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Id: biblio-902844
Autor: Aguiar, Simone Santana; Damaceno, Neiva; Forte, Wilma Carvalho Neves.
Título: Exames para avaliar a sensibilização ao aspergillus fumigatus em fibrose cística / Tests to assess sensitization to aspergillus fumigatus in cystic fibrosis
Fonte: Rev. paul. pediatr;35(3):252-257, jul.-set. 2017. tab, graf.
Idioma: pt.
Resumo: RESUMO Objetivo: Avaliar os resultados dos exames utilizados para identificar a sensibilização IgE-mediada ao Aspergillus fumigatus em pacientes com fibrose cística. Métodos: Estudo transversal descritivo com amostra de conveniência de 86 pacientes com fibrose cística, acompanhados em Serviço de Referência de Fibrose Cística de hospital universitário terciário. Realizaram-se exames para avaliar sensibilização ao A. fumigatus em pacientes com fibrose cística: IgE sérica total, contagem de eosinófilos sanguíneos, identificação do fungo por swab de orofaringe ou por cultura de escarro, IgE sérica específica e testes cutâneos de hipersensibilidade imediata. Foram comparados os resultados dos diferentes exames realizados. Resultados: Em 33 (38,4%) pacientes com fibrose cística, com faixa etária de 1 a 33 anos (mediana de 8 anos), os resultados dos exames sobre sensibilização IgE mediada ao A. fumigatus foram: em 16 pacientes, aumento de IgE sérica específica (>0,35 kU/L); em 23, positividade aos testes cutâneos; e seis mostraram sensibilização a partir dos dois exames. Foram observados dois pacientes com eosinofilia (>1.000 eosinófilos/mm3) e sete com aumento de IgE sérica total (>1.000 UI/mL), sem que esses apresentassem positividade aos testes cutâneos ou aumento de IgE específica ao A. fumigatus. Em nenhum paciente foi isolado A. fumigatus no swab de orofaringe e/ou na cultura de escarro. Conclusões: Concluímos que, entre os exames para avaliar a sensibilização ao A. fumigatus na fibrose cística, são necessários os teste cutâneos de hipersensibilidade imediata e a dosagem de IgE sérica específica ao A. fumigatus. A eosinofilia sérica e a cultura de secreções respiratórias não foram essenciais neste estudo.

ABSTRACT Objective: To evaluate the results of the tests used to identify the IgE mediated sensitization to Aspergillus fumigatus in patients with cystic fibrosis. Methods: This is a cross-sectional descriptive study with a convenience sample of 86 patients diagnosed with cystic fibrosis in the Reference Service in Cystic Fibrosis at a tertiary teaching hospital. The following tests were performed to assess the sensitization to A. fumigatus in patients with cystic fibrosis: Total serum IgE, eosinophil count, fungus detection through oropharyngeal swab or sputum culture, serum-specific IgE, and immediate-type hypersensitivity (IgE) skin tests. We compared the results of the different tests performed. Results: In 33 (38.4%) patients with cystic fibrosis, with ages ranging from 1 to 33 years (median of 8 years), the IgE-mediated A. fumigatus sensitization test results were: in 16 patients, there was an increase in serum-specific IgE (>0.35 kU/L); in 23, skin tests were positive; and six had sensitization in both tests. We observed two patients with eosinophilia (>1,000 eosinophils/mm3) and seven with increasing total serum IgE (>1,000 IU/mL), all of whom obtained negative results in skin tests and had no IgE increase specific to A. fumigatus. A. fumigatus was not detected in oropharyngeal swabs and/or sputum culture of any patients. Conclusions: We conclude that, among the tests used to assess sensitization to A. fumigatus in cystic fibrosis patients, both serum-specific IgE and immediate-type hypersensitivity (IgE) skin tests are required. Serum eosinophilia and respiratory secretion culture were not essential in this study.
Descritores: Aspergillus fumigatus/imunologia
Imunoglobulina E
Fibrose Cística/imunologia
Hipersensibilidade Imediata/diagnóstico
-Estudos Transversais
Limites: Humanos
Masculino
Feminino
Lactente
Pré-Escolar
Criança
Adolescente
Responsável: BR1.1 - BIREME


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Id: biblio-887060
Autor: Ding, Shu; Deng, Qiancheng; Xiang, Yaping; Chen, Jing; Huang, Jinhua; Lu, Jianyun.
