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Id: biblio-887250
Autor: Jaruvongvanich, Veeravich; Sanguankeo, Anawin; Riangwiwat, Tanawan; Upala, Sikarin.
Título: Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Fonte: Ann. hepatol;16(3):382-394, May.-Jun. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Introduction and aim. Endogenous sex hormones are associated with the risk of diabetes and metabolic syndrome. Recent studies suggested the role of these hormones in nonalcoholic fatty liver disease (NAFLD). We conducted a systematic review and meta-analysis of observational studies investigating the association between sex hormones and NAFLD. Material and methods. A comprehensive search of the databases of the MEDLINE and EMBASE was performed from inception through April 2016. The inclusion criterion was the observational studies that assessed the association of serum total testosterone (TT) and sex-hormone binding globulin (SHBG) and NAFLD. We calculated pooled effect estimates of TT and SHBG with 95% confidence intervals (Cl) comparing between subjects with and without NAFLD by using random-effects model. Results. Sixteen trials comprising 13,721 men and 5,840 women met the inclusion criteria. TT levels were lower in men with NAFLD (MD = -2.78 nmol/l, 95%CI -3.40 to -2.15, I2 = 99%) than in those without. Men with higher TT levels had lower odds of NAFLD whereas higher TT levels increased the odds of NAFLD in women. In both sexes, SHBG levels were lower in patients with NAFLD than controls and this inverse association was stronger in women than men and higher SHBG levels were associated with reduced odds of NAFLD. Conclusion. Our meta-analysis demonstrated a sex-dependent association between TT and NAFLD. Lower TT levels are associated with men with NAFLD and inversely associated with women with NAFLD, whereas higher SHBG levels are associated with lower NAFLD odds in both men and women.
Descritores: Testosterona/sangue
Globulina de Ligação a Hormônio Sexual/análise
Hepatopatia Gordurosa não Alcoólica/diagnóstico
Hepatopatia Gordurosa não Alcoólica/etiologia
Hepatopatia Gordurosa não Alcoólica/sangue
-Biomarcadores/sangue
Razão de Chances
Fatores Sexuais
Fatores de Risco
Limites: Humanos
Tipo de Publ: Metanálise
Revisão Sistemática
Responsável: BR1.1 - BIREME


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Id: biblio-838408
Autor: Jaworski, Paulo Eduardo Dietrich; Ramos, Anderson; Nicoleit, Arthur Radaelli; Bacarin, Luis Fernando de Almeida; Olivo Neto, Pedro.
Título: Importance of abdominal circumference and body mass index values in predicting male hypogonadism – A practical approach
Fonte: Arch. endocrinol. metab. (Online);61(1):76-80, Jan.-Feb. 2017. tab.
Idioma: en.
Resumo: ABSTRACT Objective The objective of this study was to correlate the values of abdominal circumference (AC) and body mass index (BMI) with the levels of total testosterone (TT), free testosterone (FT) and sexual hormone binding globulin (SHBG). We aimed to analyze the association between the anthropometric values and variations in the hormonal levels. Subjects and methods A transversal prospective study was conducted. A total of 159 patients were included in the study. Results BMI was inversely correlated with TT and SHBG (p = 0.02 and p = 0.006, respectively). AC was also inversely correlated withTT and SHBG (p = 0.006 and p < 0.0001, respectively). However, BMI did not correlate signicantly with these hormonal levels after adjusting for age. Conclusion This finding led to the conclusion that AC had a stronger inverse correlation than BMI with TT and SHBG. Our data suggested that AC alone can be used as an anthropometric parameter to help simplify the identification of men with low serum TT levels.
Descritores: Testosterona/sangue
Globulina de Ligação a Hormônio Sexual/análise
Índice de Massa Corporal
Circunferência da Cintura
Hipogonadismo/diagnóstico
-Biomarcadores/sangue
Estudos Transversais
Estudos Prospectivos
Hipogonadismo/sangue
Limites: Humanos
Masculino
Pessoa de Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


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Reis, Rosana Maria dos
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Id: biblio-1019352
Autor: Ribeiro, Victor Barbosa; Kogure, Gislaine Satyko; Lopes, Iris Palma; Silva, Rafael Costa; Pedroso, Daiana Cristina Chielli; Ferriani, Rui Alberto; Furtado, Cristiana Libardi Miranda; Reis, Rosana Maria dos.
