Base de dados : LILACS
Pesquisa : D12.776.157 [Categoria DeCS]
Referências encontradas : 141 [refinar]
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Id: biblio-1119938
Autor: Vasconcelos, Flavia da Cunha.
Título: Análise da expressão e atividade das moléculas de influxo e de efluxo de drogas em células da leucemia mielóide crônica / Analysis of the expression and activity of drug influx and efflux molecules in chronic myeloid leukemia cells.
Fonte: Rio de Janeiro; s.n; 2012. 180 p. ilus, tab, graf.
Idioma: pt.
Tese: Apresentada a Instituto Nacional de Câncer José Alencar Gomes da Silva. Coordenação de Pesquisa. Coordenação de Pós-graduação Stricto sensu em Oncologia para obtenção do grau de Doutor.
Resumo: "A leucemia mielóide crônica (LMC) é caracterizada pela presença da translocação t(9:22) que codifica a proteína quimérica oncogênica BCR-ABL. Imatinibe é uma droga alvo-específica que inibe a atividade tirosina quinase (TK) da proteína BCR-ABL. Entretanto, os níveis intracelulares do imatinibe podem ser alterados pelas proteínas transportadoras de efluxo de drogas: glicoproteína P (Pgp), proteína da resistência em câncer de mama (BCRP) e proteína relacionada à resistência à múltiplas drogas (MRP1), assim como a proteína transportadora de influxo de drogas (OCT1). O objetivo do presente estudo foi analisar a participação dessas proteínas, isoladamente ou em associação, na resistência ao imatinibe em linhagens celulares e células de pacientes com LMC. Para análise da atividade das proteínas transportadoras de efluxo, foi utilizado o fluorocromo rodamina-123 associado ao modulador ciclosporina-A (Rho+CSA) e o pheophorbide A associado ao fumitremorgin C (PhA+FTC), ambos através de citometria de fluxo. A análise dos RNAm dos genes ABCB1, ABCG2 e SLC22A1 que codificam as proteínas Pgp, BCRP e OCT1, respectivamente, foi realizada por PCR em tempo real. A inibição da TK BCR-ABL foi mensurada através dos níveis de fosforilação de CrkL (pCrkL), seu principal alvo de ativação. Observamos uma maior positividade para o ensaio Rho+CSA nas amostras que expressavam Pgp comparada com as que expressavam MRP1, sugerindo menor atividade dessa proteína em pacientes com LMC, ou ainda que tal ensaio possa ser menos específico para a atividade da MRP1. O ensaio PhA+FTC foi capaz de identificar a atividade da proteína BCRP em linhagens celulares e células de pacientes. Níveis reduzidos dos RNAm ABCB1 e SLC22A1, mas não do RNAm ABCG2, foram observados quando comparados com as amostras de indivíduos saudáveis. Não houve correlação entre os níveis da proteína Pgp e do RNAm ABCB1. A expressão de Pgp foi detectada na maioria das amostras de LMC, independente da fase da doença, e não foi associada com o prognóstico desfavorável. Variações nos níveis de expressão da Pgp foram observadas durante a evolução da LMC e relacionadas com o tratamento prévio. O imatinibe foi capaz de aumentar a expressão da Pgp, assim como os níveis do RNAm ABCB1 na linhagem K562-Lucena 1, Pgp+. Além disso, observamos uma maior redução de pCrkL e um maior percentual de morte celular nas células K562, Pgp-, quando comparadas à K562-Lucena 1, evidenciando um possível papel do imatinibe como substrato para a Pgp. Este fármaco também demonstrou ter potencial para funcionar como agente modulador da bomba de efluxo, uma vez que impediu o exporte de Rho das células K562-Lucena 1. Amostras de pacientes resistentes ao imatinibe exibiram altos níveis de atividade das proteínas transportadoras de efluxo de drogas (ensaio Rho+CSA). Nossos dados mostram que a atividade e/ou expressão dos transportadores de efluxo e influxo de drogas encontram-se alterados na maioria dos pacientes com LMC, porém não há correlação com a resposta ao imatinibe e o prognóstico na LMC. Entretanto, o conjunto dos resultados sugere um papel para a Pgp na resistência in vitro ao imatinibe"(AU)

