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Pesquisa : D12.776.124.486.485.114.185 [Categoria DeCS]
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  1 / 231 LILACS  
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Id: biblio-841755
Autor: Luna, Expedito JA; Furucho, Celia R; Silva, Rubens A; Wanderley, Dalva M; Carvalho, Noemia B; Satolo, Camila G; Leite, Ruth M; Silveira, Cassio; Silva, Lia MB; Aith, Fernando M; Carneiro Jr, Nivaldo; Shikanai-Yasuda, Maria A.
Título: Prevalence of Trypanosoma cruzi infection among Bolivian immigrants in the city of São Paulo, Brazil
Fonte: Mem. Inst. Oswaldo Cruz;112(1):70-74, Jan. 2017. tab.
Idioma: en.
Projeto: CNPq.
Resumo: With the urbanisation of the population in developing countries and the process of globalisation, Chagas has become an emerging disease in the urban areas of endemic and non-endemic countries. In 2006, it was estimated that the prevalence of Chagas disease among the general Bolivian population was 6.8%. The aim of the present study was to determine the prevalence of Trypanosoma cruzi infection among Bolivian immigrants living in São Paulo, Brazil. This study had a sample of 633 volunteers who were randomly selected from the clientele of primary care units located in the central districts of São Paulo, Brazil. Infection was detected by two different ELISA assays with epimastigote antigens, followed by an immunoblot with trypomastigote antigens as a confirmatory test. The prevalence of the infection was 4.4%. Risk factors independently associated with the infection were: a history of rural jobs in Bolivia, knowledge of the vector involved in transmission, and having relatives with Chagas disease. Brazil has successfully eliminated household vector transmission of T. cruzi, as well as its transmission by blood transfusion. The arrival of infected immigrants represents an additional challenge to primary care clinics to manage chronic Chagas disease, its vertical transmission, and the blood derivatives and organ transplant programs.
Descritores: Trypanosoma cruzi/imunologia
Ensaio de Imunoadsorção Enzimática
Anticorpos Anti-Helmínticos/sangue
Estudos Soroepidemiológicos
Doença de Chagas/diagnóstico
Doença de Chagas/epidemiologia
Emigrantes e Imigrantes/estatística & dados numéricos
-Bolívia/etnologia
Brasil/epidemiologia
Prevalência
Fatores de Risco
Limites: Seres Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Responsável: BR1.1 - BIREME


  2 / 231 LILACS  
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Id: biblio-841794
Autor: Cevallos, William; Calvopiña, Manuel; Nipáz, Victoria; Vicente-Santiago, Belén; López-Albán, Julio; Fernández-Soto, Pedro; Guevara, Ángel; Muro, Antonio.
Título: Enzyme-linked immunosorbent assay for diagnosis of Amphimerus spp. liver fluke infection in Humans
Fonte: Mem. Inst. Oswaldo Cruz;112(5):364-369, May 2017. tab, graf.
Idioma: en.
Projeto: DGIP-Universidad Central del Ecuador; . IBSAL-CIETUS; . IBSAL-CIETUS.
Resumo: BACKGROUND Amphimerus spp. is a liver fluke that infects humans and domestic animals. It is highly prevalent in some Ecuadorian communities. Currently, diagnosis is based on the microscopic observation of eggs in faeces, but this has variable sensitivity. More sensitive methods are needed for diagnostic testing. OBJECTIVE The main objective of this work was to develop an enzyme-linked immunosorbent assay (ELISA) using crude antigens from Amphimerus spp. adult worms to detect anti-Amphimerus IgG in human sera. METHODS Crude somatic antigens were obtained from adult Amphimerus spp. worms. Human sera from 119 patients were tested: 48 from individuals with a confirmed Amphimerus spp. infection, 78 from non-infected Ecuadorians living in the endemic region, 60 from persons living in non-endemic areas (20 Ecuadorians, 20 Europeans, and 20 Africans), and 33 who had other parasitic and non-parasitic infections. PRINCIPAL FINDINGS Results were analysed using the receiver-operator characteristic (ROC) curve analysis with an area under curve (AUC) value of 0.967. The accuracy of the ELISA was high. The sensitivity was 85.0% [95% confidence interval (CI): 80.3-89.7%] and the specificity was 71.0% (95% CI: 65.2-76.8%). Some cross reactivity was detected against Paragonimus mexicanus, Fasciola hepatica, Schistosomiasis, Taenia solium, Strongyloides stercoralis, Mansonella spp., and Vampirolepis nana. MAIN CONCLUSIONS We have developed the first ELISA technique that detects anti-Amphimerus IgG in human sera with good sensitivity, repeatability and reproducibility. However, more specific antigens are needed to further enhance performance of this assay. Regardless, this ELISA test could be useful for early diagnosis and prompt treatment of human Amphimerus spp. infections.
Descritores: Opisthorchidae/imunologia
Infecções por Trematódeos/diagnóstico
Imunoglobulina G/sangue
Ensaio de Imunoadsorção Enzimática
Anticorpos Anti-Helmínticos/sangue
Antígenos de Helmintos/imunologia
-Reprodutibilidade dos Testes
Curva ROC
Sensibilidade e Especificidade
Área Sob a Curva
Limites: Seres Humanos
Animais
Responsável: BR1.1 - BIREME


