2 en 40 pacientes operados, antes de la cirugía, en los derivados sanguíneos y 24 horas después de la transfusión. Se obtuvieron valores promedio de 3,98 U/mL; 3,18 U/mL e indetectable para IL-2 y de de 678,2; 1 402 y 90,34 pg/mL para RsIL-2, en los períodos respectivos. El declive de la función linfocitaria después de cirugía y transfusión se atribuye a cambios intrínsecos o a la redistribución de células T reactivas de la sangre hacia los tejidos, a factores séricos como prostaglandinas y corticoesteroides, inhibidores de IL-2 que, con los elevados valores de RsIL-2 hallados en la bolsa, explican los niveles indetectables de IL-2 a las 24 horas de la transfusión
Descritores: Transfusão de Sangue
Interleucina-2
Receptores de Interleucina-2
Procedimentos Cirúrgicos Operatórios
Limites: Humanos
Adulto
Pessoa de Meia-Idade
Responsável: CU1.1 - Biblioteca Médica Nacional



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