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Id: biblio-1056050
Autor: Silva, Stefany Martins; Rodrigues, Izabella Caroline Gebrim; Santos, Rodrigo da Silva; Ternes, Yves Mauro Fernandes.
Título: The direct and indirect effects of the pneumococcal conjugated vaccine on carriage rates in children aged younger than 5 years in Latin America and the Caribbean: a systematic review / Efeitos diretos e indiretos da vacina pneumocócica conjugada no estado de portador em crianças menores de 5 anos, na América Latina e no Caribe: uma revisão sistemática
Fonte: Einstein (Säo Paulo);18:eRW4890, 2020. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective To demonstrate the impact of pneumococcal conjugate vaccine in Streptococcus pneumoniae carriage status in children younger than 5 years in Latin America and the Caribbean. Methods A systematic literature review was carried out on the direct and indirect effects of pneumococcal vaccine in the carriage status, after implementation in childhood immunization programs. Studies carried out in children younger than 5 years were selected from the PubMed® and Virtual Health Library databases, and data collected after implementation of pneumococcal vaccine in Latin America and the Caribbean, between 2008 and 2018. Results From 1,396 articles identified, 738 were selected based on titles and abstracts. After duplicate removal, 31 studies were eligible for full-text reading, resulting in 6 publications for analysis. All selected publications were observational studies and indicated a decrease in the carriage and vaccine types, and an increase in the circulation of non-vaccine serotypes, such as 6A, 19A, 35B, 21 and 38. We did not identify changes in the antimicrobial resistance after vaccine implementation. Conclusion A decrease in the carriage status of vaccine types and non-vaccine types was detected. The continuous monitoring of pneumococcal vaccine effect is fundamental to demonstrate the impact of the carriage status and, consequently, of invasive pneumococcal disease, allowing better targeting approaches in countries that included pneumococcal vaccine in their immunization programs. Our study protocol was registered in PROSPERO (www.crd.york.ac.uk/prospero) under number CRD42018096719.

RESUMO Objetivo Demonstrar o impacto das vacinas pneumocócicas conjugadas no estado de portador de Streptococcus pneumoniae em crianças menores de 5 anos na América Latina e no Caribe. Métodos Foi realizada revisão sistemática da literatura sobre os efeitos diretos e indiretos da vacina pneumocócica no estado de portador em crianças menores de 5 anos, após a implantação da vacina nos calendários de imunização infantil. A partir de dados da PubMed®e da Biblioteca Virtual da Saúde, foram selecionados estudos de portador em crianças menores de 5 anos, com dados coletados após implementação da vacina de 2008 a 2018, na América Latina e no Caribe. Resultados Dos 1.396 artigos identificados, 738 foram selecionados mediante leitura de títulos e resumos. Após a extração dos duplicados, 31 foram elegíveis para leitura do texto completo, restando 6 artigos para análise. Todos os estudos selecionados eram observacionais e indicavam diminuição do portador e tipos vacinais, e aumento da circulação de sorotipos não vacinais, como 6A, 19A, 35B, 21 e 38. Não foi observada alteração na resistência antimicrobiana após a introdução da vacina. Conclusão Detectou-se redução no estado de portador, dos tipos vacinais e não vacinais. O monitoramento contínuo do efeito das vacinas pneumocócicas é fundamental, para demonstrar o impacto do estado de portador e, consequentemente, da doença pneumocócica invasiva, permitindo o melhor direcionamento nas ações em saúde para os países que incluíram a vacina no calendário de imunização. Nosso protocolo de estudo foi registrado no PROSPERO (www.crd.york.ac.uk/prospero) sob o número CRD42018096719.