Título: Association of measures of central fat accumulation indices with body fat distribution and metabolic, hormonal, and inflammatory parameters in women with polycystic ovary syndrome
Fonte: Arch. endocrinol. metab. (Online);63(4):417-426, July-Aug. 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective To investigate the associations among visceral adiposity index (VAI), lipid accumulation product (LAP), body fat percentage (%), and android/gynoid ratio (A/G ratio) in women with polycystic ovary syndrome (PCOS) and verify if the parameters representative of visceral obesity correlate with and exhibit the same frequency as body composition variables; anthropometric indices; and metabolic, hormonal, and inflammatory parameters. Subjects and methods This was a cross-sectional study that included 94 women with PCOS. Hormonal, metabolic, and inflammatory parameters were analyzed in all women. Free androgen index (FAI) and homeostasis model assessment (HOMA-IR), as well as LAP, VAI, and anthropometric indices, were calculated. The regions of interest (ROIs) in body composition and body composition indices were evaluated using a dual X-ray absorptiometry (DXA). Overall, 32 variables were selected as markers of body fat distribution. Results Among the 32 markers evaluated, 29 correlated with LAP, whereas 25 correlated with VAI, 19 with body fat (%), and 30 with A/G ratio. Additionally, some markers correlated with the four adiposity indices evaluated: ROIs, except for total mass and leg fat (%); body composition (body mass index, waist circumference, and hip circumference) indices; fasting insulin; and C-reactive protein. Conclusion LAP and VAI may be sensitive measures for screening and preventing metabolic syndrome and insulin resistance in PCOS, with LAP being more sensitive than VAI, and the A/G ratio may be more sensitive than body fat percentage.
Descritores: Síndrome do Ovário Policístico/sangue
Gordura Intra-Abdominal
Distribuição da Gordura Corporal
-Testosterona/sangue
Glicemia/análise
Composição Corporal
Proteína C-Reativa/análise
Globulina de Ligação a Hormônio Sexual/análise
Biomarcadores/sangue
Estudos Transversais
Sensibilidade e Especificidade
Mediadores da Inflamação/sangue
Sobrepeso/sangue
Produto da Acumulação Lipídica
Insulina/sangue
Limites: Humanos
Feminino
Adolescente
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


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Verreschi, Ieda Therezinha Nascimento
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Id: lil-705375
Autor: Sá, Emmanuela Quental Callou de; Sá, Francisco Carleial Feijó de; Oliveira, Kelly Cristina; Feres, Fausto; Verreschi, Ieda Therezinha Nascimento.
Título: Association between sex hormone-binding globulin (SHBG) and metabolic syndrome among men / Associação entre globulina de ligação a hormônio sexual (SHBG) e síndrome metabólica em homens
Fonte: Säo Paulo med. j;132(2):111-115, 2014. tab.
Idioma: en.
Resumo: CONTEXT AND OBJECTIVE: Metabolic syndrome consists of a set of factors that imply increased risk of cardiovascular diseases. The objective here was to evaluate the association between sex hormone-binding globulin (SHBG), sex hormones and metabolic syndrome among men. DESIGN AND SETTING: Retrospective analysis on data from the study "Endogenous oestradiol but not testosterone is related to coronary artery disease in men", conducted in a hospital in São Paulo. METHODS: Men (aged 40-70) who underwent coronary angiography were selected. The age, weight, height, waist circumference, body mass index and prevalence of dyslipidemia, hypertension and diabetes of each patient were registered. Metabolic syndrome was defined in accordance with the criteria of the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (NCEP-ATPIII). Serum samples were collected to assess the levels of glucose, total cholesterol, HDL-cholesterol (high density lipoprotein), triglycerides, albumin, SHBG, estradiol and total testosterone (TT). The levels of LDL-cholesterol (low density lipoprotein) were calculated using Friedewald's formula and free testosterone (FT) and bioavailable testosterone (BT) using Vermeulen's formula. RESULTS: 141 patients were enrolled in the study. The prevalence of metabolic syndrome was significantly higher in the first SHBG tercile than in the second and third terciles. A statistically significant positive association between the SHBG and TT values was observed, but no such association was seen between SHBG, BT and FT. CONCLUSION: Low serum levels of SHBG are associated with higher prevalence of metabolic syndrome among male patients, but further studies are required to confirm this association. .