"Chronic myeloid leukemia (CML) is characterized by the presence of the t(9:22) encoding the BCR-ABL chimeric oncogenic protein. Imatinib is a target specific drug that inhibits the activity of the tyrosine kinase (TK) protein BCR-ABL. However, imatinib intracellular concentration may be altered by transporter proteins. It was described that efflux proteins, P-glycoprotein (Pgp), breast cancer resistance protein (BCRP) and multidrug resistance related protein (MRP1), and the influx protein, the organic cation transporter protein (OCT1) may contribute for imatinib clinical resistance. The aim of this study was to evaluate the role of these proteins in imatinib resistance in cell lines and leukemic cells from CML patients. To analyze the activity of the efflux transporter proteins, fluorochrome rhodamine-123 associated with the modulator cyclosporin A (Rho+CSA) and pheophorbide A associated with fumitremorgin C (PhA+FTC) were used by flow cytometry. Analysis of ABCG1, ABCG2 and SLC22A1 genes, that encode the Pgp, BCRP and OCT1 proteins, respectively, was performed by real time PCR. The inhibition of BCR-ABL TK was measured by the levels of CrkL phosphorylation (pCrkL), its main target of activation. We observed a higher positivity for Rho+CSA assay in samples expressing Pgp, when compared with the ones expressing MRP1. These results suggest that patients with CML have lower activity of this protein, or this assay might be less specific to indicate the activity of MRP1. The PhA+FTC assay was able to identify BCRP activity in cell lines and cells from patients. Reduced levels of ABCB1 and SLC22A1, but not ABCG2 mRNA were observed when compared with samples from healthy individuals. There was no correlation between the levels of Pgp protein and ABCB1 mRNA. Pgp expression was detected in most samples of CML, regardless of disease stage and was not associated with poor prognosis. Changes in Pgp expression levels have been observed during the development of CML and were related to pretreatment. Imatinib was able to increase Pgp expression as well as ABCB1 mRNA levels in Pgp+ K562Lucena 1 cells. Moreover, we observed a greater pCrkL reduction and a higher percentage of cell death in Pgp- K562 cells compared to K562-Lucena 1, indicating a possible role of imatinib as a Pgp substrate. This drug has also been shown to have potential as an efflux pump modulating agent, once efflux of Rho was prevented in K562-Lucena 1. Imatinib resistant patient samples exhibited high levels of efflux transporter proteins activity (Rho+CSA assay). Our data show that the activity and / or expression of influx and efflux transporters of drugs are altered in most patients with CML, but no correlation with prognosis and response to imatinib in CML was observed. However, our results suggest a role for Pgp in imatinib resistance"(AU)
Descritores: Fosforilação
Neoplasias da Mama
Leucemia Mielogênica Crônica BCR-ABL Positiva
Membro 1 da Subfamília B de Cassetes de Ligação de ATP
Células K562
Citometria de Fluxo
Mesilato de Imatinib
-Rodaminas
Técnicas In Vitro
RNA Mensageiro
Preparações Farmacêuticas
Proteínas de Transporte
Tratamento Preliminar
Ciclosporina
Morte Celular
Resistência a Múltiplos Medicamentos
Reação em Cadeia da Polimerase em Tempo Real
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Ensaio Clínico Controlado
Responsável: BR440.1 - Biblioteca Geraldo Matos de Sá . Hospital do Câncer I


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Id: biblio-1118436
Autor: Colombo, María Isabel.
Título: Destruir para construir un nuevo esqueleto: participación de la autofagia como mecanismo clave en este reciclaje / Remodeling the cytoskeleton: a key role of autophagy in this recycling process
Fonte: Actual. osteol;13(1):7-8, Ene - Abr. 2017.
Idioma: es.
Descritores: Osteogênese/fisiologia
Proteínas Relacionadas à Autofagia/metabolismo
-Esqueleto/citologia
Autofagia/fisiologia
Transdução de Sinais
Proteínas de Transporte
Fenômenos Fisiológicos Celulares
Células/metabolismo
Senescência Celular
Proteínas Relacionadas à Autofagia/fisiologia
Limites: Humanos
Tipo de Publ: Editorial
Responsável: AR2.1 - Biblioteca Central


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Id: biblio-1053486
Autor: Lv, Runling; Liu, Yuwei; Gong, Xiaodong; Han, Jianmin; Gu, Shouqin; Dong, Jingao.
