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Id: biblio-886185
Autor: Arruda, Eduardo Gustavo Pires de; Munhoz, Alexandre Mendonça; Matsumoto, Walter; Ueda, Thiago; Coudry, Renata de Almeida; Gemperli, Rolf.
Título: Qualitative analysis of the viability of autogenous fat grafts grafted in different environments of interstitial pressure. Preliminary results and description of a new experimental model in mini-pigs
Fonte: Acta cir. bras;32(11):891-902, Nov. 2017. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Abstract Purpose: To evaluate the feasibility of an experimental model of autologous fat graft (AFG) in different interstitial pressure (IP) environments. Methods: Three mini-pigs(Minipig-BR) with age of 8 months (weight: 25-30 kg) were used. AFG were collected from the bucal fat pad, and grafted in the intramuscular pocket (biceps femoralis muscle). IP model was based on a fusiform ressection followed by primary closure "under tension". A blood pressure catheter located in the intramuscular region connected to a pressure module was applied to quantify IP. Results: The mean operative time was 236 min (210 - 272 min). All the AFG and muscular segments were removed successfully. Average interstitial pressure CP and H were 3 and 10.6 mmHg respectively. The AFG were biopsied for histopathological analysis 30 days after graft. Hematoxylin-eosin staining and immunohistochemical analyzes (TNF-alpha, CD31 and Perilipine with monoclonal antibodies) were employed. Conclusion: The data show that minipigs model could be used as a recipient site for autologous fat graft techniques and allow the development of studies to explore the AFG intake and pathophysiology response.
Descritores: Transplante Autólogo/métodos
Tecido Adiposo/transplante
Procedimentos Cirúrgicos Reconstrutivos/métodos
Modelos Animais de Doenças
-Pressão
Suínos
Porco Miniatura
Transplante Autólogo/normas
Imuno-Histoquímica
Estudos de Viabilidade
Fator de Necrose Tumoral alfa
Molécula-1 de Adesão Celular Endotelial de Plaquetas/análise
Procedimentos Cirúrgicos Reconstrutivos/normas
Perilipinas/análise
Sobrevivência de Enxerto
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME



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