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Id: biblio-1135228
Autor: Barbosa, Tatiane Alves; Laboratório de Referência Nacional para Esquistossomose-MalacologiaThiengo, Silvana Carvalho; Laboratório de Referência Nacional para Esquistossomose-MalacologiaFernandez, Monica Ammon; Núcleo de Doenças InfecciosasGraeff-Teixeira, Carlos; Morassutti, Alessandra Loureiro; Mourão, Fábio Rodrigo Paixão; Miranda, Clóvis Omar Sá; Jorge, Michel de Moraes; Laboratório de Referência Nacional para Esquistossomose-MalacologiaCosta, Liliane Freitas; Laboratório de Referência Nacional para Esquistossomose-MalacologiaGomes, Suzete Rodrigues.
Título: Infection by Angiostrongylus cantonensis in both humans and the snail Achatina (Lissachatina) fulica in the city of Macapá, in the Amazon Region of Brazil
Fonte: Mem. Inst. Oswaldo Cruz;115:e200115, 2020.
Idioma: en.
Resumo: In January and February 2019, a malacological survey was conducted in the area surrounding the residence of a 12-year-old child that had contracted cerebral angiostrongyliasis in the municipality of Macapá, capital of the Amapá State, northern Brazil. The serological examination was positive for Angiostrongylus cantonensis infection, the principal etiological agent of this parasitosis. A sample of 54 molluscs was artificially and individually digested for parasitological analysis, containing 38 specimens of Achatina fulica, nine specimens of Bulimulus tenuissimus and seven specimens of Sarasinula linguaeformis. A. fulica was the most abundant mollusc, and the only species infected with A. cantonensis, as well as presenting co-infections with other nematodes. This is the first report of cerebral angiostrongyliasis in the Amazon Region, and the first record of A. fulica infected with A. cantonensis in Amapá. These findings highlight the potential risks of human angiostrongyliasis, and the need to implement public health measures to control the spread of the disease.
Descritores: Caramujos/parasitologia
Infecções por Strongylida/diagnóstico
Infecções por Strongylida/veterinária
Angiostrongylus cantonensis/isolamento & purificação
-Brasil
Anticorpos Anti-Helmínticos
Cidades
Infecções por Strongylida/parasitologia
DNA de Helmintos/genética
DNA de Helmintos/química
Limites: Humanos
Animais
Criança
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
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Id: biblio-844442
Autor: Cardona-Arias, Jaiberth Antonio; Carrasquilla-Agudelo, Yoneida Elena; Restrepo-Posada, Deisy Cristina.
Título: Validez de tres métodos de inmuno-diagnóstico de neurocisticercosis: revisión sistemática de la literatura con meta-análisis 1960-2014 / Validity of three methods for inmuno-diagnostic of neurocysticercosis: systematic review of the literature with meta-analysis 1960-2014
Fonte: Rev. chil. infectol;34(1):33-44, feb. 2017. ilus, graf, tab.
Idioma: es.
Resumo: Introduction: The screening of neurocysticercosis is complex and immunological methods have varying validity. Objective: To evaluate the validity of ELISA for antigen and antibody, and EITB for antibody in the screening of neurocysticercosis. Methods: Meta-analysis of diagnostic tests with an ex-ante protocol implemented in five databases with 15 search strategies, ensuring reproducibility in the selection and extraction of information. Sensitivity, specificity, likelihood ratios (LR), diagnostic odds ratio and ROC curve were estimated in MetaDiSc, and predictive values, and Youden index were estimated in Epidat. Results: EITB presented sensitivity of 85.7% (95% CI 83.5-87.7), specificity 93.9% (95% CI = 92.7-95.0), PLR 19.6 (95% CI = 8,6-44.6), NLR 0.16 (95% CI = 0.12-0.21), OR diagnostic 136.2 (95% CI = 54.7-342.6) and area under the curve 0.926. In ELISA for antibody sensitivity was 87.5% (95% CI = 86.1-88.8), specificity 92.2% (95% CI = 91.4-93.0), PLR 11.3 (95% CI = 8.45-15.11), NLR 0.15 (95% CI = 0.13-0.18), diagnostic OR 87.4 (95% CI = 60.1-127.1) and area under the curve 0.950. ELISA for antigen showed low diagnostic validity. No differences were found in these parameters by sample, antigen or antibody type. Conclusion: ELISA for antibodies and EITB have a similar diagnostic value, detection of serum and CSF showed a similar validity.

