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Id: lil-762615
Autor: Nieto, Elena; Roco, Ángela; Moreno, Marcelo; Carrasco, Victoria; Geraldo, Angel; Rodríguez, Betty; Zagmutt, Omar; Gallardo, Carlos; Peters, Jacqueline.
Título: Calidad de las tromboplastinas utilizadas en el laboratorio clínico y en los equipos POCT y su impacto en la dosificación de acenocumarol en pacientes con terapia anticoagulante oral / Types of thromplastin used for INR determination in patients under chronic oral anticoagulant treatment: discrepancies that may affect the dose of coumarin derivatives needed for treatment safety
Fonte: Rev. chil. cardiol;34(2):134-139, 2015. graf, tab.
Idioma: es.
Resumo: Antecedentes: El monitoreo del tratamiento con anticoagulantes cumarínicos se realiza a través del INR (International Normalized Ratio) que es el parámetro estandarizado del Tiempo de Protrombina. Las recomendaciones de la OMS indican que la precisión en el cálculo del INR puede ser mejorada usando reactivo de tromboplastina con Indice de Sensibilidad Internacional (ISI) bajo, considerándose como ISI de referencia internacional el valor 1,0. Debido a incongruencias observadas en los INR de pacientes controlados en el Servicio de Salud Metropolitano Occidente, comparando valores de muestra venosa con resultados de INR capilar obtenidos en el mismo paciente el mismo día y hora (con reactivos Tromboplastina de distinto ISI), se efectuó un ensayo clínico cruzado entre los distintos métodos. Materiales y métodos: En 100 pacientes se comparó INR venoso con dos tromboplastinas de diferente ISI (1,3 y 1,0) vs aquel efectuado con muestra capilar (ISI 1,0). Resultados: Los resultados del estudio muestran que a partir de valores de INR 3,0 las determinaciones obtenidas usando Tromboplastina de cerebro de conejo ISI=1,3 subestiman el valor de INR para un mismo paciente y una misma muestra. Conclusiones: El uso de Tromboplastina recombinante humana ISI 1,0 permite evitar la subestimación del INR en pacientes con mayor riesgo tromboembóli-co (indicación de INR objetivo más alto). Por ello, este método se adoptó en el control del TACO en pacientes controlados en el Servicio de Salud Occidente.

Background: INR (International Normalized Ratio) is the standard Prothrombin Time parameter for monitoring anticoagulant treatment with coumarin derivatives Recommendations of WHO indicate that precision in the calculation of the INR can be improved using thromboplastins with a low Index of International Sensibility (ISI=1,0). Discrepancies in INR obtained using either this technique or conventional rabbit brain derived reagents in the same sample in patients attending the Servicio de Salud Metropolitano Occidente (West Metropolitan Health Service) were observed. Our objective was to evaluate these discrepancies in a systematic way. Materials and methods: A comparative study was conducted using two thromboplastins of different ISI (1.0 and 1.3) for the calculation of venous INR in comparison with capillary INR in 100 patients. Results: The study showed that INR values may differ significantly according to the method used. In particular, rabbit brain thromboplastin ISI = 1.3 underestimates the value of INR in the range of INR ≥3.0. Conclusions: The use of human recombinant thromboplastin ISI= 1.0. for determination of INR may significantly decrease the risk of hemorrhagic complications in patients requiring higher levels of anticoagulation.
Descritores: Coagulação Sanguínea/efeitos dos fármacos
Tromboplastina/administração & dosagem
Tromboplastina/normas
Acenocumarol/administração & dosagem
-Tempo de Protrombina
Hemostáticos/administração & dosagem
Administração Oral
Coeficiente Internacional Normatizado
Anticoagulantes
Limites: Seres Humanos
Masculino
Feminino
Meia-Idade
Idoso
Tipo de Publ: Estudo Comparativo
Responsável: CL1.1 - Biblioteca Central


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Id: lil-633034
Autor: Detarsio, Germán Alejandro; Soler, Cristina; Paredes, Josefina; Milani, Ángela Cristina; Ordi-Ros, José.
Título: Anticoagulante Lúpico: Sensibilidad de 19 reactivos comerciales de tiempo de tromboplastina parcial activado / Lupus Anticoagulant: Sensitivity of 19 commercial activated partial thromboplastin time reagents
Fonte: Acta bioquím. clín. latinoam;41(4):533-539, oct.-dic. 2007. graf, tab.
Idioma: es.