Descritores: Ensaio de Imunoadsorção Enzimática/métodos
Técnica Indireta de Fluorescência para Anticorpo/métodos
Dengue/diagnóstico
-Arbovírus/isolamento & purificação
Padrões de Referência
Brasil
Imunoglobulina G/imunologia
Imunoglobulina M/imunologia
Ensaio de Imunoadsorção Enzimática/normas
Testes Sorológicos/métodos
Testes Sorológicos/normas
Reação em Cadeia da Polimerase
Sensibilidade e Especificidade
Técnica Indireta de Fluorescência para Anticorpo/normas
Dengue/imunologia
Vírus da Dengue/isolamento & purificação
Anticorpos Antivirais/imunologia
Limites: Humanos
Tipo de Publ: Estudo Comparativo
Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-1056051
Autor: Arai, Karina Emy; Bo, Carolina Rodrigues Dal; Silva, Ana Paula Marques Aguirra da; Rodrigues, Silvia Sanches; Mangueira, Cristóvão Luis Pitangueira.
Título: Performance evaluation of an indirect immunofluorescence kit for the serological diagnosis of dengue / Avaliação do desempenho de kit de imunofluorescência indireta para o diagnóstico sorológico de dengue
Fonte: Einstein (Säo Paulo);18:eAO5078, 2020. tab.
Idioma: en.
Resumo: ABSTRACT Objective: To evaluate the performance of indirect immunofluorescence for serological diagnosis of dengue virus in a population with high prevalence of arboviruses. Methods: Two-hundred serum samples from patients with clinical suspicion of dengue fever were tested by immunoenzymatic and indirect immunofluorescence assay BIOCHIP® mosaic. Specificity, sensitivity and Kappa coefficient were calculated. Discordant samples were tested by polymerase chain reaction for confirmation. Results: Of the 200 samples, 20% were positive and 80% negative for anti-dengue virus IgM antibodies in the immunoenzymatic test. Of the 40 positives, 25% were negative in indirect immunofluorescence. Of these ten discordant results, only 20% were also negative in the polymerase chain reaction (PCR). Of the 160 negatives in the immunoenzymatic test, 5% were positive in indirect immunofluorescence. Of these nine discordant results, 33% were positive in the PCR. The Kappa coefficient was 0.7 (0.572-0.829). Sensitivity and specificity of indirect immunofluorescence were respectively 75% and 94%. For anti-dengue virus IgG antibodies, of the 200 samples, 15.5% were positive and 84.5% were negative in the immunoenzymatic test. Of the 31 positives, 12.9% were negative in indirect immunofluorescence. Of these four discordant results, 25% were negative in the PCR. Of the 169 negatives, 8% were positive in indirect immunofluorescence. Of these 14 discordant results, 64% were also positive in the PCR. The Kappa coefficient was 0.695 (0.563-0.83). Sensitivity and specificity of indirect immunofluorescence were 87.1% and 91.7%, respectively. Conclusion: For diagnosis of acute infection, the immunoenzymatic test is enough, and the use of additional methods is not warranted. Replacing the immunoenzymatic test by indirect immunofluorescence would compromise the sensitivity for IgM. However, indirect immunofluorescence can distinguish three arboviruses simultaneously, an advantage during concomitant epidemics.

RESUMO Objetivo: Avaliar o desempenho da imunofluorescência indireta no diagnóstico sorológico de dengue em uma população com alta prevalência de arboviroses. Métodos: Duzentas amostras de soro de pacientes com suspeita clínica de dengue foram testadas por ensaio imunoenzimático e imunofluorescência indireta mosaico BIOCHIP®. Foram calculados especificidade, sensibilidade e coeficiente Kappa. Nas amostras discordantes, realizou-se reação em cadeia da polimerase como método confirmatório. Resultados: Das 200 amostras, 20% foram positivas e 80% negativas para IgM antivírus da dengue no ensaio imunoenzimático. Das 40 positivas, 25% foram negativas na imunofluorescência indireta. Destas dez negativas, apenas 20% eram também negativas na reação em cadeia da polimerase. Das 160 negativas no ensaio imunoenzimático, 5% foram positivas na imunofluorescência indireta. Por fim, dentre as nove discordantes, 33% tiveram vírus da dengue detectado na reação em cadeia da polimerase. O coeficiente Kappa foi 0,70 (0,57-0,82). Sensibilidade e especificidade por imunofluorescência indireta foram, respectivamente, 75% e 94%. Para IgG antivírus da dengue, de 200 amostras, 15,5% foram positivas e 84,5% negativas no ensaio imunoenzimático. Das 31 positivas, 12,9% foram negativas na imunofluorescência indireta. Destas quatro discordantes, 25% apresentaram vírus da dengue não detectado na reação em cadeia da polimerase. Das 169 negativas, 8% foram positivas na imunofluorescência indireta. Destas, 64% foram positivas também na reação em cadeia da polimerase. O coeficiente Kappa foi 0,695 (0,56-0,83). Sensibilidade e a especificidade por imunofluorescência indireta foram, respectivamente, 87,1% e 91,7%. Conclusão: Ensaio imunoenzimático seria suficiente para diagnóstico sorológico de infecção aguda, não justificando a incorporação da imunofluorescência indireta. Substituir ensaio imunoenzimático pela imunofluorescência indireta poderia comprometer a sensibilidade para IgM. Contudo, a imunofluorescência indireta auxilia diferenciar três arboviroses simultaneamente, sendo vantajoso em epidemias concomitantes.
