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Pesquisa : D12.776 [Categoria DeCS]
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Id: biblio-1285513
Autor: Dabaghi, Nazanin; Seyfoddin, Vahid; Toliyat, Tayebeh; Ataie, Zahra.
Título: Preparation and in vitro release profiling of PLGA microspheres containing BSA as a model protein
Fonte: Braz. J. Pharm. Sci. (Online);56:e18748, 2020. tab, graf.
Idioma: en.
Projeto: Vice Chancellor for Research, International campus of Tehran University of Medical Sciences.
Resumo: Conventional drug formulations are incapable of adequate delivery of proteins and peptides for therapeutic purposes. As these molecules have very short biological half-life, multiple dosing is required to achieve the desirable therapeutic effects. Microspheres are able to encapsulate proteins and peptide in the polymeric matrix while protecting them from enzymatic degradation. In this study Bovine Serum Albumin (BSA) matrix type microspheres were fabricated using Polylactide-co-glycolide (PLGA) by double emulsion solvent evaporation method. The effects of variables such as homogenizer speed, molecular weight of polymer and the effect of pH of the water phases, were investigated against factors such as drug loading, encapsulation efficiency, morphology, size, drug distribution and release profile of the microspheres. Results, suggested that an increase in homogenization speed leads to a decrease in microsphere size. The increase in homogenization speed also caused a significant effect on the release profile only when higher molecular weight of polymer had been used.. The pH change of the internal aqueous phase led to modification of surface morphology of spheres to a porous structure that significantly increased the total amount of released protein. Integrity of protein structure was intact as shown by SDS-PAGE. According to the results, it can be concluded that we achieved a reproducible method regarding controlled protein delivery for different sizes of particles.
Descritores: Técnicas In Vitro/métodos
Preparações Farmacêuticas/análise
Proteínas
Microesferas
-Soroalbumina Bovina/administração & dosagem
Eficiência/classificação
Eletroforese em Gel de Poliacrilamida/instrumentação
Emulsões
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-1138594
Autor: Ferreira, Ana Carolina Roos de Menezes; Cruz, Melissa Mercadante Santana; Siviero, Larissa; Rabito, Estela Iraci.
Título: Can oral nutritional supplements increase energy and protein intake among hospitalized patients? / ¿Los suplementos nutricionales orales pueden aumentar la energía y la proteína en pacientes hospitalizados?
Fonte: Rev. chil. nutr;47(4):597-603, ago. 2020. tab.
Idioma: en.
Resumo: ABSTRACT Background: Oral nutritional supplements aim at offsetting dietary deficits and helping to meet energy and protein targets. Due to the absence of data about their role in food intake, it is necessary to evaluate the contribution of these products to the estimated needs of hospitalized patients. Methods: This is a prospective longitudinal study with hospitalized patients over 18 years of age, admitted to a public university hospital, who were given oral nutritional supplements, according to clinical guidelines. Food intake was quantified throughout the period such products were prescribed. Results: 805-day food intake follow-up and record of 128 patients, who took supplements for 6.4 days on average. The use of nutritional supplements demonstrated a significant contribution to the input of both energy (1576 kcal/day versus 1263 kcal/day, p<0.001) and protein (68.7 g/day versus 50.3 g/day, p<0.001). Conclusions: Nutritional supplements help increase food intake and achieve nutritional goals when prescribed in a hospital setting.