Título: Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient
Fonte: An. bras. dermatol;92(5,supl.1):34-36, 2017. graf.
Idioma: en.
Resumo: Abstract: Bullous pemphigoid is a blistering autoimmune disease characterized by two hemidesmosomal proteins (anti-BP180 and 230). Pemphigus, by contrast, is characterized by two autoantibodies (anti-desmoglein 1 and 3). Coexistence of autoantibodies of bullous pemphigoid and pemphigus in a patient is rare. A 25-year-old male patient was admitted to our hospital, reporting a 3-month history of multiple papules, vesicles, and erosions over an extensive erythema on the entire body. Laboratory tests showed high levels of serum IgE, anti-BP180 antibodies, and anti-desmoglein 1 and 3. Histopathologic and immunopathologic features were characterized by bullous pemphigoid. No improvement was seen with systemic corticosteroid therapy, however, pulse corticosteriod therapy combined with methylprednisolone, immunosuppressants, immunomodulators, and plasmapheresis led to the recovery of his condition with numerous milia.
Descritores: Imunoglobulina E/sangue
Penfigoide Bolhoso/imunologia
Penfigoide Bolhoso/patologia
Desmogleínas/imunologia
Ceratose/imunologia
Ceratose/patologia
-Pele/patologia
Autoanticorpos/sangue
Autoantígenos/sangue
Biópsia
Metilprednisolona/uso terapêutico
Penfigoide Bolhoso/tratamento farmacológico
Colágenos não Fibrilares/sangue
Lesão por Pressão/patologia
Glucocorticoides/uso terapêutico
Ceratose/tratamento farmacológico
Limites: Humanos
Masculino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-975595
Autor: Demir, Mehmet Gokhan.
Título: Comparison of 1α-25-dihydroxyvitamin D3 and IgE Levels between Allergic Rhinitis Patients and Healthy People
Fonte: Int. arch. otorhinolaryngol. (Impr.);22(4):428-431, Oct.-Dec. 2018. tab.
Idioma: en.
Resumo: Abstract Introduction Allergic rhinitis is one of the most common allergic diseases that cause a decrease in quality of life. Over the last decades, the increase in the number of cases is supposed to be a result of industrialization and lifestyle changes. Vitamin D, which is a steroid hormone, has a significant immunomodulatory and antioxidant role in the human body. Objective The objective of the present study is to investigate the role of 1α-25-dihydroxyvitamin D3 levels in allergic rhinitis patients and to compare them to the levels found in the healthy population. Methods A total of 256 participants were included in the present study. Allergic rhinitis is diagnosed with the help of the Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines confirmed through skin prick tests. Control subjects were selected among people without allergy history, which was also confirmed through skin prick tests. The levels of 1α-25-dihydroxyvitamin D3, immunoglobulin E (IgE), and eosinophil counts were measured in blood samples from both groups. Results The mean value of serum levels of 1α-25-hydroxyvitamin D3 was 25.5 ± 3.74 in the allergic rhinitis group, and 31.58 ± 3.85 in the control subjects. This difference reveals statistically-decreased levels in the allergic rhinitis group (p< 0.05). The total IgE levels are increased in the allergic rhinitis group (p< 0.05) and negatively correlated with the serum levels of 1α-25-hydroxyvitamin D3 (r = - 0.259, p< 0.05). Conclusion Lower serum levels of 1α-25-hydroxyvitamin D3 were detected in the allergic rhinitis population. This data is also correlated to the IgE response in the study group. A supplement of 1α-25-hydroxyvitamin D3 in deficient patients might be helpful to relieve symptoms and signs of allergic rhinitis, but further studies are needed.
Descritores: Colecalciferol/sangue
Rinite Alérgica/diagnóstico
-Turquia
Vitamina D/sangue
Deficiência de Vitamina D/diagnóstico
Imunoglobulina E/sangue
Testes Cutâneos
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Tipo de Publ: Estudo Comparativo
Responsável: BR66.1 - Divisão de Biblioteca e Documentação


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Id: biblio-887135
Autor: Espinoza, Iris; Navarrete, Jorge; Benedetto, Juana; Borzutzky, Arturo; Roessler, Patricia; Ortega-Pinto, Ana.