Resumo: El Anticoagulante Lúpico (AL) constituye una familia de inmunoglobulinas que interfieren las pruebas de coagulación dependientes de fosfolípidos. Hay una gran variedad de pruebas que permiten detectar y confirmar la presencia de AL en el plasma de un paciente. Sin embargo, el tiempo de tromboplastina parcial activado (TTPA) sigue siendo una de las pruebas más utilizadas para la detección de dicho inhibidor. Teniendo en cuenta la importancia clínica de su diagnóstico de laboratorio, se dicidió estudiar la sensibilidad, para detectar AL, de 19 reactivos comerciales de TTPA. Se obtuvieron varias conclusiones importantes: No se encontró relación entre sensibilidad y tamaño de los liposomas; tampoco con la uniformidad de los mismos. La fuente de fosfolípido y el tipo de activador no son suficientes para explicar las diferencias en sensibilidad de los reactivos. Finalmente, se encontró una correlación negativa entre la sensibilidad y la concentración total de fosfolípido del reactivo. A menor concentración de fosfolípido, mayor sensibilidad.

Lupus anticoagulants (LA) are immunoglobulins which interfere in in vitro phospholipid-dependent coagulation tests. Various methods have been proposed; however, activated partial thromboplastin time (APTT) is the most used screening test for lupus anticoagulant. Previous studies have shown that sensitivity to the lupus anticoagulant defect varies considerably with different APTT reagents. In view of the undoubted clinical importance of lupus anticoagulants, the sensitivity of 19 commercial APTT reagents has been evaluated. The study raises several important conclusions: No difference was found in sensitivity associated with a narrower distribution of liposomes' diameter, considering the latter as a marker of uniformity in phospholipid distribution. The source of the platelet substitute and the nature of the contact phase activator are unlikely to determine such varied sensitivity. Finally, a significant negative correlation between APTT sensitivity and total phospholipid concentration was found. The lower the phospholipid concentration, the higher the APTT sensitivity to AL.
Descritores: Tempo de Tromboplastina Parcial
Síndrome Antifosfolipídica
Anticoagulantes
-Trombose
Tromboplastina
Hemostasia
Limites: Seres Humanos
Criança
Adolescente
Adulto
Meia-Idade
Idoso
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas


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Id: biblio-841176
Autor: GOCMEN, Gokhan; AKTOP, Sertac; TÜZÜNER, Burcin; GOKER, Bahar; YARAT, Aysen.
Título: Effects of hyaluronic acid on bleeding following third molar extraction
Fonte: J. appl. oral sci;25(2):211-216, Mar.-Apr. 2017. tab, graf.
Idioma: en.
Resumo: Abstract Objective To explore the effects of hyaluronic acid (HA) on bleeding and associated outcomes after third molar extraction. Methods Forty patients who had undergone molar extraction were randomly divided into two groups; 0.8% (w/v) HA was applied to the HA group (n=20) whereas a control group (n=20) was not treated. Salivary and gingival tissue factor (TF) levels, bleeding time, maximum interincisal opening (MIO), pain scored on a visual analog scale (VAS), and the swelling extent were compared between the two groups. Results HA did not significantly affect gingival TF levels. Salivary TF levels increased significantly 1 week after HA application but not in the control group. Neither the VAS pain level nor MIO differed significantly between the two groups. The swelling extent on day 3 and the bleeding time were greater in the HA group than in the control group. Conclusions Local injection of HA at 0.8% prolonged the bleeding time, and increased hemorrhage and swelling in the early postoperative period after third molar extractions.
Descritores: Anti-Inflamatórios/efeitos adversos
Ácido Hialurônico/efeitos adversos
Dente Serotino/cirurgia
Hemorragia Pós-Operatória/induzido quimicamente
Extração Dentária/efeitos adversos
-Tempo de Sangramento
Gengiva/química
Medição da Dor
Estudos Prospectivos
Valores de Referência
Saliva/química
Estatísticas não Paramétricas
Tromboplastina/análise
Fatores de Tempo
Extração Dentária/métodos
Resultado do Tratamento
Cicatrização/efeitos dos fármacos
Limites: Seres Humanos
Adolescente
Adulto
Adulto Jovem
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: biblio-833158
Autor: Soares, Andréia Assunção; Vicente, Johany Diego; Possamai, Monique Catarine Fischer; Santos, Gabriela Rocha; Otutumi, Luciana Kazue; Piau Júnior, Ranulfo; Almada, André Felipe Berto; Germano, Ricardo de Melo.