RESUMEN Antecedentes: los suplementos nutricionales orales tienen como objetivo compensar los déficits dietéticos y ayudar a cumplir los objetivos de energía y proteínas. Debido a la ausencia de datos sobre su papel en la ingesta de alimentos, es necesario evaluar la contribución de estos productos a las necesidades estimadas de los pacientes hospitalizados. Métodos: Este es un estudio longitudinal prospectivo con pacientes hospitalizados mayores de 18 años, ingresados en un hospital universitario público, que recibieron suplementos nutricionales orales, según la derivación clínica. La ingesta de alimentos se cuantificó durante todo el período en que se prescribieron dichos productos. Resultados: seguimiento de la ingesta alimentaria de 805 días y registro de 128 pacientes, que tomaron suplementos durante 6,4 días en promedio. El uso de suplementos nutricionales demostró una contribución significativa al aporte de energía (1576 kcal/día versus 1263 kcal/día, p< 0,001) y proteína (68,7 g/día versus 50,3 g/día, p<0,001). Conclusiones: los suplementos nutricionales ayudan a aumentar la ingesta de alimentos y alcanzar objetivos nutricionales cuando se prescriben en un entorno hospitalario.
Descritores: Proteínas
Suplementos Nutricionais
Ingestão de Alimentos
-Pacientes
Apoio Nutricional
Hospitais
Limites: Adulto
Pessoa de Meia-Idade
Tipo de Publ: Artigo Clássico
Responsável: CL334.1 - Biblioteca UBO


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Id: biblio-1281415
Autor: Flórez, Andrés; Rojas, William; Reverend , Carlos; Torres-Tobar, Lilian; Quintero, Gloria.
Título: Proteína moduladora de la actividad del receptor de aril actividad del receptor hidrocarburos (AIP): genética, hidrocarburos (AIP): genética, bioquímica e impacto clínico / Aryl hydrocarbon receptor interacting protein (AIP): genetics, biochemistry and clinical impact
Fonte: Repert. med. cir;30(1):13-21, 2021. Ilus., tab..
Idioma: en.
Resumo: El gen AIP (proteína moduladora de la actividad del receptor de aril hidrocarburos) se localiza en la región 11q13.2 y codifica para una proteína de 330 aminoácidos que interactúa con el factor de transcripción AhR (receptor para aril hidrocarburos). Las mutaciones en este gen se han asociado con adenomas pituitarios aislados de tipo familiar (APAF). Se caracterizan por una presentación temprana (alrededor de 20 años), por lo regular producen hormona de crecimiento y/o prolactina, tienen un comportamiento clínico agresivo y poca respuesta a análogos de somatostatina.

The AIP gene (aryl hydrocarbon receptor interacting protein) is located on chromosome 11q13.2 and encodes a 330 amino acid protein which interacts with the aryl hydrocarbon receptor (AHR) transcription factor. Mutations in the AIP gene have been associated with familial isolated pituitary adenomas (FIPA). They characterize by an early-onset (around the age of 20 years old) and for being aggressive, growth hormone and/or prolactin-secreting tumors, with poor response to somatostatin analogues.
Descritores: Proteínas
-Doenças da Hipófise
Neoplasias Hipofisárias
Acromegalia
Receptores de Hidrocarboneto Arílico
Gigantismo
Hidrocarbonetos
Limites: Humanos
Masculino
Feminino
Adolescente
Tipo de Publ: Revisão
Responsável: CO304.1 - Biblioteca Arturo Aparicio Jaramillo