Título: Orofacial granulomatosis and diet therapy: a review of the literature and two clinical cases
Fonte: An. bras. dermatol;93(1):80-85, Jan.-Feb. 2018. tab, graf.
Idioma: en.
Resumo: Abstract: Orofacial granulomatosis is a nonspecific term that contains a wide variety of granulomatous entities, which share a clinical and histopathological presentation. It manifests as persistent or recurrent orofacial swelling, amongst other findings. Idiopathic orofacial granulomatosis, characterized by an absence of systemic granulomatous disease, is a diagnosis of exclusion. The main differential diagnosis is Crohn's disease. Its pathogenesis is unknown, however, it seems to be immune-mediated. Patch-test sensitivity to multiple allergens is well documented. Currently, therapeutic options consider restrictive diets, topical, intralesional, and systemic agents. First-line therapy is currently a matter of debate. We present a review of the value of diet therapy in this syndrome, along with two illustrative cases.
Descritores: Granulomatose Orofacial/dietoterapia
-Imunoglobulina E/sangue
Testes Cutâneos
Granulomatose Orofacial/diagnóstico
Granulomatose Orofacial/patologia
Mucosa Bucal/patologia
Limites: Humanos
Masculino
Adolescente
Adulto
Adulto Jovem
Tipo de Publ: Relatos de Casos
Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-977068
Autor: Rosario, Nelson A; Riedi, Carlos A.
Título: Sensibilização ao aspergillus fumigatus em fibrocísticos / Sensitization to aspergillus fumigatus in fibrocystics
Fonte: Rev. Paul. Pediatr. (Ed. Port., Online);36(3):382-382, jul.-set. 2018.
Idioma: pt.
Descritores: Aspergilose Broncopulmonar Alérgica/imunologia
Aspergillus fumigatus
Imunoglobulina E
Fibrose Cística/complicações
Tipo de Publ: Carta
Responsável: BR1.1 - BIREME


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Id: biblio-977067
Autor: Oliveira, Luciano Machado Ferreira Tenório de; Silva, Alison Oliveira da; Santos, Marcos André Moura dos; Ritti-Dias, Raphael Mendes; Diniz, Paula Rejane Beserra.
Título: Exercício físico ou atividade física: qual apresenta maior associação com a percepção da qualidade do sono de adolescentes? / Exercise or physical activity: which is more strongly associated with the perception of sleep quality by adolescents?
Fonte: Rev. Paul. Pediatr. (Ed. Port., Online);36(3):322-328, jul.-set. 2018. tab, graf.
Idioma: pt.
Resumo: RESUMO Objetivo: Analisar a associação do exercício físico e da atividade física com a percepção da qualidade do sono em adolescentes. Métodos: Trata-se de um estudo com abordagem quantitativa que integra o levantamento epidemiológico transversal de base escolar e abrangência estadual cuja amostra foi constituída por 6.261 adolescentes (14 a 19 anos), selecionados por meio de uma estratégia de amostragem aleatória de conglomerados. Os dados foram coletados a partir do questionário Global School-based Student Health Survey. O teste do qui-quadrado e a regressão logística binária foram utilizados nas análises dos dados. Resultados: Na amostra, 29% dos adolescentes não faziam exercício e não foram classificados como fisicamente ativos. Os adolescentes que não praticavam exercício físico tinham mais chances de apresentar uma percepção negativa da qualidade do sono (OR 1,13, IC95% 1,04-1,28; p=0,043). Não foi encontrada associação entre o nível de atividade física e a percepção da qualidade do sono (OR 1,01, IC95% 0,89-1,14; p=0,868). Ao serem avaliadas as práticas de forma isolada ou simultânea, constatou-se que aqueles que praticavam exercício físico apresentavam menor chance de terem uma percepção negativa da qualidade do sono (OR 0,82, IC95% 0,71-0,95) e, ao praticarem exercício e, paralelamente, terem uma vida fisicamente ativa, essas chances diminuíam ainda mais (OR 0,79, IC95% 0,68-0,93). Conclusões: Ser classificado como fisicamente ativo, por si só, não foi suficiente para uma melhor percepção da qualidade do sono, pois apenas a prática de exercício físico apresentou tal associação.

