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Texto completo SciELO Chile
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Id: biblio-1043142
Autor: González, Fernando; Méndez, Gonzalo; Navarrete, Daniela; Roessler B, Emilio.
Título: Mujer joven, hija de padre con síndrome de Alport, debuta con síndrome nefrótico impuro / Young woman, daughter of a father with Alport's syndrome, debuts with a impure nephrotic syndrome
Fonte: Rev. méd. Chile;145(5):623-629, mayo 2017. ilus.
Idioma: es.
Descritores: Nefrite Lúpica/diagnóstico
Nefrite Intersticial/diagnóstico
Síndrome Nefrótica/diagnóstico
-Pressão Sanguínea
Nefrite Lúpica/patologia
Albumina Sérica/análise
Proteínas Sanguíneas/análise
Biópsia Guiada por Imagem
Glomérulos Renais/patologia
Nefrite Hereditária/diagnóstico
Nefrite Hereditária/genética
Nefrite Intersticial/patologia
Síndrome Nefrótica/patologia
Limites: Humanos
Feminino
Adulto
Adulto Jovem
Tipo de Publ: Relatos de Casos
Conferência Clínica
Responsável: CL1.1 - Biblioteca Central


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Moreira, Emilia Addison Machado
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Id: biblio-904131
Autor: Ventura, Julia Carvalho; Hauschild, Daniela Barbieri; Moreira, Emília Addison Machado; Pereira, Letícia Cristina Radin; Rosa, Anauã Franco; Barbosa, Eliana; Ludwig-Neto, Norberto; Rosa, Julia Salvan da; Fröde, Tânia Silvia; Moreno, Yara Maria Franco.
Título: C-reactive protein/albumin ratio is associated with lung function among children/adolescents with cystic fibrosis: a three-year longitudinal study
Fonte: Säo Paulo med. j;136(1):29-36, Jan.-Feb. 2018. tab, graf.
Idioma: en.
Projeto: Brazilian National Council for Scientific and Technological Development.
Resumo: ABSTRACT BACKGROUND: Chronic lung infections, inflammation and depletion of nutritional status are considered to be prognostic indicators of morbidity in patients with cystic fibrosis. The aim of this study was to investigate the association between inflammatory markers and lung function, nutritional status and morbidity among children/adolescents with cystic fibrosis. DESIGN AND SETTINGS: Prospective three-year longitudinal study conducted in an outpatient clinic in southern Brazil. METHODS: Children/adolescents aged 1-15 years with cystic fibrosis were enrolled. Nutritional status was determined from weight-to-length and body mass index-to-age z-scores and was classified as acceptable, at risk or nutritional failure. Tumor necrosis factor-α, interleukin-1β, myeloperoxidase, C-reactive protein and C-reactive protein/albumin ratio were analyzed. Lung function was evaluated based on the forced expiratory volume in the first second and morbidity according to the number of hospitalizations for pulmonary exacerbation and infections by Pseudomonas aeruginosa. Lung function, nutritional status and morbidity were the outcomes. Odds ratios and 95% confidence intervals were to evaluate the effect of baseline inflammatory markers on the clinical outcomes after three years of follow-up and p-values < 0.05 were considered significant. RESULTS: We evaluated 38 children/adolescents with cystic fibrosis: 55% female; median age (with interquartile range), 3.75 years (2.71-7.00). Children/adolescents with high C-reactive protein/albumin ratio at baseline had odds of 18 (P = 0.018) of presenting forced expiratory volume in the first second ≤ 70% after three years. The other inflammatory markers were not associated with the outcomes. CONCLUSION: C-reactive protein/albumin ratio was associated with forced expiratory volume in the first second ≤ 70% after three years.