CONTEXTO E OBJETIVO: A síndrome metabólica (SM) consiste em um conjunto de fatores que implicam risco elevado para doenças cardiovasculares. O objetivo foi avaliar a associação entre a globulina ligadora de esteroides sexuais (SHBG), hormônios sexuais e a SM em homens. TIPO DE ESTUDO E LOCAL: Análise retrospectiva de dados do estudo "Estradiol mas não testosterona se correlaciona com doença arterial coronariana em homens", conduzido em um hospital em São Paulo. MÉTODOS: Foram selecionados pacientes do sexo masculino com idade entre 40 e 70 anos, submetidos a angiografia coronária. A idade, a prevalência de dislipidemia, hipertensão e diabetes, o peso, a altura, cintura e o índice de massa corpórea de cada paciente foram coletados. A definição de SM seguiu os critérios do NCEP-ATPIII. Amostras séricas foram coletadas para análises da glicose, colesterol total, colesterol-HDL (high density lipoprotein), triglicerídeos, albumina, SHBG, estradiol e testosterona total (TT). O colesterol-LDL (low density lipoprotein) foi calculado pela fórmula de Friedewald e as testosteronas livre (TL) e biodisponível (TB) pela fórmula de Vermeulen. RESULTADOS: Entraram no estudo 141 pacientes. A prevalência de SM foi significativamente maior no primeiro tercil de SHBG em comparação ao segundo e terceiro tercis. Foi verificada uma associação positiva e significativa ente os valores de SHBG e TT, porém essa associação não foi verificada entre SHBG e TB e TL. CONCLUSÃO: Baixos níveis séricos de SHBG estiveram associados com alta prevalência da SM em pacientes do sexo masculino. Faz-se necessário que estudos avaliem essa associação. .
Descritores: Hormônios Esteroides Gonadais/sangue
Síndrome Metabólica/sangue
Globulina de Ligação a Hormônio Sexual/análise
-Análise de Variância
Glicemia/análise
Índice de Massa Corporal
Brasil/epidemiologia
Doenças Cardiovasculares/sangue
Colesterol/sangue
Síndrome Metabólica/epidemiologia
Prevalência
Valores de Referência
Estudos Retrospectivos
Medição de Risco
Fatores de Risco
Circunferência da Cintura
Limites: Humanos
Masculino
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-1014737
Autor: Peixoto, Clayton; Carrilho, Carolina Gomes; Ribeiro, Tatiana Teixeira de Siqueira Bilemjian; da Silva, Lucy Maria; Gonçalves, Emerson Andrade; Fernandes, Luísa; Nardi, Antonio Egidio; Cardoso, Adriana; Veras, André Barciela.
Título: Relationship between sexual hormones, quality of life and postmenopausal sexual function / Relação entre hormônios sexuais, qualidade de vida e função sexual na pós-menopausa
Fonte: Trends psychiatry psychother. (Impr.);41(2):136-143, Apr.-June 2019. tab.
Idioma: en.
Projeto: Conselho Nacional de Desenvolvimento Científico e Tecnológico.
Resumo: Abstract Objective To assess the relationship between sexual hormones, sexual function and quality of life in postmenopausal women. Method A cross-sectional study was conducted with a convenience sample of 36 postmenopausal women between the ages of 45 and 65 in follow-up at a climacteric outpatient clinic. Mood, quality of life, sexual function and hormonal profile were assessed. Results With regard to sexual hormones and sexual function, a relationship was found between orgasm and luteinizing hormone (r=0.37), orgasm and sex hormone-binding globulin (SHBG) (r=0.39), SHBG and less pain (r=0.44), dehydroepiandrosterone (DHEA) and desire (r=-0.45), as well as between prolactin and lubrication (r=0.33). Sexual hormones and quality of life were related as follows: progesterone and limitations due to physical aspects (r=0.35), SHBG and social aspects (r=0.35), cortisol and pain (r=0.46), DHEA and social aspects (r=-0.40). Finally, the following relationships were found between sexual function and quality of life: sexual desire and vitality, social aspects, state of general health and mental health (r=0.46, r=0.51, r=0.35, and r=0.38, respectively). Arousal, orgasm and satisfaction with sexual life showed a relationship with less physical pain (r=0.40, r=0.42, and r=0.43, respectively). Satisfaction with sexual life was correlated with vitality (r=0.33). Conclusion Different correlations than expected were found in this study regarding the effect of some hormones on sexual function and some aspects of the quality of life of postmenopausal women.