Título: Avaliação da peroxidação lipídica no plasma de ratos submetidos à lesão tecidual e tratados com hidrogel de poliamido de mandioca / Evaluación de la peroxidación de lípidos en plasma de ratas sometidas a lesión tisular y tratadas con hidrogel de poliamida de yuca / Evaluación de la peroxidación de lípidos en plasma de ratas sometidas a lesión tisular y tratadas con hidrogel de poliamida de yuca
Fonte: Arq. ciênc. vet. zool. UNIPAR;19(3):175-178, jul.-set. 2016. tab.
Idioma: pt.
Resumo: As espécies reativas ao oxigênio (EROS) são produzidas como mecanismo de defesa celular, participando dos processos de cicatrização celular. Entretanto, altos níveis de EROS podem causar danos como a peroxidação lipídica (PL). O presente estudo teve como objetivo, verificar os níveis de PL por meio da determinação das substâncias reativas ao ácido tiobarbitúrico (TBARS) no plasma de ratos com lesão tecidual induzida. Foram utilizados 32 ratos machos, Rattus norvegicus albinus da linhagem Wistar, os quais foram pesados e da média ± 10% do peso foram distribuídos em quatro grupos: A ­ controle negativo; B - Vetaglós®; C ­ hidrogel de poliamido de mandioca+ Vetaglós®; D ­ Hidrogel de poliamido de mandioca. Após 21 dias, todos os animais foram anestesiados com isoflurano e foi feita a coleta de sangue por punção cardíaca, e os plasmas foram obtidos após centrifugação, na sequência por superdosagem do anestésico foi realizada a eutanásia. Os níveis de PL nos plasmas dos ratos foram determinados pelo método do TBARS. Não houve diferença significativa entre os grupos em relação à PL, indicando um equilíbrio entre as defesas antioxidantes celulares e os níveis de EROS produzidos durante o processo de cicatrização celular. Essa ausência nos diferentes grupos experimentais, em relação à PL, deixa claro a importância de se contemplar estudos de parâmetros de bioindicadores de estresse oxidativo em protocolos experimentais.

Reactive oxygen species (ROS) are produced as a cellular defense mechanism, participating in the processes of cellular healing. However, high levels of ROS can cause damages such as lipid peroxidation (LPO). This study aimed to verify the levels of LPO through the determination of reactive substances to thiobarbituric acid (TBARS) in rat plasma with induced tissue injury. A total of 32 Rattus norvegicus albinus Wistar were used, with a mean weight ± 10%. They were divided into four groups: A ­ negative control; B - Vetaglós®; C - Polyamide cassava; D - Polyamide cassava + Vetaglós®. After 21 days, all animals were anesthetized with isoflurane and blood was collected by cardiac puncture. Plasma was obtained after centrifugation. Euthanasia was performed with administration of an overdose of inhalational anesthetic previously used. The LPO levels in rat plasma were determined using the TBARS method. There was no significant difference between the groups in relation to LPO, indicating a balance between antioxidant defenses and cellular levels of ROS produced during the cellular healing process. This absence in the different experimental groups in relation to LPO emphasizes the importance of further studies related to the bio-indicator parameters for oxidative stress in experimental protocols.

Las especies reactivas al oxígeno (EROS) se producen como mecanismo de defensa celular, que participan en los procesos de curación celulares. Sin embargo, los altos niveles de EROS pueden causar daños como la peroxidación lipídica (PL). Este estudio tuvo como objetivo verificar los niveles de peroxidación lipídica por sustancias reactivas al ácido tiobarbitúrico (TBARS) en el plasma de ratas con lesión tisular inducida. Se han utilizado 32 ratas machos, Rattus norvegicus albinus de linaje Wistar, que se pesaron y la media ± 10% en peso, y se dividieron en cuatro grupos: A ­ control negativo; B - Vetaglós®; C ­ hidrogel de poliamida de yuca + Vetaglós®; D ­ Hidrogel de poliamida de yuca. Después de 21 días, todos los animales fueron anestesiados con isoflurano y se hizo la extracción de sangre por punción cardiaca, y se obtuvieron los plasmas después de la centrifugación, enseguida con sobredosis de anestésico se realizó la eutanasia. Los niveles de PL en los plasmas de las ratas se determinaron por el método de TBARS. No hubo diferencia significativa entre los grupos en relación a la peroxidación lipídica, lo que indica un equilibrio entre las defensas antioxidantes celulares y los niveles de EROS producidos durante el proceso de curación celular. Esa ausencia en los diferentes grupos experimentales, en relación a la PL, pone de manifiesto la importancia de contemplarse estudios de parámetros de bioindicadores de estrés oxidativo en los protocolos experimentales.