ABSTRACT Objective: To analyze the association of exercises and physical activity with the perception of sleep quality by adolescents. Methods: This is a cross-sectional epidemiological survey with statewide coverage, whose sample was composed of 6,261 adolescents (14-19 years old) who were selected by random sampling of conglomerates. The Global School-Based Student Health Survey questionnaire was used for data collection. The chi-square test and the binary logistic regression were applied for data analyses. Results: In the sample, 29% of adolescents did not exercise and were not classified as physically active. Adolescents who did not exercise were more likely to present a negative perception of sleep quality (OR 1.13, 95%CI 1.04-1.28, p=0.043). No association between the level of physical activity and the perception of sleep quality was found (OR 1.01, 95%CI 0.89-1.14, p=0.868). Those who practiced exercises only had less chance of perceiving sleep quality as poor (OR 0.82, 95%CI 0.71-0.95). However, those who practiced exercise and had a physically active life had less chances of having a negative perception of their sleep (OR 0.79, 95%CI 0.68-0.93). Conclusions: Practicing physical activity alone was not enough to increase the chances of positive sleep quality perception. Only physical exercise had a positive association with sleep quality perception.
Descritores: Aspergilose Broncopulmonar Alérgica/imunologia
Aspergillus fumigatus
Imunoglobulina E
Fibrose Cística/complicações
Limites: Humanos
Criança
Tipo de Publ: Carta
Responsável: BR1.1 - BIREME


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Id: biblio-837968
Autor: Marques, Raquel Zappa Silva; Criado, Roberta Fachini Jardim; Machado Filho, Carlos D'Apparecida Santos; Tamanini, Juliana Milhomem; Mello, Cristina van Blarcum de Graaff; Speyer, Carolina.
Título: Correlation between the histopathology of chronic urticaria and its clinical picture
Fonte: An. bras. dermatol;91(6):760-763, Nov.-Dec. 2016. tab.
Idioma: en.
Resumo: Abstract BACKGROUND: Chronic urticaria is characterized by transient, pruritic lesions of varying sizes, with central pallor and well-defined edges, with disease duration longer than six weeks. Its cellular infiltrate consists of neutrophils, lymphocytes and eosinophils. There is a subgroup of patients with eosinophilic or neutrophilic urticaria, resistant to the treatment with antihistamines, but that respond to a combination of antihistamine with other drugs. OBJECTIVE: To evaluate the present infiltration in chronic urticaria biopsies and correlate it with the clinical disease activity and response to treatment. METHODS: Forty-one patients with chronic urticaria were classified according to the score of severity of the disease, response to treatment and type of perivascular infiltrate. Inflammatory infiltrates were divided in eosinophilic (46.30%), neutrophilic and mixed. RESULTS: An association was found between the eosinophilic infiltrate and clinical scores of greater severity (p = 0.002). CONCLUSION: This association shows that the eosinophilic inflammatory infiltrates denote high clinical activity, which means more severe and exuberant clinical pictures of the disease.
Descritores: Urticária/fisiopatologia
Urticária/patologia
Infiltração de Neutrófilos/fisiologia
Eosinófilos/patologia
-Valores de Referência
Urticária/terapia
Biópsia
Índice de Gravidade de Doença
Proteína C-Reativa/análise
Imunoglobulina E/análise
Doença Crônica
Estudos Transversais
Resultado do Tratamento
Estatísticas não Paramétricas
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-887014
Autor: Liu, Fang; Hu, Wenxing; Liu, Haibo; Zhang, Min; Sang, Hong.
Título: Episodic angioedema associated with eosinophilia
Fonte: An. bras. dermatol;92(4):534-536, July-Aug. 2017. graf.
Idioma: en.
Resumo: Abstract: We report a 12-year-old girl who presented with recurrent angioedema on the face, trunk, and extremities, and concomitant marked weight gain for 5 years. During the episode, her white blood cell count increased to 47.7×109/L with 89.9% eosinophils, followed by elevated serum level of IL-5, IgE, IgM, and LDH. Histopathology showed perivascular eosinophilic infiltration and diffuse eosinophilic infiltration throughout the dermis. Possible causes of hypereosinophilia and eosinophilic infiltration of vital organs were ruled out. We also tested the FIP1L1/PDGFRa and ETV6/PDGFRb fusion gene to exclude the possibility of myeloid and lymphatic vessel neoplasms. The patient was treated with methylprednisolone and discharged with an oral prednisolone taper, which resulted in complete remission of the edema and normalization of peripheral blood eosinophil count, serum IL-5 level, IgE, IgM, and LDH.