Introducción: La tamización de neurocisticercosis es compleja y los métodos inmunológicos presentan validez variable y generalmente bajos tamaños de muestra. Objetivo: Evaluar la validez de ELISA para detección de antígeno y anticuerpo, y EITB para detección de anticuerpo en la tamización de neurocisticercosis. Métodos: Meta-análisis de pruebas diagnósticas con un protocolo ex-ante aplicado en cinco bases de datos con 15 estrategias de búsqueda, garantizando reproducibilidad en la selección y extracción de la información. Se estimó sensibilidad, especificidad, cocientes de probabilidad (CP), razón de odds diagnósticas y curva ROC en MetaDiSC, y valores predictores, índice de Youden y exactitud en Epidat. Resultados: EITB presentó sensibilidad de 85,7% (IC 95% = 83,5-87,7), especificidad 93,9% (IC9 5% = 92,7-95,0), CPP 19,6 (IC 95% = 8,6-44,6), CPN 0,16 (IC 95% = 0,12-0,21), OR diagnóstica 136,2 (IC 95% = 54,7-342,6) y área bajo la curva 0,926. En ELISA para anticuerpos la sensibilidad fue 87,5% (IC 95% = 86,1-88,8), especificidad 92,2% (IC 95% = 91,4-93,0), CPP 11,3 (IC 95% = 8,45-15,11), CPN 0,15 (IC 95% = 0,13-0,18), OR diagnóstica 87,4 (IC 95% = 60,1-127,1) y área bajo la curva 0,950. ELISA para antígeno presentó baja validez diagnóstica. No se hallaron diferencias en estos parámetros según tipo de muestra, antígeno o anticuerpo. Conclusión: ELISA para anticuerpos y EITB presentan una utilidad diagnóstica similar, la detección de suero presentó una validez similar al líquido cefalorraquídeo.
Descritores: Taenia/imunologia
Anticorpos Anti-Helmínticos/sangue
Técnicas Imunoenzimáticas/métodos
Neurocisticercose/diagnóstico
Antígenos de Helmintos/imunologia
-Ensaio de Imunoadsorção Enzimática
Reprodutibilidade dos Testes
Curva ROC
Sensibilidade e Especificidade
Limites: Humanos
Tipo de Publ: Revisão
Metanálise
Estudo de Validação
Revisão Sistemática
Responsável: CL1.1 - Biblioteca Central


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Chieffi, Pedro P
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Id: biblio-1011925
Autor: Toledo, Beatriz; Corral, Marcelo A; Meisel, Dirce Mary C L; Gottardi, Maiara; Abdala, Edson; Costa, Silvia F; Pierrotti, Lígia Camera; Lescano, Susana A Z; Gonçalves, Elenice M N; Castilho, Vera L P; Chieffi, Pedro P; Gryschek, Ronaldo C B; Paula, Fabiana M.
Título: Screening of Strongyloides infection using an ELISA test in transplant candidates
Fonte: Clinics;74:e698, 2019. graf.
Idioma: en.
Projeto: FAPESP.
Resumo: OBJECTIVES: Hyperinfection or disseminated strongyloidiasis has been frequently reported after transplants and is related to high mortality. This study aimed to screen for strongyloidiasis using serological diagnoses in transplant candidates. METHODS: An ELISA test was performed with filariform larvae of Strongyloides venezuelensis as a source of antigen. RESULTS: In the serum from transplant candidates, anti-Strongyloides IgG antibodies were detected in 35/150 (23.3%) samples by soluble fractions in phosphate buffered saline (PBS), 31/150 (20.7%) samples by soluble fractions in Tris-HCl, 27/150 (18.0%) samples by membrane fractions in PBS and 22/150 (14.7%) samples by membrane fractions in Tris-HCl. CONCLUSIONS: The present results suggest the ELISA test, ideally using soluble fractions of filariform larvae S. venezuelensis in PBS, as an additional strategy for the diagnosis of strongyloidiasis in transplant candidates.
