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Pesquisa : D12.776.124.050.475 [Categoria DeCS]
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Id: biblio-892897
Autor: Benli, Erdal; Ayyildiz, Sema Nur; Cirrik, Selma; Noyan, Tevfik; Ayyildiz, Ali; Cirakoglu, Abdullah.
Título: Early term effect of ureterorenoscopy (URS) on the Kidney: research measuring NGAL, KIM-1, FABP and CYS C levels in urine
Fonte: Int. braz. j. urol;43(5):887-895, Sept.-Oct. 2017. tab.
Idioma: en.
Projeto: Ordu University Scientific Research Projects Coordination Department.
Resumo: ABSTRACT Aim: URS is a very commonly used procedure for treatment of ureter stones. Increased hydrostatic pressure in the collecting system linked to fluids used during the procedure may cause harmful effects on the kidney. The aim of this study is to determine whether the URS procedure has a negative effect on the kidney by investigating NGAL, KIM-1, FABP and Cys C levels in urine. Material and Methods: This study included 30 patients undergoing ureterorenoscopy (URS) for ureter stones. Urine samples were collected 5 times; before the URS procedure (control) and at 1, 3, 5 and 12 hours following the procedure. NGAL, KIM-1, FBAP and Cys C levels were measured in urine and compared with the control values. Results: The NGAL levels in urine before the procedure and at 1, 3, 5 and 12 hours after the procedure were 34.59±35.34; 62.72±142.32; 47.15±104.48; 45.23±163.16 and 44.99±60.79ng/mL, respectively (p=0.001). Similarly, the urinary KIM-1, FABP and Cys C levels were found to increase compared to control values; however this increase did not reach statistical significance (p >0.05). Conclusions: After the URS procedure, there were important changes in NGAL, FABP, KIM-1 and Cys C levels. These changes reached statistical significance for NGAL, but did not reach significance for the other parameters. In conclusion, the URS procedure significantly affects the kidney; however, this effect disappears over time.
Descritores: Biomarcadores/urina
Cálculos Ureterais/cirurgia
Ureteroscopia/métodos
Pessoa de Meia-Idade
-Cálculos Ureterais/urina
Cistatinas/urina
Ureteroscopia/efeitos adversos
Proteínas de Ligação a Ácido Graxo/urina
Lipocalina-2/urina
Receptor Celular 1 do Vírus da Hepatite A/análise
Limites: Humanos
Masculino
Feminino
Adulto
Idoso
Responsável: BR1.1 - BIREME


  2 / 6 LILACS  
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Carmona, Maria José C
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Id: biblio-1133410
Autor: Silva, Wallace Andrino da; Varela, Carlo Victor A; Pinheiro, Aline Macedo; Scherer, Paula Castro; Francisco, Rossana P; Torres, Marcelo Luis Abramides; Carmona, Maria José C; Bliacheriene, Fernando; Andrade, Lúcia C; Pelosi, Paolo; Malbouisson, Luiz Marcelo S.
Título: Restrictive versus liberal fluid therapy for post-cesarean acute kidney injury in severe preeclampsia: a pilot randomized clinical trial
Fonte: Clinics;75:e1797, 2020. tab, graf.
Idioma: en.
Resumo: OBJECTIVES: The aim of this study was to determine whether a restrictive compared to a liberal fluid therapy will increase postoperative acute kidney injury (AKI) in patients with severe preeclampsia. METHODS: A total of 46 patients (mean age, 32 years; standard deviation, 6.8 years) with severe preeclampsia were randomized to liberal (1500 ml of lactated Ringer's, n=23) or restrictive (250 ml of lactated Ringer's, n=23) intravenous fluid regimen during cesarean section. The primary outcome was the development of a postoperative renal dysfunction defined by AKI Network stage ≥1. Serum cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) were evaluated at postoperative days 1 and 2. ClinicalTrials.gov: NCT02214186. RESULTS: The rate of postoperative AKI was 43.5% in the liberal fluid group and 43.5% in the restrictive fluid group (p=1.0). Intraoperative urine output was higher in the liberal (116 ml/h, IQR 69-191) than in the restrictive fluid group (80 ml/h, IQR 37-110, p<0.05). In both groups, serum cystatin C did not change from postoperative day 1 compared to the preoperative period and significantly decreased on postoperative day 2 compared to postoperative day 1 (p<0.05). In the restrictive fluid group, NGAL levels increased on postoperative day 1 compared to the preoperative period (p<0.05) and decreased on postoperative day 2 compared to postoperative day 1 (p<0.05). CONCLUSION: Among patients with severe preeclampsia, a restrictive fluid regimen during cesarean section was not associated with increased postoperative AKI.
Descritores: Pré-Eclâmpsia
Injúria Renal Aguda/etiologia
Injúria Renal Aguda/terapia
-Biomarcadores
Cesárea/efeitos adversos
Hidratação
Lipocalina-2
Lactato de Ringer
Limites: Humanos
Feminino
Gravidez
Adulto
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


