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Id: biblio-1136248
Autor: Guo, Jun-Cheng; Li, Xiang; Guo, Min; Gao, Yun-Suo; Fu, Lin-Qiu; Jiang, Xiang-Ling; Fu, Lin-Mei; Huang, Tao.
Título: Association of BDNF gene polymorphism with endophenotypes in posttraumatic stress disorder
Fonte: Rev Assoc Med Bras (1992);66(5):615-622, 2020. tab.
Idioma: en.
Projeto: 2016 Hainan Priority Research and Development Plan; . National Natural Science Fund.
Resumo: SUMMARY OBJECTIVE To explore the association of brain-derived neurotrophic factor gene (BDNF) polymorphism with the latent cognitive endophenotype of posttraumatic stress disorder (PTSD) after major natural disasters in Hainan Province, China. METHODS A total of 300 patients with PTSD and 150 healthy controls (HC) were surveyed by psychoanalysis scale to assess their cognitive functions. Polymerase chain reaction (PCR) and polyacrylamide gel electrophoresis (PAGE) were used to detect the BDNF gene polymorphism. RESULTS In terms of the cognitive function, the scores in the PTSD group were worse than those of the HC group (P < 0.05 or P < 0.01). There was a significant difference in the distribution of BDNF genotype and allele frequency between the two groups (P < 0.05). PTSD endophenotypes were significantly different among the BDNF genotypes in the PTSD group (P ≤ 0.01). CONCLUSION There is a statistically significant difference in the polymorphism of BDNF gene between PTSD and HC groups, and the alleles are associated with the incidence of PTSD. Thus, it may be a risk factor for PTSD.

RESUMO OBJETIVO Explorar a associação do polimorfismo do gene fator neurotrófico derivado do cérebro (BDNF) com o endofenótipo cognitivo latente de transtorno de estresse pós-traumático (TEPT) após grandes desastres naturais na província de Hainan, China. MÉTODOS Um total de 300 doentes com TEPT e 150 controles saudáveis (HC) foi investigado pela escala de psicanálise para avaliar as suas funções cognitivas. A reação em cadeia polimerase (PCR) e a eletroforese em gel de poliacrilamida (Page) foram usadas para detectar o polimorfismo do gene BDNF. RESULTADOS Em termos de função cognitiva, as pontuações no grupo TEPT foram piores do que as do grupo HC (P<0,05 ou P<0,01). Houve uma diferença significativa na distribuição do genótipo de BDNF e frequência do alelo entre os dois grupos (P<0,05). Os endofenótipos de TEPT foram significativamente diferentes entre os genótipos de BDNF do grupo TEPT (P≤0,01). CONCLUSÃO Existe uma diferença estatisticamente significativa no polimorfismo do gene BDNF entre o TEPT e os grupos HC, e os alelos estão associados à incidência do TEPT. Assim, pode ser um fator de risco para TEPT.
Descritores:
Fator Neurotrófico Derivado do Encéfalo/genética
-Polimorfismo Genético
Transtornos de Estresse Pós-Traumáticos
China
Polimorfismo de Nucleotídeo Único
Alelos
Endofenótipos
Genótipo
Limites: Humanos
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
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Id: biblio-950905
Autor: Lin, Ruhui; Li, Long; Zhang, Yingzheng; Huang, Sheng; Chen, Shangjie; Shi, Jiao; Zhuo, Peiyuan; Jin, Hao; Li, Zuanfang; Liu, Weilin; Wang, Zhifu; Chen, Lidian; Tao, Jing.
Título: Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice
Fonte: Biol. Res;51:21, 2018. graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Fujian Rehabilitation Technology of Collaborative Innovation Center; . Fujian Rehabilitation Technology of Collaborative Innovation Center; . Fujian Rehabilitation Technology of Collaborative Innovation Center; . Fujian Natural Science Foundation of China; . Fujian University of Traditional Chinese Medicine.
