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Id: biblio-1001568
Autor: Wu, Tao; Zhang, Qianrui; Song, Hongping.
Título: Swertiamarin attenuates carbon tetrachloride (CCl4)-induced liver injury and inflammation in rats by regulating the TLR4 signaling pathway
Fonte: Braz. J. Pharm. Sci. (Online);54(4):e17449, 2018. graf.
Idioma: en.
Resumo: The aim of the present study is to illustrate the effects of swertiamarin (STM), a natural iridoid from herbal medicines, on hepatic inflammation induced by carbon tetrachloride (CCl4) in rats. Male Sprague Dawley rats were exposed to CCl4 with or without STM co-administration for 8 weeks. Our results revealed that STM administration (100 and 200 mg/kg b.w.) significantly attenuated inflammation in livers of CCl4-treated rats. STM remarkably reduced the production of interleukin-1ß (IL-1ß), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), macrophage inflammatory protein-1a (MIP-1α), and monocyte chemotactic protein-1 (MCP-1) in liver tissue of CCl4-treated rats. In addition, STM treatment downregulated connective tissue growth factor (CTGF) and ser307pIRS-1 expression, which was induced by CCl4 exposure. In the process of exploring the anti-inflammatory mechanisms of STM action, we demonstrated that STM significantly inhibited Toll-like receptor 4 (TLR4) and nuclear factor kappa B (NF-κB) p65 expression in the liver. In conclusion, these results suggested that the inhibition of CCl4-induced inflammation by STM was, at least in part, due to its regulation of the TLR4 /NF-κB signaling pathway
Descritores: Tetracloreto de Carbono/farmacologia
Receptor 4 Toll-Like
Doença Hepática Induzida por Substâncias e Drogas/diagnóstico
-NF-kappa B
Gentianaceae/classificação
Glicosídeos/efeitos adversos
Inflamação/tratamento farmacológico
Limites: Animais
Masculino
Ratos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-987183
Autor: Aldana Raudales, Alejandra María; Corea, Dulce María; Caballero Castro, Héctor Rubén.
Título: Incontinencia pigmenti. Presentación de un caso / Pigmenti incontinence. Presentation of a case
Fonte: Acta pediátr. hondu;8(1):725-730, abr.-sept. 2017. ilus.
Idioma: es.
Resumo: La incontinentia pigmenti es una genoderma-tosis que afecta la pigmentación de la piel y suele estar asociada con una gran variedad de alteraciones en ojos, uñas, pelo, dientes, esque-leto, corazón y sistema nervioso central. La mayoría de los casos de incontinencia pigmen-ti se producen en forma esporádica como resultado de una mutación de novo consisten-te en la deleción de gran parte del gen NEMO (Nuclear Factor Kappa B Essential Modi er).Se presenta una paciente de 6 años de edad con lesiones hiperpigmentadas siguiendo las líneas de Blaschko. No tiene antecedentes durante el periodo perinatal, nació vía vaginal sin complicaciones, con un desarrollo cogniti-vo normal para su edad, sin afectación neuroló-gica, lo cual llama la atención pues aunque esta enfermedad afecta principalmente a la piel, hay que considerar otros trastornos asociados, incluyendo defectos dentales, episodios convulsivos, retraso mental, anoma-lías oculares y neoplasias infantiles...(AU)
Descritores: Incontinência Pigmentar/diagnóstico
Pigmentação da Pele
-NF-kappa B
Limites: Seres Humanos
Feminino
Criança
Tipo de Publ: Ensaio Clínico
Responsável: HN1.1 - Biblioteca Médica Nacional


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Id: biblio-971959
Autor: Magalhães, Patrícia Andréa da Fonseca.
Título: Acidose metabólica agrava a lesão renal em modelo experimental de isquemia/reperfusão.
Fonte: Fortaleza; s.n; 2016. 110 p. ilus, tab.
Idioma: pt.
Tese: Apresentada a Universidade Federal do Ceará para obtenção do grau de Doutor.
