Base de dados : LILACS
Pesquisa : D12.776.157.125.750.625 [Categoria DeCS]
Referências encontradas : 5 [refinar]
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Id: biblio-896422
Autor: Tang, Jianhua; Zhen, Yuqing; Yu, Ling; Lv, Cui; Zheng, Juan; Liang, Hui.
Título: Analyzing the neuropsychological characteristics and changes in serum markers of patients with chronic cerebral circulation insufficiency
Fonte: Rev. Assoc. Med. Bras. (1992);64(1):41-46, Jan. 2018. tab, graf.
Idioma: en.
Resumo: Summary Objective: To investigate the neuropsychological characteristics and changes in CRP, S100B, MBP, HSP-7, and NSE in serum. Method: Sixty-six (66) patients treated in our hospital as CCCI group were chosen for our study, and 90 patients with depression were selected as the depression group. The patients in both groups were examined with CT perfusion, depression, anxiety and cognition evaluation. Their serum CRP, S100B, MBP, HSP-70 and NSE levels were detected. Neuropsychological and serum markers characteristics were compared. Results: The CBF and CBV in bilateral basal ganglia, frontal lobes, greater oval center, brain stem, and left and right regions of occipital lobes of the patients in CCCI group were significantly lower than in the depression group. The HAMD and HAMA scores of CCCI group patients were significantly lower than in the depression group; CCCI group performed better regarding attention, memory, abstract terms and delayed recall. CCCI also had significantly higher total scores than the depression group. Serum CRP, S100B, MBP, HSP-70 and NSE levels in CCCI group were significantly higher than in the depression group. The differences reach statistical significance (p<0.05). Conclusion: CCCI patients who are accompanied by minor depressive disorder have different degrees of cognitive impairment and experience a significant rise in serum CRP, S100B, MBP, HSP-70 and NSE.
Descritores: Ansiedade/diagnóstico
Biomarcadores/sangue
Circulação Cerebrovascular/fisiologia
Transtornos Cerebrovasculares/sangue
Transtorno Depressivo/diagnóstico
-Fosfopiruvato Hidratase/sangue
Proteína C-Reativa/análise
Tomografia Computadorizada por Raios X
Transtornos Cerebrovasculares/diagnóstico
Transtornos Cerebrovasculares/fisiopatologia
Reação em Cadeia da Polimerase
Doença Crônica
Fatores de Risco
Proteínas de Choque Térmico HSP70/sangue
Proteína Básica da Mielina/sangue
Subunidade beta da Proteína Ligante de Cálcio S100/sangue
Pessoa de Meia-Idade
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Idoso
Responsável: BR1.1 - BIREME


  2 / 5 LILACS  
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Id: biblio-886639
Autor: DANI, CAROLINE; ANDREAZZA, ANA CRISTINA; GONÇALVES, CARLOS ALBERTO; KAPIZINSKI, FLÁVIO; HENRIQUES, JOÃO A P; SALVADOR, MIRIAN.
Título: Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats
Fonte: An. acad. bras. ciênc;89(1):155-161, Jan,-Mar. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Several studies have shown that a high consumption of vegetables and fruits is consistently associated with a low risk of oxidative stress-induced diseases, which includes some degenerative diseases such as amyotrophic lateral sclerosis, Alzheimer and Parkinson. Therefore, the objective of this study is to verify the effects of conventional and organic grape juice in the modulation of the neurotrophic factor (BDNF) and astrocytic markers protein (S100B) in hippocampus and frontal cortex of Wistar rats. In this study, 24 male Wistar rats were divided into three groups. To the first one, it was given organic purple grape juice; to the second, conventional grape juice, while the last one received only saline. After 30 days, all rats were sacrificed and hippocampus and frontal cortex were dissected. The animals that received organic and conventional grape juice showed, in frontal cortex, an elevated BNDF levels in relation to saline group. However, S100B levels did not change. These results showed that grape juices are able to modulate important marker in brain tissue, and could be an important factor to prevent brain diseases.
Descritores: Fator Neurotrófico Derivado do Encéfalo/análise
Vitis/química
Subunidade beta da Proteína Ligante de Cálcio S100/análise
Sucos de Frutas e Vegetais
Lobo Frontal/química
Hipocampo/química
-Valores de Referência
Distribuição Aleatória
Reprodutibilidade dos Testes
Ratos Wistar
Fator Neurotrófico Derivado do Encéfalo/efeitos dos fármacos
Alimentos Orgânicos
Subunidade beta da Proteína Ligante de Cálcio S100/efeitos dos fármacos
Lobo Frontal/efeitos dos fármacos
Hipocampo/efeitos dos fármacos
Antioxidantes/farmacologia
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-899361
Autor: Guloksuz, Selin Aktan; Abali, Osman; Aktas Cetin, Esin; Bilgic Gazioglu, Sema; Deniz, Gunnur; Yildirim, Abdurrahman; Kawikova, Ivana; Guloksuz, Sinan; Leckman, James F.
Título: Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders
Fonte: Rev. bras. psiquiatr;39(3):195-200, July-Sept. 2017. tab, graf.
Idioma: en.
Projeto: EU-GEI.
Resumo: Objective: To investigate plasma concentrations of S100B (a calcium-binding protein derived primarily from the glia) and inflammatory cytokines in children with autism and the relationship between S100B and cytokine concentrations. Methods: Plasma levels of S100B, tumor necrosis factor alpha (TNF-α), interferon gamma, interleukin (IL)-1β, IL-4, IL-6, IL-10, and IL-17A were measured in 40 unmedicated children with autism and 35 normally developing healthy children. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS). Results: Concentrations of both S100B and TNF-α were higher in children with autism before and after adjusting for a priori-selected confounders (age, sex, and body mass index). S100B concentrations were higher in children with severe autism compared to children with mild-moderate autism. However, this association remained as a trend after adjusting for confounders. S100B concentrations correlated positively with TNF-α concentrations. Conclusion: Our findings showing an increase in peripheral concentrations of S100B and TNF-α provide limited support to the hypothesis about the roles of altered immune function and S100B in autism spectrum disorder (ASD). Studies of larger numbers of well-characterized individuals with ASD are needed to clarify the potential role of the immune system in the pathophysiology of this disorder.
Descritores: Fator de Necrose Tumoral alfa/sangue
Subunidade beta da Proteína Ligante de Cálcio S100/sangue
Transtorno do Espectro Autista/sangue
-Índice de Gravidade de Doença
Biomarcadores/sangue
Índice de Massa Corporal
Estudos Transversais
Interleucinas/sangue
Limites: Humanos
Masculino
Feminino
Pré-Escolar
Criança
Responsável: BR1.1 - BIREME