Descritores: Hidrogel de Polietilenoglicol-Dimetacrilato/análise
Peroxidação de Lipídeos
Espécies Reativas de Oxigênio/análise
-Tromboplastina/administração & dosagem
Limites: Animais
Ratos
Responsável: BR1532.9 - CEDIC - Coordenadoria de Editoração e Divulgação Científica


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Id: lil-796907
Autor: Nogueira, Maria Renata Sales; Latini, Ana Carla Pereira; Nogueira, Maria Esther Salles.
Título: The involvement of endothelial mediators in leprosy
Fonte: Mem. Inst. Oswaldo Cruz;111(10):635-641, Oct. 2016. tab, graf.
Idioma: en.
Projeto: CNPq.
Resumo: Leprosy is a chronic infectious disease that requires better understanding since it continues to be a significant health problem in many parts of the world. Leprosy reactions are acute inflammatory episodes regarded as the central etiology of nerve damage in the disease. The activation of endothelium is a relevant phenomenon to be investigated in leprosy reactions. The present study evaluated the expression of endothelial factors in skin lesions and serum samples of leprosy patients. Immunohistochemical analysis of skin samples and serum measurements of VCAM-1, VEGF, tissue factor and thrombomodulin were performed in 77 leprosy patients and 12 controls. We observed significant increase of VCAM-1 circulating levels in non-reactional leprosy (p = 0.0009). The immunostaining of VEGF and tissue factor was higher in endothelium of non-reactional leprosy (p = 0.02 for both) than healthy controls. Patients with type 1 reaction presented increased thrombomodulin serum levels, compared with non-reactional leprosy (p = 0.02). In type 2 reaction, no significant modifications were observed for the endothelial factors investigated. The anti-inflammatory and antimicrobial activities of the endotfhelial factors may play key-roles in the pathogenesis of leprosy and should be enrolled in studies focusing on alternative targets to improve the management of leprosy and its reactions.
Descritores: Hanseníase/metabolismo
Pele/patologia
Trombomodulina/análise
Tromboplastina/análise
Molécula 1 de Adesão de Célula Vascular/análise
Fator A de Crescimento do Endotélio Vascular/análise
-Biomarcadores/análise
Biomarcadores/metabolismo
Ensaio de Imunoadsorção Enzimática
Imuno-Histoquímica
Hanseníase/patologia
Trombomodulina/metabolismo
Tromboplastina/metabolismo
Molécula 1 de Adesão de Célula Vascular/metabolismo
Fator A de Crescimento do Endotélio Vascular/metabolismo
Limites: Seres Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: lil-746995
Autor: Oscanoa-Espinoza, Teodoro; Lizaraso-Soto, Frank.
Título: Antiinflamatorios no esteroides: seguridad gastrointestinal, cardiovascular y renal / Nonsteroidal antiinflammatory drugs: gastrointestinal and cardiovascular and renal safety
Fonte: Rev. gastroenterol. Perú;35(1):63-71, ene. 2015. tab.
Idioma: es.
Resumo: La selección de un medicamento específico perteneciente a una clase farmacológica es bajo criterios de eficacia, seguridad, costo y conveniencia. Los Antiinflamatorios No Esteroideos (AINEs) actualmente se constituyen en uno de los medicamentos más consumidos en el mundo, por lo tanto es de gran importancia la revisión de los aspectos de seguridad de este grupo farmacológico. El presente trabajo tiene el objetivo de analizar bajo las evidencias disponibles hasta la actualidad, la seguridad de los AINES con 3 criterios principales: gastrolesividad, cardiotoxicidad y nefrotoxicidad.

The choice of a specific medication belonging to a drug class is under the criteria of efficacy, safety, cost and suitability. NSAIDs currently constitute one of the most consumed drugs in the world, so it is very important review of the safety aspects of this drug class. This review has the objective of analyze the safety of NSAIDs on 3 main criteria: gastrolesivity, cardiotoxicity and nephrotoxicity.