Descritores: Estrongiloidíase/diagnóstico
Imunoglobulina G/sangue
Transplante de Órgãos
Strongyloides stercoralis/imunologia
Antígenos de Helmintos/imunologia
-Estrongiloidíase/parasitologia
Ensaio de Imunoadsorção Enzimática
Anticorpos Anti-Helmínticos/sangue
Biomarcadores/sangue
Programas de Rastreamento
Sensibilidade e Especificidade
Hospedeiro Imunocomprometido
Antígenos de Helmintos/isolamento & purificação
Limites: Humanos
Animais
Masculino
Feminino
Criança
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-1041452
Autor: Machicado, Claudia; Bertani, Stéphane; Herrera-Velit, Patricia; Espinoza, Jose; Ruiz, Eloy; Marcos, Luis.
Título: Negative serology of Fasciola hepatica infection in patients with liver cancer in Peru: a preliminary report
Fonte: Rev. Soc. Bras. Med. Trop;51(2):231-233, Mar.-Apr. 2018. tab.
Idioma: en.
Projeto: Third Cancer Plan of the French National Alliance for Life Sciences and Health.
Resumo: Abstract INTRODUCTION: The etiology of several hepatocellular carcinoma (HCC) cases remains largely unknown. Although Fasciola hepatica has been associated with liver fibrosis in Latin America, it has not yet been associated with HCC. This study aimed to determine the existence of specific IgG antibodies against F. hepatica in the serum samples of HCC patients. METHODS In total, 13 serum samples from 13 HCC patients were screened using Fas2-ELISA. RESULTS Fas2-ELISA demonstrated negative results in all HCC patients included in this study. CONCLUSIONS The pre-existence of F. hepatica infection in HCC patients needs to be further investigated in epidemiological and experimental studies.
Descritores: Imunoglobulina G/sangue
Anticorpos Anti-Helmínticos/sangue
Carcinoma Hepatocelular/parasitologia
Fasciola hepatica/imunologia
Fasciolíase/complicações
Neoplasias Hepáticas/parasitologia
-Peru
Ensaio de Imunoadsorção Enzimática
Fatores de Risco
Carcinoma Hepatocelular/sangue
Fasciolíase/diagnóstico
Neoplasias Hepáticas/sangue
Pessoa de Meia-Idade
Limites: Humanos
Animais
Masculino
Feminino
Adulto
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1041472
Autor: Fernandes, Erica de Souza; Lorena, Virgínia Maria de Barros; Sales, Iana Rafaela Fernandes; Albuquerque, Mônica Camelo Pessoa de Azevedo; Gomes, Yara de Miranda; Costa, Vlaudia Maria Assis; Souza, Valdênia Maria Oliveira de.
Título: Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
Fonte: Rev. Soc. Bras. Med. Trop;51(4):546-549, July-Aug. 2018. graf.
Idioma: en.
Resumo: Abstract INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry. RESULTS: BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells. CONCLUSIONS: Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.
Descritores: Esquistossomose mansoni/imunologia
Anticorpos Anti-Helmínticos/imunologia
Interleucina-2/imunologia
Interleucina-10/imunologia
Linfócitos T Reguladores/imunologia
Animais Lactentes/imunologia
-Ovalbumina/imunologia
Citometria de Fluxo
Animais Lactentes/parasitologia
Camundongos
Limites: Animais
Feminino
Responsável: BR1.1 - BIREME


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Costa-Cruz, Julia Maria
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Id: biblio-1041491
Autor: Nunes, Juliana Barbosa; Emídio, Thamy Cristina de Oliveira; Marques, Marcos José; Caldas, Ivo Santana; Souza, Raquel Lopes Martins; Kanamura, Herminia Yohko; Costa-Cruz, Julia Maria.
Título: Seroepidemiological aspects of human infection by Strongyloides stercoralis in Alfenas, southern Minas Gerais, Brazil
Fonte: Rev. Soc. Bras. Med. Trop;51(6):855-859, Nov.-Dec. 2018. tab, graf.
Idioma: en.
