Base de dados : LILACS
Pesquisa : D12.776.157.530.400.600.150 [Categoria DeCS]
Referências encontradas : 3 [refinar]
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Texto completo SciELO Chile
Texto completo
Id: biblio-1038781
Autor: Nevoral, Jan; Zalmanova, Tereza; Hoskova, Kristyna; Stiavnicka, Miriam; Hosek, Petr; Petelak, Ales; Petr, Jaroslav.
Título: Involvement of K+ATP and Ca2+ channels in hydrogen sulfide-suppressed ageing of porcine oocytes
Fonte: Biol. Res;51:38, 2018. graf.
Idioma: en.
Projeto: National Agency of Agriculture Sciences; . Czech Ministry of Agriculture; . Charles University Research Fund; . Ministry of Education, Youth and Sports of the Czech Republic.
Resumo: BACKGROUND: Hydrogen sulfide has been shown to improve the quality of oocytes destined for in vitro fertilization. Although hydrogen sulfide is capable of modulating ion channel activity in somatic cells, the role of hydrogen sulfide in gametes and embryos remains unknown. Our observations confirmed the hypothesis that the KATP and L-type Ca2+ ion channels play roles in porcine oocyte ageing and revealed a plausible contribution of hydrogen sulfide to the modulation of ion channel activity. RESULTS: We confirmed the benefits of the activation and suppression of the KATP and L-type Ca2+ ion channels, respectively, for the preservation of oocyte quality. CONCLUSIONS: Our experiments identified hydrogen sulfide as promoting the desired ion channel activity, with the capacity to protect porcine oocytes against cell death. Further experiments are needed to determine the exact mechanism of hydrogen sulfide in gametes and embryos.
Descritores: Oócitos/efeitos dos fármacos
Canais de Cálcio/fisiologia
Senescência Celular/fisiologia
Canais de Potássio Cálcio-Ativados/fisiologia
Sulfeto de Hidrogênio/farmacologia
Bloqueadores dos Canais de Cálcio/farmacologia
Canais de Cálcio/efeitos dos fármacos
Transdução de Sinais/efeitos dos fármacos
Trifosfato de Adenosina
Canais de Potássio Cálcio-Ativados/efeitos dos fármacos
Limites: Animais
Responsável: CL1.1 - Biblioteca Central

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Texto completo SciELO Chile
Texto completo
Id: lil-742580
Autor: Delgado Córdova, Margarita; Peñaloza, Juan Carlos.
Título: Diabetes mellitus e hipertensión: importancia del cribado de albuminuria / Diabetes mellitus and hypertension: the relevance of checking albuminuria
Fonte: Rev. méd. Chile;143(2):266-267, feb. 2015.
Idioma: es.
Descritores: Fatores Biológicos/metabolismo
Endotélio Vascular/fisiologia
-Pressão Sanguínea/fisiologia
Endotélio Vascular/metabolismo
Endotélio Vascular/fisiopatologia
Músculo Liso Vascular/metabolismo
Músculo Liso Vascular/fisiologia
Músculo Liso Vascular/fisiopatologia
Canais de Potássio Cálcio-Ativados/metabolismo
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central

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Texto completo SciELO Brasil
Texto completo
Id: lil-405536
Autor: Rodrigues, A. R. A; Castro, M. S. A; Francischi, J. N; Perez, A. C; Duarte, I. D. G.
Título: Participation of ATP-sensitive K+ channels in the peripheral antinociceptive effect of fentanyl in rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;38(1):91-97, Jan. 2005. graf.
Idioma: en.
Resumo: We examined the effect of several K+ channel blockers such as glibenclamide, tolbutamide, charybdotoxin (ChTX), apamin, tetraethylammonium chloride (TEA), 4-aminopyridine (4-AP), and cesium on the ability of fentanyl, a clinically used selective æ-opioid receptor agonist, to promote peripheral antinociception. Antinociception was measured by the paw pressure test in male Wistar rats weighing 180-250 g (N = 5 animals per group). Carrageenan (250 æg/paw) decreased the threshold of responsiveness to noxious pressure (delta = 188.1 ± 5.3 g). This mechanical hyperalgesia was reduced by fentanyl (0.5, 1.5 and 3 æg/paw) in a peripherally mediated and dose-dependent fashion (17.3, 45.3 and 62.6 percent, respectively). The selective blockers of ATP-sensitive K+ channels glibenclamide (40, 80 and 160 æg/paw) and tolbutamide (80, 160 and 240 æg/paw) dose dependently antagonized the antinociception induced by fentanyl (1.5 æg/paw). In contrast, the effect of fentanyl was unaffected by the large conductance Ca2+-activated K+ channel blocker ChTX (2 æg/paw), the small conductance Ca2+-activated K+ channel blocker apamin (10 æg/paw), or the non-specific K+ channel blocker TEA (150 æg/paw), 4-AP (50 æg/paw), and cesium (250 æg/paw). These results extend previously reported data on the peripheral analgesic effect of morphine and fentanyl, suggesting for the first time that the peripheral æ-opioid receptor-mediated antinociceptive effect of fentanyl depends on activation of ATP-sensitive, but not other, K+ channels.
Descritores: Analgesia
Analgésicos Opioides/antagonistas & inibidores
Analgésicos Opioides/farmacologia
Fentanila/antagonistas & inibidores
Canais de Potássio Cálcio-Ativados
Bloqueadores dos Canais de Potássio/farmacologia
Canais de Potássio/efeitos dos fármacos
-Medição da Dor/efeitos dos fármacos
Ratos Wistar
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME

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