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Pesquisa : D12.644.276.400.245 [Categoria DeCS]
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Id: lil-358750
Autor: Sanjuliani, Antonio Felipe.
Título: Fisiopatologia da hipertensão arterial: conceitos teóricos úteis para a prática clínica / Physiopathology of the arterial hypertension: theoretical concepts for the practice
Fonte: Rev. SOCERJ;15(4):210-218, out.-dez. 2002. graf.
Idioma: pt.
Descritores: Hipertensão/complicações
Sistema Nervoso
Sistema Renina-Angiotensina
Medicina Clínica
Óxido Nítrico
Grupos de Risco
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR44.1 - Serviço de Biblioteca, Documentação Científica e Didática Prof. Dr. Luiz Venere Décourt

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Texto completo SciELO Brasil
Texto completo
Id: lil-304108
Autor: Dupin, Elisabeth; Real, Carla; LeDouarin, Nicole.
Título: The neural crest stem cells: control of neural crest cell fate and plasticity by endothelin-3
Fonte: An. acad. bras. ciênc;73(4):533-545, dec. 2001.
Idioma: en.
Resumo: How the considerable diversity of neural crest (NC)-derived cell types arises in the vertebrate embryo has long been a key question in developmental biology. The pluripotency and plasticity of differentiation of the NC cell population has been fully documented and it is well-established that environmental cues play an important role in patterning the NC derivatives throughout the body. Over the past decade, in vivo and in vitro cellular approaches have unravelled the differentiation potentialities of single NC cells and led to the discovery of NC stem cells. Although it is clear that the final fate of individual cells is in agreement with their final position within the embryo, it has to be stressed that the NC cells that reach target sites are pluripotent and further restrictions occur only late in development. It is therefore a heterogenous collection of cells that is submitted to local environmental signals in the various NC-derived structures. Several factors were thus identified which favor the development of subsets of NC-derived cells in vitro. Moreover, the strategy of gene targeting in mouse has led at identifying new molecules able to control one or several aspects of NC cell differentiation in vivo. Endothelin peptides (and endothelin receptors) are among those. The conjunction of recent data obtained in mouse and avian embryos and reviewed here contributes to a better understanding of the action of the endothelin signaling pathway in the emergence and stability of NC-derived cell phenotypes
Descritores: Células-Tronco/fisiologia
Diferenciação Celular/fisiologia
Crista Neural
Plasticidade Neuronal
-Embrião de Galinha
Diferenciação Celular/genética
Variação Genética
Crista Neural
Plasticidade Neuronal
Limites: Animais
Responsável: BR1.1 - BIREME

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