Resumo: Lesão renal por isquemia/reperfusão (I/R) e acidose metabólica (AM) são duascondições críticas que ocorrem frequentemente na prática clínica. O resultado dessacombinação pode ser prejudicial para os rins, mas esta questão não tem sidoexaustivamente estudada até hoje. O presente estudo avaliou em ratos a influênciado baixo pH sistêmico em vários parâmetros da função renal mediante lesão renalpor I/R. A acidose metabólica foi induzida em ratos Wistar machos através daingestão de cloreto de amônio (NH4CI) dissolvido na água de beber, iniciando 2 diasantes da indução de lesão renal por isquemia/reperfusão e mantida durante todo oestudo. Isquemia/reperfusão renal foi induzida por clampeamento bilateral dasartérias renais durante 45 min, seguido por 48 h de reperfusão. Ao final do estudo,foram obtidas amostras de sangue arterial, urina e tecido renal. Os animais foramdivididos em quatro grupos: controle (submetido à cirurgia sham, n = 8), I/R (n = 8),acidose metabólica (AM; solução de NH4CI 0,28 M + cirurgia sham, n = 6), e AM+I/R(solução de NH4CI 0,28 M + I/R, n = 9). Em comparação com grupo I/R, ratosAM+I/R apresentaram maior mortalidade (50% vs. 11%), redução significativa de pHsanguíneo (7,00 ± 0,04 vs. 7,35 ± 0,03), bicarbonato plasmático (pBic; 9,0 ± 1,4 vs.21,4 ± 0,9 mmol/L), e excesso de base (SBE; -23,8 ± 1,5 vs. -2,7 ± 0,9 mmol/L), comdeclínio no ritmo de filtração glomerular (0,05 ± 0,02 vs. 0,14 ± 0,03 mL/min/100 g) efunção tubular...

Ischemia/reperfusion (I/R) injury and metabolic acidosis (MA) are two criticalconditions that frequently occur in the clinical practice. The result of this combinationcan be harmful to the kidneys, but this issue has not been thoroughly investigatedhitherto. The present study evaluated the influence of low systemic pH on severalkidney function parameters in rats subjected to experimental model of renal I/Rinjury. Metabolic acidosis was induced in male Wistar rats by ingesting ammoniumchloride (NH4Cl) in tap water, beginning 2 days before ischemic insult and maintainedduring the entire study. Ischemia/reperfusion was induced by clamping both renalarteries for 45 min, followed by 48 h of reperfusion. At the end of the study, arterialblood samples and urine were collected and left kidneys were harvested. Fourgroups were studied: control (subjected to sham surgery, n = 8), I/R (n = 8),metabolic acidosis (MA; 0.28 M NH4Cl solution and sham surgery, n = 6), andMA+I/R (0.28 M NH4Cl solution plus I/R, n = 9). Compared with I/R rats, MA+I/R ratsexhibited higher mortality (50% vs. 11%), significant reduction of blood pH (7.00 ±0.04 vs. 7.35 ± 0.03), plasma bicarbonate (pBic; 9.0 ± 1.4 vs. 21.4 ± 0.9 mmol/L), andstandard base excess (SBE; -23.8 ± 1.5 vs. -2.7 ± 0.9 mmol/L), with a severe declinein the glomerular filtration rate (0.05 ± 0.02 vs. 0.14 ± 0.03 mL/min/100 g) and tubularfunction. In addition, tubular changes were more intense determining higher scores oftubular injury...
Descritores: Cetose
Heme Oxigenase-1
NF-kappa B
Lesão Renal Aguda
Limites: Seres Humanos
Responsável: BR6.1 - BCS - Biblioteca de Ciências da Saúde
BR6.1


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Id: biblio-971363
Autor: Vara-Messler, Marianela.
Título: Efecto del aceite de Chia rico en ácidos graso w-3 sobre el desarrollo de un adenocarcinoma de mama murino.
Fonte: Córdoba; s.n; 2015. 109 p. graf, tab, ilus.
Idioma: es.
Tese: Apresentada a Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Secretaría de Graduados en Ciencias de la Salud. Doctor en Ciencias de la Salud para obtenção do grau de Doutor.