Resumo Objetivo Avaliar a relação entre hormônios sexuais, função sexual e qualidade de vida em mulheres na pós-menopausa. Métodos Estudo transversal com amostra de conveniência de 36 mulheres na pós-menopausa, com idades entre 45 e 65 anos, em seguimento ambulatorial de climatério. Humor, qualidade de vida, função sexual e perfil hormonal foram avaliados. Resultados Entre hormônios sexuais e função sexual, foi encontrada relação entre orgasmo e hormônio luteinizante (r=0,37), orgasmo e globulina ligadora de hormônios sexuais (SHBG) (r=0,39), SHBG e menos dor (r=0,44), desidroepiandrosterona (DHEA) e desejo (r=-0,45), bem como entre prolactina e lubrificação (r=0,33). Entre hormônios sexuais e qualidade de vida: progesterona e limitações por aspectos físicos (r=0,35), SHBG e aspectos sociais (r=0,35), cortisol e dor (r=0,46), DHEA e aspectos sociais (r=-0,40). Por fim, entre função sexual e qualidade de vida: desejo sexual e vitalidade, aspectos sociais, estado geral de saúde e saúde mental (r=0,46, r=0,51, r=0,35 e r=0,38, respectivamente). Excitação, orgasmo e satisfação com a vida sexual mostraram uma relação com menos dor física (r=0,40, r=0,42 e r=0,43, respectivamente). A satisfação com a vida sexual foi correlacionada com a vitalidade (r=0,33). Conclusão Correlações diferentes das esperadas foram encontradas neste estudo em relação ao efeito de alguns hormônios sobre a função sexual e alguns aspectos da qualidade de vida de mulheres na pós-menopausa.
Descritores: Qualidade de Vida/psicologia
Comportamento Sexual/psicologia
Pós-Menopausa/psicologia
Pós-Menopausa/sangue
-Orgasmo/fisiologia
Satisfação Pessoal
Progesterona/sangue
Globulina de Ligação a Hormônio Sexual/análise
Hormônio Luteinizante/sangue
Estudos Transversais
Inquéritos e Questionários
Desidroepiandrosterona/sangue
Pessoa de Meia-Idade
Limites: Humanos
Feminino
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-834791
Autor: Botero Arango, Andrés Federico; Duque Ramírez, Mauricio; Duque González, Laura.
Título: Deficiencia de andrógenos y enfermedad cardiovascular en el hombre / Androgens deficiency and cardiovascular disease in the man
Fonte: Med. lab;2014, 20(1-2):43-56, 2014. tab, ilus.
Idioma: es.
Resumo: El hipogonadismo masculino, manifestado por la disminución de los niveles séricos de testosterona,representa una causa importante de morbimortalidad en pacientes mayores de 40 años. Su prevalencia es proporcional a la edad, y las diversas manifestaciones clínicas, de índole física, sicológica y sexual, conllevan a un marcado deterioro clínico del paciente. El impacto de la deficiencia de testosterona sobre el aparato cardiovascular acelera la progresión de la enfermedad coronaria, disminuye la sensibilidad a la insulina y aumenta la mortalidad global. Según la Sociedad Americana de Endocrinología,el diagnóstico bioquímico se realiza con valores de testosterona total <300 mg/dL. Definir el inicio de la terapia de reemplazo con testosterona siempre deberá incluir la clínica y las mediciones de laboratorio. El efecto sistémico de la terapia se verá reflejado en la mejoría de la fatiga, de la libido y del mejor control de los factores de riesgo cardiovascular, que incluye la disminución de la grasa visceral, mejoría de la sensibilidad a la insulina, del perfil lipídico, de las cifras de presión arterial y en algunos casos, disminución de la mortalidad.

Male hypogonadism, manifested by decreased serum testosterone levels, is an important cause of morbidity and mortality in patients older than 40 years. Its prevalence is proportional to age, and several clinical manifestations, as physical, psychological and sexual, lead to a marked clinical deterioration. The impact of testosterone deficiency on the cardiovascular system accelerates the progression of coronary artery disease, decreases insulin sensitivity and increases overall mortality. American Society for Endocrinology accepted serum values lower than 300 ng/dL as a diagnostic support. To define the start of testosterone replacement therapy should always include clinical and laboratory measurements. Systemic therapy effects will be reflected in the fatigue eradication, libido improvement, and better control of cardiovascular risk factors, including decreased abdominal fat, improved insulin sensitivity, lipid profile, arterial blood pressure, and in some cases, reduction of the mortality.
