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Rizzo, Luiz Vicente
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Id: biblio-1012009
Autor: Giavina-Bianchi, Mara Huffenbaecher; Giavina-Bianchi, Pedro; Rizzo, Luiz Vicente.
Título: Dupilumab in the treatment of severe atopic dermatitis refractory to systemic immunosuppression: case report / Dupilumabe no tratamento da dermatite atópica grave refratária à imunossupressão sistêmica: relato de caso
Fonte: Einstein (Säo Paulo);17(4):eRC4599, 2019. graf.
Idioma: en.
Resumo: ABSTRACT Case report of a patient with severe atopic dermatitis who showed a good response to dupilumab. She had already used two immunosuppressive agents, cyclosporine A and mycophenolate mofetil, for the treatment of atopic dermatitis with no proper control of the disease. She had also been taking all measures to control severe cases of the disease: bath and environmental controls, topical potent corticosteroids and emollients. She presented constant pruritus and skin lesions, frequent skin infections e poor quality of life. She also developed depression due to her disease. Recently, dupilumab, a new biological agent, was approved for the treatment of moderate/severe atopic dermatitis in many countries, including Brazil. Dupilumab is a monoclonal antibody with a common alpha chain of interleukin (IL) 4 and IL-13 receptors, two cytokines involved in the Th2 profile immune response that promote atopic inflammation. In a pioneer way in Brazil, the patient initiated the treatment with an attack dose of 600mg subcutaneous of dupilumab and 300mg subcutaneous every other week. Up to now, she has taken four applications, presenting a great improvement of the disease and her quality of life. There were no adverse effects, nor in the injection site nor of other kind. Patient and her family are very satisfied, and the medical team evaluates that the treatment is being well succeed. The case report described here subsidizes the use of dupilumab in the treatment of severe atopic dermatitis refractory to use of immunosuppressive agents.

RESUMO Relatamos o caso de uma paciente com dermatite atópica grave, que mostrou boa resposta ao dupilumabe. Ela já tinha usado dois agentes imunossupressores, a ciclosporina A e o micofenolato de mofetila, para o tratamento da dermatite atópica, sem obter o controle adequado da doença. Ela também vinha fazendo uso de todas as medidas de controle para casos graves da doença: cuidados com o banho, controle ambiental, corticosteroides potentes tópicos e emolientes. Apresentava prurido e lesões cutâneas constantes, infeções de pele frequentes e qualidade de vida ruim. Passou a apresentar depressão devido à sua doença. Recentemente, o dupilumabe, um agente biológico novo, foi aprovado para o tratamento de dermatite atópica moderada a severa em muitos países, incluindo o Brasil. Dupilumabe é um anticorpo monoclonal cujo alvo é a cadeia alfa comum aos receptores da interleucina (IL) 4 e IL-13, duas citocinas envolvidas no perfil de resposta imune Th2, que promove inflamação atópica. De modo pioneiro no Brasil, a paciente iniciou o tratamento, com dose de ataque de 600mg por via subcutânea de dupilumabe e 300mg também por via subcutânea a cada 2 semanas. Até o momento deste relato, ela realizou quatro aplicações, apresentando grande melhora da doença e da qualidade de vida. Não houve efeitos adversos, nem no local da injeção e nem de outro tipo. A paciente e sua família estão muito satisfeitas, e os médicos que a tratam avaliam que a terapia está sendo bem-sucedida. Este relato de caso subsidia o uso de dupilumabe no tratamento da dermatite atópica grave refratária ao uso de imunossupressores.
Descritores: Dermatite Atópica/tratamento farmacológico
Imunossupressores/administração & dosagem
Anticorpos Monoclonais/administração & dosagem
-Qualidade de Vida
Índice de Gravidade de Doença
Brasil
Imunossupressão
Interleucina-4
Interleucina-13
Anticorpos Monoclonais Humanizados
Injeções Subcutâneas
Limites: Humanos
Feminino
Adolescente
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-950711
Autor: Promphet, Porkaew; Bunarsa, Sirirat; Sutheerawattananonda, Manote; Kunthalert, Duangkamol.