Título: Expression and purification of the transcription factor StMsn2 from Setosphaeria turcica in Escherichia coli
Fonte: Electron. j. biotechnol;40:65-70, July. 2019. ilus.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Natural Science Foundation of Hebei Province.
Resumo: Background: In Saccharomyces cerevisiae, Msn2, which acts as a key transcription factor downstream the MAPKHOG cascade pathway, also regulates the expression of genes related to stress responses. However, little is known about the regulation mechanisms of the transcription factor in Setosphaeria turcica. Results: In this study, a zinc finger DNA-binding protein, designated as StMSN2, was cloned from S. turcica. Sequencing results showed that StMSN2 had a 1752 bp open reading frame (ORF), which was interrupted by an intron (135 bp) and encoded a putative 538-amino acid protein. Phylogenetic analysis further revealed that StMsn2 was more closely related to Msn2 of Aspergillus parasiticus. StMSN2 was cloned into the pET-28a vector with His (Histidine) tags and induced with 1 mM IPTG (isopropyl-ß-D-thiogalactoside) at 37°C. The recombinant His-tagged StMsn2 was purified, and a band of size approximately 58.8 kDa was obtained. The high specificity of the polyclonal antibody Msn2-2 was detected with the StMsn2 protein from S. turcica and prokaryotic expression system, respectively. Conclusions: A new gene, named StMSN2, with 1617 bp ORF was cloned from S. turcica and characterized using bioinformatics methods. StMsn2 was expressed and purified in a prokaryotic system. A polyclonal antibody, named Msn2-2, against StMsn2 with high specificity was identified.
Descritores: Doenças das Plantas
Ascomicetos/genética
Ascomicetos/patogenicidade
Fatores de Transcrição/isolamento & purificação
-Ascomicetos/metabolismo
Estresse Fisiológico
Fatores de Transcrição/genética
Fatores de Transcrição/metabolismo
Proteínas de Transporte
Expressão Gênica
Western Blotting
Fases de Leitura Aberta
Dedos de Zinco
Clonagem Molecular
Zea mays
Escherichia coli
Helminthosporium
Epitopos
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
Tendler, Miriam
Texto completo
Id: lil-295892
Autor: Ramos, Celso Raul Romero; Vilar, Mônica Magno; Nascimento, Ana Lúcia Tabet Oller; Ho, Paulo Lee; Thaumaturgo, Nilton; Edelenyi, Ricardo; Almeida, Marília; Dias, Waldely de Oliveira; Diogo, Catia Maria; Tendler, Miriam.
Título: r-Sm14 - pRSETA efficacy in experimental animals
Fonte: Mem. Inst. Oswaldo Cruz;96(suppl):131-135, Sept. 2001. ilus, tab.
Idioma: en.
Resumo: Previous studies carried out with Sm14 in experimental vaccination against Schistosoma mansoni or Fasciola hepatica infections were performed with recombinant Sm14 (rSm14) produced in Escherichia coli by the pGEMEX system (Promega). The rSm14 was expressed as a 40 kDa fusion protein with the major bacteriophage T7 capsid protein. Vaccination experiments with this rSm14 in animal models resulted in consistent high protective activity against S. mansoni cercariae challenge and enabled rSm14 to be included among the vaccine antigens endorsed by the World Health Organization for phase I/II clinical trials. Since the preparation of pGEMEX based rSm14 is time consuming and results in low yield for large scale production, we have tested other E. coli expression systems which would be more suitable for scale up and downstream processing. We expressed two different 6XHis-tagged Sm14 fusion proteins in a T7 promoter based plasmids. The 6XHis-tag fusions allowed rapid purification of the recombinant proteins through a Ni+2-charged resin. The resulted recombinant 18 and 16 kDa proteins were recognized by anti-Sm14 antibodies and also by antiserum against adult S. mansoni soluble secreted/excreted proteins in Western-Blot. Both proteins were also protective against S. mansoni cercariae infection to the same extent as the rSm14 expressed by the pGEMEX system
Descritores: Schistosoma mansoni/imunologia
Proteínas Recombinantes
Anticorpos Anti-Helmínticos/fisiologia
Proteínas de Helminto/fisiologia
-Plasmídeos
Proteínas Recombinantes/isolamento & purificação
Proteínas de Transporte
Proteínas de Helminto/isolamento & purificação
Western Blotting
Sequência de Aminoácidos
Vacinação
DNA Complementar
Modelos Animais
Eletroforese em Gel de Poliacrilamida
Escherichia coli
Ácidos Graxos
Limites: Animais
Feminino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo
Id: biblio-886202
Autor: Yeda, Xiao; Shaoqing, Lei; Yayi, Huang; Bo, Zhao; Huaxin, Wang; Hong, Cao; Zhongyuan, Xia.
