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Id: biblio-974341
Autor: Kandil, Mona; Khalil, Gihane; El-Attar, Eman; Shehata, Gihan; Hassan, Salwa.
Título: Accuracy of heparin binding protein: as a new marker in prediction of acute bacterial meningitis
Fonte: Braz. j. microbiol;49(supl.1):213-219, 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Background: Cerebrospinal fluid bacterial culture is the gold-standard for confirmation of acute bacterial meningitis, but many cases are not culture confirmed. Antibiotics reduce the chance of a microbiological diagnosis. Objective to evaluate efficacy of Heparin-binding protein in diagnosis of bacterial meningitis. Patients: 30 patients diagnosed with acute bacterial meningitis, 30 viral meningitis, and 30 subjects with normal CSF findings. Design: Diagnosis was based on history, clinical criteria, CSF examination, latex agglutination & culture, and sensitivities and response to therapy. HBP was measured using enzyme-linked immunosorbent technique in both serum & CSF. Results: Cerebrospinal fluid HBP levels averaged 0.82 ± 0.3 ng/mL in controls, 3.3 ± 1.7 ng/mL in viral and 174.8 ± 46.7 ng/mL in bacterial meningitis. Mean serum level was 0.84 ± 0.3 ng/mL in the controls, 3.7 ± 1.9 ng/mL in viral, and 192.2 ± 56.6 ng/mL in bacterial meningitis. Both HBP levels were significantly higher in patients with bacterial meningitis. Cut-offs of 56.7 ng/ml and 45.3 ng/ml in cerebrospinal fluid & serum showed 100% overall accuracy. Even in patients who received prior antibiotics, remained elevated. Conclusion: Serum Heparin-binding protein serves as a non-invasive potential marker of acute bacterial meningitis even in partially treated cases.
Descritores: Proteínas Sanguíneas/líquido cefalorraquidiano
Heparina/metabolismo
Proteínas de Transporte/líquido cefalorraquidiano
Proteínas de Transporte/sangue
Meningites Bacterianas/diagnóstico
Peptídeos Catiônicos Antimicrobianos/líquido cefalorraquidiano
Peptídeos Catiônicos Antimicrobianos/sangue
-Biomarcadores/líquido cefalorraquidiano
Biomarcadores/sangue
Estudos Transversais
Meningites Bacterianas/líquido cefalorraquidiano
Meningites Bacterianas/microbiologia
Meningites Bacterianas/sangue
Meia-Idade
Limites: Seres Humanos
Masculino
Feminino
Lactente
Pré-Escolar
Criança
Adolescente
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


  2 / 137 LILACS  
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Id: lil-623625
Autor: Rimoldi, M. T; Tenner, A. J; Bobak, D. A; Joiner, K. A.
Título: Enhanced invasion of mononuclear phagocytes by serumtreated Trypanosoma cruzi is due to Clq
Fonte: Mem. Inst. Oswaldo Cruz;83(supl.1):456-458, Nov. 1988.
Idioma: en.
Conferência: Apresentado em: Annual Meeting on Basic Research in Chagas's disease, 15, Apresentado em: Meeting of the Brazilian Society of Protozoology4, Caxambu, 7-10 Nov. 1988.
Descritores: Enzimas Ativadoras do Complemento/fisiologia
Glicoproteínas de Membrana
Proteínas de Transporte
-Complemento C1
Receptores de Hialuronatos
Técnicas de Cultura
Macrófagos/parasitologia
Responsável: BR1.1 - BIREME


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Id: biblio-1022150
Autor: Wang, Zisheng; Zhang, Qihuan; Meng, Fancui; Li, Shuai; Xu, Qiaoqin; Qi, Zhitao.
Título: Characterization of the ligand binding of PGRP-L in half-smooth tongue sole (Cynoglossus semilaevis) by molecular dynamics and free energy calculation
Fonte: Electron. j. biotechnol;31:93-99, Jan. 2018. ilus, graf, tab.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Jiangsu Province; . Biotechnology of Marine Wetland.