Descritores: Proteína C-Reativa/análise
Albumina Sérica/análise
Fator de Necrose Tumoral alfa/sangue
Peroxidase/sangue
Mediadores da Inflamação/sangue
Fibrose Cística/sangue
Interleucina-1beta/sangue
-Testes de Função Respiratória
Biomarcadores/sangue
Estado Nutricional
Estudos Prospectivos
Estudos Longitudinais
Fibrose Cística/fisiopatologia
Limites: Humanos
Masculino
Feminino
Criança
Adolescente
Responsável: BR1.1 - BIREME


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Id: lil-782867
Autor: Ko, Young Hwii; Ji, Yoon Seob; Park, Sin-Youl; Kim, Su Jin; Song, Phil Hyun.
Título: Procalcitonin determined at emergency department as an early indicator of progression to septic shock in patient with sepsis associated with ureteral calculi
Fonte: Int. braz. j. urol;42(2):270-276, Mar.-Apr. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT Introduction: To investigate the role of initial procalcitonin (PCT) level as an early predictor of septic shock for the patient with sepsis induced by acute pyelonephritis (APN) secondary to ureteral calculi. Materials and Methods: The data from 49 consecutive patients who met criteria of sepsis due to APN following ureteral stone were collected and divided into two groups: with (n=15) or without (n=34) septic shock. The clinical variables including PCT level for this outcome were retrospectively compared by univariate analysis, followed by multivariable logistic regression model. Results: All subjects had hydronephrosis, and were hospitalized with the mean of 11.8 days (3–42 days). The mean size of the ureteral stones was 7.5mm (3–30mm), and 57% were located in upper ureter. At univariate analysis, patients with septic shock were significantly older, a higher proportion had hypertension, lower platelet count and serum albumin level, higher CRP and PCT level, and higher positive blood culture rate. Multivariate models indicated that lower platelet count and higher PCT level are independent risk factors (p=0.043 and 0.046, respectively). In ROC curve, the AUC was significantly wider in PCT (0.929), compared with the platelet count (0.822, p=0.004). At the cut-off of 0.52ng/mL, the sensitivity and specificity were 86.7% and 85.3%. Conclusion: Our study demonstrated elevated initial PCT levels as an early independent predictor to progress into septic shock in patients with sepsis associated with ureteral calculi.
Descritores: Pielonefrite/sangue
Choque Séptico/sangue
Calcitonina/sangue
Cálculos Ureterais/sangue
-Contagem de Plaquetas
Pielonefrite/etiologia
Valores de Referência
Choque Séptico/etiologia
Proteína C-Reativa/análise
Albumina Sérica/análise
Biomarcadores/sangue
Cálculos Ureterais/complicações
Doença Aguda
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
Estudos Retrospectivos
Fatores de Risco
Curva ROC
Análise de Variância
Estatísticas não Paramétricas
Progressão da Doença
Serviço Hospitalar de Emergência
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adulto
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: lil-777330
Autor: Karaguzel, Ersagun; Bayraktar, Cemil; Kutlu, Omer; Yulug, Esin; Mentese, Ahmet; Okatan, Ali Ertan; Colak, Fatih; Ozer, Serap; O. Kazaz, Ilke.
Título: The possible protective effects of dipyridamole on ischemic reperfusion injury of priapism
Fonte: Int. braz. j. urol;42(1):146-153, Jan.-Feb. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT Purpose To investigate the protective effects against ischemia reperfusion injury of dipyridamole in a model of induced priapism in rats. Materials and Methods Twenty-four male Sprague-Dawley rats were divided into four groups, control, P/R, P/R+DMSO and P/R+D. 3ml blood specimens were collected from vena cava inferior in order to determine serum MDA, IMA, TAS, TOS and OSI values, and penile tissue was taken for histopathological examination in control group. Priapism was induced in P/R group. After 1h, priapism was concluded and 30 min reperfusion was performed. In P/R+DMSO group 1ml/kg DMSO was administered intraperitoneally 30 min before reperfusion, while in P/R+D group 10mg/kg dipyridamole was administered intraperitoneally 30 min before reperfusion. Blood and penis specimens were collected after the end of 30 min reperfusion period. Sinusoidal area (µm2), tears in tunica albuginea and injury parameters in sinusoidal endothelium of penis were investigated. Results Histopathological examination revealed no significant changes in term of sinusoidal area. A decrease in tears was observed in P/R+D group compared to P/R group (p<0.05). Endothelial injury decreased in P/R+D group compared to P/R group (p>0.05). There were no significant differences in MDA and IMA values between groups. A significant increase in TOS and OSI values was observed in P/R+D group compared to P/R group. A significant decrease in TAS levels was observed in P/R+D group compared to the P/R group. Conclusions The administration of dipyridamole before reperfusion in ischemic priapism model has a potential protective effect against histopathological injury of the penis.