Título: Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the P38-MAPK/TXNIP signaling activation in streptozotocin induced diabetic rats
Fonte: Acta cir. bras;32(6):429-439, June 2017. graf.
Idioma: en.
Projeto: The Basic Scientific Research of Central University Fund.
Resumo: Abstract Purpose: To determine whether dexmedetomidine (DEX) could attenuate acute kidney injury (AKI) induced by ischemia/reperfusion (I/R) in streptozotocin (STZ)-induced diabetic rats. Methods: Four groups each containing six rats were created (sham control(S), diabetes-sham (DS), diabetes I/R (DI/R), and diabetes-I/R-dexmedetomidine (DI/R-DEX). In diabetes groups, single-dose (65 mg/kg) STZ was administered intraperitoneally (i.p.). In Group DI/R, ischemia reperfusion was produced via 25 min of bilateral renal pedicle clamping followed by 48 h of reperfusion. In Group DI/R-DEX, 50 μg/kg dexmedetomidine was administered intraperitoneally 30 minutes before ischemia. Renal function, histology, apoptosis, the levels of TNF-α, IL-1β, and oxidative stress in diabetic kidney were determined. Moreover, expression of P38 mitogen-activated protein kinase (P38-MAPK), phosphorylated-P38-MAPK(p-P38-MAPK) and thioredoxin-interacting protein (TXNIP) were assessed. Results: The degree of renal I/R injury was significantly increased in DI/R group compared with S group and DS group. The levels of TNF-α, IL-1β, oxidative stress and apoptosis were found significantly higher in DI/R Group when compared with S Group and DS Group. The protein expression of p-P38-MAPK and TXNIP were significantly increased after I/R. All these changes were reversed by DEX treatment. Conclusion: The renoprotective effects of DEX-pretreatment which attenuates I/R-induced AKI were partly through inhibition of P38-MAPK activation and expression of TXINP in diabetic kidney.
Descritores: Traumatismo por Reperfusão/tratamento farmacológico
Substâncias Protetoras/uso terapêutico
Dexmedetomidina/uso terapêutico
Diabetes Mellitus Experimental/complicações
Rim/efeitos dos fármacos
-Traumatismo por Reperfusão/etiologia
Traumatismo por Reperfusão/metabolismo
Transdução de Sinais/efeitos dos fármacos
Proteínas de Transporte/efeitos dos fármacos
Proteínas de Transporte/metabolismo
Ratos Sprague-Dawley
Estreptozocina
Proteínas Quinases p38 Ativadas por Mitógeno/efeitos dos fármacos
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
Rim/lesões
Rim/patologia
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Texto completo
Id: biblio-974341
Autor: Kandil, Mona; Khalil, Gihane; El-Attar, Eman; Shehata, Gihan; Hassan, Salwa.
Título: Accuracy of heparin binding protein: as a new marker in prediction of acute bacterial meningitis
Fonte: Braz. j. microbiol;49(supl.1):213-219, 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Background: Cerebrospinal fluid bacterial culture is the gold-standard for confirmation of acute bacterial meningitis, but many cases are not culture confirmed. Antibiotics reduce the chance of a microbiological diagnosis. Objective to evaluate efficacy of Heparin-binding protein in diagnosis of bacterial meningitis. Patients: 30 patients diagnosed with acute bacterial meningitis, 30 viral meningitis, and 30 subjects with normal CSF findings. Design: Diagnosis was based on history, clinical criteria, CSF examination, latex agglutination & culture, and sensitivities and response to therapy. HBP was measured using enzyme-linked immunosorbent technique in both serum & CSF. Results: Cerebrospinal fluid HBP levels averaged 0.82 ± 0.3 ng/mL in controls, 3.3 ± 1.7 ng/mL in viral and 174.8 ± 46.7 ng/mL in bacterial meningitis. Mean serum level was 0.84 ± 0.3 ng/mL in the controls, 3.7 ± 1.9 ng/mL in viral, and 192.2 ± 56.6 ng/mL in bacterial meningitis. Both HBP levels were significantly higher in patients with bacterial meningitis. Cut-offs of 56.7 ng/ml and 45.3 ng/ml in cerebrospinal fluid & serum showed 100% overall accuracy. Even in patients who received prior antibiotics, remained elevated. Conclusion: Serum Heparin-binding protein serves as a non-invasive potential marker of acute bacterial meningitis even in partially treated cases.