Descritores: Terapia de Reposição Hormonal
Hipogonadismo
Globulina de Ligação a Hormônio Sexual
Testosterona
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CO373.9 - EDIMECO - Editora Médica Colombiana S.A.


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Id: lil-734401
Autor: Danilowicz, Karina; Bruno, Oscar D; Mana, Daniela; Serra, Hector A; Cross, Graciela; Rey, Jorge A.
Título: Female hyperandrogenemia and normal serum levels of testosterone and sex hormone binding globulin
Fonte: Medicina (B.Aires);74(5):359-362, oct. 2014. tab.
Idioma: en.
Resumo: It is well known that the reference values usually employed for endocrine biochemical measurements are those suggested by the suppliers of commercial kits despite their advice that each laboratory should set its own reference values. Our objectives were to (i) determine reference ranges for serum testosterone (T) and sex hormone binding globulin (SHBG) appropriate to our laboratory and population, and (ii) to analyze their influence on evaluating hyperandrogenemia. SHBG and T were measured, and free and bioavailable testosterone calculated, in (a) 30 selected non-hyperandrogenic women, (b) 87 non-selected healthy female blood donors, (c) 53 women with hyperandrogenism, and (d) 38 women with hyperandrogenic disorders but without biochemical hyperandrogenemia according to normal ranges suggested by the kit manufacturer. Mean serum SHBG concentrations were significantly different among all four groups. SHBG levels were significantly higher in selected normal women (group a). Using our results for this selected control group as new reference values, 12 out of 38 (31.6%) women with hyperandrogenic disorders without apparent hyperandrogenemia (group d) were recategorized as hyperandrogenemic. Similarly, 4 out of 63 (6.4%) non-selected, normal weight, women (group b), were recategorized as hyperandrogenic. Therefore, the diagnosis of hyperandrogenemia would improve accuracy by using customized reference SHBG values instead of those suggested by the suppliers.

Con frecuencia los valores de referencia utilizados para las evaluaciones bioquímicas endocrinológicas son los sugeridos por los kits utilizados, a pesar de las recomendaciones de que cada laboratorio debiera obtener sus propios valores de normalidad. Nuestros objetivos fueron (i) analizar los rangos de referencia para testosterona (T) y globulina ligadora de esteroides sexuales (SHBG) apropiados para nuestro laboratorio y población, y (ii) analizar su influencia en la evaluación de la hiperandrogenemia. Se midió T y SHBG y se calculó testosterona libre y biodisponible en un grupo (a) control de 30 mujeres no hiperandrogénicas, (b) 87 mujeres no seleccionadas donantes de sangre, (c) 53 mujeres con hiperandrogenismo, y (d) 38 mujeres con desórdenes hiperandrogénicos pero sin hiperandrogenemia de acuerdo a los rangos de normalidad sugeridos por el kit. La concentración media de SHBG fue significativamente diferente entre los cuatro grupos. Los niveles de SHBG fueron significativamente más altos en las mujeres controles seleccionadas (grupo a). Tomando en consideración los resultados obtenidos en este grupo y estableciendo los rangos de referencia adecuados, 12 de 38 mujeres (31.6%) hiperandrogénicas sin hiperandrogenemia (grupo d) fueron recategorizadas como con exceso androgénico bioquímico. De igual manera, al analizar mujeres normopesas no seleccionadas, en edad reproductiva (grupo b), 4 de 63 (6.4%) pudieron ser definidas como hiperandrogénicas. Utilizando valores adecuados de referencia para SHBG, se mejora la precisión del diagnóstico de exceso androgénico.
Descritores: Androgênios/sangue
Hiperandrogenismo/diagnóstico
Globulina de Ligação a Hormônio Sexual/análise
Testosterona/sangue
-Acne Vulgar/diagnóstico
Alopecia/diagnóstico
Biomarcadores/sangue
Dermatite Seborreica/diagnóstico
Hirsutismo/diagnóstico
Hiperandrogenismo/etiologia
Estudos Prospectivos
Síndrome do Ovário Policístico/complicações
Valores de Referência
Kit de Reagentes para Diagnóstico/normas
Limites: Adulto
Feminino
Humanos
Pessoa de Meia-Idade
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas


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Srougi, Miguel
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Id: lil-711704
Autor: Antunes, Alberto A.; Araújo, Luiz Henrique; Nakano, Elcio; Muracca, Eduardo; Srougi, Miguel.