Resumo: Background: Peptidoglycan (PGN) recognition proteins (PGRPs) are important pattern recognition receptors of the host innate immune system that are involved in the immune defense against bacterial pathogens. PGRPs have been characterized in several fish species. The PGN-binding ability is important for the function of PGRPs. However, the PGRP-PGN interaction mechanism in fish remains unclear. In the present study, the 3-D model of a long PGRP of half-smooth tongue sole (Cynoglossus semilaevis) (csPGRP-L), a marine teleost with great economic value, was constructed through the comparative modeling method, and the key amino acids involved in the interaction with Lys-type PGNs and Dap-type PGNs were analyzed by molecular dynamics and molecular docking methods. Results: csPGRP-L possessed a typical PGRP structure, consisting of five ß-sheets and four α-helices. Molecular docking showed that the van der Waals forces had a slightly larger contribution than Coulombic interaction in the csPGRP-L-PGN complex. Moreover, the binding energies of csPGRP-L-PGNs computed by MM-PBSA method revealed that csPGRP-L might selectively bind both types of MTP-PGNs and MPP-PGNs. In addition, the binding energy of each residue of csPGRP-L was also calculated, revealing that the residues involved in the interaction with Lys-type PGNs were different from that with Dap-type PGNs. Conclusions: The 3-D structure of csPGRP-L possessed typical PGRP structure and might selectively bind both types of MTP- and MPP-PGNs, which provided useful insights to understanding the functions of fish PGRPs.
Descritores: Língua/imunologia
Linguados/imunologia
Linguados/metabolismo
-Sítios de Ligação
Linguados/genética
Peptidoglicano
Proteínas de Transporte
Receptores Toll-Like
Simulação de Dinâmica Molecular
Simulação de Acoplamento Molecular
Ligantes
Limites: Animais
Responsável: CL1.1 - Biblioteca Central


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Id: lil-632975
Autor: Enriori, Pablo J; Vico, Clelia M; Enriori, Carlos L.
Título: El dilema de la obesidad en ambos sexos / Dilemma of obesity in both sexes
Fonte: Acta bioquím. clín. latinoam;38(2):165-171, mar.-jun. 2004.
Idioma: es.
Resumo: En la obesidad glúteo-femoral, las consecuencias metabólicas son comparativamente escasas y los efectos endocrinos resultan directamente ligados al exceso de tejido adiposo. En la obesidad abdominal -en cambio- la actividad hormonal es muy importante: resistencia a la insulina e hiperinsulinemia, aumento de la actividad de los factores de crecimiento insulin-análogos (IGFs), aumento de la producción de testosterona (T), dihidrotestosterona (DHT) y estradiol (E2) "biodisponibles", por disminución de la proteína ligadora de andrógenos y estradiol (GLAE). Estas condiciones sugieren una posible asociación con el cáncer mamario y/o endometrial. La secreción de la hormona de crecimiento (HC) se reduce significativamente en la obesidad, junto con los factores hipotalámicos, hipofisarios y periféricos que contribuyen a la secreción anormal de la HC, jugando así un importante papel en la conformación corporal y en el balance de energía. La leptina circulante, producto que se expresa en los adipocitos con el gen ob, ejerce un efecto estimulante sobre la HC. Finalmente, una serie de pacientes seleccionados por su obesidad han sido identificados con importantes aumentos en los factores de crecimiento con valores descendidos de las proteínas portadoras de los IGFs. La obesidad abdominal se caracteriza también por la hiperinsulinemia de ayuno y una exagerada liberación de la insulina después de la carga de glucosa.

In the gluteo-femoral obesity, the metabolic consequences are comparative scarce and the endocrine effects are directly linked to the excess of adipose tissue. In abdominal obesity the endocrine effects are very important: insulin resistance and hyperinsulinemia, increase of IGF-I activity, increase of active androgen production by ovarian estroma, important reduction of sex-hormone-binding-globulin (SHBG) and increasing "bioavailable" estradiol (E2), testosterone (T) and dihidrotestosterone (DHT). In short, obesity and abnormal endocrinology appear to be associated with the development of endometrium and breast cancer in women. Growth hormone (GH) secretion is markedly reduced in obesity, and hypothalamic, pituitary and peripheral factors may contribute to the abnormal GH secretion. GH plays a critical rol in the regulation of body composition and energy balance. The circulating leptin is a product of specific adipocyte ob-gene that exerts stimulating effect on GH release. Furthermore, selected series of obese patients have shown that high free insulin like growth factor (IGF-I) and low IGF-binding proteins generally increased in overweight subjects. Obesity is also characterized by fasting hyperinsulinemia and exaggerated insulin release after a glucose load. Recently it has also demonstrated that leptine plays an important role in the reproductive system at all levels of the hypothalamus-pituitary-gonadal axis.
Descritores: Hormônio do Crescimento Humano
Androgênios
Obesidade
Obesidade/complicações
-Proteínas de Transporte/análise
Endocrinologia
Insulina/análogos & derivados
Limites: Seres Humanos
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas


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Id: biblio-866000
Autor: Demeda, Clarissa Favero.