Descritores: Pênis/irrigação sanguínea
Priapismo/prevenção & controle
Vasodilatadores/farmacologia
Traumatismo por Reperfusão/prevenção & controle
Dipiridamol/farmacologia
Isquemia/prevenção & controle
-Pênis/patologia
Priapismo/patologia
Fatores de Tempo
Ereção Peniana/efeitos dos fármacos
Albumina Sérica
Biomarcadores/sangue
Distribuição Aleatória
Reprodutibilidade dos Testes
Resultado do Tratamento
Oxidantes/sangue
Ratos Sprague-Dawley
Estresse Oxidativo
Precondicionamento Isquêmico/métodos
Modelos Animais de Doenças
Albumina Sérica Humana
Malondialdeído/sangue
Antioxidantes/análise
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-777331
Autor: Ozgen, Serpil Ustalar; Ozveren, Bora; Kilercik, Meltem; Aksu, Ugur; Ay, Binnaz; Tufek, Ilter; Kural, Ali Riza; N. Turkeri, Levent; Toraman, Fevzi.
Título: Ischemia modified albumin: does it change during pneumoperitoneum in robotic prostatectomies?
Fonte: Int. braz. j. urol;42(1):69-77, Jan.-Feb. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT Background The unique positioning of the patient at steep Trendelenburg with prolonged and increased intra-abdominal pressure (IAP) during robotic radical prostatectomy may increase the risk of splanchnic ischemia. We aimed to investigate the acute effects of IAP and steep Trendelenburg position on the level of ischemia modified albumin (IMA) and to test if serum IMA levels might be used as a surrogate marker for possible covert ischemia during robotic radical prostatectomies. Patients and Methods Fifty ASA I-II patients scheduled for elective robotic radical prostatectomy were included in this investigation. Exclusion criteria The patients were excluded from the study when an arterial cannulation could not be accomplished, if the case had to be converted to open surgery or if the calculated intraoperative bleeding exceeded 300ml. All the patients were placed in steep (45 degrees) Trendelenburg position following trocar placement. Throughout the operation the IAP was maintained between 11-14mmHg. Mean arterial blood pressure (MAP), cardiac output (CO) were continuously monitored before the induction and throughout the surgery. Blood gases, electrolytes, urea, creatinine, alanine transferase (ALT), aspartate transferase (AST) were recorded. Additionally, IMA levels were measured before, during and after surgery. Results (1) MAP, CO, lactate and hemoglobin (Hb) did not significantly change in any period of surgery (p>0.05); (2) sodium (p<0.01), potassium (p<0.05) and urea (p<0.05) levels decreased at postoperative period, and no significant changes at creatinine, AST, ALT levels were observed in these patients; (3) At the end of surgery (180 min) pCO2, pO2, HCO3 and BE did not change compared to after induction values (p>0.05) but mild acidosis was present in these patients (p<0.01 vs. after induction); (4) IMA levels were found to be comparable before induction (0.34±0.04), after induction (0.31±0.06) ...