Resumo: El cáncer de mama (CM) es el tumor más frecuente entre las mujeres. Aproximadamente, el 75% de los casos son receptor de estrógeno (ER) positivo. En particular, ERα promueve el desarrollo tumoral mientras que ERβ tendría efectos anti-proliferativos. Ha sido demostrado que los acidos grasos poliinsaturados (PUFAs) y sus derivados modulan el proceso carcinogénico. Sin embargo, aún no se conocen totalmente los mecanismos que emplean estas moléculas para regular este proceso. Nos propusimos estudiar el efecto de los PUFAs ω-3 en variables biológicas implicadas en el desarrollo de un carcinoma de mama murino, tanto in vivo como in vitro. El aceite de chía es rico en ácido αlinolénico (ALA 18:3 ω-3), mientras que el de maíz es fuente de ácido linoleico (LA 18:2 ω-6). ALA y LA son precursores de eicosanoides con efectos opuestos en el CM y también producen especies reactivas del oxígeno (ROS) que pueden modular la expresión de NFκB, un factor de transcripción con un rol controversial en la carcinogénesis. Nos propusimos determinar los posibles procesos que pueden ser activados por los PUFAs ω-3 en el CM. 40 ratones BALB/c fueron alimentados con una dieta rica en aceite de chía (ChO) o aceite de maíz (CO) y se inocularon con una línea celular murina de CM, LM3. Después de 35 días, la incidencia tumoral fue mayor en los ratones alimentados con CO en comparación con los ratones alimentados con ChO (100 vs 85%, p <0,05). El peso (1,0±0,2 vs 2,2±0,2 g, p <0,05) y el volumen tumoral (4,4±0,4 vs 7,2 ± 1,0 mm3, p <0,05), así como el número de metástasis (7,4±0,8 vs 10,0±0,1, p <0.05) fueron más bajos, mientras que el tiempo de latencia del tumor (22±1 vs 15±2 d, p <0,05) fue mayor en los ratones alimentados con la dieta ChO. Se observó una disminución del número de mitosis y un mayor número de cuerpos apoptóticos, además de una mayor infiltración de linfocitos-T (células CD3+) en el grupo ChO, respecto del grupo CO (p <0,05).

Breast cancer (BC) is the most common tumour where estrogen receptor (ER) plays a key role. ERα promotes tumour growth, while ERβ has an anti-proliferative effect. It has been demonstrated that ω-3 polyunsaturated fatty acid (PUFA) consumption as well as its derivated metabolites are allowed to modulate carcinogenesis although the molecular mechanisms are not fully understood. The study was aimed to determine the possible mechanisms that are activated by dietary lipids regulating BC growth in-vivo and in-vitro. Chia oil is rich in α-linolenic acid (ALA 18:3 ω-3), while corn oil is rich in linoleic acid (LA 18:2 ω-6). ALA and LA are precursors of eicosanoid with opposite effects in BC and also generate reactive oxygen species (ROS), which could affect NFκB, a transcription factor with a controversial role in carcinogenesis. 40 BALB/c mice were fed with a diet rich in Chia Oil (ChO) or Corn Oil (CO) and inoculated with LM3, a BC murine cell line. After 35 days, tumour incidence was higher in CO-fed mice compared with ChO-fed mice (100 vs 85%, p <0.05). Tumour weight (1.0±0.2 vs 2.2±0.2 g, p <0.05) and volume (4.4±0.4 vs 7.2±1.0 mm, p <0.05) as well as metastasis number (7.4±0.8 vs 10.0±0.1, p <0.05) were lower, whereas tumour latency time (22±1 vs 15±2 d, p <0.05) was longer in ChO-fed mice. A lower number of mitosis and a higher number of apoptotic bodies besides higher T-lymphocyte infiltration was observed in ChO with respect to COgroup (p <0.05). Tumours cell membranes from ChO-fed mice showed a higher percentage of PUFAs ω-3 compared with those from CO-fed mice and generated lower amounts of ω-6 pro-inflammatory eicosanoids such as 13(S)-HODE, 15(S)HETE and 5(S)-HETE (p <0.05).
Descritores: Neoplasias da Mama
Ácidos Graxos/imunologia
/imunologia
FATTY ACIDS, OMEGA-ABATTOIRS/imunologia
Receptor beta de Estrogênio
NF-kappa B
-Argentina
Limites: Masculino
Feminino
Seres Humanos
Tipo de Publ: Estudos de Validação
Responsável: AR32.1 - Biblioteca Prof. Dr. J. M. Allende
AR32.1; TCS, V-3 2015


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Id: biblio-954136
Autor: Núñez-R, Daniela; Balboa-P, Natalia; Quilaqueo-P, Nelson; Alvear-Z, Marysol; Paredes-H, Marco.
Título: Evaluación de la actividad inmunomoduladora de extractos metanólicos y de alcaloides de Berberis darwinii H. (Berberidaceae) / Evaluation of the immunomodulatory activity of methanolic extracts and alkaloids of Berberis darwinii H. (Berberidaceae)
Fonte: Int. j. morphol;36(2):454-459, jun. 2018. graf.
Idioma: es.
Projeto: Departamento de Ciencias Básicas, de Ciencias Químicas y Recursos Naturales y al BIOREN de la Universidad de La Frontera; . CONICYT.