Título: Immune enhancement activities of silk lutein extract from Bombyx mori cocoons
Fonte: Biol. Res;47:1-10, 2014. graf, tab.
Idioma: en.
Resumo: BACKGROUND: Declining immune function poses an important clinical challenge worldwide and supplementation with natural products that possessing immune enhancing properties is a promising approach for preventing or delaying immune function decline. Cocoons from yellow silkworms are a significant source of lutein, and this unexplored silk extract could be a viable alternative source for dietary lutein. This study assessed immunomodulatory activities of the silk lutein extract. Female BALB/c mice orally received lutein, either as silk or marigold extracts (10 or 20 mg/kg daily), or vehicle only (1% tween 80 in PBS pH 7.4) for 4 weeks. Natural killer (NK) cell activity, specific antibody production, lymphocyte subpopulations, mitogen-induced lymphocyte proliferation, and cytokine production were examined. RESULTS: Silk lutein extract increased NK cell activity, and the effect was dose-related whereas marigold lutein extract was ineffective. Silk lutein extract dose-dependently enhanced antibody production in pre-immunized mice but marigold lutein extract had no effect. Feeding with silk lutein extract increased the populations of CD3+ and CD4 + CD3 + cells. Silk lutein extract also stimulated concanavalin A- and lipopolysaccharide-induced proliferations of T and B lymphocytes, respectively. Moreover, silk lutein extract increased IL-2 and IFN-γ production while the effect of marigold lutein extract was undetectable. CONCLUSIONS: Together, silk lutein extract enhanced both innate and adaptive immune functions. This preparation may prove to be an effective supplement for strengthened immunity.
Descritores: Bombyx/imunologia
Extratos de Tecidos/imunologia
Luteína/imunologia
Seda/imunologia
Exoesqueleto/química
Fatores Imunológicos/análise
-Pupa/imunologia
Pupa/metabolismo
Bombyx/metabolismo
Extratos de Tecidos/farmacologia
Luteína/isolamento & purificação
Anticorpos Heterófilos/sangue
Extratos Vegetais/imunologia
Linfócitos B/efeitos dos fármacos
Células Matadoras Naturais/efeitos dos fármacos
Células Matadoras Naturais/imunologia
Linfócitos T/efeitos dos fármacos
Interleucina-4/análise
Interferon gama/análise
Interleucina-2/análise
Interleucina-10/análise
Tagetes/imunologia
Flores/imunologia
Seda/química
Proliferação de Células/efeitos dos fármacos
Citometria de Fluxo
Camundongos Endogâmicos BALB C
Limites: Animais
Feminino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950736
Autor: Berenguer, Anabela Gonçalves; Fernandes, Ana Teresa; Oliveira, Susana; Rodrigues, Mariana; Ornelas, Pedro; Romeira, Diogo; Serrão, Tânia; Rosa, Alexandra; Câmara, Rita.
Título: Genetic polymorphisms and asthma: findings from a case - control study in the Madeira island population
Fonte: Biol. Res;47:1-11, 2014. tab.
Idioma: en.
Projeto: FEDER; . Fundação para a Ciência e Tecnologia.
