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Id: biblio-1171775
Autor: Camussone Cecilia M; Calvinho Luis F.
Título: Factores de virulencia de Staphylococcus aureus asociados con infecciones mamarias en bovinos: relevancia y rol como agentes inmunógenos / [Virulence factors of Staphylococcus aureus associated with intramammary infections in cows: relevance and role as immunogens].
Fonte: Rev. argent. microbiol;45(2):119-30, jun. 2013.
Idioma: es.
Resumo: Staphylococcus aureus is the most prevalent mastitis pathogen in Argentina and worldwide. Lack of effectiveness of traditional control measures based on milking hygiene and antibiotic therapy against this organism has led to the development of alternatives directed to prevent the disease. Among them, the manipulation of host immune mechanisms through vaccination has been explored. The identification of virulence factors able to stimulate host immune defenses is key to developing a rational vaccine. S. aureus has multiple virulence factors that interact with the host at different stages of an intramammary infection. The use of some of these factors as immunogens has been shown to elicit protective responses in the host. The structure, function, and use as immunogens of S. aureus virulence factors considered to be relevant at different stages of intrammamary infections caused by this organism are reviewed in this article.
Descritores: Fatores de Virulência/imunologia
Mastite Bovina/imunologia
Mastite Bovina/microbiologia
Staphylococcus aureus/patogenicidade
-Animais
Biofilmes
Bovinos
Coagulase/fisiologia
Esfingomielina Fosfodiesterase/fisiologia
Feminino
Fibronectinas/fisiologia
Proteínas Hemolisinas/fisiologia
Staphylococcus aureus/fisiologia
Toxinas Bacterianas
Tipo de Publ: Resumo em Inglês
Artigo de Revista
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Responsável: AR5.1 - Centro de Gestión del Conocimiento y las Comunicaciónes


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Id: biblio-950193
Autor: Kalkan, Ali Kemal; Cakmak, Huseyin Altug; Erturk, Mehmet; Kalkan, Kübra Erol; Uzun, Fatih; Tasbulak, Omer; Diker, Vesile Ornek; Aydin, Suleyman; Celik, Ahmet.
Título: Adropin and Irisin in Patients with Cardiac Cachexia / Adropina e Irisina em Pacientes com Caquexia Cardíaca
Fonte: Arq. bras. cardiol;111(1):39-47, July 2018. tab, graf.
Idioma: en.
Resumo: Abstract Background: Cardiac cachexia is an important predictive factor of the reduction in survival of patients with heart failure with reduced ejection fraction. Objectives: The aims of the present study were to evaluate adropin and irisin levels in cachectic and non-cachectic subjects and the relationships between the levels of these proteins and clinical and laboratory parameters in patients with HFrEF. Methods: The clinical records of patients who were admitted to the cardiology outpatient clinic for heart failure with reduced ejection fraction were screened. Cachectic patients were identified and assigned to the study group (n = 44, mean age, 65.4 ± 11.2 y; 61.4% men). Heart failure with reduced ejection fraction patients without weight loss were enrolled as the control group (n = 42, mean age, 61.0 ± 16.5 y; 64.3% men). The serum adropin and irisin levels of all patients were measured. A p-value < 0.05 was considered significant. Results: Serum adropin and irisin levels were significantly higher in the cachexia group than in the controls (Adropin (ng/L); 286.1 (231.3-404.0) vs 213.7 (203.1-251.3); p < 0.001, Irisin (µg/mL); 2.6 (2.2-4.4) vs 2.1 (1.8-2.4); p = 0.001). Serum adropin and irisin levels were positively correlated with brain natriuretic peptide (BNP) levels and New York Heart Association (NYHA) class and negatively correlated with body mass index (BMI) and serum albumin levels (all p values: < 0.001). In a multivariate analysis, adropin was the only independent predictor of cachexia in the heart failure with reduced ejection fraction patients (OR: 1.021; 95% CI: 1.004−1.038; p = 0.017). Conclusions: The results suggest that adropin and irisin may be novel markers of cardiac cachexia in heart failure with reduced ejection fraction patients. Adropin and irisin are related with the severity of heart failure.