Resumo: Abstract INTRODUCTION: In most Strongyloides stercoralis infected individuals, nematoidosis occurs asymptomatically, but in immunocompromised patients, it can cause hyperinfection. Serological techniques seem to be a good alternative for detecting this parasite. METHODS The frequency of seropositivity for strongyloidiasis in Alfenas, MG, was estimated using the enzyme linked immunosorbent assay on blood samples, between May and August of 2015. RESULTS: Out of 258 samples tested, 53.9% were positive, and the frequency of seropositive individuals was higher in the peripheral districts of the municipality. CONCLUSIONS: The results indicate high seropositivity rates for strongyloidiasis among the residents of Alfenas city.
Descritores: Estrongiloidíase/epidemiologia
Anticorpos Anti-Helmínticos/sangue
Strongyloides stercoralis/imunologia
-Estrongiloidíase/diagnóstico
Estrongiloidíase/transmissão
Brasil/epidemiologia
Imunoglobulina G/sangue
Ensaio de Imunoadsorção Enzimática
Estudos Soroepidemiológicos
Pessoa de Meia-Idade
Limites: Humanos
Animais
Masculino
Feminino
Recém-Nascido
Lactente
Pré-Escolar
Criança
Adolescente
Adulto
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Coelho, Paulo Marcos Zech
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Id: biblio-1041506
Autor: Gusmão, Michélia Antônia do Nascimento; Emídio, Nayara Braga; Marconato, Danielle Gomes; Farani, Priscila Silva Grijó; Maniezzi, Luiz Felipe; Coelho, Paulo Marcos Zech; Oliveira, Rodrigo Correa; Vasconcelos, Eveline Gomes; Faria-Pinto, Priscila de.
Título: IgE antibodies from schistosomiasis patients to recognize epitopes in potato apyrase
Fonte: Rev. Soc. Bras. Med. Trop;52:e20180139, 2019. graf.
Idioma: en.
Projeto: Conselho Nacional de Pesquisa (CNPq).
Resumo: Abstract INTRODUCTION: High percentages of structural identity and cross-immunoreactivity have been reported between potato apyrase and Schistosoma mansoni ATP diphosphohydrolase (SmATPDases) isoforms, showing the existence of particular epitopes shared between these proteins. METHODS: Potato apyrase was employed using ELISA, western blot, and mouse immunization methods to verify IgE reactivity. RESULTS: Most of the schistosomiasis patient's (75%) serum was seropositive for potato apyrase and this protein was recognized using western blotting, suggesting that parasite and plant proteins share IgE-binding epitopes. C57BL/6 mice immunized with potato apyrase showed increased IgE antibody production. CONCLUSIONS: Potato apyrase and SmATPDases have IgE-binding epitopes.
Descritores: Apirase/imunologia
Schistosoma mansoni/imunologia
Esquistossomose mansoni/imunologia
Solanum tuberosum/enzimologia
Imunoglobulina E/imunologia
Anticorpos Anti-Helmínticos/imunologia
Epitopos/imunologia
-Ensaio de Imunoadsorção Enzimática
Western Blotting
Reações Cruzadas
Camundongos Endogâmicos C57BL
Limites: Animais
Feminino
Responsável: BR1.1 - BIREME


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Chieffi, Pedro Paulo
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Id: lil-761169
Autor: Lescano, Susana A Zevallos; Santos, Sergio Vieira dos; Assis, Jesiel Maurício Lemos; Chieffi, Pedro Paulo.
Título: Efficacy of nitazoxanide against toxocara canis: larval recovery and humoral immune response in experimentally infected mice / Eficácia da nitazoxanida contra Toxocara canis: recuperação larvária e resposta imune humoral em camundongos experimentalmente infectados
Fonte: Rev. Inst. Med. Trop. Säo Paulo;57(4):337-341, July-Aug. 2015. tab, ilus.
Idioma: en.
