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| Id: |
lil-60265
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| Autor: |
Fregoneze, J. B; Silva, E. Castro e; Valença, M. M; Rodrigues, J. Antunes. |
| Título: |
Role of opiates in the regulation of water and salt metabolism: effects of the FK33-824 injection into the subfornical organ of both normal and hypophysectomized rats |
| Fonte: |
Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;21(3):641-4, Mar. 1988. tab.
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| Idioma: |
en.
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| Conferência: |
Apresentado em: Annual meeting of the Federaçäo de Sociedades de Biologia Experimental, 3, Caxambu, June 29-July 3, 1988.
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| Resumo: |
The present study was performed to evaluate the participation of the subfornical organ (SFO) in the opioid modulation of urinary volume (Uv), and of sodium and potassium excretion. Intact and hypophysectomized (HYPOX) adult male rats were implanted with a cannula into the SFO, and injected with the opiate agonist FK 33-824 (FK). FK induced a significant decrease in Uv and in Na+ and K+ excretion in both intact and HYPOX rats. The data show that opioids play an important role in the regulation of hydromineral metabolism by the SFO
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| Descritores: |
D-Ala(2),MePhe(4),Met(0)-ol-encefalina/farmacologia
Diurese/efeitos dos fármacos
Potássio/urina
Sódio/urina
Órgão Subfornical/fisiologia
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-Hipofisectomia
Ratos Endogâmicos
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| Limites: |
Ratos
Animais
Masculino
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| Responsável: |
BR1.1 - BIREME
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