Resumo Fundamento: A caquexia cardíaca é um importante preditor de redução de sobrevida em pacientes com insuficiência cardíaca com fração de ejeção reduzida (ICFER). O objetivo deste estudo foi avaliar os níveis de adropina e irisina em pacientes com ICFER caquéticos e não caquéticos, assim como a relação entre os níveis dessas proteínas e os parâmetros clínicos e laboratoriais nesses pacientes. Objetivos: Os objetivos do presente estudo foram avaliar os níveis de adropina e irisina em indivíduos caquéticos e não caquéticos e as relações entre os níveis dessas proteínas e os parâmetros clínicos e laboratoriais em pacientes com ICFEN. Métodos: Os prontuários de pacientes atendidos no ambulatório de cardiologia para ICFER foram triados. Aqueles com ICFER caquéticos foram identificados e constituíram o grupo de estudo (n = 44; idade média, 65,4 ± 11,2 anos; 61,4% de homens). Aqueles com ICFER e sem perda de peso foram arrolados como grupo controle (n = 42; idade média, 61,0 ± 16,5 anos; 64,3% de homens). Os níveis séricos de adropina e irisina de todos os pacientes foram medidos. Considerou-se significativo um p-valor < 0,05. Resultados: Os níveis séricos de adropina e irisina foram significativamente mais altos nos pacientes caquéticos do que nos controles [adropina (ng/l): 286,1 (231,3-404,0) vs 213,7 (203,1-251,3); p < 0,001; irisina (µg/ml): 2,6 (2,2-4,4) vs 2,1 (1,8-2,4); p = 0,001]. Os níveis séricos de adropina e irisina correlacionaram-se positivamente com os níveis de peptídeo natriurético cerebral (BNP) e a classe funcional da New York Heart Association (NYHA), e negativamente com o índice de massa corporal (IMC) e os níveis séricos de albumina (todos os p-valores: < 0,001). Na análise multivariada, a adropina foi o único preditor independente de caquexia nos pacientes com ICFER (OR: 1,021; IC 95%: 1,004−1,038; p = 0,017). Conclusões: Os resultados sugerem que a adropina e a irisina possam ser novos marcadores de caquexia cardíaca em pacientes com ICFER. Adropina e irisina estão relacionadas com a gravidade da insuficiência cardíaca.
Descritores: Peptídeos/sangue
Caquexia/sangue
Fibronectinas/sangue
Disfunção Ventricular Esquerda/sangue
Insuficiência Cardíaca/sangue
-Caquexia/etiologia
Proteínas Sanguíneas
Biomarcadores/sangue
Estudos de Casos e Controles
Disfunção Ventricular Esquerda/complicações
Peptídeos e Proteínas de Sinalização Intercelular
Insuficiência Cardíaca/complicações
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
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Id: biblio-1011425
Autor: Wei, Haiying; Lin, Lili; Zhang, Xiaomei; Feng, Zhuolei; Wang, Yeqing; You, Yan; Wang, Xiaodan; Hou, Yongsheng.
Título: Effect of cytoglobin overexpression on extracellular matrix component synthesis in human tenon fibroblasts
Fonte: Biol. Res;52:23, 2019. graf.
Idioma: en.
Projeto: The National Natural Science Foundation of China.
Resumo: BACKGROUND: Conjunctival filtering bleb scar formation is the main reason for the failure of glaucoma filtration surgery. Cytoglobin (Cygb) has been reported to play an important role in extracellular matrix (ECM) remodeling, fibrosis and tissue damage repairing. This study aimed to investigate the role of Cygb in anti-scarring during excessive conjunctival wound healing after glaucoma filtration surgery. METHODS: Cygb was overexpressed in human tenon fibroblasts (hTFs) by transfecting hTFs with lentiviral particles encoding pLenti6.2-FLAG-Cygb. Changes in the mRNA and protein levels of fibronectin, collagen I, collagen III, TGF-ß1, and HIF1α were determined by RT-PCR and western blotting respectively. RESULTS: After Cygb overexpression, hTFs displayed no significant changes in visual appearance and cell counts compared to controls. Whereas, Cygb overexpression significantly decreased the mRNA and protein expression levels of collagen I, collagen III and fibronectin compared with control (p < 0.01). There was also a statistically significant decrease in the mRNA and protein levels of TGF-ß1 and HIF-1α in hTFs with overexpressed Cygb compared with control group (p < 0.05). CONCLUSION: Our study provided evidence that overexpression of Cygb decreased the expression levels of fibronectin, collagen I, collagen III, TGF-ß1 and HIF-1α in hTFs. Therefore, therapies targeting Cygb expression in hTFs may pave a new way for clinicians to solve the problem of post-glaucoma surgery scarring.
Descritores: Matriz Extracelular/metabolismo
Cápsula de Tenon/metabolismo
Fibroblastos/metabolismo
Citoglobina/metabolismo
-RNA Mensageiro/análise
Colágeno/análise
Fibronectinas/análise
Fator A de Crescimento do Endotélio Vascular/metabolismo
Matriz Extracelular/efeitos dos fármacos
Citoglobina/farmacologia
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1096129
Autor: Shennan, Andrew H; Ridout, Alexandra; Ross, Georgia.
Título: El parto pretérmino: herramientas predictivas y preventivas en la práctica clinica / Preterm birth: predictive and preventive tools in clinical practice
Fonte: Salud(i)ciencia (Impresa) = Salud(i)ciencia (En linea);22(4):331-337, dic.-mar. 2017.
Idioma: es.
Resumo: Despite advances in both neonatal care and our understanding of the pathophysiology of the condition as a whole, preterm birth is a phenomenon that continues to have significant impact globally. It remains the leading cause of perinatal morbidity and mortality worldwide, and the prevalence is increasing. Not only does it carry significant social cost, preterm birth places huge economic burden on the healthcare system. It is increasingly recognised that preterm birth is a multifactorial syndrome, rather than a single condition and we have seen a number of exciting advances in predictive and preventative tools for clinical practice. The ability of quantitative fetal fibronectin to predict spontaneous preterm birth in both high and low risk women has been one of these recent promising developments. Exploration continues into the potential for quantitative fetal fibronectin to be used in synergy with transvaginal ultrasound measurement of cervical length to improve predictive accuracy. Developments focus on enabling clinicians to predict risk at the point of care. Research continues to explore cervical cerclage, progesterone and the Arabin pessary as prophylactic interventions for women at risk of preterm birth, with increasing evidence for their potential role. Latest exploration of reactive management for imminent preterm birth is altering our clinical approach and is likely to improve outcomes. This review article will discuss some of the recent developments we have seen in this exciting area