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Id: biblio-1224606
Autor: Ji, Jing; Shi, Shengqing; Chen, Wei; Xie, Tiantian; Du, Changjian; Sun, Jiacheng; Shi, Zheng; Gao, Rongfu; Jiang, Zeping; Xiao, Wenfa.
Título: Effects of exogenous γ-Aminobutyric acid on the regulation of respiration and protein expression in germinating seeds of mungbean (Vigna radiata) under salt conditions
Fonte: Electron. j. biotechnol;47:1-9, sept. 2020. graf, tab.
Idioma: en.
Projeto: National Natural Science Foundation of China; . National Key Research and Development Program of the Ministry of Science and Technology of China; . Research Funds of Key Laboratory of Tree Breeding and Cultivation of State Forestry Administration; . Fundamental Research Funds for the Central Non-Profit Research Institution of CAF.
Resumo: BACKGROUND: γ-Aminobutyric acid (GABA) bypasses the TCA cycle via GABA shunt, suggesting a relationship with respiration. However, little is known about its role in seed germination under salt conditions. RESULTS: In this study, exogenous GABA was shown to have almost no influence on mungbean seed germination, except 0.1 mM at 10 h, while it completely alleviated the inhibition of germination by salt treatment. Seed respiration was significantly inhibited by 0.1 and 0.5 mM GABA, but was evidently enhanced under salt treatment, whereas both were promoted by 1 mM GABA alone or with salt treatment. Mitochondrial respiration also showed a similar trend at 0.1 mM GABA. Moreover, proteomic analysis further showed that 43 annotated proteins were affected by exogenous GABA, even 0.1 mM under salt treatment, including complexes of the mitochondrial respiratory chain. CONCLUSIONS: Our study provides new evidence that GABA may act as a signal molecule in regulating respiration of mungbean seed germination in response to salt stress.
Descritores: Sementes/crescimento & desenvolvimento
Vigna
Ácido gama-Aminobutírico
-Respiração
Estresse Fisiológico
Proteínas
Germinação
Proteômica
Tolerância ao Sal
Estresse Salino
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1049076
Autor: Espinosa-Hernández, Edgar; Morales-Camacho, Jocksan Ismael; Fernández-Velasco, D. Alejandro; Benítez-Cardoza, Claudia G; Rosas-Cárdenas, Flor de Fátima; Luna-Suárez, Silvia.
Título: The insertion of bioactive peptides at the C-terminal end of an 11S globulin changes the structural stability and improves the antihypertensive activity
Fonte: Electron. j. biotechnol;37:18-24, Jan. 2019. tab, ilus, graf.
Idioma: en.
Projeto: Secretaría de Investigación y Posgrado IPN, México; . Consejo Nacional de Ciencia y Tecnología, México.
Resumo: BACKGROUND: The 11S globulin from amaranth is the most abundant storage protein in mature seeds and is well recognized for its nutritional value. We used this globulin to engineer a new protein by adding a four valinetyrosine antihypertensive peptide at its C-terminal end to improve its functionality. The new protein was named AMR5 and expressed in the Escherichia coli BL21-CodonPlus(DE3)-RIL strain using a custom medium (F8PW) designed for this work. RESULTS: The alternative medium allowed for the production of 652 mg/L expressed protein at the flask level, mostly in an insoluble form, and this protein was subjected to in vitro refolding. The spectrometric analysis suggests that the protein adopts a ß/α structure with a small increment of α-helix conformation relative to the native amaranth 11S globulin. Thermal and urea denaturation experiments determined apparent Tm and C1/2 values of 50.4°C and 3.04 M, respectively, thus indicating that the antihypertensive peptide insertion destabilized the modified protein relative to the native one. AMR5 hydrolyzed by trypsin and chymotrypsin showed 14- and 1.3-fold stronger inhibitory activity against angiotensin I-converting enzyme (IC50 of 0.034 mg/mL) than the unmodified protein and the previously reported amaranth acidic subunit modified with antihypertensive peptides, respectively. CONCLUSION: The inserted peptide decreases the structural stability of amaranth 11S globulin and improves its antihypertensive activity.
Descritores: Peptídeos/metabolismo
Proteínas/metabolismo
Globulinas/metabolismo
Anti-Hipertensivos/metabolismo
-Sementes
Temperatura
Meios de Cultura
Amaranthus
Estabilidade Proteica
Compostos Fitoquímicos
Responsável: CL1.1 - Biblioteca Central


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Srougi, Miguel
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Id: biblio-1278924
Autor: Santos, Gabriel Arantes dos; Reis, Sabrina T; Leite, Katia Ramos Moreira; Srougi, Miguel.
Título: Telomere Attrition and p53 Response 1 (TAPR1): a new player in cancer biology?
Fonte: Clinics;76:e2997, 2021. graf.
Idioma: en.
Descritores: Proteínas/genética
Neoplasias/genética
Limites: Humanos
Tipo de Publ: Editorial
Responsável: BR1.1 - BIREME