Título: Estudo da imunoexpressão dos transportadores de glicose 1 e 3 em carcinomas epidemóides de lábio inferior e sua relação com parâmetros clínico-patológicos / Study of the immunoexpression of glucose transporters 1 and 3 in epidemóides carcinomas of the lower lip and its relationship with clinicopathological parameters.
Fonte: Natal; s.n; ago. 2012. 140 p. (BR).
Idioma: pt.
Tese: Apresentada a UFRN para obtenção do grau de Mestre.
Símbolo: BR.
Descritores: Proteínas de Transporte
Carcinoma de Células Escamosas/etiologia
Carcinoma de Células Escamosas/patologia
Imuno-Histoquímica/métodos
Estadiamento de Neoplasias
-Estatísticas não Paramétricas
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos
BR1264.1; D79, D376e


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Id: lil-764505
Autor: Liu, Huanle; Lv, Jingnan; Qi, Xiuqin; Ding, Yu; Li, Dan; Hu, Longhua; Wang, Liangxing; Yu, Fangyou.
Título: The carriage of the serine-aspartate repeat protein-encodingsdr genes among Staphylococcus aureuslineages
Fonte: Braz. j. infect. dis;19(5):498-502tab.
Idioma: en.
Projeto: National Natural Science Fund of China.
Resumo: ABSTRACTThe serine-aspartate repeat proteins (Sdr) are members of a family of surface proteins and contribute to the pathogenicity of Staphylococcus aureus. Among 288 S. aureus isolates including 158 and 130 associated with skin and soft tissue infections and bloodstream infection, respectively; 275 (95.5%) were positive for at least one of threesdr genes tested. The positivity rates for sdrC, sdrD, and sdrE among S. aureusisolates were 87.8% (253/288), 63.9% (184/288), and 68.1% (196/288), respectively. 224 (77.8%) of 288 isolates were concomitantly positive for two or three sdr genes. There was an association between carriage ofsdrE and methicillin-resistant S. aureus(MRSA) isolates, while the carriage rates of sdrC andsdrD in MRSA isolates were similar to those in methicillin-sensitive S. aureus (MSSA) isolates. The prevalence of co-existence of sdrC and sdrE among MRSA isolates was significantly higher than that among MSSA isolates (p < 0.05). All ST1, ST5, ST7, and ST25 isolates were positive for sdrD. While all ST121 and ST398 isolates were negative for sdrD. All ST59 and ST88 isolates were positive forsdrE. All ST1 isolates were concomitantly positive forsdrC and sdrD. Concomitant carriage ofsdrC, sdrD, and sdrE was found among all ST5, 75.0% (9/12) of ST1, 69.2% (9/13) of ST6, 78.6% (11/14) of ST25, and 90.9% (20/22) of ST88 isolates. sdrD was linked to CC5, CC7 and CC88 isolates, especially CC88 isolates. There was a strong association between the presence of sdrE and CC59, CC88, and CC5 isolates. A significant correlation between concomitant carriage of sdrC, sdrD, and sdrE and CC88 isolates was found.sdrC-positive, sdrD-positive andsdrE-negative gene profile was significantly associated with CC7 clone. There was an association between sdrC-positive,sdrD-negative, and sdrE-positive gene profile and CC59 isolates. A correlation between sdrC-positive,sdrD-negative, and sdrE-negative gene profile and CC121 clone was found. More CC59 isolates carriedsdrC-negative, sdrD-negative, andsdrE-positive gene profile relative to other four CCs isolates. All ST1 and ST5, 95.2% (20/21) of ST188 and 95.2% (20/21) of ST630 isolates were positive for sdrC. Taken together, our investigation indicated that different S. aureus lineages were associated with specific patterns of carriage of sdr genes.
Descritores: Proteínas de Bactérias/genética
Proteínas de Ligação ao Cálcio/genética
Proteínas de Transporte/genética
Staphylococcus aureus Resistente à Meticilina/genética
Infecções Estafilocócicas/microbiologia
-Tipagem de Sequências Multilocus
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Limites: Seres Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-761496
Autor: Zhang, Li-min; Song, Wen; Cui, Hao; Xing, Li-qiang; Du, Hui-bo; Cui, Ying; Chen, Wei-hong; Zhao, Zi-gang; Niu, Chun-yu.
Título: Normal mesenteric lymph ameliorates lipopolysaccharide challenge-induced spleen injury
Fonte: Acta cir. bras;30(9):604-610, Sep. 2015. ilus.
Idioma: en.
Projeto: Foundation of Hundred Innovative Talents in Universities of Hebei Province.