Descritores: Pneumoperitônio Artificial/métodos
Pressão
Prostatectomia/métodos
Posicionamento do Paciente/métodos
Procedimentos Cirúrgicos Robóticos/métodos
-Pneumoperitônio Artificial/efeitos adversos
Prostatectomia/efeitos adversos
Valores de Referência
Circulação Esplâncnica
Fatores de Tempo
Gasometria
Albumina Sérica
Débito Cardíaco
Biomarcadores/sangue
Análise de Variância
Laparoscopia/métodos
Decúbito Inclinado com Rebaixamento da Cabeça
Posicionamento do Paciente/efeitos adversos
Pressão Arterial
Procedimentos Cirúrgicos Robóticos/efeitos adversos
Albumina Sérica Humana
Hemodinâmica
Isquemia/etiologia
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-975627
Autor: Koparal, Murat Yavuz; Polat, Fazlı; Çetin, Serhat; Bulut, Ender Cem; Sözen, Tevfik Sinan.
Título: Prognostic role of preoperative albumin to globulin ratio in predicting survival of clear cell renal cell carcinoma
Fonte: Int. braz. j. urol;44(5):933-946, Sept.-Oct. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Purpose: To investigate the prognostic role of preoperative albumin/globulin ratio (AGR) in predicting disease-free survival (DFS) and overall survival (OS) in localized and locally advanced clear cell renal cell carcinoma (RCC) patients. Patients and Methods: 162 patients who met the criteria specified were included in the study. The DFS and OS ratios were determined using the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were performed to determine the prognostic factors affecting DFS and OS. Results: Median follow-up period was 27.5 (6-89) months. There was a statistically significant relationship between low AGR and high pathological tumor (pT) stage, presence of collecting system invasion, presence of tumor necrosis, and a high platelet count (p = 0.012, p = 0.01, p = 0.001, and p = 0.004, respectively). According to the Kaplan-Meier survival analysis, both OS and DFS were found to be significantly lower in the low AGR group (p = 0.006 and p = 0.012). In the multivariate Cox regression analysis, collecting system invasion and tumor necrosis were found to be independent prognostic factors in predicting OS and pT stage was found to be an independent prognostic factor in predicting DFS (HR: 4.08, p = 0.043; HR: 8.64, p = 0.003 and HR: 7.78, p = 0.041, respectively). Conclusion: In our study, low AGR was found to be associated with increased mortality and disease recurrence in localized and locally advanced RCC.
Descritores: Albumina Sérica/análise
Carcinoma de Células Renais
Globulinas/análise
Neoplasias Renais/sangue
-Prognóstico
Carcinoma de Células Renais/cirurgia
Carcinoma de Células Renais/mortalidade
Biomarcadores Tumorais/sangue
Valor Preditivo dos Testes
Estudos Retrospectivos
Sensibilidade e Especificidade
Intervalo Livre de Doença
Neoplasias Renais/cirurgia
Neoplasias Renais/mortalidade
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1012322
Autor: Suyama, Taisuke; Kanbe, Shigeki; Maegawa, Masanobu; Shimizu, Hirofumi; Nakajima, Koichi.
Título: Prognostic significance of inflammation-based prognostic scoring in patients with upper urinary tract urothelial carcinoma
Fonte: Int. braz. j. urol;45(3):541-548, May-June 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objectives: To investigate whether Glasgow Prognostic Score has prognostic significance in patients with upper urinary urothelial carcinoma. Patients and methods: We retrospectively reviewed the clinical records of 74 patients with upper urinary urothelial carcinoma. We set the cut-off value for C-reactive protein as 1.0mg/dL, and 3.5mg/dL for albumin as Glasgow Prognostic Score. Their blood data including albumin and C-reactive protein for Glasgow Prognostic Score and cytokeratin 19 fragment 21-1 as a tumor marker were measured before starting treatment. The patients were stratified into three groups with Glasgow Prognostic Score: The Group-1, albumin ≥3.5g/dL and C-reactive protein < 1.0mg/dL; Group-2, albumin < 3.5g/dL or C-reactive protein ≥1.0mg/dL; Group-3, albumin < 3.5g/dL and C-reactive protein ≥1.0mg/dL. Results: The median follow-up for all patients was 26.9 months (range: 10.9-91.1 months), during which 37 (50%) patients died. There was a significant difference in the estimated survival rate among the 3 groups stratified by Glasgow Prognostic Score. The estimated survival rate in the Group-1 was significantly higher than those in Groups 2 and 3. In the univariate analysis C-reactive protein, serum cytokeratin 19 fragment 21-1 and Glasgow Prognostic Score were significant predictors of overall survival. On the multivariate analysis, serum cytokeratin 19 fragment 21-1 and Glasgow Prognostic Score were independently associated with shorter overall survival. Conclusion: Our review suggests Glasgow Prognostic Score may play as a prognostic predictor for upper urinary urothelial carcinoma.