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Id: biblio-1282373
Autor: Arce, Camila Pilar; Di Iorio, Micaela Soledad; Olaverry, Pilar; Sica, Sabrina; Torresani, María Elena.
Título: Efecto sobre la saciedad y glucemia postprandial de un yogur hiperproteico vs otro normoproteico en mujeres adultas / Effect on post-prandial saciety and glucemia of a hyperproteic vs another normoproteic yogurt in adult women
Fonte: Actual. nutr;21(3):80-87, Julio-Septiembre de 2020.
Idioma: es.
Resumo: Introducción: las proteínas presentes en los alimentos juegan un rol saciógeno y pueden actuar sobre la respuesta insulínica y la glucemia plasmática postprandial. Objetivos: evaluar saciedad y glucemia postprandial luego del consumo de yogur hiperproteico vs normoproteico en mujeres adultas aparentemente sanas, residentes de la Ciudad Autóno-ma Buenos Aires y el Gran Buenos Aires. Materiales y métodos: ensayo clínico cruzado simple ciego, sobre una muestra de 79 mujeres adultas (25-65 años), no diabéticas ni intolerantes a la glucosa. Se comparó saciedad, impacto glucémico y agradabilidad de dos yogures ofrecidos como merienda, con diferente aporte proteico, controlados en grasas y carbohidratos, con relación proteínas/carbohidratos: 0,56 en yogur hiperproteico y 0,33 en normoproteico. Se va-loró estado nutricional mediante índice de masa corporal (bajo peso <18,5 kg/m2, normopeso: 18,5 a 24,9 kg/m2, sobrepeso u obesidad: ≥25 kg/m2) y riesgo cardiometabólico mediante índice cintura/talla (≥0,50). Estadística mediante software SPSS 22.0, aplicando prueba de Wilcoxon y chi cuadrado o prueba exacta de Fisher, con nivel de significación estadística <0,05. Resultados: edad promedio: 34,4±11 años. El 65,8% con ade-cuado estado nutricional según IMC y 26,6% con riesgo cardio-metabólico aumentado, ambas variables asociadas en forma di-recta con la edad (p=0,0000 y p=0,001 respectivamente).El yogur hiperproteico fue más aceptado (p=0,03) con mejor res-puesta sobre saciedad post ingesta que el yogur normoproteico, a la hora y a las dos horas de ingerido (p=0,001 y p=0,000 res-pectivamente). A su vez, impactó significativamente más sobre la respuesta glucémica postprandial sólo a los 30 minutos de consu-mido (p=0,02), pero no a los 60 minutos (p=0,59). Conclusiones: el yogur hiperproteico alcanzó mayor agra-dabilidad y otorgó, a igual porción estándar, mayor saciedad postprandial que un yogur similar normoproteico, sin afectar la glucemia postprandial.
Descritores: Saciação
Mulheres
Iogurte
Glicemia
Proteínas
Responsável: AR605.1 - Biblioteca


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Texto completo SciELO Chile
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Id: biblio-1138601
Autor: Bragança, Guilherme; Ávila, Bianca; Rockenbach, Reni; Santos, Magda; Alves, Gabriela; Santos, Mônica de los; Bortolini, Vera; Monks, Jander; Peres, William; Elias, Moacir.
Título: Effects of different hydration treatments on technological, physical, nutritional, and bioactive parameters of lentils / Efectos de diferentes tratamientos de hidratación sobre los parámetros tecnológicos, físicos, nutricionales y bioactivos de las lentejas
Fonte: Rev. chil. nutr;47(4):658-668, ago. 2020. tab, graf.
Idioma: en.
Resumo: ABSTRACT Regular lentil consumption may improve health and prevent certain chronic diseases. Lentils have high antioxidant activity and contain proteins, essential amino acids, fiber, minerals, and bioactive compounds. However, few studies have investigated the physicochemical characteristics of lentils when subjected to various soaking and cooking methods. We aimed to evaluate the effects of different hydration and cooking practices on the hydration coefficient, cooking time, primary metabolism compounds (lipids, proteins, fibers, carbohydrates), energy value, soluble protein, color and texture characteristics, amino acid and mineral profiles, bioactive compounds, antioxidant activity, and antinutritional factors (phytates and tannins) in lentils. Hydration water was preheated to initial temperatures of 25°C or 90°C. Lentils pre-hydrated with water at 90°C needed less cooking time, obtained greater softness, and had less decreases in amino acids, minerals, bioactive compounds, and antioxidant activity.