Resumo: PURPOSE: This study was conducted to investigate the effect of normal mesenteric lymph (NML) from mice on the spleen injury induced by lipopolysaccharide (LPS) challenge.METHODS: Mice in the LPS and LPS+NML groups received an intraperitoneal injection of LPS (35 mg/kg) and kept for 6 h.. The mice in the LPS+NML group received NML treatment at 1 h after LPS injection. Afterward, the splenic morphology, the levels of lipopolysaccharide-binding protein (LBP), cluster of differentiation 14 (CD14), phosphorylation mitogen-activated protein kinases (MAPKs), and inflammatory mediators in splenic tissue were investigated.RESULTS:LPS injection induced spleen injury, increased the levels of LBP, CD14, tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and interferon γ (IFN-γ), and decreased the IL-4 content in the spleen. By contrast, NML treatment reversed these changes. Meanwhile, the LPS challenge decreased the phosphorylation levels of p38 MAPK, extracellular regulated protein kinases 1/2, and c-Jun N-terminal kinase (JNK). Moreover, the phosphorylation levels of p38 MAPK and JNK were further decreased by the NML administration.CONCLUSION:rRdThe normal mesenteric lymph treatment alleviated lipopolysaccharide induced spleen injury by attenuating LPS sensitization and production of TNF-α, IL-6, and IFN-γ.
Descritores: Lipopolissacarídeos/administração & dosagem
Linfonodos/transplante
Mesentério
Esplenopatias/terapia
-Proteínas da Fase Aguda/análise
/análise
ANTIGENS, CDCONGENITAL ABNORMALITIES/análise
Proteínas de Transporte/análise
Citocinas/análise
Ensaio de Imunoadsorção Enzimática
Injeções Intraperitoneais
Camundongos Endogâmicos BALB C
Glicoproteínas de Membrana/análise
Quinases de Proteína Quinase Ativadas por Mitógeno/análise
Distribuição Aleatória
Reprodutibilidade dos Testes
Resultado do Tratamento
Limites: Animais
Tipo de Publ: Estudos de Avaliação
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-748307
Autor: J.F., Donaldson.
Título: In the era of flexible ureteroscopy is there still a place for Shock-wave lithotripsy?: Opinion: YES
Fonte: Int. braz. j. urol;41(2):199-202, Mar-Apr/2015.
Idioma: en.
Descritores: /metabolismo
1-ACYLGLYCEROL-ABATTOIRS-PHOSPHATE O-ACYLTRANSFERASE/metabolismo
Adipócitos/metabolismo
Proteínas de Transporte/metabolismo
Lipólise/fisiologia
Proteínas de Membrana/metabolismo
Fosfoproteínas/metabolismo
-/genética
1-ACYLGLYCEROL-ABATTOIRS-PHOSPHATE O-ACYLTRANSFERASE/genética
ABATTOIRSTABATTOIRS-L1 CELLS
Adipócitos/citologia
Proteínas de Transporte/genética
Proteínas de Membrana/genética
Estrutura Terciária de Proteína
Proteólise
Fosfoproteínas/genética
Complexo de Endopeptidases do Proteassoma/genética
Complexo de Endopeptidases do Proteassoma/metabolismo
Limites: Animais
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-747147
Autor: Silva, Daniela da; Lopez, Priscila; Mantovani, Jair Cortez.
Título: Auditory Brainstem Response in Term and Preterm Infants with Neonatal Complications: The Importance of the Sequential Evaluation
Fonte: Int. arch. otorhinolaryngol. (Impr.);19(2):161-165, Apr-Jun/2015. tab.
Idioma: en.
Resumo: Introduction Literature data are not conclusive as to the influence of neonatal complications in the maturational process of the auditory system observed by auditory brainstem response (ABR) in infants at term and preterm. Objectives Check the real influence of the neonatal complications in infants by the sequential auditory evaluation. Methods Historical cohort study in a tertiary referral center. A total of 114 neonates met inclusion criteria: treatment at the Universal Neonatal Hearing Screening Program of the local hospital; at least one risk indicator for hearing loss; presence in both evaluations (the first one after hospital discharge from the neonatal unit and the second one at 6 months old); all latencies in ABR and transient otoacoustic emissions present in both ears. Results The complications that most influenced the ABR findings were Apgar scores less than 6 at 5 minutes, gestational age, intensive care unit stay, peri-intraventricular hemorrhage, and mechanical ventilation. Conclusion Sequential auditory evaluation is necessary in premature and term newborns with risk indicators for hearing loss to correctly identify injuries in the auditory pathway. .