  3 / 231 LILACS  
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Id: lil-623563
Autor: Doenhoff, M. J.
Título: The immune-dependence of chemotherapy in experimental schistosomiasis
Fonte: Mem. Inst. Oswaldo Cruz;84(supl.1):31-37, 1989.
Idioma: en.
Conferência: Apresentado em: Simpósio Internacional de Esquistossomose, 2, Apresentado em: Reunião Nacional de Esquistossomose2, Belo Horizonte, 22-27 out. 1989.
Resumo: Experimental evidence indicates that immune effector mechanisms can enhance the activity of schistosomicidal drugs. Praziquantel, oxamniquine, hycanthone and antimony were less effective against Schistosoma mansoni infections in mice immunosuppressed by T cell-deprivation, than against comparable infection in normal mice. The schistosomicidal activities of praziquantel, oxamniquine and antimony have been experimentally enhanced by the synergistic action of immune sera. In passive serum transfer experiments a s. mansoni antigen of Mr 27 kD with non-specific esterase activity was identified as a potentially sensitive target for the antibodies that interact with praziquantel. Indirect immunofluorescence indicated that this antigen was exposed on the worm surface as a result of praziquantel treatment.
Descritores: Schistosoma mansoni/imunologia
Esquistossomicidas/uso terapêutico
Esquistossomose mansoni/tratamento farmacológico
Anticorpos Anti-Helmínticos/imunologia
Soros Imunes/administração & dosagem
-Praziquantel/uso terapêutico
Tolerância Imunológica
Limites: Animais
Cobaias
Coelhos
Responsável: BR1.1 - BIREME


  4 / 231 LILACS  
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Id: lil-623708
Autor: Horta, M. de Fátima M; Ramalho-Pinto, F. J.
Título: Levels of lethal antibody during the course of infection with Schistosoma mansoni in rats and mice
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):283-284, 1987.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Resumo: Schistosoma mansoni infected hosts produce an IgG that mediates the complement-dependent killing of schistosomula in vitro. In this study, we followed the levels of serum lethal antibody during infection of rats and mice. Rats presented detectable lethal activity early in the course of infection with a peak in the 6-8th week of infection. This activity declined to non-detectable levels within 2 weeks, remaining low up to the 20-26th week. In mice, lethal antibody was not detected before 7-12 weeks of infection, but raised to higher levels, as compared to non-infected animals, up to 20-24 weeks after infection. We correlate lethal antibody and protective immunity suggesting that the antibody-mediated complement-dependent cytotoxicity to schistosomula play a role in the immunity to reinfection.
Descritores: Schistosoma mansoni/crescimento & desenvolvimento
Schistosoma mansoni/imunologia
-Schistosoma mansoni/anatomia & histologia
Anticorpos Anti-Helmínticos/imunologia
Responsável: BR1.1 - BIREME


  5 / 231 LILACS  
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Araripe, J. R
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Id: lil-623704
Autor: Lenzi, J. A; Sobral, A. C. L; Araripe, J. R; Grimaldi Filho, G.
Título: Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):257-267, 1987. ilus, graf, tab.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Projeto: CNPq.
Resumo: Modification of the immune response to schistosomal infection in children or offspring born to mother R infected with Schistosoma mansoni has been demonstrated in human and in experimental schistosomiasis. One of the hypothesis to explain this fact could be the transfer of circulating antigens and antibodies from mother to foetus through the placenta or from mother to child by milk. The results of this spontaneous transference are controversial in the literature. In an attempt to investigate these questions, we studied one hundred and twenty offspring (Swiss mice), sixty born to infected-mothers (group A) and sixty born to non-infected mothers (group B). These were percutaneously infected with 50 cercariae/mouse, and divided in six sub-groups (20 mice/sub-group), according to the following schedule: after birth (sub-groups A.I and B.I), 10 days old (sub-groups A.II and B.II) and 21 days old (sub-groups A.III and B.III). After the exposure period, the young mice returned to their own mothers for nursing. Six weeks later, the mice were killed. We obtained the following results: 1) There is transference of antibody to cercariae (CAP), adult worms (SWAP) and egg antigens (SEA) from the infected mothers to the offspring, probably through placenta and milk; 2) Offspring born to infected mothers exhibit much less coagulative hepatic necrosis and show a lower number of eggs in the small intestine and a less intense and predominant exsudative stage of the hepatic granulomas when compared with the exsudative-productive stage of the control groups. The findings suggest that congenital and nursing factors can interfere on the development of the schistosomiasis infection, causing an hyporesponse to the eggs.
Descritores: Complicações Infecciosas na Gravidez/fisiopatologia
Esquistossomose mansoni/congênito
Esquistossomose mansoni/fisiopatologia
Anticorpos Anti-Helmínticos/imunologia
-Óvulo/imunologia
Complicações Infecciosas na Gravidez
Troca Materno-Fetal
Limites: Animais
Cobaias
Camundongos
Responsável: BR1.1 - BIREME