Descritores: Proteínas Sanguíneas/líquido cefalorraquidiano
Heparina/metabolismo
Proteínas de Transporte/líquido cefalorraquidiano
Proteínas de Transporte/sangue
Meningites Bacterianas/diagnóstico
Peptídeos Catiônicos Antimicrobianos/líquido cefalorraquidiano
Peptídeos Catiônicos Antimicrobianos/sangue
-Biomarcadores/líquido cefalorraquidiano
Biomarcadores/sangue
Estudos Transversais
Meningites Bacterianas/líquido cefalorraquidiano
Meningites Bacterianas/microbiologia
Meningites Bacterianas/sangue
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Lactente
Pré-Escolar
Criança
Adolescente
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: lil-623625
Autor: Rimoldi, M. T; Tenner, A. J; Bobak, D. A; Joiner, K. A.
Título: Enhanced invasion of mononuclear phagocytes by serumtreated Trypanosoma cruzi is due to Clq
Fonte: Mem. Inst. Oswaldo Cruz;83(supl.1):456-458, Nov. 1988.
Idioma: en.
Conferência: Apresentado em: Annual Meeting on Basic Research in Chagas's disease, 15, Apresentado em: Meeting of the Brazilian Society of Protozoology4, Caxambu, 7-10 Nov. 1988.
Descritores: Enzimas Ativadoras do Complemento/fisiologia
Glicoproteínas de Membrana
Proteínas de Transporte
-Complemento C1
Receptores de Hialuronatos
Técnicas de Cultura
Macrófagos/parasitologia
Responsável: BR1.1 - BIREME


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Id: biblio-1022150
Autor: Wang, Zisheng; Zhang, Qihuan; Meng, Fancui; Li, Shuai; Xu, Qiaoqin; Qi, Zhitao.
Título: Characterization of the ligand binding of PGRP-L in half-smooth tongue sole (Cynoglossus semilaevis) by molecular dynamics and free energy calculation
Fonte: Electron. j. biotechnol;31:93-99, Jan. 2018. ilus, graf, tab.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Jiangsu Province; . Biotechnology of Marine Wetland.
Resumo: Background: Peptidoglycan (PGN) recognition proteins (PGRPs) are important pattern recognition receptors of the host innate immune system that are involved in the immune defense against bacterial pathogens. PGRPs have been characterized in several fish species. The PGN-binding ability is important for the function of PGRPs. However, the PGRP-PGN interaction mechanism in fish remains unclear. In the present study, the 3-D model of a long PGRP of half-smooth tongue sole (Cynoglossus semilaevis) (csPGRP-L), a marine teleost with great economic value, was constructed through the comparative modeling method, and the key amino acids involved in the interaction with Lys-type PGNs and Dap-type PGNs were analyzed by molecular dynamics and molecular docking methods. Results: csPGRP-L possessed a typical PGRP structure, consisting of five ß-sheets and four α-helices. Molecular docking showed that the van der Waals forces had a slightly larger contribution than Coulombic interaction in the csPGRP-L-PGN complex. Moreover, the binding energies of csPGRP-L-PGNs computed by MM-PBSA method revealed that csPGRP-L might selectively bind both types of MTP-PGNs and MPP-PGNs. In addition, the binding energy of each residue of csPGRP-L was also calculated, revealing that the residues involved in the interaction with Lys-type PGNs were different from that with Dap-type PGNs. Conclusions: The 3-D structure of csPGRP-L possessed typical PGRP structure and might selectively bind both types of MTP- and MPP-PGNs, which provided useful insights to understanding the functions of fish PGRPs.