Descritores: Ensaio de Imunoadsorção Enzimática/métodos
Técnica Indireta de Fluorescência para Anticorpo/métodos
Dengue/diagnóstico
-Arbovírus/isolamento & purificação
Padrões de Referência
Brasil
Imunoglobulina G/imunologia
Imunoglobulina M/imunologia
Ensaio de Imunoadsorção Enzimática/normas
Testes Sorológicos/métodos
Testes Sorológicos/normas
Reação em Cadeia da Polimerase
Sensibilidade e Especificidade
Técnica Indireta de Fluorescência para Anticorpo/normas
Dengue/imunologia
Vírus da Dengue/isolamento & purificação
Anticorpos Antivirais/imunologia
Tipo de Publ: Estudo Comparativo
Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-1090042
Autor: Oliveira, Henrique Souza Barros de; Araujo, Patricia Padial de; Sousa, Jamile Rafaela Poltronieri de; Donis, Ana Carolina Gariba; Moreira, Deise; Makssoudian, Andrea.
Título: Serious adverse event: late neurotropic disease associated with yellow fever vaccine / Evento adverso grave: doença neurotrópica tardia associada à vacina da febre amarela
Fonte: Einstein (Säo Paulo);18:eRC5041, 2020. tab.
Idioma: en.
Resumo: ABSTRACT The yellow fever is a systemic disease that was under control due to the effective campaigns against the vector and promotion of vaccines programs. However, since 1999, outbreaks appeared because of inefficient control of the vector, and led to the need of amplifying the immunization in large scale against the yellow fever virus, and consequently, raising the risk of adverse reactions to the vaccine. We report a case of previously healthy infant, who was referred to our care service, after 3 days with fever, chills, nausea and vomits, he received support therapy and was discharged from the hospital. After 24 hours of supportive measures, he was discharge. The patient returned to our service with general condition decline, strabismus, inability to control of cervical musculature and reduced force of the legs. The patient vaccine had received all vaccines from the calendar, and he was vaccinated for yellow fever 20 days before symptoms. During the hospitalization, liquor was collected, and ceftriaxone and aciclovir were administered. After negative cultures from the liquor, the antibiotics were suspended. The computed tomography of patient's brain showed no alterations. Research for antibodies against yellow fever was requested, being positive for IgM in the liquor, and confirming the neurotropic disease associated with the yellow fever vaccine. On the fifth day of hospitalization, the patient showed improvement on the strabismus, cervical tonus, and musculature force. On the tenth day of hospitalization, patient showed complete improvement, and his laboratory exams no alterations. Subsequently, patient was discharged. The vaccine against yellow fever is safe, efficient and highly recommended, however it is not completely free from serious adverse reactions, including death.