Resumo: BACKGROUND: Asthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. We categorized 98 asthma patients according to the Global Initiative for Asthma (GINA) guidelines, established their sensitization profile, and measured their forced expiratory volume in 1second (FEV1) and forced vital capacity (FVC) indexes. Selected single nucleotide polymorphisms (SNPs) were analysed as potential markers for asthma susceptibility and severity in the interleukin 4 (IL4), interleukin 13 (IL13), beta-2-adrenergic receptor (ADRB2), a disintegrin and metalloprotease 33 (ADAM33), gasdermin-like (GSDML) and the signal transducer and activator of transcription 6 (STAT6) genes comparatively to a population reference set. RESULTS: Although mites are the major source of allergic sensitization, no significant difference was found amongst asthma severity categories. IL4-590*CT/TT and IL4-RP2*253183/183183 were found to predict the risk (2-fold) and severity (3 to 4-fold) of asthma and were associated with a lower FEV1 index. ADRB2-c.16*AG is a risk factor (3.5-fold), while genotype GSDML-236*TT was protective (4-fold) for moderate-severe asthma. ADAM33-V4*C was associated to asthma and mild asthma by the transmission disequilibrium test (TDT). Finally, ADAM33-V4*CC and STAT6-21*TT were associated with higher sensitization (mean wheal size ≥10mm) to house dust (1.4-fold) and storage mite (7.8-fold). CONCLUSION: In Madeira, IL4-590C/T, IL4-RP2 253/183, GSDML-236C/T and ADAM33-V4C/G SNPs are important risk factors for asthma susceptibility and severity, with implications for asthma healthcare management.
Descritores: Polimorfismo Genético/genética
Asma/genética
-Portugal
Índice de Gravidade de Doença
Biomarcadores
Estudos de Casos e Controles
Capacidade Vital/genética
Volume Expiratório Forçado/genética
Fatores de Risco
Interleucina-4/análise
Interleucina-4/genética
Receptores Adrenérgicos beta 2/análise
Receptores Adrenérgicos beta 2/genética
Estatísticas não Paramétricas
Interleucina-13/análise
Interleucina-13/genética
Desintegrinas/análise
Desintegrinas/genética
Polimorfismo de Nucleotídeo Único/genética
Proteínas ADAM/análise
Proteínas ADAM/genética
Fator de Transcrição STAT6/análise
Fator de Transcrição STAT6/genética
Genótipo
Proteínas de Neoplasias/análise
Proteínas de Neoplasias/genética
Limites: Humanos
Masculino
Feminino
Criança
Adolescente
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-838865
Autor: Silva, Hidelberto Matos; Vinaud, Marina Clare; Lino Júnior, Ruy de Souza.
Título: Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis / Neurocisticercose experimental: ausência de IL-4 induz menos encefalite
Fonte: Arq. neuropsiquiatr;75(2):96-102, Feb. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Neurocysticercosis (NCC) is the most severe clinical manifestation of cysticercosis. One of the factors responsible for its symptomatology is the host inflammatory response. Therefore the influence of interleukin 4 (IL-4) on the induction of encephalitis in experimental NCC was evaluated. Methods BALB/c (WT) and BALB/c (IL-4-KO) mice were inoculated intracranially with Taenia crassiceps cysticerci and euthanized at 7, 30, 60 and 90 days later, the encephala removed and histopathologically analyzed. Results The absence of IL-4 induced greater parasitism. In the initial phase of the infection, IL-4-KO showed a lower intensity in the inflammatory infiltration of polimorphonuclear cells in the host-parasite interface and intra-parenquimatous edema. The IL-4-KO animals, in the late phase of the infection, showed lower intensity of ventriculomegaly, encephalitis, and meningitis, and greater survival of the parasites in comparison with the WT animals. Conclusion The absence of IL-4 induced lower inflammatory infiltration, ventriculomegaly and perivasculitis in experimental NCC.