  3 / 6 LILACS  
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Id: biblio-1143983
Autor: Sahinalp, Sahin; Temiztürk, Zeki; Çeviker, Kadir; Özisik, Kanat; Kiziltepe, Ugursay.
Título: Cardiac output values and correlation of renal injury with neutrophil gelatinase-associated lipocalin levels in off-pump coronary artery bypass patients
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);35(6):906-912, Nov.-Dec. 2020. tab, graf.
Idioma: en.
Resumo: Abstract Objective: To investigate the correlation between cardiac output values and renal neutrophil gelatinase-associated lipocalin (NGAL) levels as a biomarker of renal ischemia. Methods: Forty patients, who underwent off-pump coronary artery bypass (OPCAB) surgery and in whom the positioning of the heart was fixed with simple suspension sutures without a mechanical stabilizer, were included in the study. Continuous cardiac output (CO) measurements were recorded using the arterial pressure waveform analysis method (FloTrac sensor system) in the perioperative period. CO was recorded every minute during non-anatomical cardiac positioning for left anterior descending artery (LAD), diagonal artery (D), circumflex artery (Cx), and right coronary artery (RCA) bypasses. Serum NGAL samples were analyzed in the preoperative, perioperative, and postoperative periods. Results: The CO values measured at various non-anatomical cardiac positions during distal anastomosis for LAD, D, Cx, and RCA were significantly lower than pre- and postoperative values measured with the heart in normal anatomical position (3.45±0.78, 2.9±0.71, 3.11±0.56, 3.19±0.81, 5.03±1.4, and 4.85±0.78, respectively, P=0.008). There was no significant difference between CO values measured at various non-anatomical cardiac positions during distal anastomosis. Although there was no significant correlation between NGAL levels and age, duration of surgery, preoperative CO, D-CO, RCA-CO, and postoperative CO measurements, there was a significant correlation between NGAL levels and LAD-CO (P=0.044) and Cx-CO (P=0.018) at the postoperative 12th hour. Conclusion: Full revascularization may be achieved by employing the OPCAB technique while using simple suspension sutures without a mechanical stabilizer and by providing safe CO levels and low risk of renal ischemia.
Descritores: Ponte de Artéria Coronária sem Circulação Extracorpórea
Lipocalina-2/metabolismo
-Débito Cardíaco
Vasos Coronários
Rim
Limites: Humanos
Masculino
Responsável: BR1.1 - BIREME


  4 / 6 LILACS  
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Id: biblio-1053211
Autor: Pokorska, Joanna; Piestrzynska-Kajtoch, Agata; Kulaj, Dominika; Ochrem, Andrzej; Radko, Anna.
Título: Polymorphism of bovine lipocalin-2 gene and its impact on milk production traits and mastitis in Holstein Friesian cattle
Fonte: Electron. j. biotechnol;40:17-21, July. 2019. tab, ilus.
Idioma: en.
Projeto: Ministry of Science and Higher Education in Poland.
Resumo: Background: Mastitis is one of the most serious diseases of dairy cattle, causing substantial financial losses. While predisposition to reduced somatic cell count in milk has been considered for in cattle breeding programs as the key indicator of udder health status, scientists are seeking genetic markers of innate immune response, which could be helpful in selecting cows with improved immunity to mastitis. Lipocalin-2 (LCN2) is a protein involved in the response of the immune system by eliminating iron ions which are necessary for the growth of pathogenic bacteria, so LCN2 may be considered as a natural bacteriostatic agent and could become a marker of infection. Results: A total of five SNPs were identified in LCN2 gene (one in the promoter, three in exon 1, and one in intron 1). A single haplotype block was identified. The locus g.98793763GNC was found to have a significant impact on protein levels in milk, and alleles of this locus were identified to have a significant positive dominance effect on this trait. None of the four analysed loci had a statistically significant impact on the milk yield, fat levels in milk or the somatic cell score. LCN-2 gene had no significant impact on the incidence of mastitis in the cows. Conclusions: Although the identified SNPs were not found to have any impact on the somatic cell count or the incidence of mastitis in cows, it seems that further research is necessary, covering a larger population of cattle, to confirm the association between lipocalin-2 and milk production traits and mastitis.
Descritores: Polimorfismo Genético
Leite/imunologia
Lipocalina-2/genética
Mastite Bovina/genética
-Haplótipos
Cruzamento
Polimorfismo de Nucleotídeo Único
Alelos
Lipocalina-2/química
Glândulas Mamárias Animais
Mastite Bovina/imunologia
Limites: Animais
Bovinos
Responsável: CL1.1 - Biblioteca Central