RESUMO A febre amarela é uma doença sistêmica que estava controlada graças às efetivas campanhas de combate ao vetor e aos programas de vacinação. Porém, desde 1999, os surtos reiniciaram-se, devido à ineficácia do controle do vetor, levando à necessidade da imunização em larga escala contra o vírus da febre amarela, gerando aumento do risco de ocorrência de reação adversa à vacina. O presente estudo se propôs a relatar o caso de um lactente previamente saudável, que procurou pronto atendimento, pois, há 3 dias, apresentava febre, calafrios, náusea e vômitos. Em 24 horas após medidas de suporte e alta, evoluiu com queda do estado geral, estrabismo, falta de controle da musculatura cervical e redução da força muscular de membros inferiores. O caderno vacinal encontrava-se completo, tendo recebido vacina contra febre amarela há 20 dias. Durante a internação, foi realizada coleta do liquor, e foram administrados ceftriaxona e aciclovir. Após cultura negativa do liquor, o antibiótico foi suspenso. A tomografia computadorizada de crânio não apresentou alterações. Solicitou-se pesquisa de anticorpos contra o vírus da febre amarela no liquor, sendo positiva para IgM e confirmando a doença neurotrópica associada à vacina da febre amarela. A partir do quinto dia de internação, o paciente evoluiu com melhora do estrabismo, do tônus cervical e da força muscular. No décimo dia de internação, apresentou melhora completa do quadro, sem alterações laboratoriais, recebendo alta. A vacina contra febre amarela é segura, eficaz e fortemente recomendada, porém não está completamente isenta de reações adversas graves, inclusive podendo levar a quadros fatais.
Descritores: Vacina contra Febre Amarela/efeitos adversos
Doenças do Sistema Nervoso/etiologia
-Imunoglobulina M/análise
Estrabismo/etiologia
Debilidade Muscular/etiologia
Limites: Humanos
Masculino
Lactente
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-1281757
Autor: Meni Battaglia, Luciana; Balestracci, Alejandro; Toledo, Ismael; Martin, Sandra M; Careaga, Claudia M; Gogorza, María C; Caupolican, Alvarado; Cao, Gabriel.
Título: Nefropatía por inmunoglobulina M: características histopatológicas y clínicas. Serie de casos / Immunoglobulin M nephropathy: histopathological and clinical characteristics. Case series
Fonte: Arch. argent. pediatr;119(4):e335-e339, agosto 2021. ilus.
Idioma: es.
Resumo: La nefropatía por inmunoglobulina M (NIgM) es una glomerulopatía idiopática caracterizada por depósitos mesangiales globales y difusos de IgM. Se realizó un estudio retrospectivo de las características clínicas e histopatológicas de los pacientes con NIgM atendidos en nuestro servicio. De 241 biopsias renales, 21 correspondieron a NIgM (8,7 %). Se incluyeron 18 pacientes (14 de sexo femenino, mediana de edad: 3,08 años). Se excluyó a 1 paciente por enfermedad sistémica asociada y a 2 por seguimiento menor a 1 año. Catorce pacientes se manifestaron con síndrome nefrótico (SN) y 4 con proteinuria aislada o asociada a hematuria. En la microscopia óptica, 13 presentaron hiperplasia mesangial, y 5 esclerosis focal y segmentaria. De los pacientes con SN, 7 fueron corticorresistentes, 4 corticodependientes y 3 presentaban recaídas frecuentes. Todos los pacientes con SN y 1 con proteinuria-hematuria recibieron inmunosupresores; los 18 pacientes recibieron, además, antiproteinúricos. Luego de 5,2 años (2-17,5) de seguimiento, 6 pacientes evolucionaron a enfermedad renal crónica

Immunoglobulin M nephropathy (IgMN) is an idiopathic glomerulopathy characterized by diffuse global mesangial deposits of IgM. We retrospectively studied the clinical and histopathological characteristics of the patients with IgMN seen in our service. Of 241 renal biopsies, 21 corresponded to IgMN (8.7 %). One patient was excluded due to associated systemic disease and 2 due to follow-up less than 1 year, 18 were included (14 girls, median age 3.08 years). Fourteen manifested with nephrotic syndrome (NS) and the remaining with proteinuria (isolated or associated with hematuria). On light microscopy, 13 had hyperplasia with mesangial expansion and 5 had focal and segmental sclerosis. Of the patients with NS, 7 were steroid-resistant, 4 steroid-dependent, and 3 frequent relapsers. All patients with NS and 1 with proteinuria-hematuria received immunosuppressants; the 18 patients also received antiproteinuric drugs. After 5.2 years (2-17.5) of follow-up, 6 patients developed chronic kidney disease.