Título: Obesity may influence the relationship between sex hormones and lower urinary tract symptoms
Fonte: Int. braz. j. urol;40(2):240-246, Mar-Apr/2014. tab.
Idioma: en.
Resumo: PurposeThe effects of serum testosterone in the lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH) are not well established. The objective of the study is to evaluate the association of sex hormones with LUTS and control the results by patient weight.Materials and MethodsThe study comprised a cross-sectional analysis of 725 men included in a prostate cancer screening program at University of Sao Paulo Medical School. The serum concentrations of total testosterone (TT), free testosterone (FT) and sex hormone binding globulin (SHBG) were measured. Variables analyzed were age, American Urological Association (AUA) symptom score, storage symptoms, voiding symptoms, quality of life score, prostate specific antigen levels and prostate volume. Obesity was measured through the calculation of body mass index (BMI). A regression analysis model was performed.ResultsMedian patient age was 65 years (48 to 94). A higher TT level was significantly associated with a severe AUA symptom score only among patients with a BMI ≥ 25. Median TT was 371, 370 and 427ng/dL (p = 0.017) in patients with mild, moderate and severe LUTS respectively. The multivariate regression analysis in patients with BMI ≥ 25 showed that only age, TT and sex score were related to LUTS.ConclusionsA higher TT is associated with a severe AUA score symptom index only in obese patients. Further analysis are necessary to evaluate the mechanisms through which testosterone may influence LUTS in these patients.
Descritores: Sintomas do Trato Urinário Inferior/sangue
Obesidade/sangue
Globulina de Ligação a Hormônio Sexual/análise
Testosterona/sangue
-Análise de Variância
Índice de Massa Corporal
Estudos Transversais
Sintomas do Trato Urinário Inferior/fisiopatologia
Tamanho do Órgão
Obesidade/fisiopatologia
Antígeno Prostático Específico/sangue
Hiperplasia Prostática/sangue
Hiperplasia Prostática/fisiopatologia
Valores de Referência
Estatísticas não Paramétricas
Limites: Idoso
Idoso de 80 Anos ou mais
Humanos
Masculino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Coelho, Julio Cezar Uili
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Id: lil-706999
Autor: NITSCHE, Rodrigo; COELHO, Júlio Cezar Uili; FREITAS, Alexandre Coutinho Teixeira de; ZENI NETO, Clementino; MARTINS, Eduardo.
Título: Testosterone chnnges in patients with liver cirhosis before and after orthotoppic liver transplantation and its correlation with meld / Alterações nos níveis de testosterona em pacientes com cirrose hepática após transplante hepático ortotópico e sua correlação com o MELD
Fonte: Arq. gastroenterol;51(1):59-63, Jan-Mar/2014. tab, graf.
Idioma: en.
Resumo: Context Hypogonadism is a common clinical situation in male patients with liver cirrhosis. Objectives The aim of the present study was to evaluate the effects of orthotopic liver transplantation on testosterone, free testosterone and sex hormone-binding globulin in male with advanced liver disease and also to determine the relationship of these changes with Model for End-stage Liver Disease (MELD) score. Methods In a prospective study, serum levels of testosterone, free testosterone and sex hormone-binding globulin of 30 male adult patients with end-stage liver disease were measured 2 to 4 hours before and 6 months after orthotopic liver transplantation. Results Total testosterone levels increased after orthotopic liver transplantation and the number of patients with normal testosterone levels increased from 18 to 24. Free testosterone mean level in the pre-transplant group was 7.8 pg/mL and increased to 11.5 pg/mL (P = 0.10) and sex hormone-binding globulin level decreased after orthotopic liver transplantation returning to normal levels in MELD ≤18 - group (A) (P<0.05). Conclusions Serum level changes of testosterone, free testosterone and sex hormone-binding globulin are more pronounced in cirrhotic males with MELD ≤18. Serum levels of testosterone and free testosterone increase and serum levels of sex hormone-binding globulin decrease after orthotopic liver transplantation. .