Descritores: Prognóstico
Carcinoma/sangue
Neoplasias Urológicas/sangue
-Valores de Referência
Proteína C-Reativa/análise
Albumina Sérica/análise
Carcinoma/patologia
Biomarcadores Tumorais/sangue
Modelos de Riscos Proporcionais
Reprodutibilidade dos Testes
Estudos Retrospectivos
Sensibilidade e Especificidade
Neoplasias Urológicas/patologia
Estatísticas não Paramétricas
Urotélio/patologia
Queratina-19/sangue
Estimativa de Kaplan-Meier
Pessoa de Meia-Idade
Antígenos de Neoplasias/sangue
Limites: Humanos
Masculino
Feminino
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Id: biblio-1020487
Autor: Ozgunay, Seyda Efsun; Ozsin, Kadir Kaan; Ustundag, Yasemin; Karasu, Derya; Ozyaprak, Buket; Balcı, Burak; Erel, Ozcan; Yavuz, Senol.
Título: The effect of continuous ventilation on thiol-disulphide homeostasis and albumin-adjusted ischemia-modified albumin during cardiopulmonary bypass
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);34(4):436-443, July-Aug. 2019. tab, graf.
Idioma: en.
Resumo: Abstract Objective: To investigate the effect of continuous lung ventilation with low tidal volume on oxidation parameters, such as thiol/disulphide homeostasis and albumin-adjusted ischemia-modified albumin (AAIMA), during cardiopulmonary bypass (CBP) in coronary artery bypass grafting (CABG). Methods: Seventy-four patients who underwent elective CABG with CPB were included in the study. Blood samples were taken in the preoperative period, 10 minutes after CPB, and six and 24 hours postoperatively. Patients were assigned to the continuous ventilation group (Group 1, n=37) and the non-ventilated group (Group 2, n=37). The clinical characteristics, thiol/disulphide homeostasis, ischemia-modified albumin (IMA), and AAIMA levels of the patients were compared. Results: A significant difference was found between the groups regarding native thiol, total thiol, and IMA levels at the postoperative 24th hour (P=0.030, P=0.031, and P=0.004, respectively). There was no difference between the groups in terms of AAIMA. AAIMA levels returned to preoperative levels in Groups 1 and 2, at the 6th and 24th postoperative hours, respectively. Length of hospital stay was significantly shorter in Group 1 (P<0.001) than in Group 2. Conclusion: Continuous ventilation during CPB caused an increase in native and total thiol levels, an earlier return of AAIMA levels, and shorter hospital stay. Continuous ventilation may reduce the negative effects of CPB on myocardium (Table 2, Figure 1, and Reference 31).
Descritores: Respiração Artificial
Compostos de Sulfidrila/sangue
Albumina Sérica/análise
Ponte Cardiopulmonar/efeitos adversos
Dissulfetos/sangue
-Complicações Pós-Operatórias/prevenção & controle
Biomarcadores/sangue
Ponte Cardiopulmonar/métodos
Ponte de Artéria Coronária
Método Duplo-Cego
Estudos Prospectivos
Lesão Pulmonar/etiologia
Albumina Sérica Humana
Homeostase/fisiologia
Antioxidantes
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: lil-796052
Autor: Ozdemir, Hasan Huseyin.