Descritores: Imunoglobulina M
Síndrome Nefrótica/patologia
Síndrome Nefrótica/terapia
-Nefropatias
Síndrome Nefrótica/diagnóstico
Limites: Humanos
Masculino
Feminino
Recém-Nascido
Lactente
Pré-Escolar
Criança
Adolescente
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica


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Carvalho, Werther Brunow de
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Id: biblio-1278905
Autor: Calil, Valdenise Martins Laurindo Tuma; Palmeira, Patricia; Zheng, Yingying; Krebs, Vera Lúcia Jornada; Carvalho, Werther Brunow de; Carneiro-Sampaio, Magda.
Título: CoronaVac can induce the production of anti-SARS-CoV-2 IgA antibodies in human milk
Fonte: Clinics;76:e3185, 2021. graf.
Idioma: en.
Projeto: FAPESP.
Descritores: SARS-CoV-2
Leite Humano
-Imunoglobulina M
Anticorpos Antivirais
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Editorial
Responsável: BR1.1 - BIREME


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Id: biblio-1280391
Autor: Cancino Mesa, José Francisco; Luna López, Abel Ernesto; Casí Torres, Jorge.
Título: Lupus eritematoso sistémico en actividad y cociente albúmina/globulina invertido, ¿hallazgo propio de la enfermedad? / Systemic Erythematosus Lupus and Albumin-Globulin Index, a specific finding in lupus flares?
Fonte: Rev. cuba. reumatol;22(supl.1):e853graf.
Idioma: es.
Resumo: Introducción: El lupus eritematoso sistémico es el modelo clásico de enfermedad autoinmune. En el desarrollo de la enfermedad intervienen varios tipos de inmunoglobulinas, con predominio de la IgG, IgM e IgA. Objetivo: Describir la utilidad del cociente albúmina/globulina como un indicador de actividad en el lupus eritematoso sistémico. Desarrollo: Se estima que el 50 por ciento de los pacientes con lupus eritematoso sistémico muestran una hipoalbuminemia con una hipergammaglobulinemia. La hipoalbuminemia en mayor medida está relacionada con la presencia de nefritis lúpica. La mitad de los pacientes con nefritis lúpica presentan proteinuria en el orden del síndrome nefrótico. Esta proteinuria iguala o invierte parcialmente el valor del cociente albúmina/globulina. El cociente albúmina/globulina invertido por sí solo es insuficiente para afirmar la presencia de actividad en el lupus eritematoso sistémico. Se deben excluir otras entidades clínicas causantes de hipergammaglobulinemia policlonal. Los criterios de actividad del lupus eritematoso sistémico incrementan la sensibilidad del cociente albúmina/globulina invertido. Conclusiones: La interpretación del cociente albúmina/globulina debe ir aparejada a la estimación de actividad por los criterios clínicos de mayor uso (SLICC, SLEDAI, BILAG). No en todos los pacientes con lupus eritematoso sistémico puede interpretarse como criterio de actividad, por lo que es necesario excluir otras entidades clínicas(AU)

Introduction: Systemic lupus erythematosus is the model of autoimmune disease. Several types of immunoglobulins are involved in the development of the disease, mainly IgG, IgM and IgA. Objective: To describe the potential use of the albumin/globulin ratio as an indicator of activity in systemic lupus erythematosus. Development: fifty percent of patients with systemic lupus erythematosus exhibit hypoalbuminemia with hypergammaglobulinemia. Hypoalbuminemia is mainly related to the presence of lupus nephritis. The half of patients with lupus nephritis develops proteinuria with values of nephrotic syndrome. The proteinuria equals or partially reverses the albumin/globulin ratio. The inverted albumin/globulin ratio is insufficient to establish the presence of lupus activity. Other clinical entities producing polyclonal hypergammaglobulinaemia should be excluded. The systemic lupus erythematosus activity criteria increase the sensitivity of the inverted albumin/globulin ratio. Conclusions: The interpretation of the albumin/globulin ratio requires the activity estimation by different clinical criteria (SLICC, SLEDAI, BILAG). The inverted albumin/globulin ratio cannot be interpreted as a stand-alone indicator of disease activity in every systemic lupus erythematosus patients(AU)