Descritores: Macrófagos/metabolismo
Tromboplastina/metabolismo
Trombose/sangue
Trombose/terapia
-Apolipoproteínas E/metabolismo
Coagulação Sanguínea/fisiologia
MICE, INBRED CABDOMENABDOMINAL INJURIESBL
Trombose/prevenção & controle
Limites: Animais
Feminino
Seres Humanos
Camundongos
Tipo de Publ: Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: lil-723966
Autor: Silva, Daniel D'Oliveira; Noronha, Jorge Antonio Pastro; Silva, Vinicius Duval da; Carvalhal, Gustavo Franco.
Título: Increased Tissue Factor Expression is an Independent Predictor of Mortality in Clear Cell Carcinoma of the Kidney
Fonte: Int. braz. j. urol;40(4):499-506, Jul-Aug/2014. tab, graf.
Idioma: en.
Resumo: Purpose Increased expression of tissue factor (TF), a primary initiator of the extrinsic coagulation pathway, has been associated with a worse prognosis in a variety of solid tumors. We report for the first time the correlation of the immunohistochemical expression of tissue factor with clinical and pathological outcomes in clear cell carcinomas of the kidney. Materials and Methods immunohistochemical expression of tissue factor was evaluated in 58 paraffin-embedded samples of clear cell carcinomas of the kidney treated at the same university hospital, that was correlated with clinical and pathological variables and with overall survival. Results high intensity tissue factor expression (TF area > 10µm2) was observed in 22.4% of the tumors (13 patients), and was an important predictor of overall mortality, both in univariate and multivariate analysis (p < 0.05). Median overall survival for both groups was 66 months; 78.2 months for patients in the group of lower TF expression and 27.5 months for patients in the group of higher TF expression (log rank p < 0.001). The hazard ratio for mortality was 9.7 (CI 3.7-25.6) for tumors with increased TF expression. Conclusions Increased immunohistochemical expression of TF was an important independent predictor of mortality in a contemporary cohort of patients with clear cell carcinoma of the kidney. Further studies are necessary to define the role of TF in clinical practice. .
Descritores: Carcinoma de Células Renais/mortalidade
Neoplasias Renais/mortalidade
Tromboplastina/metabolismo
Biomarcadores Tumorais/metabolismo
-Estudos de Coortes
Carcinoma de Células Renais/metabolismo
Carcinoma de Células Renais/patologia
Imuno-Histoquímica
Estimativa de Kaplan-Meier
Neoplasias Renais/metabolismo
Neoplasias Renais/patologia
Análise Multivariada
Valor Preditivo dos Testes
Prognóstico
Fatores de Tempo
Carga Tumoral
Limites: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-573690
Autor: Dong, Xia; Song, Li-ping; Zhu, Dun-wan; Zhang, Hai-ling; Liu, Lan-xia; Leng, Xi-gang.
Título: Impact of the tissue factor pathway inhibitor gene on apoptosis in human vascular smooth muscle cells
Fonte: Genet. mol. biol;34(1):25-30, 2011. graf.
Idioma: en.
Resumo: Tissue factor pathway inhibitor (TFPI) plays a vitally important role in the blood coagulation pathway. Recent studies indicated that TFPI induces apoptosis in vascular smooth-muscle cells (VSMCs) in animals. The present study investigated whether the TFPI gene could also induce apoptosis in human vascular smooth-muscle cells (hVSMCs). Such cells were isolated from human umbilical arteries and subsequently transfected with pIRES-TFPI plasmid (2 μg/mL). MTT assaying and cell counting were applied to measure cell viability and proliferation, RT-PCR was utilized to analyze TFPI gene expression in the cells. Apoptosis was analyzed by fluorescence activated cell sorting (FACS). Several key proteins involved in apoptosis were examined through Western blotting. It was shown that TFPI gene transfer led to its increased cellular expression, with a subsequent reduction in hVSMC proliferation. Further investigation demonstrated that TFPI gene expression resulted in lesser amounts of procaspase-3, procaspase-8 and procascase-9, and an increased release of mitochondrial cytochrome c (cyt-c) into cytoplasm, thereby implying the involvement of both extrinsic and intrinsic pathways in TFPI gene-induced apoptosis in hVSMCs.
Descritores: Apoptose
Músculo Liso Vascular
Tromboplastina
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Carvalho, Maria das Gracas
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Id: lil-571635
Autor: Ferreira, Cláudia Natália; Sousa, Marinez de Oliveira; Dusse, Luci Maria Sant'Ana; Carvalho, Maria das Graças.
Título: O novo modelo da cascata de coagulação baseado nas superfícies celulares e suas implicações / A cell-based model of coagulation and its implications
Fonte: Rev. bras. hematol. hemoter;32(5):416-421, 2010. ilus.