Título: Analysis of the albumin level, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio in Guillain-Barré syndrome / Análise do nível de albumina, da relação neutrófilo-linfócito e linfócito-plaquetas na síndrome de Guillain-Barré
Fonte: Arq. neuropsiquiatr;74(9):718-722, Sept. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT The purpose of this study was to investigate the prognostic value of the pretreatment and post-treatment albumin level, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) in subtypes of Guillain-Barré syndrome (GBS). A retrospective analysis of 62 patients with GBS treated between 2011 and 2015 in Dicle University Hospital, Turkey, was carried out. The pretreatment and post-treatment albumin, NLR, and PLR were documented, together with acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy, motor sensory axonal neuropathy, and Hughes’ scores. Post-treatment albumin levels in GBS were significantly reduced, and albumin level was negatively correlated with the Hughes scores. Elevated pretreatment NLRs and PLRs were significantly associated with AIDP. There were no correlations between the Hughes scores, NLR, and PLR. The results point to a negative correlation between albumin levels and GBS disability and suggest that the NLR and PLR may be promising blood biomarkers of AIDP.

RESUMO O objetivo deste estudo foi investigar o valor prognóstico dos níveis pré e pós-tratamento de albumina , da relação neutrófilo/linfócito (RNL) e da relação plaqueta/linfócito (RPL) em subtipos de síndrome de Guillain-Barré (SGB). Realizou-se uma análise retrospectiva de 62 pacientes com GBS, tratados entre 2011 e 2015 no Hospital da Universidade Dicle, na Turquia. Os valores pré e pós-tratamento de albumina, RNL e RPL foram documentados, juntamente com polirradiculoneuropatia desmielinizante inflamatória aguda, (PDIA) neuropatia axonal motora aguda, neuropatia axonal sensorial motora e pontuações de Hughes. Os níveis de albumina reduziram significativamente pós-tratamento e correlacionaram-se negativamente com as pontuações de Hughes. RNLs e RPLs pré-tratamento elevados foram significativamente associados à PDIA. Não houve correlação entre as pontuações de Hughes, RNL e RPL. Os resultados apontam uma correlação negativa entre os níveis de albumina e a deficiência na SGB e sugerem que a RNL e a RPL possam ser promissores biomarcadores sanguíneos para PDIA.
Descritores: Plaquetas
Albumina Sérica/análise
Linfócitos
Síndrome de Guillain-Barré/sangue
Neutrófilos
-Prognóstico
Valores de Referência
Contagem de Células Sanguíneas
Biomarcadores/sangue
Estudos Retrospectivos
Análise de Variância
Sensibilidade e Especificidade
Estatísticas não Paramétricas
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-976864
Autor: Almeida, Hákylla Rayanne Mota de; Santos, Eduila Maria Couto; Dourado, Keila; Mota, Cláudia; Peixoto, Rafaella.
Título: Malnutrition associated with inflammation in the chronic renal patient on hemodialysis
Fonte: Rev. Assoc. Med. Bras. (1992);64(9):837-844, Sept. 2018. tab.
Idioma: en.