Descritores: Proteinúria
Doenças Autoimunes
Imunoglobulina A/análise
Imunoglobulina G/análise
Imunoglobulina M/análise
Hipoalbuminemia
Hipergamaglobulinemia/diagnóstico
Lúpus Eritematoso Sistêmico/diagnóstico
Síndrome Nefrótica
-Razão de Chances
Albuminas/análise
Limites: Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


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Szwarcwald, Célia Landmann
Pôrto, Luís Cristóväo de Moraes Sobrino
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Id: biblio-1127233
Autor: Amorim Filho, Luiz; Szwarcwald, Célia Landmann; Mateos, Sheila de Oliveira Garcia; Leon, Antonio Carlos Monteiro Ponce de; Medronho, Roberto de Andrade; Veloso, Valdiléa Gonçalves; Lopes, Josiane Iole França; Porto, Luis Cristovão de Moraes Sobrino; Chieppe, Alexandre; Werneck, Guilherme Loureiro.
Título: Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
Fonte: Rev. saúde pública (Online);54:69, 2020. tab, graf.
Idioma: en.
Resumo: ABSTRACT OBJECTIVE To estimate the seroprevalence of antibodies to SARS-CoV-2 among blood donors in the state of Rio de Janeiro, Brazil. METHODS Data were collected on 2,857 blood donors from April 14 to 27, 2020. This study reports crude prevalence of antibodies to SARS-CoV-2, population weighted prevalence for the state, and prevalence adjusted for test sensitivity and specificity. Logistic regression models were used to establish the correlates of SARS-CoV-2 prevalence. For the analysis, we considered collection period and site, sociodemographic characteristics, and place of residence. RESULTS The proportion of positive tests for SARS-Cov-2, without any adjustment, was 4.0% (95%CI 3.3-4.7%), and the weighted prevalence was 3.8% (95%CI 3.1-4.5%). We found lower estimates after adjusting for test sensitivity and specificity: 3.6% (95%CI 2.7-4.4%) for the non-weighted prevalence, and 3.3% (95%CI 2.6-4.1%) for the weighted prevalence. Collection period was the variable most significantly associated with crude prevalence: the later the period, the higher the prevalence. Regarding sociodemographic characteristics, the younger the blood donor, the higher the prevalence, and the lower the education level, the higher the odds of testing positive for SARS-Cov-2 antibody. We found similar results for weighted prevalence. CONCLUSIONS Our findings comply with some basic premises: the increasing trend over time, as the epidemic curve in the state is still on the rise; and the higher prevalence among both the youngest, for moving around more than older age groups, and the less educated, for encountering more difficulties in following social distancing recommendations. Despite the study limitations, we may infer that Rio de Janeiro is far from reaching the required levels of herd immunity against SARS-CoV-2.
Descritores: Pneumonia Viral/imunologia
Doadores de Sangue/estatística & dados numéricos
Infecções por Coronavirus/imunologia
Betacoronavirus/imunologia
Anticorpos Antivirais/sangue
-Pneumonia Viral/sangue
Pneumonia Viral/epidemiologia
Brasil/epidemiologia
Imunoglobulina G/sangue
Imunoglobulina M/sangue
Estudos Soroepidemiológicos
Prevalência
Estudos Transversais
Análise de Regressão
Sensibilidade e Especificidade
Infecções por Coronavirus/sangue
Infecções por Coronavirus/epidemiologia
Pandemias
SARS-CoV-2
COVID-19
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adulto
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1011897
Autor: Aydemir, Yasemin Gul; Kocakusak, Ahmet.