Resumo: SUMMARYThe efficacy of nitazoxanide (NTZ) against toxocariasis was investigated in an experimental murine model and results were compared to those obtained using mebendazole. Sixty male BALB/c mice, aged six to eight weeks-old, were divided into groups of 10 each; fifty were orally infected with 300 larvaed eggs of T. canisand grouped as follows, G I: infected untreated mice; G II: infected mice treated with MBZ (15 mg/kg/day) 10 days postinfection (dpi); G III: infected mice treated with NTZ (20 mg/kg/day) 10 dpi; G IV: infected mice treated with MBZ 60 dpi; G V: infected mice treated with NTZ 60 dpi; GVI: control group comprising uninfected mice. Mice were bled via retro-orbital plexus on four occasions between 30 and 120 dpi. Sera were processed using the ELISA technique to detect IgG anti- Toxocaraantibodies. At 120 dpi, mice were sacrificed for larval recovery in the CNS, liver, lungs, kidneys, eyes and carcass. Results showed similar levels of anti- ToxocaraIgG antibodies among mice infected but not submitted to treatment and groups treated with MBZ or NTZ, 10 and 60 dpi. Larval recovery showed similar values in groups treated with NTZ and MBZ 10 dpi. MBZ showed better efficacy 60 dpi, with a 72.6% reduction in the parasite load compared with NTZ, which showed only 46.5% reduction. We conclude that administration of these anthelmintics did not modify the humoral response in experimental infection by T. canis. No parasitological cure was observed with either drug; however, a greater reduction in parasite load was achieved following treatment with MBZ.

RESUMOFoi investigada a eficácia da nitazoxanida (NTZ) na toxocaríase murina experimental e os resultados comparados com os obtidos usando mebendazol (MBZ). Sessenta camundongos BALB/c machos, com idade entre seis e oito semanas foram divididos em grupos de 10 cada, 50 foram infectados oralmente com 300 ovos larvados de T. canise agrupados a seguir: GI: camundongos infectados não tratados; GII: camundongos infectados tratados com MBZ (15 mg/kg/dia) 10 dias pós-infecção (dpi); GIII: camundongos infectados tratados com NTZ (20 mg/kg/dia) 10 dpi, GIV: camundongos infectados tratados com MBZ 60 dpi; GV: camundongos infectados tratados com NTZ 60 dpi; GVI: controle não infectado. Os camundongos foram sangrados via plexo retro orbitário em quatro ocasiões entre o 30º e 120º dpi. Os soros foram processados pela técnica de ELISA para detecção de anticorpos IgG anti- Toxocara.Aos 120 dpi, os animais foram sacrificados para a recuperação larvária do SNC, fígado, pulmões, rins, olhos e carcaça. Os resultados mostraram níveis similares de anticorpos IgG anti- Toxocaraentre os camundongos infectados mas não submetidos a tratamento e os grupos infectados e tratados com MBZ ou NTZ, aos 10 e 60 dpi. Os valores da recuperação larval foram similares nos grupos tratados com NTZ e MBZ 10 dpi. MBZ mostrou melhor eficácia aos 60 dpi, com redução de 72,6% da carga parasitária comparada com NTZ, que mostrou redução somente de 46,5%. Concluímos que a administração destes anti-helmínticos não modificou a resposta humoral na infecção experimental por T. canis. Não foi observada cura parasitológica com nenhuma das drogas; porém maior redução na carga parasitária foi obtida após o tratamento com MBZ.
Descritores: Anti-Helmínticos/administração & dosagem
Anticorpos Anti-Helmínticos/sangue
Mebendazol/administração & dosagem
Tiazóis/administração & dosagem
Toxocara canis/efeitos dos fármacos
Toxocaríase/tratamento farmacológico
-Modelos Animais de Doenças
Imunidade Humoral
Larva/efeitos dos fármacos
Camundongos Endogâmicos BALB C
Contagem de Ovos de Parasitas
Toxocaríase/imunologia
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: biblio-1057249
Autor: Santos, João Hugo Abdalla; Bührer-Sékula, Samira; Melo, Gisely Cardoso; Cordeiro-Santos, Marcelo; Pimentel, João Paulo Diniz; Gomes-Silva, Adriano; Costa, Allyson Guimarães; Saraceni, Valeria; Da-Cruz, Alda Maria; Lacerda, Marcus Vinícius Guimarães.
Título: Ascaris lumbricoides coinfection reduces tissue damage by decreasing IL-6 levels without altering clinical evolution of pulmonary tuberculosis or Th1/Th2/Th17 cytokine profile
Fonte: Rev. Soc. Bras. Med. Trop;52:e20190315, 2019. tab, graf.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado do Amazonas.