  5 / 6 LILACS  
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Id: biblio-949360
Autor: Ozturk, Omur; Eroglu, Huseyin Avni; Ustebay, Sefer; Kuzucu, Mehmet; Adali, Yasemen.
Título: An experimental study on the preventive effects of N-acetyl cysteine and ozone treatment against contrast-induced nephropathy
Fonte: Acta cir. bras;33(6):508-517, June 2018. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To compare the preventive effects of N-acetyl cysteine (NAC), ozone preconditioning and ozone treatment against contrast-induced nephropathy (CIN) in an experimental rat model. Methods: Thirty adult male Wistar rats were randomly distributed into five groups (n=6 for each group). Group I served as control and Group II had only contrast agent, while Group III received NAC and Group IV received intraperitoneal ozone 6 hours before and 6 hours after introduction of contrast agent. Ozone treatment was applied for 5 days after the contrast agent was introduced in Group V. After induction of CIN, groups were compared in terms of serum levels of urea, creatinine, neutrophil gelatinase associated lipocalin, protein carbonyl, total antioxidant capacity (TAC) as well as degree of renal injury at histopathologic level. Results: Groups II-V displayed more obvious histopathological alterations such as hemorrhage and renal tubular injury compared with Group I. TAC (p=0.043) and creatinine (p=0.046) levels increased significantly in Group II after the intervention. In Group III, protein carbonyl level diminished remarkably (p=0.046), while creatinine level was increased (p=0.046) following the intervention. TAC level was higher in Group IV (p=0.028) and Group V (p=0.026) following the procedure. Conclusion: The N-acetyl cysteine and ozone treatment may alleviate the biochemical and histopathological deleterious effects of contrast-induced nephropathy via enhancement of total antioxidant capacity and decreasing oxidative stress.
Descritores: Ozônio/farmacologia
Acetilcisteína/farmacologia
Meios de Contraste/efeitos adversos
Nefropatias/induzido quimicamente
Nefropatias/prevenção & controle
Antioxidantes/farmacologia
-Valores de Referência
Espectrofotometria/métodos
Ureia/sangue
Ácido Ioxáglico/efeitos adversos
Distribuição Aleatória
Reprodutibilidade dos Testes
Resultado do Tratamento
Ratos Wistar
Estresse Oxidativo/efeitos dos fármacos
Creatinina/sangue
Carbonilação Proteica
Lipocalina-2/sangue
Rim/efeitos dos fármacos
Rim/patologia
Nefropatias/patologia
Limites: Animais
Masculino
Tipo de Publ: Estudo Comparativo
Estudo de Avaliação
Responsável: BR1.1 - BIREME


  6 / 6 LILACS  
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Id: biblio-839292
Autor: Lobato, GR; Lobato, MR; Thomé, FS; Veronese, FV.
Título: Performance of urinary kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, and N-acetyl-beta-D-glucosaminidase to predict chronic kidney disease progression and adverse outcomes
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(5):e6106, 2017. tab.
Idioma: en.
Resumo: Urinary biomarkers can predict the progression of chronic kidney disease (CKD). In this study, kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and N-acetyl-β-D-glucosaminidase (NAG) were correlated with the stages of CKD, and the association of these biomarkers with CKD progression and adverse outcomes was determined. A total of 250 patients, including 111 on hemodialysis, were studied. Urinary KIM-1, NGAL, and NAG were measured at baseline. Patients not on dialysis at baseline who progressed to a worse CKD stage were compared with those who did not progress. The association of each biomarker and selected covariates with progression to more advanced stages of CKD, end-stage kidney disease, or death was evaluated by Poisson regression. NGAL was moderately correlated (rs=0.467, P<0.001) with the five stages of CKD; KIM-1 and NAG were also correlated, but weakly. Sixty-four patients (46%) progressed to a more advanced stage of CKD. Compared to non-progressors, those patients exhibited a trend to higher levels of KIM-1 (P=0.064) and NGAL (P=0.065). In patients not on dialysis at baseline, NGAL was independently associated with progression of CKD, ESKD, or death (RR=1.022 for 300 ng/mL intervals; CI=1.007-1.037, P=0.004). In patients on dialysis, for each 300-ng/mL increase in urinary NGAL, there was a 1.3% increase in the risk of death (P=0.039). In conclusion, urinary NGAL was associated with adverse renal outcomes and increased risk of death in this cohort. If baseline urinary KIM-1 and NGAL predict progression to worse stages of CKD is something yet to be explored.
Descritores: Acetilglucosaminidase/urina
Receptor Celular 1 do Vírus da Hepatite A/análise
Lipocalina-2/urina
Insuficiência Renal Crônica/patologia
Insuficiência Renal Crônica/urina
-Fatores Etários
Análise de Variância
Biomarcadores/urina
Creatinina/sangue
Creatinina/urina
Progressão da Doença
Taxa de Filtração Glomerular
Valor Preditivo dos Testes
Padrões de Referência
Valores de Referência
Diálise Renal
Insuficiência Renal Crônica/complicações
Insuficiência Renal Crônica/fisiopatologia
Reprodutibilidade dos Testes
Fatores de Risco
Fatores Sexuais
Estatísticas não Paramétricas
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME



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