  4 / 5 LILACS  
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Id: biblio-886968
Autor: Salem, Samar Abdallah M; El-Khateeb, Ekramy Ahmed; Harvy, Mervat; Emam, Hanaa Mohamed El-Sayed; Abdelaal, Wafaa; Nemr, Reham El; El-Hagry, Omneya Osama.
Título: Study of serum levels and skin expression of S100B protein in psoriasis
Fonte: An. bras. dermatol;92(3):323-328, May-June 2017. tab, graf.
Idioma: en.
Resumo: Abstract Background: S100B protein was reported to be elevated in psoriatic patients' serum, with no previous evaluation of its skin expression, in contrast to the extensively studied S100 protein. Objective: To evaluate the serum level and skin expression of S100B in psoriasis to assess its possible involvement in its pathogenesis. Methods: Serum level of S100B protein was estimated in 40 psoriatic patients of different clinical varieties and 10 healthy controls. S100B protein expression was assessed immunohistochemically in lesional and non-lesional skin of patients and in normal skin of controls. Relation to disease severity was also evaluated. Results: Serum level of S100B protein was significantly higher in psoriatic patients (0.15±0.03 µg/l) than in controls (0.03±0.007 µg/l) (P-value <0.001) with no significant correlation with PASI score. On comparing grades of S100B protein skin expression in lesional and non-lesional skin biopsies, a statistically significant difference was found (P=0.046) with higher percentage of strong S100B skin expression (60%) in non-lesional than in lesional (42%) skin. All the control biopsies showed negative expression. Study limitations: Relatively small sample size with a limited range of low PASI scores. Conclusion: This study points to a potential link between psoriasis and S100B protein with higher serum and skin expression in patients than in controls.
Descritores: Psoríase/sangue
Subunidade beta da Proteína Ligante de Cálcio S100/sangue
-Psoríase/patologia
Biópsia
Índice de Gravidade de Doença
Ensaio de Imunoadsorção Enzimática
Imuno-Histoquímica
Biomarcadores/sangue
Estudos de Casos e Controles
Limites: Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-889105
Autor: Du, Juan; Zhang, Chunyan; Na, Xueqing; Li, Aizhi; Zhang, Qingfeng; Li, Kezhong; Ding, Yongbo.
Título: Andrographolide protects mouse astrocytes against hypoxia injury by promoting autophagy and S100B expression
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(6):e7061, 2018. graf.
Idioma: en.
Resumo: Andrographolide (ANDRO) has been studied for its immunomodulation, anti-inflammatory, and neuroprotection effects. Because brain hypoxia is the most common factor of secondary brain injury after traumatic brain injury, we studied the role and possible mechanism of ANDRO in this process using hypoxia-injured astrocytes. Mouse cortical astrocytes C8-D1A (astrocyte type I clone from C57/BL6 strains) were subjected to 3 and 21% of O2 for various times (0-12 h) to establish an astrocyte hypoxia injury model in vitro. After hypoxia and ANDRO administration, the changes in cell viability and apoptosis were assessed using CCK-8 and flow cytometry. Expression changes in apoptosis-related proteins, autophagy-related proteins, main factors of JNK pathway, ATG5, and S100B were determined by western blot. Hypoxia remarkably damaged C8-D1A cells evidenced by reduction of cell viability and induction of apoptosis. Hypoxia also induced autophagy and overproduction of S100B. ANDRO reduced cell apoptosis and promoted cell autophagy and S100B expression. After ANDRO administration, autophagy-related proteins, S-100B, JNK pathway proteins, and ATG5 were all upregulated, while autophagy-related proteins and s100b were downregulated when the jnk pathway was inhibited or ATG5 was knocked down. ANDRO conferred a survival advantage to hypoxia-injured astrocytes by reducing cell apoptosis and promoting autophagy and s100b expression. Furthermore, the promotion of autophagy and s100b expression by ANDRO was via activation of jnk pathway and regulation of ATG5.
Descritores: Astrócitos/efeitos dos fármacos
Autofagia/efeitos dos fármacos
Hipóxia Celular/efeitos dos fármacos
Diterpenos/farmacologia
Subunidade beta da Proteína Ligante de Cálcio S100/efeitos dos fármacos
-Apoptose/efeitos dos fármacos
Astrócitos/fisiologia
Western Blotting
Sobrevivência Celular/efeitos dos fármacos
Reação em Cadeia da Polimerase em Tempo Real
Subunidade beta da Proteína Ligante de Cálcio S100/metabolismo
Fatores de Tempo
Transfecção
Limites: Animais
Camundongos
Responsável: BR1.1 - BIREME



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