Idioma: pt.
Resumo: O conceito da cascata da coagulação descreve as interações bioquímicas dos fatores da coagulação, entretanto, tem falhado como um modelo do processo hemostático in vivo. A hemostasia requer a formação de um tampão de plaquetas e fibrina no local da lesão vascular, bem como a permanência de substâncias procoagulantes ativadas nesse processo no sítio da lesão. O controle da coagulação sanguínea é realizado por meio de reações procoagulantes em superfícies celulares específicas e localizadas, evitando a propagação da coagulação no sistema vascular. Uma análise crítica do papel das células no processo hemostático permite a construção de um modelo da coagulação que melhor explica hemorragias e tromboses in vivo. O modelo da coagulação baseado em superfícies celulares substitui a tradicional hipótese da "cascata" e propõe a ativação do processo de coagulação sobre diferentes superfícies celulares em quatro fases que se sobrepõem: iniciação, amplificação, propagação e finalização. O modelo baseado em superfícies celulares permite um maior entendimento de como a hemostasia funciona in vivo e esclarece o mecanismo fisiopatológico de certos distúrbios da coagulação.

The concept of a coagulation cascade describes the biochemical interactions of the coagulation factors, but it is flawed as a model of the in vivo hemostatic process. Hemostasis requires both platelet and fibrin plug formation at the site of vessel injury and that the procoagulant substances activated in this process remain at the site of injury. This control of blood coagulation is accomplished as the procoagulant reactions only exist on specific cell surfaces to keep coagulation from spreading throughout the vascular system. A model of coagulation that better explains bleeding and thrombosis in vivo created after considering the critical role of cells. The cellbased model of hemostasis replaces the traditional "cascade" hypothesis, and proposes that coagulation takes place on different cell surfaces in four overlapping steps: initiation, amplification, propagation and termination. The cell-based model allows a more thorough understanding of how hemostasis works in vivo, and sheds light on the pathophysiological mechanism for certain coagulation disorder.
Descritores: Anticoagulantes
Antitrombinas
Coagulação Sanguínea
Fatores de Coagulação Sanguínea
Hemostasia
Proteína C
Proteína S
Plaquetas/metabolismo
Tromboplastina
Transtornos da Coagulação Sanguínea/fisiopatologia
Limites: Seres Humanos
Responsável: BR408.1 - Biblioteca da Faculdade de Medicina - BFM


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Id: lil-543572
Autor: Meis, E. de; Azambuja, D; Ayres-Silva, J. P; Zamboni, M; Pinheiro, V. R; Levy, R. A; Monteiro, R. Q.
Título: Increased expression of tissue factor and protease-activated receptor-1 does not correlate with thrombosis in human lung adenocarcinoma
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;43(4):403-408, Apr. 2010. ilus, tab, graf.
Idioma: en.
Resumo: A correlation between cancer and hypercoagulability has been described for more than a century. Patients with cancer are at increased risk for thrombotic complications and the clotting initiator protein, tissue factor (TF), is possibly involved in this process. Moreover, TF may promote angiogenesis and tumor growth. In addition to TF, thrombin seems to play a relevant role in tumor biology, mainly through activation of protease-activated receptor-1 (PAR-1). In the present study, we prospectively studied 39 lung adenocarcinoma patients in relation to the tumor expression levels of TF and PAR-1 and their correlation with thrombosis outcome and survival. Immunohistochemical analysis showed TF positivity in 22 patients (56 percent), most of them in advanced stages (III and IV). Expression of PAR-1 was found in 15 patients (39 percent), most of them also in advanced stages (III and IV). Remarkably, no correlation was observed between the expression of TF or PAR-1 and risk for thrombosis development. On the other hand, patients who were positive for TF or PAR-1 tended to have decreased long-term survival. We conclude that immunolocalization of either TF or PAR-1 in lung adenocarcinoma may predict a poor prognosis although lacking correlation with thrombosis outcome.
Descritores: Adenocarcinoma/complicações
Neoplasias Pulmonares/complicações
Receptor PAR-1/metabolismo
Tromboplastina/metabolismo
Trombose/etiologia
-Adenocarcinoma/metabolismo
Imuno-Histoquímica
Neoplasias Pulmonares/metabolismo
Inoculação de Neoplasia
Prognóstico
Estudos Prospectivos
Receptor PAR-1/análise
Tromboplastina/análise
Trombose/metabolismo
Limites: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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