Resumo: OBJECTIVE: To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. Methods N -Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot. RESULTS: EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice. CONCLUSION: These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice.
Descritores: Eletroacupuntura/métodos
Ácido Aspártico/análogos & derivados
Ácido Glutâmico/metabolismo
Hipocampo/química
Aprendizagem/fisiologia
Memória/fisiologia
-Proteínas Tirosina Quinases/análise
Imagem por Ressonância Magnética
Glicoproteínas de Membrana/análise
Camundongos Transgênicos
Espectroscopia de Ressonância Magnética
Distribuição Aleatória
Western Blotting
Ácido Aspártico/metabolismo
Aprendizagem em Labirinto
Fator Neurotrófico Derivado do Encéfalo
Modelos Animais
Teste de Esforço
Hipocampo/diagnóstico por imagem
Inositol/análise
Limites: Animais
Masculino
Camundongos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1039188
Autor: Cordeiro, Cynthia Azeredo; Vieira, Erica Leandro Marciano; Rocha, Natália Pessoa; Castro, Vinicius Monteiro; Oréfice, Juliana Lambert; Barichello, Tatiana; Costa, Rogerio Alves; Oréfice, Fernando; Young, Lucy; Teixeira, Antonio Lucio.
Título: Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis
Fonte: Braz. j. infect. dis;21(2):176-179, Mar.-Apr. 2017. graf.
Idioma: en.
Resumo: Abstract Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment. Methods: Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay. Results: BDNF levels were significantly higher in patients before treatment when compared with controls (p = 0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors. Conclusion: BDNF may be released in the context of the active TR inflammatory response.
Descritores: Biomarcadores/sangue
Toxoplasmose Ocular/sangue
Coriorretinite/sangue
-Ensaio de Imunoadsorção Enzimática
Estudos de Casos e Controles
Coriorretinite/parasitologia
Fator Neurotrófico Derivado do Encéfalo/sangue
Fator de Crescimento Neural/sangue
Neurotrofina 3/sangue
Fator Neurotrófico Derivado de Linhagem de Célula Glial/sangue
Fatores de Crescimento Neural/sangue
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-886639
Autor: DANI, CAROLINE; ANDREAZZA, ANA CRISTINA; GONÇALVES, CARLOS ALBERTO; KAPIZINSKI, FLÁVIO; HENRIQUES, JOÃO A P; SALVADOR, MIRIAN.
Título: Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats
Fonte: An. acad. bras. ciênc;89(1):155-161, Jan,-Mar. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Several studies have shown that a high consumption of vegetables and fruits is consistently associated with a low risk of oxidative stress-induced diseases, which includes some degenerative diseases such as amyotrophic lateral sclerosis, Alzheimer and Parkinson. Therefore, the objective of this study is to verify the effects of conventional and organic grape juice in the modulation of the neurotrophic factor (BDNF) and astrocytic markers protein (S100B) in hippocampus and frontal cortex of Wistar rats. In this study, 24 male Wistar rats were divided into three groups. To the first one, it was given organic purple grape juice; to the second, conventional grape juice, while the last one received only saline. After 30 days, all rats were sacrificed and hippocampus and frontal cortex were dissected. The animals that received organic and conventional grape juice showed, in frontal cortex, an elevated BNDF levels in relation to saline group. However, S100B levels did not change. These results showed that grape juices are able to modulate important marker in brain tissue, and could be an important factor to prevent brain diseases.
Descritores: Fator Neurotrófico Derivado do Encéfalo/análise
Vitis/química
Subunidade beta da Proteína Ligante de Cálcio S100/análise
Sucos de Frutas e Vegetais
Lobo Frontal/química
Hipocampo/química
-Valores de Referência
Distribuição Aleatória
Reprodutibilidade dos Testes
Ratos Wistar
Fator Neurotrófico Derivado do Encéfalo/efeitos dos fármacos
Alimentos Orgânicos
Subunidade beta da Proteína Ligante de Cálcio S100/efeitos dos fármacos
Lobo Frontal/efeitos dos fármacos
Hipocampo/efeitos dos fármacos
Antioxidantes/farmacologia
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Roesler, Rafael
Brunetto, Algemir Lunardi
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Id: biblio-1003087
Autor: Antunes, Bruno Pereira; Becker, Ricardo Gehrke; Brunetto, André Tesainer; Pavei, Bruno Silveira; de-Farias, Caroline Brunetto; Rivero, Luís Fernando da Rosa; Santos, Julie Francine Cerutti; de-Oliveira, Bruna Medeiros; Gregianin, Lauro José; Roesler, Rafael; Brunetto, Algemir Lunardi; Pagnussato, Fernando; Galia, Carlos Roberto.
Título: Expressão de neurotrofinas e de seus receptores no osteossarcoma primário / Expression of neurotrophins and their receptors in primary osteosarcoma
Fonte: Rev. Col. Bras. Cir;46(2):e2094, 2019. tab, graf.
Idioma: pt.
Resumo: RESUMO Objetivo: determinar a expressão de neurotrofinas e seus receptores tirosina quinases em pacientes com osteossarcoma (OS) e sua correlação com desfechos clínicos. Métodos: biópsias de tumores primários de pacientes com OS tratados em uma única instituição, consecutivamente, entre 2002 e 2015, foram analisados através de imuno-histoquímica para expressão de receptores de tirosina quinase A e B (TrKA e TrKB), fator de crescimento neural (NGF) e fator neurotrófico derivado do cérebro (BDNF). De forma independente, dois patologistas classificaram os marcadores de imuno-histoquímica como negativos (negativos e focais fracos) ou positivos (moderado focal/difuso ou forte focal/difuso). Resultados: foram analisados dados de 19 pacientes (10 do sexo feminino e 9 do masculino) com mediana de idade de 12 anos (5 a 17,3 anos). Dos tumores, 83,3% estavam localizados em membros inferiores e 63,2% dos pacientes eram metastáticos ao diagnóstico. A sobrevida global em cinco anos foi de 55,3%. BDNF foi positivo em 16 pacientes (84%) e NGF em 14 pacientes (73%). TrKA e TrKB apresentaram coloração positiva em quatro (21,1%) e oito (42,1%) pacientes, respectivamente. A análise de sobrevida não demonstrou diferença significativa entre receptores TrK e neurotrofinas. Conclusão: amostras de OS primário expressam neurotrofinas e receptores TrK através de imuno-histoquímica. Estudos futuros podem auxiliar na identificação do papel das mesmas na patogênese do OS e determinar se há possível correlação prognóstica.

ABSTRACT Objective: to determine the expression of neurotrophins and their tyrosine-kinase receptors in patients with osteosarcoma (OS) and their correlation with clinical outcomes. Methods: we applied immunohistochemistry to biopsy specimens of patients consecutively treated for primary OS at a single institution between 2002 and 2015, analyzing them for expression receptors of tyrosine kinase A and B (TrKA and TrKB), neural growth factor (NGF) and brain derived neurotrophic factor (BDNF). Independently, two pathologists classified the immunohistochemical markers as negative (negative or weak focal) or positive (moderate focal/diffuse or strong focal/diffuse). Results: we analyzed data from 19 patients (10 females and 9 males), with median age of 12 years (5 to 17.3). Tumors' location were 83.3% in the lower limbs, and 63.2% of patients had metastases at diagnosis. Five-year overall survival was 55.3%. BDNF was positive in 16 patients (84%) and NGF in 14 (73%). TrKA and TrKB presented positive staining in four (21,1%) and eight (42,1%) patients, respectively. Survival analysis showed no significant difference between TrK receptors and neurotrophins. Conclusion: primary OS samples express neurotrophins and TrK receptors by immunohistochemistry. Future studies should explore their role in OS pathogenesis and determine their prognostic significance in larger cohorts.
Descritores: Neoplasias Ósseas/patologia
Osteossarcoma/patologia
Fator Neurotrófico Derivado do Encéfalo/análise
Receptor trkA/análise
Receptor trkB/análise
Fatores de Crescimento Neural/análise
-Valores de Referência
Neoplasias Ósseas/mortalidade
Imuno-Histoquímica
Biomarcadores Tumorais
Osteossarcoma/mortalidade
Fatores de Risco
Estatísticas não Paramétricas
Estimativa de Kaplan-Meier
Limites: Humanos
Masculino
Feminino
Pré-Escolar
Criança
Adolescente
Responsável: BR1.1 - BIREME


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Lafer, Beny
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Id: lil-792748
Autor: Nery, Fabiano G; Gigante, Alexandre D; Amaral, Jose A; Fernandes, Francy B; Berutti, Mariangeles; Almeida, Karla M; Stertz, Laura; Bristot, Giovana; Kapczinski, Flavio; Lafer, Beny.
Título: Serum BDNF levels in unaffected first-degree relatives of patients with bipolar disorder
Fonte: Rev. bras. psiquiatr;38(3):197-200, July-Sept. 2016. tab, graf.
Idioma: en.
Projeto: CNPq; . CAPES;; . FAPESP; . INCT-TM.
Resumo: Objective: Unaffected relatives of bipolar disorder (BD) patients have been investigated for the identification of endophenotypes in an attempt to further elucidate the pathophysiology of the disease. Brain-derived neurotrophic factor (BDNF) is considered to be implicated in the pathophysiology of BD, but its role as an endophenotype has been poorly studied. We investigated abnormal serum BDNF levels in BD patients, in their unaffected relatives, and in healthy controls. Methods: BDNF levels were obtained from 25 DSM-IV bipolar I disorder patients, 23 unaffected relatives, and 27 healthy controls. All BD patients were in remission. The unaffected subjects were first-degree relatives of the proband who had no lifetime DSM-IV diagnosis of axis I disorder. BDNF serum levels were determined by sandwich ELISA using monoclonal BDNF-specific antibodies. Results: There were no statistical differences in BDNF levels among BD patients, relatives, and healthy controls. Conclusion: Serum BDNF levels may not indicate high genetic risk for BD, possibly acting as state markers rather than trait markers of the disease.
Descritores: Transtorno Bipolar/sangue
Família
Fator Neurotrófico Derivado do Encéfalo/sangue
-Escalas de Graduação Psiquiátrica
Valores de Referência
Transtorno Bipolar/genética
Ensaio de Imunoadsorção Enzimática
Biomarcadores/sangue
Estudos de Casos e Controles
Fatores de Risco
Análise de Variância
Endofenótipos/sangue
Limites: Humanos
Masculino
Feminino
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-844184
Autor: Azeredo, Lucas A de; De Nardi, Tatiana; Levandowski, Mateus L; Tractenberg, Saulo G; Kommers-Molina, Julia; Wieck, Andrea; Irigaray, Tatiana Q; Silva Filho, Irênio G da; Grassi-Oliveira, Rodrigo.
Título: The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults
Fonte: Rev. bras. psiquiatr;39(2):90-94, Apr.-June 2017. tab, graf.
Idioma: en.
Projeto: CNPq.
Resumo: Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Methods: Eighty-seven subjects aged > 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. Results: BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). Conclusion: These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults.
Descritores: Valina/genética
Fator Neurotrófico Derivado do Encéfalo/genética
Polimorfismo de Nucleotídeo Único
Transtornos da Memória/genética
Metionina/genética
-Análise e Desempenho de Tarefas
Escalas de Wechsler
Análise Multivariada
Fatores de Risco
Fatores Etários
Estatísticas não Paramétricas
Predisposição Genética para Doença
Alelos
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Id: biblio-1039115
Autor: Bristot, Giovana; Ascoli, Bruna M; Scotton, Ellen; Géa, Luiza P; Pfaffenseller, Bianca; Kauer-Sant'Anna, Márcia.
Título: Effects of lithium on inflammatory and neurotrophic factors after an immune challenge in a lisdexamfetamine animal model of mania
Fonte: Braz. J. Psychiatry (São Paulo, 1999, Impr.);41(5):419-427, Sept.-Oct. 2019. tab, graf.
Idioma: en.
Resumo: Objective: To evaluate whether an animal model of mania induced by lisdexamfetamine dimesylate (LDX) has an inflammatory profile and whether immune activation by lipopolysaccharides (LPS) has a cumulative effect on subsequent stimuli in this model. We also evaluated the action of lithium (Li) on inflammatory and neurotrophic factors. Methods: Adult male Wistar rats were subjected to an animal model of mania. After the open-field test, they were given LPS to induce systemic immune activation. Subsequently, the animals' blood was collected, and their serum levels of brain-derived neurotrophic factor and inflammatory markers (tumor necrosis factor [TNF]-α, interleukin [IL]-6, IL-1β, IL-10, and inducible nitric oxide synthase [iNOS]) were measured. Results: LDX induced hyperactivity in the animals, but no inflammatory marker levels increased except brain-derived neurotrophic factor (BDNF). Li had no effect on serum BDNF levels but prevented iNOS levels from increasing in animals subjected to immune activation. Conclusion: Although Li prevented an LPS-induced increase in serum iNOS levels, its potential anti-inflammatory effects in this animal model of mania were conflicting.
Descritores: Transtorno Bipolar/imunologia
Modelos Animais de Doenças
Dimesilato de Lisdexanfetamina
Lítio/farmacologia
Anti-Inflamatórios/farmacologia
Fatores de Crescimento Neural/efeitos dos fármacos
-Fatores de Tempo
Transtorno Bipolar/fisiopatologia
Transtorno Bipolar/induzido quimicamente
Ensaio de Imunoadsorção Enzimática
Lipopolissacarídeos/farmacologia
Reprodutibilidade dos Testes
Citocinas/sangue
Resultado do Tratamento
Ratos Wistar
Fator Neurotrófico Derivado do Encéfalo/sangue
Óxido Nítrico Sintase Tipo II/sangue
Locomoção/efeitos dos fármacos
Limites: Animais
Masculino
Tipo de Publ: Estudo de Validação
Responsável: BR1.1 - BIREME


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Id: biblio-899367
Autor: Lipov, Eugene; Candido, Kenneth.
Título: BDNF Val66Met polymorphism and memory performance in older adults: the Met carrier effect is more complex than previously thought
Fonte: Rev. bras. psiquiatr;39(3):276-276, July-Sept. 2017.
Idioma: en.
Descritores: Fator Neurotrófico Derivado do Encéfalo/genética
Memória
-Polimorfismo Genético
Polimorfismo de Nucleotídeo Único
Genótipo
Limites: Humanos
Adulto
Tipo de Publ: Comentário
Carta
Responsável: BR1.1 - BIREME


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Id: biblio-899358
Autor: Azeredo, Lucas A; De Nardi, Tatiana; Grassi-Oliveira, Rodrigo.
Título: BDNF Val66Met polymorphism and memory performance in older adults: the Met carrier effect is more complex than previously thought: Authors' reply
Fonte: Rev. bras. psiquiatr;39(3):276-277, July-Sept. 2017.
Idioma: en.
Descritores: Fator Neurotrófico Derivado do Encéfalo/genética
-Polimorfismo Genético
Polimorfismo de Nucleotídeo Único
Genótipo
Memória
Limites: Humanos
Adulto
Tipo de Publ: Comentário
Carta
Responsável: BR1.1 - BIREME



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