Contexto O hipogonadismo é uma situação clínica comum em pacientes do sexo masculino com cirrose hepática. Objetivos O objetivo do presente estudo foi avaliar os efeitos do transplante hepático ortotópico nos níveis de testosterona, testosterona livre e globulina de ligação do hormônio sexual na doença hepática avançada em homens e, determinar a relação dessas mudanças com o Model for End-stage Liver Disease (MELD). Métodos Em um estudo prospectivo, os níveis séricos de testosterona, testosterona livre e globulina de ligação do hormônio sexual de 30 pacientes adultos do sexo masculino com doença hepática em estágio final foram medidos 2 a 4 horas antes e 6 meses após transplante hepático ortotópico. Resultados Os níveis de testosterona total aumentaram após transplante hepático ortotópico e o número de pacientes com níveis normais de testosterona aumentou de 18 para 24. O nível médio de testosterona livre no grupo de pré-transplante foi de 7,8 pg/mL, aumentou para 11,5 pg/mL (P = 0,10) e globulina de ligação do hormônio sexual diminuiu após transplante hepático ortotópico retornando aos níveis normais no grupo com MELD ≤18 - grupo (A) (P<0,05). Conclusões As mudanças nos níveis séricos de testosterona, testosterona livre e globulina de ligação do hormônio sexual são mais pronunciadas em homens com cirrose e MELD ≤18. Os níveis séricos de testosterona e testosterona livre aumentaram e de globulina de ligação do hormônio sexual reduziram após transplante hepático ortotópico. Os níveis de testosterona livre aumentaram em pacientes com cirrose hepática avançada após transplante hepático ortotópico ...
Descritores: Cirrose Hepática/sangue
Cirrose Hepática/cirurgia
Globulina de Ligação a Hormônio Sexual/análise
Testosterona/sangue
-Doença Hepática Terminal
Transplante de Fígado
Estudos Prospectivos
Índice de Gravidade de Doença
Limites: Adulto
Humanos
Masculino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-699117
Autor: De Nunzio, Cosimo; Lombardo, Riccardo; Albisinni, Simone; Gacci, Mauro; Tubaro, Andrea.
Título: Serum levels of Sex Hormone Binding Globulin (SHBG) are not predictive of prostate cancer diagnosis and aggressiveness: results from an italian biopsy cohort
Fonte: Int. braz. j. urol;39(6):793-799, Nov-Dec/2013. tab, graf.
Idioma: en.
Resumo: Purpose To explore the association between serum levels of Sex Hormone Binding Globulin (SHBG) and the risk of developing prostate cancer (PCa) as well as high grade disease in men undergoing prostate biopsy. Materials and Methods Between 2006 and 2012, we prospectively enrolled 740 patients with no history of PCa undergoing prostate biopsy. Before biopsy general data of the patient DRE, PSA and BMI were recorded. The risk of detecting cancer and high grade cancer was assessed as a function of SHBG using crude and adjusted logistic regressions. Results Serum levels of SHBG were not associated with an increased risk of PCa or high grade disease. Age (OR 1.027 95% CI 1.003-1.052 p = 0.027), DRE (OR 3.391 95% CI 2.258-5.092 p = 0.000) and PSA (OR 1.078 95% CI 1.037-1.120 p = 0.000) were found to be independent predictors of prostate cancer risk. Age (OR 1.051 95% CI 1.009-1.095 p = 0.016), DRE (OR 2.519 95% CI 1.384-4.584 p = 0.000), BMI (OR 1.098 95% CI 1.011-1.193 p = 0.027) and PSA (OR 1.074 95% CI 1.014-1.137 p = 0.015) were found to be independent predictors of high grade disease. Conclusions In our cohort of patients, serum levels of SHBG are not predictive of PCa or high grade disease. According to our experience SHBG should not be considered a biomarker in PCa diagnosis neither a marker for high grade disease. .
Descritores: Neoplasias da Próstata/sangue
Neoplasias da Próstata/patologia
Globulina de Ligação a Hormônio Sexual/análise
Biomarcadores Tumorais/sangue
-Biópsia
Índice de Massa Corporal
Estudos de Coortes
Gradação de Tumores
Invasividade Neoplásica/patologia
Valor Preditivo dos Testes
Antígeno Prostático Específico/sangue
Próstata/patologia
Medição de Risco
Fatores de Risco
Curva ROC
Estatísticas não Paramétricas
Limites: Idoso
Humanos
Masculino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME



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