Descritores: Eosinofilia/complicações
Angioedema/complicações
Angioedema/patologia
-Recidiva
Imunoglobulina E/sangue
Imunoglobulina M/sangue
Ganho de Peso
Interleucinas/sangue
Eosinofilia/patologia
Limites: Humanos
Feminino
Criança
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-950009
Autor: Robledo Aceves, Mireya; Barrón Balderas, Alejandro; Jaime Ornelas, María de L.
Título: Virus más frecuentemente aislados en la exacerbación de asma y su correlación con nivelesde eosinófilos e inmunoglobulina E sérica total / Most commonly isolated viruses in asthma exacerbation and their correlation with eosinophil and total serum immunoglobulin E levels
Fonte: Arch. argent. pediatr;116(3):192-197, jun. 2018. tab, graf.
Idioma: en; es.
Resumo: Antecedentes. Las exacerbaciones de asma continúan siendo una causa de hospitalización en el Servicio de Urgencias. Los desencadenantesson alérgenos e infecciones, principalmente, de tipo viral. El objetivo fue determinar la relación entre los virus detectados durante la exacerbación asmática y los niveles de eosinófilos e inmunoglobulina E (IgE) sérica en pacientes pediátricos. Población y métodos. Estudio transversal analítico. Se incluyeron niños de cinco a quince años atendidos en Urgencias de Pediatría con exacerbación de asma, en el período de marzo de 2013 a febrero de 2016. Se obtuvo ácido ribonucleico viral en el aspirado nasofaríngeo con el kit CLART PneumoVir. Se cuantificaron los eosinófilos en la sangre periférica y los niveles de IgE sérica total. Se consideró eosinofilia un conteo ≥ 0,4 x 103/mm3 e IgE elevada, ≥ 350 UI/L. Se realizó la correlación de Pearson. Se definió significancia con valor de p ≤ 0,05.Resultados. De 211 niños con exacerbación de asma, en el 20%, se aisló un virus. Los virus aislados más frecuentemente fueron el rinovirus, el enterovirus y el virus sincitial respiratorio. Se encontró una correlación entre los niveles de eosinófilos e IgE sérica total en los niños con exacerbación de asma y rinovirus de 0,89, con una p= 0,0001.Conclusiones. Las infecciones por rinovirus, enterovirus y virus sincitial respiratorio son más frecuentes en las exacerbaciones de asma en menores de 15 años. Se observó una correlación entre los niveles de eosinófilos e IgE en presencia de rinovirus.

Background. Asthma exacerbations are still a cause of hospitalization at the Emergency Department. The triggers of asthma exacerbations include allergens and infections ­mostly viral­. The objective of this study was to establish the relationship between viruses detected during an asthma exacerbation and eosinophil and serum immunoglobulin E (IgE) levels in pediatric patients. Population and methods. Cross-sectional. analytical study. Children aged 5-15 years seen at the Pediatric Emergency Department with an asthma exacerbation in the period between March 2013 and February 2016 were included. Viral ribonucleic acid was extracted from nasopharyngeal aspirates using the CLART Pneumo Vir kit. Eosinophil levels were measured in peripheral blood and total IgE levels, in serum. Eosinophilia was defined as a count ≥ 0.4 x 103/mm3 and high IgE. as a level ≥ 350 IU/L. The Pearson's correlation was carried out. A value of p ≤ 0.05 was considered significant.Results. Out of 211 children with asthma exacerbation, a virus was isolated in 20%. The most commonly isolated viruses were rhinovirus. enterovirus, and respiratory syncytial virus. A correlation of 0.89 was established between eosinophil and total serum IgE levels in children with asthma exacerbation and rhinovirus, with a p value of 0.0001. Conclusions. Rhinovirus, enterovirus, and respiratory syncytial virus were the most common viruses in asthma exacerbations in children younger than 15 years. A correlation was established between eosinophil and IgE levels in the presence of rhinovirus.