Título: The evaluation of the Myxovirus Resistance 1 protein in serum and saliva to monitor disease activation in primary Sjögren's syndrome
Fonte: Clinics;74:e631, 2019. tab.
Idioma: en.
Resumo: OBJECTIVE: Primary Sjögren's syndrome (pSjS) is a chronic autoimmune disease that causes dry eye and mouth. No laboratory parameters to monitor the activation of this disease have been identified. Therefore, any possible relationships between salivary and blood myxovirus resistance 1 (MX1) and pSjS must be prospectively studied. METHODS: Thirty female patients with pSjS, 30 women with rheumatoid arthritis (RA) without secondary Sjögren's syndrome (SjS) and 28 healthy control women were enrolled in this investigation. Analyses of MX1 by the enzyme-linked immunosorbent assay (ELISA) method, SS-A (Ro) and SS-B (La) tests by the strip immunoblot method, anti-nuclear antibody (ANA) tests by immunofluorescence and the measurement of serum rheumatoid factor (RF), C3, C4, immunoglobulin A (IgA), immunoglobulin M (IgM), and immunoglobulin G (IgG) were performed. RESULTS: The serum level of MX1 in patients without Raynaud phenomenon was higher than in those with Raynaud phenomenon (p:0.029, p<0.05, statistically significant). There was a statistically significant positive association between hemoglobin levels and MX1 serum levels. No statistically significant association was found among the other parameters. Low MX1 levels were shown to be associated with both a low disease activity score based on the European League Against Rheumatism (EULAR) Sjögren's Syndrome Disease Activity Index (ESSDAI) and hydroxychloroquine use in all patients. CONCLUSION: MX1 levels have a considerable impact on the assessment of the disease activity in SjS. We believe that more-comprehensive studies should be performed on patients with pSjS who do not use hydroxychloroquine to prove this relationship and that MX1 levels should be used as a routine marker for the assessment of pSjS disease activity. Further studies are needed to create awareness of the role that MX1 has in the diagnosis of pSjS, which may help to uncover novel pathways for new therapeutic modalities.
Descritores: Saliva/química
Isotipos de Imunoglobulinas/sangue
Síndrome de Sjogren/metabolismo
Proteínas de Resistência a Myxovirus/imunologia
-Imunoglobulina G
Imunoglobulina M/sangue
Ensaio de Imunoadsorção Enzimática
Biomarcadores/análise
Síndrome de Sjogren/diagnóstico
Síndrome de Sjogren/imunologia
Anticorpos Antinucleares/sangue
Limites: Humanos
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


  9 / 694 LILACS  
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Id: biblio-1133408
Autor: Moura, Diogo Turiani Hourneaux de; McCarty, Thomas R; Ribeiro, Igor Braga; Funari, Mateus Pereira; Oliveira, Pedro Victor Aniz Gomes de; Miranda Neto, Antonio Afonso de; Monte Júnior, Epifânio Silvino do; Tustumi, Francisco; Bernardo, Wanderley Marques; Moura, Eduardo Guimarães Hourneaux de; Thompson, Christopher C.
Título: Diagnostic characteristics of serological-based COVID-19 testing: a systematic review and meta-analysis
Fonte: Clinics;75:e2212, 2020. tab, graf.
Idioma: en.