Descritores: Carcinoma in Situ/metabolismo
Carcinoma Ductal Pancreático/metabolismo
Proteínas de Transporte/metabolismo
Proteínas dos Microfilamentos/metabolismo
Neoplasias Pancreáticas/metabolismo
Fatores de Transcrição/metabolismo
-Linhagem Celular Tumoral
Carcinoma in Situ/genética
Carcinoma in Situ/patologia
Carcinoma Ductal Pancreático/genética
Carcinoma Ductal Pancreático/mortalidade
Carcinoma Ductal Pancreático/secundário
Proteínas de Transporte/genética
Modelos Animais de Doenças
Progressão da Doença
Transição Epitelial-Mesenquimal
Camundongos Knockout
Proteínas dos Microfilamentos/deficiência
Proteínas dos Microfilamentos/genética
Invasividade Neoplásica
Recidiva Local de Neoplasia
Estadiamento de Neoplasias
Prognóstico
Neoplasias Pancreáticas/genética
Neoplasias Pancreáticas/mortalidade
Neoplasias Pancreáticas/patologia
Pseudópodes/metabolismo
Interferência de RNA
Análise de Sobrevida
Fatores de Tempo
Transfecção
Fatores de Transcrição/genética
Limites: Animais
Seres Humanos
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-746612
Autor: Barbosa, Jeam Haroldo Oliveira; Santos, Antonio Carlos; Salmon, Carlos Ernesto Garrido.
Título: Susceptibility weighted imaging: differentiating between calcification and hemosiderin / Imagem ponderada em suscetibilidade magnética: diferenciando calcificação de hemossiderina
Fonte: Radiol. bras;48(2):93-100, Mar-Apr/2015. graf.
Idioma: en.
Resumo: Objective: To present a detailed explanation on the processing of magnetic susceptibility weighted imaging (SWI), demonstrating the effects of echo time and sensitive mask on the differentiation between calcification and hemosiderin. Materials and Methods: Computed tomography and magnetic resonance (magnitude and phase) images of six patients (age range 41– 54 years; four men) were retrospectively selected. The SWI images processing was performed using the Matlab’s own routine. Results: Four out of the six patients showed calcifications at computed tomography images and their SWI images demonstrated hyperintense signal at the calcification regions. The other patients did not show any calcifications at computed tomography, and SWI revealed the presence of hemosiderin deposits with hypointense signal. Conclusion: The selection of echo time and of the mask may change all the information on SWI images, and compromise the diagnostic reliability. Amongst the possible masks, the authors highlight that the sigmoid mask allows for contrasting calcifications and hemosiderin on a single SWI image. .

Objetivo: Expor em detalhes o processamento da imagem ponderada em suscetibilidade magnética (susceptibility weighted imaging – SWI), destacando o efeito da escolha do tempo de eco e da máscara sensível à diferenciação de calcificação e hemossiderina simultaneamente. Materiais e Métodos: Imagens de tomografia computadorizada e por ressonância magnética (magnitude e fase) foram selecionadas, retrospectivamente, de seis pacientes (idades entre 41 e 54 anos; quatro homens). O processamento das imagens SWI foi realizado em rotina própria no programa Matlab. Resultados: Dos seis pacientes estudados, quatro apresentaram calcificações nas imagens de tomografia computadorizada. Nestes, as imagens SWI mostraram sinal hiperintenso para as regiões de calcificações. Os outros dois pacientes não apresentaram calcificações nas imagens de tomografia computadorizada e apresentaram depósito de hemossiderina com sinal hipointenso na imagem SWI. Conclusão: A escolha do tempo de eco e da máscara pode alterar toda a informação da imagem SWI e comprometer a confiabilidade diagnóstica. Dentre as possíveis máscaras, destacamos que a máscara sigmoide permite contrastar calcificação e hemossiderina em uma única imagem SWI. .
Descritores: Processamento Alternativo/genética
Proteínas de Transporte/genética
Proteínas de Transporte/metabolismo
Proteínas Nucleares/genética
Proteínas Nucleares/metabolismo
Proteína de Ligação a Regiões Ricas em Polipirimidinas/genética
Tropomiosina/genética
-Sequência de Bases
Sítios de Ligação
Primers do DNA
Éxons
Vetores Genéticos
Ligantes
Fases de Leitura Aberta
Reação em Cadeia da Polimerase
Proteína de Ligação a Regiões Ricas em Polipirimidinas/metabolismo
Proteínas Recombinantes/metabolismo
Proteínas Repressoras/metabolismo
Transfecção
Limites: Animais
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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