Resumo: Berberis darwinii Hook es una especie que habita el sur de Chile y la Patagonia, utilizada por la etnia mapuche para el tratamiento de procesos inflamatorios, estados febriles y dolor de estomacal. El propósito del siguiente estudio fue evaluar in vitro las propiedades del extracto total y de alcaloides de raíz de B. darwinii sobre viabilidad celular y la translocación del factor nuclear NF-kB en línea celular RAW 264.7. Se observó que los extractos no afectan negativamente la viabilidad en las células e inhibieron la translocación del factor nuclear NF-kB asociado a la modulación de la inflamación solo frente al extracto total. Estos resultados indicarían que B. darwinii podría inhibir algunos mecanismos específicos de la defensa celular al modular la translocación de NF- kB.

Berberis darwinii Hook is a species that inhabits southern Chile and Patagonia, used by the Mapuche ethnic group for the treatment of inflammatory processes, febrile states and stomach pain. The purpose of the following study was to evaluate in vitro the properties of the total extract and alkaloids of the root of B. darwinii on cell viability and the translocation of the nuclear factor NF-kB in cell line RAW 264.7. It was observed that the extracts did not negatively affect the viability in the cells and inhibited the translocation of the nuclear factor NF-kB associated with the modulation of inflammation only against the total extract. These results indicate that B. darwinii could inhibit some specific mechanisms of cell defense by modulating the translocation of NF-kB.
Descritores: Extratos Vegetais/farmacologia
NF-kappa B/efeitos dos fármacos
Berberis
Células RAW 264.7/efeitos dos fármacos
-Sobrevivência Celular/efeitos dos fármacos
Imunofluorescência
Raízes de Plantas
Metanol
Alcaloides/farmacologia
Citometria de Fluxo
Fatores Imunológicos/farmacologia
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-915349
Autor: Núñez, Daniela; Balboa, Natalia; Carvajal, Fernando; Alvear, Marysol; Paredes, Marco.
Título: Efecto del extracto de alcaloides de Berberis darwinii Hook sobre respuestas celulares innatas en fagocitos murinos / Effect of the extract of Berberis darwinii Hook alkaloids on innate cellular responses in murine phagocytes
Fonte: Bol. latinoam. Caribe plantas med. aromát;17(3):259-269, mayo 2018. tab, ilus, graf.
Idioma: es.
Projeto: CONICYT.
Resumo: Berberis darwinii Hook es una especie que habita el sur de Chile y la Patagonia. Siendo utilizada por la etnia mapuche para el tratamiento de procesos inflamatorios, estados febriles, y dolor estomacal. El propósito del siguiente estudio fue evaluar in vitro las propiedades del extracto de alcaloides de raíz de B. darwinii sobre respuestas celulares en monocitos desde sangre periférica de rata. Los resultados de la cuantificación del extracto muestran una concentración de alcaloides totales de 1,67 mg/g y la caracterización por HPLC- MS determinó la presencia de berberina y palmatina. In vitro se observó que los extractos disminuyeron la capacidad de adhesión y la actividad fagocítica de los monocitos e inhibieron la translocación del factor nuclear NF-κB asociado a la modulación de la inflamación, pero no así la producción de anión superóxido. Estos resultados indicarían que los alcaloides totales de B. darwinii inhiben algunos mecanismos específicos de defensa celular.

Berberis darwinii Hook is a species that inhabits southern Chile and Patagonia. This is being used by the Mapuche ethnic group for the treatment of inflammatory processes, febrile states, and stomach pain. The purpose of the following study was to evaluate in vitro the properties of an alkaloid extract of B. darwinii root on cellular responses in monocytes from the rat peripheral blood. The results of the quantification of the extract showed a total alkaloid concentration of 1.67 mg/g and the characterization by HPLC-MS determined the presence of berberine and palmatine. In vitro, it was observed that the extracts decreased the adhesion capacity and phagocytic activity of the monocytes and inhibited the translocation of the nuclear factor NF-κB associated with the modulation of inflammation, but not the production of superoxide anion. These results indicate that the total alkaloids of B. darwinii inhibit some specific mechanisms of cellular defense.
Descritores: Berberis/química
Extratos Vegetais/farmacologia
Raízes de Plantas/química
-Alcaloides/análise
Adesão Celular/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão/métodos
Monócitos/efeitos dos fármacos
NF-kappa B/efeitos dos fármacos
Extratos Vegetais/química
Ratos Sprague-Dawley
Limites: Animais
Masculino
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-889118
Autor: Wanchao, Shi; Chen, Ma; Zhiguo, Su; Futang, Xie; Mengmeng, Shi.
Título: Protective effect and mechanism of Lactobacillus on cerebral ischemia reperfusion injury in rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(7):e7172, 2018. graf.
Idioma: en.
Resumo: The present study was designed to investigate the protective effects and mechanism of inactivated lactobacillus (ILA) on cerebral ischemia reperfusion injury (CIRI) in rats. In this experiment, 30 male Sprague Dawley rats were randomly divided into control group, IRI groups, and ILA group. A middle cerebral artery occlusion and reperfusion model was prepared. The rats were killed after 24 hours of recovery of blood flow of cerebral ischemia resulting from 60-min occlusion. The cerebral infarction volume and neurological scores were assayed by staining and behavioral observation. Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were assayed by biochemical kits. Cell apoptosis was assayed by Tunnel and the Toll-like receptor (TLR)-4, IkB, and A20 were assayed by western blot. The neurobehavioral scores in IRI rats were significantly lower compared to the control group while ILA improved the neurobehavioral scores of the ILA groups. The cerebral infarction volume and neural cell apoptosis of rats in the ILA groups decreased significantly compared with those in the IRI group. In addition, MDA level in the ILA groups decreased whereas SOD activity increased compared to the IRI group. Moreover, ILA also inhibited the expression of TLR-4 and promoted the expression of IkB and A20. ILA inhibited the apoptosis of neural cells, decreased cerebral infarction volume, and reduced oxidative stress through inhibition of TLR-4/NF-kappa B signaling, improving neurobehavioral scores. Thus from the present study it was concluded that ILA has protective effect on CIRI.
Descritores: Apoptose
Isquemia Encefálica/prevenção & controle
Infarto da Artéria Cerebral Média/complicações
Lactobacillus paracasei
Fármacos Neuroprotetores/administração & dosagem
Traumatismo por Reperfusão/prevenção & controle
-Isquemia Encefálica/etiologia
Modelos Animais de Doenças
Regulação para Baixo
NF-kappa B/sangue
Distribuição Aleatória
Ratos Sprague-Dawley
Traumatismo por Reperfusão/etiologia
Receptor 4 Toll-Like/sangue
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: biblio-889100
Autor: Ren, Keyu; Yong, Chunming; Yuan, Hao; Cao, Bin; Zhao, Kun; Wang, Jin.
Título: TNF-α inhibits SCF, ghrelin, and substance P expressions through the NF-κB pathway activation in interstitial cells of Cajal
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(6):e7065, 2018. graf.
Idioma: en.
Resumo: Ulcerative colitis is a chronic inflammatory disease of the colon where intestinal motility is disturbed. Interstitial cells of Cajal (ICC) are required to maintain normal intestinal motility. In the present study, we assessed the effect of tumor necrosis factor-alpha (TNF-α) on viability and apoptosis of ICC, as well as on the expression of stem cell factor (SCF), ghrelin, and substance P. ICC were derived from the small intestines of Swiss albino mice. Cell viability and apoptosis were measured using CCK-8 assay and flow cytometry, respectively. ELISA was used to measure the concentrations of IL-1β, IL-6, ghrelin, substance P, and endothelin-1. Quantitative RT-PCR was used to measure the expression of SCF. Western blotting was used to measure the expression of apoptosis-related proteins, interleukins, SCF, and NF-κB signaling pathway proteins. TNF-α induced inflammatory injury in ICC by decreasing cell viability and increasing apoptosis and levels of IL-1β and IL-6. TNF-α decreased the levels of SCF, ghrelin, and substance P, but had no effect on endothelin-1. TNF-α down-regulated expressions of SCF, ghrelin, and substance P by activating the NF-κB pathway in ICC. In conclusion, TNF-α down-regulated the expressions of SCF, ghrelin, and substance P via the activation of the NF-κB pathway in ICC.
Descritores: Grelina/metabolismo
Células Intersticiais de Cajal/efeitos dos fármacos
NF-kappa B/metabolismo
Fator de Células-Tronco/metabolismo
Substância P/metabolismo
Fator de Necrose Tumoral alfa/farmacologia
-Apoptose/efeitos dos fármacos
Western Blotting
Ensaio de Imunoadsorção Enzimática
Motilidade Gastrointestinal/efeitos dos fármacos
Grelina/antagonistas & inibidores
Células Intersticiais de Cajal/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Transdução de Sinais/efeitos dos fármacos
Limites: Animais
Masculino
Camundongos
Responsável: BR1.1 - BIREME


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Id: biblio-888968
Autor: Wang, WJ; Cheng, MH; Lin, JH; Weng, CS.