Resumo: SUMMARY INTRODUCTION Malnutrition-Inflammation-Atherosclerosis Syndrome is very frequent in patients with chronic kidney disease on haemodialysis. In these patients, the inflammation associated with malnutrition is observed by the Malnutrition-Inflammation Score. OBJECTIVE To analyse the relationship between malnutrition-inflammation-atherosclerosis syndrome and anthropometric and biochemical parameters of patients on haemodialysis. METHODS A cross - sectional study was performed at the Haemodialysis Clinic of the Barão de Lucena Hospital, Recife, Brazil, between July and August 2016, with patients cared at the clinic for at least six months. Patients with amputees, hospitalized, visually impaired, HIV positive, with catheters in the neck, ascites and/or oedema, and those who were unable to provide information at the time of the interview were excluded. The patients were submitted to anthropometric evaluation for the classification of the nutritional status by waist circumference, neck circumference, body mass index, waist-to-hip ratio and waist-to-height ratio. Nutritional status related to inflammation was measured by the Malnutrition-Inflammation Score and nutritional status assessment using biochemical indicators that used urea, creatinine and albumin. RESULTS Twenty-seven individuals of both genders, adults and elderly, aged 51.3 ± 13.3 years old participated in the study. The anthropometric evaluation showed that most of the population presented cardiovascular risk. The biochemical evaluation reported low frequencies of malnutrition. Malnutrition-Inflammation-Atherosclerosis syndrome was evidenced in 3.7% of the patients. The Malnutrition-Inflammation Score had a moderate negative correlation with body mass index, waist circumference, neck circumference, waist-to-height ratio and creatinine. CONCLUSION The correlation seen among the parameters suggests that most of the parameters evaluated can be used as an indirect indicator of malnutrition-inflammation-atherosclerosis syndrome.

RESUMO INTRODUÇÃO A síndrome Desnutrição-Inflamação-Aterosclerose é frequente nos pacientes com doença renal crônica em hemodiálise, acarretando perda de proteínas corporais e produção de citocinas pró-inflamatórias. OBJETIVO Verificar, entre os indicadores nutricionais estudados, aqueles que melhor se correlacionam com a síndrome Desnutrição-Inflamação-Aterosclerose em pacientes submetidos à hemodiálise. MÉTODOS O estudo foi transversal, realizado na Clínica de Hemodiálise do Hospital Barão de Lucena, no Recife (PE), entre julho e agosto de 2016, com pacientes atendidos há pelo menos seis meses. Foram excluídos pacientes amputados, internados, com deficiência visual, cateter no pescoço, HIV positivo, ascite e/ou edema e aqueles incapazes de prestar informações no momento da entrevista. Os pacientes foram submetidos à avaliação antropométrica para a classificação do estado nutricional pela circunferência da cintura, perímetro do pescoço, índice de massa corporal, relação cintura-quadril e relação cintura-estatura. O estado nutricional relacionado à inflamação foi mensurado pelo escore Desnutrição-Inflamação e a avaliação do estado nutricional pelos indicadores bioquímicos: ureia, creatinina e albumina. RESULTADOS Participaram do estudo 27 indivíduos de ambos os sexos, adultos e idosos, com idade de 51,3 ± 13,3 anos. A avaliação antropométrica mostrou que a maior parte da população apresentava risco cardiovascular. A avaliação bioquímica relatou baixas frequências de desnutrição. Foi evidenciada síndrome Desnutrição-Inflamação-Aterosclerose em 3,7% dos pacientes. O escore Desnutrição-Inflamação apresentou correlação moderada negativa com o índice de massa corporal, circunferência da cintura, perímetro do pescoço, relação cintura-estatura e creatinina. CONCLUSÃO A correlação observada entre os parâmetros sugere que a maioria dos parâmetros avaliados pode ser utilizada como indicador indireto da síndrome Desnutrição-Inflamação-Aterosclerose.
Descritores: Diálise Renal/efeitos adversos
Desnutrição/etiologia
Insuficiência Renal Crônica/complicações
Insuficiência Renal Crônica/terapia
Aterosclerose/etiologia
Inflamação/etiologia
-Valores de Referência
Síndrome
Fatores de Tempo
Ureia/sangue
Albumina Sérica/análise
Antropometria
Estado Nutricional
Estudos Transversais
Fatores de Risco
Diálise Renal/métodos
Estatísticas não Paramétricas
Creatinina/sangue
Estilo de Vida
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME



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