  6 / 231 LILACS  
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Id: lil-623700
Autor: Kojima, Somei; Janecharut, Tuenta; Hata, Hidekazu; Niimura, Munetoshi.
Título: Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):237-241, 1987. ilus.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Projeto: Japan. Ministry of Education, Science and Culture.
Resumo: We have been able to produce a mouse monoclonal IgE antibody specific to an adult worm antigen extracted from Schistosoma japonicum (Sj). The antibody was able to elicit passive cutaneous anaphylaxis in the rat skin against Sj with the highest titer of 1:256,000 but did not cross-react with S. mansoni antigen. The antibody recognized a 97-kDa molecule expressed on the surface of mechanically transformed schistosoma of S. japonicum. Passive transfer of the antibody into mice in the early stage of challenge infection resulted in a partial but significant reduction of recovery of adult worms. Induction of eosinophilia by an oral administration of embryonated eggs of Toxocara canis prior to challenge infection enhanced the reduction.
Descritores: Anafilaxia Cutânea Passiva
Anticorpos Anti-Helmínticos/administração & dosagem
Anticorpos Anti-Helmínticos/uso terapêutico
Toxocaríase/complicações
-Anticorpos Anti-Helmínticos/imunologia
Eosinofilia/complicações
Limites: Animais
Cobaias
Camundongos
Responsável: BR1.1 - BIREME


  7 / 231 LILACS  
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Carvalho, Omar S
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Id: lil-623686
Autor: Corrêa-Oliveira, Rodrigo; Oliveira, Guilherme C; Golgher, Denise B; Viana, Iramaya R. C; Colley, Daniel G; Carvalho, Omar S; Rocha, Roberto S; Katz, Naftale; Gazzinelli, Giovanni.
Título: Analysis of antibody responses of Schistosoma mansoni infected patients against schistosomal antigens
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):179-181, 1987.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Descritores: Schistosoma mansoni/parasitologia
Esquistossomose mansoni/imunologia
Anticorpos Anti-Helmínticos/análise
Antígenos de Helmintos/imunologia
-Recém-Nascido
Ensaio de Imunoadsorção Enzimática
Western Blotting
Responsável: BR1.1 - BIREME


  8 / 231 LILACS  
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Id: lil-623683
Autor: Arnon, Ruth; Espinoza-Ortega, Berta; Tarrab-Hazdai, Rebeca.
Título: Acetylcholinesterase of Schistosoma mansoni: an antigen of functional implications
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):163-170, 1987. graf, tab, ilus.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Descritores: Acetilcolinesterase/isolamento & purificação
Acetilcolinesterase/imunologia
Anticorpos Anti-Helmínticos/uso terapêutico
-Schistosoma mansoni/efeitos dos fármacos
Inibidores da Colinesterase/farmacologia
Responsável: BR1.1 - BIREME


  9 / 231 LILACS  
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Id: lil-623671
Autor: Dunne, David W; Fulford, Anthony J. C; Butterworth, Anthony E; Koech, David; Ouma, John H.
Título: Human antibody responses to Schistosoma mansoni: does antigen directed, isotype restriction result in the production of blocking antibodies?
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):101-104, 1987.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Resumo: After treatment young Kenyan schoolchildren are highly susceptible to reinfection with Schistosoma mansoni. Older children and adults are resistant to reinfection. There is no evidence that this age related resistance is due to a slow development of protective immunological mechanisms, rather, it appears that young children are susceptible because of the presence of blocking antibodies which decline with age, thus allowing the expression of protective responses. Correlations between antibody responses to different stages of the parasite life-cycle suggest that, in young children, antigen directed, isotype restriction of the response against cross-reactive polysaccharide egg antigens results in an ineffectual, or even blocking antibody response to the schistosomulum.
Descritores: Schistosoma mansoni/imunologia
Imunoglobulina M/imunologia
Anticorpos Anti-Helmínticos
-Recidiva
Suscetibilidade a Doenças
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


  10 / 231 LILACS  
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Rocha, Roberto Sena
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Id: lil-623670
Autor: Gazzinelli, Giovanni; Montesano, Maria Angela; Corrêa-Oliveira, Rodrigo; Lima, Marcondes Souza; Katz, Naftale; Rocha, Roberto Sena; Colley, Daniel G.
Título: Immune response in different clinical groups of Schistosomiasis patients
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):95-100, 1987. graf, tab.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Descritores: Schistosoma mansoni/imunologia
Esquistossomose mansoni/complicações
Interações Hospedeiro-Parasita
-Anticorpos Anti-Helmínticos/imunologia
Suscetibilidade a Doenças
Imunidade Celular
Limites: Seres Humanos
Animais
Adulto
Responsável: BR1.1 - BIREME



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