Título: Effect of a rosmarinic acid supplemented hemodialysis fluid on inflammation of human vascular endothelial cells
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(12):e6145, 2017. tab, graf.
Idioma: en.
Resumo: Chronic systemic inflammation and repetitive damage of vascular endothelia by incompatible dialysis system are probable causes of cardiovascular disease in patients on dialysis. The present study aimed to assess in vitro biocompatibility and anti-inflammatory effect of hemodialysis fluid supplemented with rosmarinic acid (RA) using human umbilical vein endothelial cells (HUVEC). HUVECs (5×106 cells/mL) were pre-exposed to 1 μg/mL of lipopolysaccharides (LPS) and incubated with RA-supplemented hemodialysis fluid (HDF). Cytotoxicity was assessed qualitatively by morphologic assessment and quantitatively by MTT assay. Expressions of proinflammatory mediators were assessed using quantitative real-time PCR and production of NO was quantified. Phosphorylation of AKT and nuclear localization of nuclear factor kappa B (NF-κB) were examined using western blotting. Exposure of HUVECs to RA-supplemented HDF had no influence on morphology and viability. Inhibition of proinflammatory mediator production in HUVECs by RA supplementation to HDF was significant in a dose-dependent manner. Exposure to RA-supplemented HDF resulted in a decrease in nitric oxide synthase expression and reduction of NO production in LPS-stimulated HUVECs. RA supplementation of HDF suppressed Akt activation in LPS-stimulated HUVECs. In addition, the level of cellular IκB was increased in parallel to a reduced nuclear translocation of NF-κB in LPS-induced endothelial cells. Our results suggest that RA-supplemented HDF is biocompatible and significantly suppressed inflammation induced in endothelial cells. In this respect, the use of HDF supplemented with RA could alleviate inflammation and improve long-term treatment of patients with renal failure on dialysis. Further clinical studies are required to confirm the effects.
Descritores: Anti-Inflamatórios não Esteroides/farmacologia
Materiais Biocompatíveis/farmacologia
Cinamatos/farmacologia
Depsídeos/farmacologia
Soluções para Hemodiálise/farmacologia
Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos
Inflamação/tratamento farmacológico
-Análise de Variância
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Citocinas/análise
Citocinas/efeitos dos fármacos
Formazans
Soluções para Hemodiálise/química
Células Endoteliais da Veia Umbilical Humana/metabolismo
Immunoblotting
Inflamação/metabolismo
Lipopolissacarídeos
NF-kappa B/análise
Óxido Nítrico/análise
Fosforilação
Reação em Cadeia da Polimerase em Tempo Real
Reprodutibilidade dos Testes
Sais de Tetrazólio
Limites: Seres Humanos
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-880562
Autor: Oliveira, Dalila Cunha de; Lima, Fabiana da Silva; Sartori, Talita; Santos, Andressa Cristina Antunes; Rogero, Marcelo Macedo; Fock, Ricardo Ambrosio.
Título: Glutamine metabolism and its effects on immune response: molecular mechanism and gene expression
Fonte: Nutrire Rev. Soc. Bras. Aliment. Nutr;41:1-10, Dec. 2016. ilus.
Idioma: en.
Resumo: This article aims to review glutamine metabolism and its effects on the immune response. Selected topics are addressed, particularly the effect of glutamine on cell survival and proliferation, as well as its importance in some biochemical pathways. The impact of glutamine on muscle, intestine, and liver metabolism are described, and a special section about glutamine regulation of the immune response is included. In this context, the modulation of glutamine on relevant signaling pathways as nuclear factor kappa B (NF-kB), mitogen-activated protein kinases (MAPKs), and heat shock protein and the influence of this amino acid on cell migration and adhesion molecules are highlighted. Some important immune response pathways modulated by glutamine were described as its action incritically ill patients. In summary, this review describes some important actions of glutamine, and a range of reactions and modulatory effects in different organs, which may inform new therapeutic strategies. However, further studies are necessary to provide information about glutamine use, especially about situations in which it can be better used as well as fine-tuning dose and administration.
Descritores: Glutamina/metabolismo
Glutamina/uso terapêutico
NF-kappa B
-Adjuvantes Imunológicos
Fígado/metabolismo
Limites: Animais
Cobaias
Camundongos
Ratos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME



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