RESUMO A Neurocisticercose (NCC) é a manifestação clínica mais severa da cisticercose, e um dos fatores responsáveis pela sintomatologia é a resposta inflamatória do hospedeiro. Desta forma avaliou-se a influência da interleucina 4 (IL-4) na indução de encefalite na NCC experimental. Métodos Camundongos das linhagens BALB/c (WT) e BALB/c (IL-4-KO) foram inoculados intracranialmente com cisticercos de Taenia crassiceps e eutanasiados aos 7, 30, 60 e 90 dias após a infecção, os encéfalos foram removidos e analisados histopatologicamente. Resultados A ausência da IL-4 induziu um maior parasitismo nos animais. Na fase inicial da infecção os animais IL-4-KO apresentaram menor intensidade tanto de infiltrado inflamatório de polimorfonucleares na interface parasito-hospedeiro quanto de edema intraparenquimatoso. Os animais IL-4-KO, na fase tardia, apresentaram menor intensidade de ventriculomegalia, encefalite, meningite e maior sobrevivência dos cisticercos em relação aos animais WT. Conclusão A ausência da IL-4 induz menos infiltrado inflamatório, ventriculomegalia e perivasculite na NCC experimental.
Descritores: Encéfalo/parasitologia
Interleucina-4/sangue
Neurocisticercose/parasitologia
Cysticercus/fisiologia
Encefalite Infecciosa/parasitologia
-Fatores de Tempo
Neurocisticercose/sangue
Modelos Animais de Doenças
Encefalite Infecciosa/sangue
Interações Hospedeiro-Parasita
Camundongos Endogâmicos BALB C
Limites: Animais
Feminino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-950537
Autor: Milhomem, Anália Cirqueira; Souza, Amanda Juliana Soaris de; Silva, Hidelberto Matos; Vinaud, Marina Clare; Oliveira, Milton Adriano Pelli de; Machado, Juliana Reis; Lino Júnior, Ruy de Souza.
Título: Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL/6 mice / Aspectos histopatológicos da cisticercose experimental e perfil de citocinas in situ em camundongos C57BL/6
Fonte: Arq. neuropsiquiatr;76(5):339-345, May 2018. tab, graf.
Idioma: en.
Projeto: CNPq.
Resumo: ABSTRACT Neurocysticercosis (NCC) is one of the parasitic infections that most affects the central nervous system. The knowledge regarding its immunopathogenesis and pathophysiology needs broadening. Taenia crassiceps cysticerci are used as the NCC experimental model. The aim of this work was to describe the general pathological processes and the in situ cytokine profile in C57BL/6 mice inoculated intracranially with viable T. crassiceps cysticerci. The histopathology analysis showed cysticerci in the extraparenchymal and intraventricular region, mononuclear inflammatory infiltration surrounding the parasite, microgliosis and meningitis. The analysis of the in situ immune profiles showed a predominance of the Th2 response. The IL-4 and IL-10 dosages were significantly increased in the infected group. The decrease in the INF-gamma dosage reflects the immunomodulation from the cysticerci. In conclusion, a T. crassiceps NCC infection in C57BL/6 mice triggers an inflammatory response, a predominance of Th2 type in situ profile, with mononuclear inflammatory cell infiltration, meningitis and microgliosis.

RESUMO Neurocisticercose (NCC) é uma das doenças parasitárias que mais afeta o sistema nervoso central. É necessário aprofundar o conhecimento em relação à sua imunopatogênese e patofisiologia. Os cisticercos de Taenia crassiceps são utilizados como modelo experimental para estudos da NCC. O objetivo deste trabalho foi descrever os processos patológicos gerais e o perfil de citocinas in situ em camundongos C57BL/6 inoculados via intracerebral com cisticercos viáveis de T. crassiceps. A análise histopatológica demonstrou cisticercos nas regiões extra-parenquimatosa e intraventricular, infiltrado inflamatório de células mononucleares ao redor do parasita, microgliose e meningite. A análise in situ do perfil de citocinas mostrou uma predominância da resposta Th2. As dosagens de IL-4 e IL-10 foram significativamente maiores no grupo infectado. Conclui-se que a NCC por T. crassiceps em camundongos C57BL/6 induz uma resposta inflamatória com predominância in situ de citocinas do perfil Th2, com infiltrado inflamatório de células mononucleares, meningite e microgliose.
Descritores: Interleucina-4/sangue
Interferon gama/sangue
Interleucina-10/sangue
Células Th2/imunologia
Neurocisticercose/imunologia
-Taenia/imunologia
Ensaio de Imunoadsorção Enzimática
Interleucina-4/imunologia
Interferon gama/imunologia
Interleucina-10/imunologia
Neurocisticercose/patologia
Modelos Animais de Doenças
Camundongos Endogâmicos C57BL
Limites: Animais
Feminino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-838087
Autor: Youn Roh, Eun; Young Song, Eun; Hyun Yoon, Jong; Oh, Sohee; Young Chang, Ju; Park, Hyunwoong; Hyun Seo, Soo; Shin, Sue.
Título: Effects of Interleukin-4 and Interleukin-12b Gene Polymorphisms on Hepatitis B Virus Vaccination
Fonte: Ann. hepatol;16(1):63-70, Jan.-Feb. 2017. graf.
Idioma: en.
Resumo: Abstract: Approximately 10% of individuals do not respond to hepatitis B virus (HBV) vaccination, i.e. non-responders (NRs). We aimed to investigate the association of interleukin (IL)-4 and IL-12B gene polymorphisms with responsiveness to the HBV vaccine in Korean infants. Among 300 healthy infants (9-12 month), SNPs for the IL-4 gene (rs2243250, rs2070874, and rs2227284) and for the IL-12B gene (rs3213094 and rs17860508) were compared between subgroups in terms of the response to HBV vaccination. The percentages of NRs (< 10 mIU/mL), low-titer responders (LRs, 10-100 mIU/mL), and high-titer responders (HRs, ≥ 100 mIU/mL) were 20.3%, 37.7% and 42.0%, respectively. No SNPs differed in frequency between NRs and responders or between LRs and HRs. We divided the subjects into two groups according to the time interval from the 3rd dose of HBV vaccination to Ab quantification: > 6 months from the 3rd dose (n = 87) and ≤ 6 months from the 3rd dose (n = 213). In the ≤ 6 month subjects, rs2243250C and rs2227284G were significantly frequent in the lower-titer individuals (NRs + LR) than HRs (40.1 vs. 25.9%, p = 0.014 and 45.1 vs. 33.0%, p = 0.018, respectively), and the rs2243250C and rs2227284G frequencies were significantly different among the three subgroups (13.2 vs. 26.9 vs. 25.9%, p = 0.040 and 15.5 vs. 29.6 vs. 33.0%, p = 0.038, respectively). In conclusion, those results suggest that IL-4 gene polymorphisms may play a role in the response to the HBV vaccine in Korean infants.
Descritores: Interleucina-4/genética
Vacinas contra Hepatite B/administração & dosagem
Polimorfismo de Nucleotídeo Único
Subunidade p40 da Interleucina-12/genética
Hepatite B/prevenção & controle
-Farmacogenética
Fenótipo
Fatores de Tempo
Biomarcadores/sangue
Anticorpos Anti-Hepatite/sangue
Esquemas de Imunização
Vacinação
Resultado do Tratamento
República da Coreia
Frequência do Gene
Hepatite B/genética
Hepatite B/imunologia
Antígenos de Superfície da Hepatite B/sangue
Limites: Humanos
Masculino
Feminino
Lactente
Responsável: BR1.1 - BIREME


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Id: biblio-1011621
Autor: Trevisan, Iara Buriola; Santos, Ubiratan de Paula; Leite, Marceli Rocha; Ferreira, Aline Duarte; Silva, Bruna Spolador de Alencar; Freire, Ana Paula Coelho Figueira; Brigida, Gabriel Faustino Santa; Ramos, Ercy Mara Cipulo; Ramos, Dionei.
Título: Burnt sugarcane harvesting is associated with rhinitis symptoms and inflammatory markers / Colheita de cana-de-açúcar queimada está associada a sintomas de rinite e marcadores inflamatórios
Fonte: Braz. j. otorhinolaryngol. (Impr.);85(3):337-343, May-June 2019. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Abstract Introduction: Burnt sugarcane harvesting requires intense physical exertion in an environment of high temperature and exposure to particulate matter. Objective: To evaluate the effects of burnt sugarcane harvesting on rhinitis symptoms and inflammatory markers in sugarcane workers. Methods: A total of 32 male sugarcane workers were evaluated with questionnaire for rhinitis symptoms, and for inflammatory markers on peripheral blood and nasal lavage, in the non-harvesting, and 3 and 6 months into the sugarcane harvesting period. Weather data and particulate matter fine concentrations were measured in the same day. Results: The particulate matter concentrations in sugarcane harvesting were 27 (23-33 µg/m3), 112 (96-122 µg/m3), and 63 (17-263 µg/m3); 24 h temperatures were 32.6 (25.4-37.4 ºC), 32.3 (26.7-36.7 ºC) and 29.7 (24.1-34.0 ºC) and relative humidities were 45.4 (35.0-59.7%), 47.9 (39.1-63.0%), and 59.9 (34.7-63.2%) in the non-harvesting period, three and 6 months of the harvesting period. The age was 37.4 ± 10.9 years. The prevalence of rhinitis symptoms was significantly higher at 3 months of the harvesting period (53.4%), compared to non-harvesting period (26.7%; p = 0.039) and at 6 months into the harvesting period (20%; p = 0.006). Concentrations of interleukin 6 (IL-6) in nasal lavage increased after 3 months of the harvesting period compared to the non-harvesting period (p = 0.012). The presence of rhinitis symptoms, after 3 months of the harvesting period, was directly associated with blood eosinophils and inversely associated with neutrophils. Conclusions: After 3 months of work in burnt sugarcane harvesting the prevalence of rhinitis symptoms and IL-6 in nasal lavage increased. Furthermore, eosinophil counts were directly associated with the rhinitis symptoms in the period of higher concentration of particulate matter.

Resumo Introdução: A colheita de cana-de-açúcar queimada requer esforço físico intenso em um ambiente com altas temperaturas e exposição a material particulado. Objetivo: Avaliar os efeitos da colheita de cana-de-açúcar queimada nos sintomas de rinite e marcadores inflamatórios de cortadores de cana-de-açúcar. Método: Foram avaliados 32 cortadores de cana-de-açúcar do sexo masculino por meio de um questionário para sintomas de rinite, e marcadores inflamatórios em sangue periférico e lavado nasal, no período de entressafra, e em 3 e 6 meses após o início da colheita da cana-de-açúcar. Os dados climáticos e as concentrações de material particulado fino foram medidos no mesmo dia. Resultados: O material particulado fino na entressafra e em 3 e 6 meses de safra foi 27 (23-33 µg/m3), 112 (96-122 µg/m3) e 63 (17-263 µg/m3), respectivamente; a temperatura de 24 horas foi 32,6 (25,4º-37,4ºC), 32,3 (26,7º-36,7ºC) e 29,7 (24,1º-340ºC) e a umidade relativa do ar foi 45,4 (35,0%-59,7%), 47,9 (39,1%-63,0%), e 59,9 (34,7%-63,2%), na entressafra, 3 e 6 meses após o início da colheita. A idade foi de 37,4 ± 10,9 anos. A prevalência de sintomas de rinite foi significativamente maior em 3 meses da S (53,4%), comparado com a entressafra (26,7%; p = 0,039) e 6 meses da safra (20%; p = 0,006). As concentrações de interleucina 6 (IL-6) no lavado nasal aumentaram após 3 meses do início da colheita comparado com a entressafra (p = 0,012). A presença de sintomas de rinite, após 3 meses do início da colheita, foi diretamente associada com eosinófilos e inversamente associada com neutrófilos. Conclusões: Após 3 meses do início da colheita da cana-de-açúcar queimada, houve aumento na prevalência de sintomas de rinite e IL-6 em LN. Além disso, as contagens de eosinófilos foram diretamente associadas aos sintomas de rinite no período de maior concentração de material particulado.
Descritores: Rinite/etiologia
Saccharum
Poluentes Ocupacionais do Ar/efeitos adversos
Material Particulado/efeitos adversos
Doenças Profissionais/etiologia
-Biomarcadores/sangue
Rinite/sangue
Prevalência
Interleucina-4/sangue
Interleucina-6/sangue
Agricultura
Doenças Profissionais/sangue
Limites: Humanos
Masculino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-949359
Autor: Shi, Qingbin; Cai, Xiuying; Shi, Guixiang; Lv, Xingle; Yu, Jinping; Wang, Feng.
Título: Interleukin-4 protects from chemotherapy-induced peripheral neuropathy in mice modal via the stimulation of IL-4/STAT6 signaling
Fonte: Acta cir. bras;33(6):491-498, June 2018. graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy. Methods: The mouse model of vincristine-induced peripheral neuropathy and interleukin (IL)-4 knockout mice were utilized to investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy. Vincristine induced increased sensitivity to mechanical stimulation was measured by von Frey hair test 7 and 14 days after intraperitoneal administration of 0.1 mg/kg vincristine in mice. Relative expression levels of cytokines were detected by quantitative real-time PCR. STAT6 expression following vincristine treatment was assessed with western blotting. Results: We discovered that IL-4/STAT6 signaling was down-regulated in vincristine-treated mice. Deletion of IL-4 in mice increased the sensitivity to mechanical allodynia. IL-4 knockout mice also produced more pro-inflammatory cytokines, including IL-1β and TNF-α. Notably, co-administration of exogenous recombination IL-4 significantly prevented vincristine-induced mechanical allodynia. Conclusion: Anti-inflammatory cytokine IL-4 protects rodent model from vincristine-induced peripheral neuropathy via the stimulation of IL-4/STAT6 signaling and inhibition of the pro-inflammatory cytokines.
Descritores: Vincristina/efeitos adversos
Interleucina-4/farmacologia
Doenças do Sistema Nervoso Periférico/prevenção & controle
Fator de Transcrição STAT6/efeitos dos fármacos
Anti-Inflamatórios/farmacologia
Antineoplásicos Fitogênicos/efeitos adversos
-Fatores de Tempo
Regulação para Baixo/efeitos dos fármacos
Western Blotting
Reprodutibilidade dos Testes
Citocinas/análise
Citocinas/efeitos dos fármacos
Resultado do Tratamento
Camundongos Knockout
Doenças do Sistema Nervoso Periférico/induzido quimicamente
Doenças do Sistema Nervoso Periférico/metabolismo
Fármacos Neuroprotetores
Modelos Animais de Doenças
Fator de Transcrição STAT6/análise
Reação em Cadeia da Polimerase em Tempo Real
Hiperalgesia/induzido quimicamente
Hiperalgesia/tratamento farmacológico
Camundongos Endogâmicos C57BL
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-894917
Autor: Curvo, Eduardo OV; Ferreira, Roberto R; Madeira, Fabiana S; Alves, Gabriel F; Chambela, Mayara C; Mendes, Veronica G; Sangenis, Luiz Henrique C; Waghabi, Mariana C; Saraiva, Roberto M.
Título: Correlation of transforming growth factor-b and tumour necrosis factor levels with left ventricular function in Chagas disease
Fonte: Mem. Inst. Oswaldo Cruz;113(4):e170440, 2018. tab, graf.
Idioma: en.
Projeto: FAPERJ; . FAPERJ; . FAPERJ; . CNPq.