Resumo: Abstract INTRODUCTION: Immunological control of Mycobacterium tuberculosis infection is dependent on the cellular immune response, mediated predominantly by Th1 type CD4+ T cells. Polarization of the immune response to Th2 can inhibit the host immune protection against pathogens. Patients with tuberculosis coinfected with helminths demonstrate more severe pulmonary symptoms, a deficiency in the immune response against tuberculosis, and an impaired response to anti-tuberculosis therapy. METHODS: We evaluated the cellular immune response and the impact of the presence of Ascaris lumbricoides on the immune and clinical response in pulmonary tuberculosis patients. Ninety-one individuals were included in the study: 38 tuberculosis patients, 11 tuberculosis patients coinfected with Ascaris lumbricoides and other helminths, 10 Ascaris lumbricoides patients, and 34 non-infected control individuals. Clinical evolution of pulmonary tuberculosis was studied on 0, 30, 60, and 90 days post-diagnosis of Mycobacterium tuberculosis and Ascaris lumbricoides. Furthermore, immune cells and plasma cytokine profiles were examined in mono/coinfection by Mycobacterium tuberculosis and Ascaris lumbricoides using flow cytometry. RESULTS: There were no statistical differences in any of the evaluated parameters and the results indicated that Ascaris lumbricoides infection does not lead to significant clinical repercussions in the presentation and evolution of pulmonary tuberculosis. CONCLUSIONS: The association with Ascaris lumbricoides did not influence the Th1, Th2, and Th17 type responses, or the proportions of T lymphocyte subpopulations. However, higher serum levels of IL-6 in tuberculosis patients may explain the pulmonary parenchymal damage.
Descritores: Ascaríase/imunologia
Tuberculose Pulmonar/imunologia
Interleucina-6/sangue
Ascaris lumbricoides
-Ascaríase/complicações
Fatores de Tempo
Tuberculose Pulmonar/complicações
Anticorpos Anti-Helmínticos/sangue
Estudos de Casos e Controles
Citocinas/imunologia
Citocinas/sangue
Interleucina-6/imunologia
Progressão da Doença
Coinfecção
Citometria de Fluxo
Pessoa de Meia-Idade
Limites: Humanos
Animais
Masculino
Feminino
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1136850
Autor: Ramírez, Angélica da Paz; Favero, Vivian; Lindholz, Catieli Gobetti; Veríssimo, Carolina de Marco; Pascoal, Vanessa Fey; Candido, Renata Russo Frasca; Morassutti, Alessandra Loureiro; Graeff-Teixeira, Carlos.
Título: Schistosomiasis: an epidemiological update on Brazils southernmost low endemic area in Esteio
Fonte: Rev. Soc. Bras. Med. Trop;53:e20200411, 2020. tab.
Idioma: en.
Projeto: Conselho Nacional de Desenvolvimeto Científico e Tecnológico.
Resumo: Abstract INTRODUCTION: Brazil's southernmost state, Rio Grande do Sul (RGS), was considered schistosomiasis-free until 1998 when a low endemic focus was identified in Esteio, a city located next to the capital of RGS. In the last two decades, the control interventions applied in the region have been apparently successful, and the absence of new cases indicated the possibility of interrupted schistosomiasis transmission. The objective of this study was to update the clinical and epidemiological data of schistosomiasis in Esteio. METHODS: We reviewed all 28 individuals diagnosed with the infection since 1997 and a survey was applied to a group of 29 school-aged children residing in Vila Pedreira, one of the most affected neighborhoods. RESULTS No eggs were detected in fecal samples using the Helmintex method, and all samples were negative for serum antibodies on examination by the western blot technique using the Schistosoma mansoni microsomal antigen (MAMA- WB). In contrast, 23 individuals (79%) tested positive for the cathodic circulating antigen with the point-of-care immunochromatographic test (POC-CCA) on urine samples. Of the 28 formerly infected individuals, only eight were located, of which four tested positive, and four tested negative for serum antibodies using the MAMA-WB technique. CONCLUSIONS: Current adverse conditions for S. mansoni transmission in Esteio and the absence of a confirmed diagnosis suggests that there is (i) a lack of specificity of the POC-CCA test in low endemic settings, and (ii) a high probability that interruption of schistosomiasis has been achieved in Esteio.
Descritores: Esquistossomose
-Brasil
Anticorpos Anti-Helmínticos
Limites: Humanos
Animais
Criança
Responsável: BR1.1 - BIREME



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde