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Id: lil-573711
Autor: Yamada, Hiroya; Takano, Toru; Matsuzuka, Fumio; Watanabe, Mikio; Miyauchi, Akira; Iwatani, Yoshinori.
Título: Transcriptional activity of the 5'-flanking region of the thyroid transcription factor-1 gene in human thyroid cell lines
Fonte: Genet. mol. biol;34(1):6-10, 2011. ilus, tab.
Idioma: en.
Projeto: Princess Takamatsu Cancer Research Fund.
Resumo: Thyroid transcription factor-1 (TTF-1, NKX2-1) is a homeodomain-containing transcriptional factor that binds to and activates the promoters of thyroid and lung-specific genes, such as thyroglobulin, thyroid peroxidase, and thyroid stimulating hormone receptor. TTF-1 is known to play a key role in the development of the thyroid. However, the precise mechanism of TTF-1 gene transcription in human thyroid cells has not been studied. The expression of transcriptional activity in various lengths of the 5'-flanking region of the human TTF -1 gene was studied in TTF-1 positive and negative human thyroid cell lines. Increased transcriptional activity was observed in thyroid cell lines containing plasmids that coded for a sequence proximal to the transcription start site of exon 1 of the TTF-1 gene. However, we did not observe any difference in promoter activity in the region up to -2.6 kb from the proximal transcription start site of the TTF-1 gene between TTF-1 positive and negative cells. These results suggest that the proximal 5'-flanking region of the human TTF -1 gene does not contain sufficient cis-active regulatory information to direct gene expression in thyroid cells,and that other cis-or trans-acting factors participate in the thyroid specific gene expression of TTF-1.
Descritores: Células-Tronco Embrionárias Humanas
Fator de Transcrição STAT3
Tenoiltrifluoracetona
Glândula Tireoide
Limites: Humanos
Responsável: BR1.1 - BIREME



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