Resumo: BACKGROUND Transforming growth factor β1 (TGF-β1) and tumour necrosis factor (TNF) have been implicated in Chagas disease pathophysiology and may correlate with left ventricular (LV) function. OBJECTIVES We determined whether TGF-β1 and TNF serum levels correlate with LV systolic and diastolic functions and brain natriuretic peptide (BNP) serum levels in chronic Chagas disease. METHODS This cross-sectional study included 152 patients with Chagas disease (43% men; 57 ± 12 years old), classified as 53 patients with indeterminate form and 99 patients with cardiac form (stage A: 24, stage B: 25, stage C: 44, stage D: 6). TGF-β1, TNF, and BNP were determined by enzyme-linked immunosorbent assay ELISA. Echocardiogram was used to determine left atrial and LV diameters, as well as LV ejection fraction and diastolic function. FINDINGS TGF-b1 serum levels were lower in stages B, C, and D, while TNF serum levels were higher in stages C and D of the cardiac form. TGF-β1 presented a weak correlation with LV diastolic function and LV ejection fraction. TNF presented a weak correlation with left atrial and LV diameters and LV ejection fraction. CONCLUSIONS TNF is increased, while TGF-β1 is decreased in the cardiac form of chronic Chagas disease. TNF and TGF-β1 serum levels present a weak correlation with LV systolic and diastolic function in Chagas disease patients.
Descritores: Ecocardiografia
Doença de Chagas/transmissão
-Interleucina-4
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-894865
Autor: Figueiredo, Webertty Mayk Eufrásio; Viana, Sayonara de Melo; Alves, Dorotheia Teixeira; Guerra, Priscila Valera; Coêlho, Zirlane Castelo Branco; Barbosa, Helene Santos; Teixeira, Maria Jania.
Título: Protection mediated by chemokine CXCL10 in BALB/c mice infected by Leishmania infantum
Fonte: Mem. Inst. Oswaldo Cruz;112(8):561-568, Aug. 2017. graf.
Idioma: en.
Projeto: CAPES.
Resumo: BACKGROUND Visceral leishmaniasis (VL) caused by Leishmania infantum is characterised by the loss of the ability of the host to generate an effective immune response. Chemokines have a direct involvement in the pathogenesis of leishmaniasis, causing a rapid change in the expression of these molecules during infection by Leishmania. OBJECTIVES Herein, it was investigated the role of CXCL10 in controlling infection by L. infantum. METHODS RAW 264.7 macrophages were infected with L. infantum in vitro and treated or not with CXCL10 (25, 50 and 100 ng/mL). Parasite load, as well as nitric oxide (NO), IL-4 and IL-10 production were assessed at 24 and 48 h after infection. In vivo, BALB/c mice were infected and treated or not with CXCL10 (5 μg/kg) at one, three and seven days of infection. Parasite load, IFN-g, IL-4, TGF-β and IL-10 were evaluated one, seven and 23 days post treatment. FINDINGS In vitro, CXCL10 reduced parasitic load, not dependent on NO, and inhibited IL-10 and IL-4 secretion. In vivo, CXCL10 was able to reduce the parasite load in both liver and spleen, four weeks after infection, representing a higher decrease in the number of parasites in these organs, also induced IFN-γ at day 23 after treatment, correlating with the decrease in parasite load, and reduced IL-10 and TGF-β. MAIN CONCLUSIONS This study suggests a partial protective role of CXCL10 against L. infantum, mediated by IFN-g, not dependent on NO, and with suppression of IL-10 and TGF-β. These data may provide information for the development of new approaches for future therapeutic interventions for VL.
Descritores: Tamanho do Órgão/fisiologia
Interleucina-4/biossíntese
Interleucina-10/biossíntese
Leishmania infantum
Quimiocina CXCL10/uso terapêutico
Leishmaniose Visceral/imunologia
Leishmaniose Visceral/parasitologia
Leishmaniose Visceral/tratamento farmacológico
Fígado/patologia
Macrófagos/efeitos dos fármacos
-Citocinas/imunologia
Interferon gama/análise
Camundongos Endogâmicos BALB C
Limites: Animais
Masculino
Camundongos
Responsável: BR1.1 - BIREME



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