Descritores: Asma/virologia
Imunoglobulina E/sangue
Eosinófilos/metabolismo
-Asma/fisiopatologia
Asma/sangue
Rhinovirus/isolamento & purificação
Estudos Transversais
Vírus Sincicial Respiratório Humano/isolamento & purificação
Infecções por Vírus Respiratório Sincicial/diagnóstico
Infecções por Vírus Respiratório Sincicial/epidemiologia
Enterovirus/isolamento & purificação
Infecções por Picornaviridae/diagnóstico
Infecções por Picornaviridae/epidemiologia
Serviço Hospitalar de Emergência
Infecções por Enterovirus/diagnóstico
Infecções por Enterovirus/epidemiologia
Limites: Humanos
Masculino
Feminino
Pré-Escolar
Criança
Adolescente
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: biblio-887343
Autor: Petriz, Natalia A; Parisi, Claudio A. S; Busaniche, Julio N; Evangelista, Patricia; Mehaudy, Romina; Orsi, Marina.
Título: Historia natural de la alergia a la leche de vaca mediada por inmunoglobulina E en una población de niños argentinos / Natural history of immunoglobulin E-mediated cow's milk allergy in a population of Argentine children
Fonte: Arch. argent. pediatr;115(4):331-335, ago. 2017. graf, tab.
Idioma: en; es.
Resumo: Introducción. La alergia a la proteína de la leche de vaca es la alergia alimentaria más frecuente en pediatría. El subtipo de las mediadas por inmunoglobulina E (IgE) presenta mayor riesgo de vida y peor pronóstico. Objetivos. Describir la evolución de la alergia a la proteína de la leche de vaca mediada por IgE y los factores de riesgo asociados a la persistencia de la enfermedad. Pacientes y método. Estudio descriptivo, retrospectivo en pacientes que consultaron a la sección de Alergia Pediátrica del Hospital Italiano entre junio de 2006 y junio de 2012 con diagnóstico de alergia a la leche de vaca mediada por IgE. Resultados: Se hallaron 72 pacientes con alergia a la leche de vaca mediada por IgE, 39 (54%) de sexo masculino. La edad promedio al momento del diagnóstico fue de 5,19 ± 3,7 meses; los síntomas de presentación más frecuentes fueron urticaria y vómitos. La rinitis y el asma fueron las enfermedades atópicas concomitantes más frecuentemente observadas. En el período de estudio, el 54,5% adquirieron tolerancia a la edad promedio de 32 meses. La presencia de pápulas mayores de 8mm en el prick test y de sensibilización a la caseína se asoció con la persistencia de la enfermedad. Conclusión. El 54,5% de los pacientes desarrolló tolerancia a los 32 meses de vida. Se encontró una asociación significativa entre el tamaño de la pápula al momento del diagnóstico y la sensibilización a la caseína con la persistencia de la enfermedad.

Introduction. Cow's milk protein allergy is the most common allergy in pediatrics. Immunoglobulin E (IgE)-mediated cow's milk allergy poses a higher risk for life and a worse prognosis. Objectives. To describe the course of IgE-mediated cow's milk protein allergy and risk factors associated with disease persistence. Patients and methods. This was a descriptive, retrospective study conducted in patients seen at the Division of Pediatric Allergy of Hospital Italiano between June 2006 and June 2012 who had been diagnosed with IgE-mediated cow's milk allergy. Results. Out of the 72 patients with IgE-mediated cow's milk allergy, 39 (54%) were boys. Patients' average age at the time of diagnosis was 5.19 ± 3.7 months old; the most common symptoms were urticaria and vomiting. Rhinitis and asthma were the most commonly observed concomitant atopic diseases. In the study period, 54.5% of patients developed tolerance at an average age of 32 months old. An 8-mm papule in the skin prick test and casein sensitization were associated with disease persistence. Conclusion. Overall, 54.5% of patients developed tolerance at 32 months old. A significant association was observed between papule size at the time of diagnosis and casein sensitization and disease persistence.
Descritores: Imunoglobulina E/imunologia
Hipersensibilidade a Leite/imunologia
-Argentina
Estudos Retrospectivos
Fatores de Risco
Tolerância Imunológica
Limites: Humanos
Masculino
Feminino
Lactente
Responsável: AR94.1 - Centro de Información Pediatrica



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