RESUMEN El consumo regular de lentejas puede mejorar la salud y prevenir ciertas enfermedades crónicas. Las lentejas tienen una alta actividad antioxidante y contienen proteínas, aminoácidos esenciales, fibra, minerales y compuestos bioactivos. Sin embargo, pocos estudios han investigado las características fisicoquímicas de las lentejas sometidas a varios métodos de remojo y cocción. El objetivo de este estudio fue evaluar los efectos de diferentes procesos de cocción e hidratación sobre el coeficiente de hidratación, el tiempo de cocción, los metabolitos primarios (lípidos, proteínas, fibras, carbohidratos), el valor energético, la proteína soluble, color y textura, los perfiles de aminoácidos y minerales, los compuestos bioactivos, la actividad antioxidante y los factores antinutricionales (fitatos y taninos) en la lenteja. El agua de hidratación se precalentó a temperaturas iniciales de 25°C o 90°C. Las lentejas prehidratadas con agua a 90°C necesitaban menos tiempo de cocción y obtuvieron una mayor suavidad, disminuyendo también la pérdida de aminoácidos, minerales, compuestos bioactivos y actividad antioxidante.
Descritores: Saúde
Doença Crônica
Lens (Planta)
Aminoácidos Essenciais
-Proteínas
Metabolismo
Minerais
Antioxidantes
Tipo de Publ: Artigo Clássico
Responsável: CL334.1 - Biblioteca UBO


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Vieira, Alexandre Rezende
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Id: biblio-1135483
Autor: Mulic, Aida; Tveit, Anne Bjorg; Vieira, Nicholas Modesto; Limesand, Kirsten; Vieira, Alexandre Rezende.
Título: Protein Profiles of Individuals with Erosive Tooth Wear
Fonte: Pesqui. bras. odontopediatria clín. integr;20:e0026, 2020. tab.
Idioma: en.
Projeto: National Institutes of Health; . National Institute of Dental and Craniofacial Research.
Resumo: Abstract Objective: To determine if protein profiles identified in saliva could be used to determine risk and severity of erosive tooth wear. Material and Methods: Three types of saliva sampling were performed to obtain saliva from 34 18-year old individuals that received regular dental check-ups, along with clinical status of the dentition and risk factor related to erosive tooth wear using the VEDE scale. Protein profiles in saliva were determined using electrophoresis and the calculation of the percentage of a specific band at a specific molecular weight in relationship to the total protein in that sample (% of total) using molecular weight standards. This quantification was repeated for each protein band across a range of molecular weights for each sample to test for association with erosive tooth wear status. Results: There were no differences in the number of detectable proteins sourced from the parotid gland, nor the unstimulated and stimulated whole saliva. Five out of the 34 individuals had no signs of erosive tooth wear despite an acidic diet and were more likely to have proteins with molecular weight smaller than 1 KDa (p=0.03). Conclusion: There is potential for the use of protein profiling to determine risks for erosive tooth wear.
Descritores: Erosão Dentária/diagnóstico
Fatores de Risco
Cárie Dentária/prevenção & controle
Esmalte Dentário
Desgaste dos Dentes
-Saliva/microbiologia
Proteínas
Distribuição de Qui-Quadrado
Inquéritos e Questionários
Fotografia Dentária/instrumentação
Noruega/epidemiologia
Limites: Humanos
Masculino
Feminino
Adolescente
Tipo de Publ: Estudo Comparativo
Ensaio Clínico
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos


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Id: lil-467877
Autor: Murador, Priscila; Deffune, Elenice.
Título: Aspectos estruturais da membrana eritrocitária / Structural aspects of the erythrocyte membrane
Fonte: Rev. bras. hematol. hemoter;29(2):168-178, abr.-jun. 2007. ilus, tab.
Idioma: pt.
Resumo: Este artigo descreve as estruturas e funções da membrana eritrocitária e sua importância na medicina transfusional. A membrana eritrocitária é uma das membranas mais conhecidas em termos de estrutura, função e genética. Como qualquer membrana plasmática, tem como função mediar transportes e, ainda, fornece ao eritrócito resistência e maleabilidade. De acordo com a International Society of Blood Transfusion (ISBT), são mais de 500 antígenos expressos na membrana das hemácias e, destes, cerca de 270 estão envolvidos nos casos de reação transfusional e doença hemolítica do feto e do recém-nascido. Na classificação feita pela ISBT, destaca-se a série de alta freqüência representada por antígenos presentes em mais de 99 por cento dos indivíduos de uma população. Estes antígenos são conhecidos também como antígenos públicos e a maioria, quando ausente, determina problemas graves do ponto de vista transfusional. Como exemplo dessa problemática, uma gestante com ausência do antígeno P já sofreu seis abortos de repetição por insuficiência placentária devido ao anticorpo formado pela ausência do antígeno. Proteínas importantes são descritas nesta revisão como: banda 3, glicoforinas, espectrina e outras. A banda 3 é a mais abundante proteína integral da membrana do eritrócito e sua principal função é mediar a troca de cloro e ânions de bicarbonato através da membrana plasmática. A segunda proteína integral mais abundante é a sialoglicoproteína glicoforina A (GPA). Com um alto conteúdo de ácido siálico, a GPA contribui com a rede de carga negativa na superfície da membrana do eritrócito, minimizando, assim, a interação célula-célula e prevenindo sua agregação. Glicoforina C (GPC) é o receptor para PfEBP-2 (baebl, EBA-140), o mais novo local de ligação identificado para o Plasmodium falciparum.O complexo terciário - espectrina, actina e 4.1R - define a rede de citoesqueleto da membrana do eritrócito e é ainda responsável pela estabilidade sob mecanismos...

This article describes the structures and functions of the erythrocyte membrane and its importance in transfusional medicine. The erythrocyte membrane is one of the best known membranes in terms of structure, function and genetic disorders. As any other plasma membrane, it mediates transport functions. It also provides the erythrocytes with their resilience and deformability. According to the International Society of Blood Transfusion (ISBT), more than 500 antigens are expressed in the erythrocyte membrane, and around 270 are involved in transfusion reaction cases and hemolytic diseases of the fetus and newborn. In the ISBT classification, the high frequency series is represented by antigens in more than 99 percent of population (high prevalence antigen). In transfusion, the absence of these antigens determines severe problems as for example, one woman without the P antigen suffered 6 repetitive miscarriages due to placental insufficiency, which was caused by an antibody formed against the absent P antigen. Some important erythrocyte membrane proteins are described here including Band 3, Glycophorins and spectrin. The most abundant integral membrane protein is Band 3 and its main function is to mediate exchange of chloride and bicarbonate anions across the plasma membrane. The second most abundant integral membrane protein in the human erythrocyte is sialoglycoprotein glycophorin A (GPA). With its high sialic acid content, GPA is the main contributor to the net negative cell-surface charge and is thus critical for minimizing cell-cell interactions and preventing red cell aggregation. Glycophorin C (GPC) is the receptor for PfEBP-2 (baebl, EBA-140), the newly identified erythrocyte binding ligand of Plasmodium falciparum. The ternary complex of spectrin, actin and 4.1R defines the nodes of the erythrocyte membrane skeletal network, and is inseparable from membrane stability when under mechanical stress. This erythrocyte membrane review...
Descritores: Membrana Eritrocítica
-Transfusão de Sangue
Glicoforinas
Proteínas
Membrana Celular
Reação Transfusional
Proteínas de Membrana
Antígenos
Tipo de Publ: Revisão
Responsável: BR408.1 - Biblioteca da Faculdade de Medicina - BFM



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