Descritores: Língua/imunologia
Linguados/imunologia
Linguados/metabolismo
-Sítios de Ligação
Linguados/genética
Peptidoglicano
Proteínas de Transporte
Receptores Toll-Like
Simulação de Dinâmica Molecular
Simulação de Acoplamento Molecular
Ligantes
Limites: Animais
Responsável: CL1.1 - Biblioteca Central


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Id: lil-632975
Autor: Enriori, Pablo J; Vico, Clelia M; Enriori, Carlos L.
Título: El dilema de la obesidad en ambos sexos / Dilemma of obesity in both sexes
Fonte: Acta bioquím. clín. latinoam;38(2):165-171, mar.-jun. 2004.
Idioma: es.
Resumo: En la obesidad glúteo-femoral, las consecuencias metabólicas son comparativamente escasas y los efectos endocrinos resultan directamente ligados al exceso de tejido adiposo. En la obesidad abdominal -en cambio- la actividad hormonal es muy importante: resistencia a la insulina e hiperinsulinemia, aumento de la actividad de los factores de crecimiento insulin-análogos (IGFs), aumento de la producción de testosterona (T), dihidrotestosterona (DHT) y estradiol (E2) "biodisponibles", por disminución de la proteína ligadora de andrógenos y estradiol (GLAE). Estas condiciones sugieren una posible asociación con el cáncer mamario y/o endometrial. La secreción de la hormona de crecimiento (HC) se reduce significativamente en la obesidad, junto con los factores hipotalámicos, hipofisarios y periféricos que contribuyen a la secreción anormal de la HC, jugando así un importante papel en la conformación corporal y en el balance de energía. La leptina circulante, producto que se expresa en los adipocitos con el gen ob, ejerce un efecto estimulante sobre la HC. Finalmente, una serie de pacientes seleccionados por su obesidad han sido identificados con importantes aumentos en los factores de crecimiento con valores descendidos de las proteínas portadoras de los IGFs. La obesidad abdominal se caracteriza también por la hiperinsulinemia de ayuno y una exagerada liberación de la insulina después de la carga de glucosa.

In the gluteo-femoral obesity, the metabolic consequences are comparative scarce and the endocrine effects are directly linked to the excess of adipose tissue. In abdominal obesity the endocrine effects are very important: insulin resistance and hyperinsulinemia, increase of IGF-I activity, increase of active androgen production by ovarian estroma, important reduction of sex-hormone-binding-globulin (SHBG) and increasing "bioavailable" estradiol (E2), testosterone (T) and dihidrotestosterone (DHT). In short, obesity and abnormal endocrinology appear to be associated with the development of endometrium and breast cancer in women. Growth hormone (GH) secretion is markedly reduced in obesity, and hypothalamic, pituitary and peripheral factors may contribute to the abnormal GH secretion. GH plays a critical rol in the regulation of body composition and energy balance. The circulating leptin is a product of specific adipocyte ob-gene that exerts stimulating effect on GH release. Furthermore, selected series of obese patients have shown that high free insulin like growth factor (IGF-I) and low IGF-binding proteins generally increased in overweight subjects. Obesity is also characterized by fasting hyperinsulinemia and exaggerated insulin release after a glucose load. Recently it has also demonstrated that leptine plays an important role in the reproductive system at all levels of the hypothalamus-pituitary-gonadal axis.
Descritores: Hormônio do Crescimento Humano
Androgênios
Obesidade
Obesidade/complicações
-Proteínas de Transporte/análise
Endocrinologia
Insulina/análogos & derivados
Limites: Humanos
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas


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Id: biblio-866000
Autor: Demeda, Clarissa Favero.
Título: Estudo da imunoexpressão dos transportadores de glicose 1 e 3 em carcinomas epidemóides de lábio inferior e sua relação com parâmetros clínico-patológicos / Study of the immunoexpression of glucose transporters 1 and 3 in epidemóides carcinomas of the lower lip and its relationship with clinicopathological parameters.
Fonte: Natal; s.n; ago. 2012. 140 p. (BR).
Idioma: pt.
Tese: Apresentada a UFRN para obtenção do grau de Mestre.
Símbolo: BR.
Descritores: Proteínas de Transporte
Carcinoma de Células Escamosas/etiologia
Carcinoma de Células Escamosas/patologia
Imuno-Histoquímica/métodos
Estadiamento de Neoplasias
-Estatísticas não Paramétricas
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos
BR1264.1; D79, D376e



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