Resumo: Serologic testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promises to assist in assessing exposure to and confirming the diagnosis of coronavirus disease 2019 (COVID-19), and to provide a roadmap for reopening countries worldwide. Considering this, a proper understanding of serologic-based diagnostic testing characteristics is critical. The aim of this study was to perform a structured systematic review and meta-analysis to evaluate the diagnostic characteristics of serological-based COVID-19 testing. Electronic searches were performed using Medline (PubMed), EMBASE, and Cochrane Library. Full-text observational studies that reported IgG or IgM diagnostic yield and used nucleic acid amplification tests (NAATs) of respiratory tract specimens, as a the reference standard in English language were included. A bivariate model was used to compute pooled sensitivity, specificity, positive/negative likelihood ratio (LR), diagnostic odds ratio (OR), and summary receiver operating characteristic curve (SROC) with corresponding 95% confidence intervals (CIs). Five studies (n=1,166 individual tests) met inclusion criteria. The pooled sensitivity, specificity, and diagnostic accuracy for IgG was 81% [(95% CI, 61-92);I2=95.28], 97% [(95% CI, 78-100);I2=97.80], and 93% (95% CI, 91-95), respectively. The sensitivity, specificity, and accuracy for IgM antibodies was 80% [(95% CI, 57-92);I2=94.63], 96% [(95% CI, 81-99);I2=92.96] and 95% (95% CI, 92-96). This meta-analysis demonstrates suboptimal sensitivity and specificity of serologic-based diagnostic testing for SARS-CoV-2 and suggests that antibody testing alone, in its current form, is unlikely to be an adequate solution to the difficulties posed by COVID-19 and in guiding future policy decisions regarding social distancing and reopening of the economy worldwide.
Descritores: Pneumonia Viral/diagnóstico
Testes Sorológicos
Infecções por Coronavirus/diagnóstico
Anticorpos Antivirais/sangue
-Imunoglobulina G/sangue
Imunoglobulina M/sangue
Sensibilidade e Especificidade
Técnicas de Laboratório Clínico
Pandemias
Betacoronavirus
Teste para COVID-19
SARS-CoV-2
COVID-19
Limites: Humanos
Tipo de Publ: Metanálise
Revisão Sistemática
Responsável: BR1.1 - BIREME


  10 / 694 LILACS  
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Id: lil-776532
Autor: Wambier, Carlos Gustavo; Wambier, Sarah Perillo de Farias; Furini, Renata Bazan; Simão, João Carlos Lopes; Frade, Marco Andrey Cipriani; Foss, Norma Tiraboschi.
Título: Factors associated with seropositivity for APGL-Iamong household contacts of leprosy patients
Fonte: Rev. Soc. Bras. Med. Trop;49(1):83-89, Jan.-Feb. 2016. tab, graf.
Idioma: en.
Resumo: Abstract: INTRODUCTION: Leprosy is mainly transmitted among family members who share genetic and ambient factors. The clinical form of leprosy in the index case and kinship could be risk factors for leprosy transmission. High antibody levels in household contacts (HC) in the absence of neural or skin lesions may characterize latent infection. This study aimed to evaluate the association between seropositivity for anti-phenolic glycolipid-I immunoglobulin M antibodies (APGL-I) in HC and the clinical classification of the index case and to analyze the association between APGL-I positivity with other factors such as age, kinship, and gender. METHODS: We performed a survey among 320 HC of 120 leprosy patients who were evaluated and followed-up in a leprosy outpatient clinic of a university hospital. All HC underwent complete skin examination, peripheral nerve palpation, skin sensory tests, and serologic tests for the detection and quantification of APGL-I. RESULTS: The overall seropositivity rate was 20%, and was greatly affected by kinship. APGL-I seropositivity was higher in siblings (41%), followed by parents (28%), spouses (26%), other (19%), and offspring (14%). Independent risk factors for seropositivity were being siblings (OR 3.3) and being a HC of an index case with indeterminate leprosy (OR 5.3). APGL-I seropositivity was associated with index cases with a bacillary index of 4 (88%; p<.001). Seropositivity among HC was not significantly associated with their gender and age. There was no statistical difference in the seropositivity rates of HC of index patients with paucibacillary and multibacillary leprosy. CONCLUSIONS: Strict evaluation and follow-up of HC with positive results for APGL-I is recommended. Special attention should be paid during the screening of siblings of the index cases, HC of patients with a high bacillary index, and HC of patients with indeterminate leprosy.
Descritores: Imunoglobulina M/sangue
Glicolipídeos/sangue
Hanseníase/diagnóstico
Hanseníase/transmissão
Anticorpos Antibacterianos/sangue
Antígenos de Bactérias/sangue
-Ensaio de Imunoadsorção Enzimática
Características da Família
Fatores de Risco
Busca de Comunicante
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Responsável: BR1.1 - BIREME



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