A pesar de los avances en la atención prenatal y en la comprensión de la fisiopatología del cuadro como un todo, el parto pretérmino es un fenómeno que continúa provocando un impacto significativo global. Continúa como la causa principal de morbilidad y mortalidad perinatal en todo el mundo y su prevalencia está en aumento. No solamente conlleva un costo social significativo, sino que el parto pretérmino produce una carga económica importante para el sistema de salud. Cada vez más, hay datos que indican que el parto pretérmino es un síndrome multifactorial, más que un cuadro único y nosotros documentamos un gran número de avances en las herramientas predictivas y preventivas en la práctica clínica. Uno de estos avances más recientes es la capacidad de la fibronectina fetal cuantitativa para predecir un parto pretérmino espontáneo, tanto en mujeres de alto riesgo como de bajo riesgo. La investigación continúa hacia el uso potencial de la fibronectina fetal cuantitativa en sinergia con la medición de la longitud cervical por ecografía transvaginal para mejorar la precisión predictiva. Los avances están dirigidos a que los clínicos puedan predecir el riesgo en el lugar de atención. Las investigaciones continúan con la evaluación del cerclaje cervical, la progesterona y el pesario de Arabin como intervenciones profilácticas para las mujeres en riesgo de parto pretérmino, con pruebas crecientes para su papel potencial. Las exploraciones ulteriores con terapia reactiva para el parto pretérmino inminente alteran nuestro enfoque clínico y probablemente mejoren los desenlaces clínicos. Esta revisión analizará algunos de los avances recientes observados en esta área apasionante
Descritores: Fibronectinas
Cerclagem Cervical
Medida do Comprimento Cervical
Trabalho de Parto Prematuro
Trabalho de Parto Prematuro/prevenção & controle
Limites: Humanos
Feminino
Gravidez
Tipo de Publ: Relatório Técnico
Responsável: AR392.1 - Biblioteca


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Queiroz, Lélia Maria Guedes
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Id: lil-536681
Autor: Carvalho, Marianne de Vasconcelos; Alves, Pollianna Muniz; Oliveira, Renata Souza de; Ramalho, Lucyana da Silva; Queiroz, Lélia Maria Guedes.
Título: Estudo imuno-histoquímico da tenascina-C e fibronectina em lesões proliferativas não-neoplásicas de mucosa oral / Immunohistochemistry study of tenascin-C and fibronectin in noneoplasic proliferative lesions of oral mucosa
Fonte: Odontol. clín.-cient;8(4):353-357, out.-dez.2009. tab, ilus.
Idioma: pt.
Resumo: As lesões proliferativas não-neoplásicas correspondem a respostas teciduais decorrentes de estímulos crônicos de longa duração. Dentro deste grupo enquadra-se o granuloma piogênico, lesão periférica de células gigantes, fibroma ossificante periférico e hiperplasia fibrosa. O objetivo da pesquisa foi observar através da técnica da imuno-histoquímica, se existem diferenças na intensidade, padrão, continuidade e localização da expressão das proteínas da matriz extracelular representadas pela tenascina-C e fibronectina, com a finalidade de contribuir para o melhor entendimento dessas lesões. Utilizou-se 05 casos de cada entidade patológica supracitada, além de 05 espécimes de mucosa oral normal com finalidade comparativa. Observou-se a expressão da tenascina-C e fibronectina na interface epitélio-conjuntivo, bem como na proximidade de vasos sanguíneos nas hiperplasias fibrosas inflamatórias, lesão periférica de células gigantes e fibromas ossificantes, evidenciando o seu envolvimento nos processos de remodelação tecidual. Nossos resultados demonstram que a tenascina-C e a fibronectina são componentes teciduais importantes no desenvolvimento dessas patologias.

The no neoplasic proliferative lesions correspond the tissue reactive originating of long duration chronic stimulus. In this group frame pyogenic granuloma, peripheral giant cell granuloma, peripheral fibroma ossifying and fibrous hyperplasia. The aim of the research was observe, using immunohistochemical technique, if to exist differences in intensity, pattern, continuity and localization of the expression of the proteins of the matrix extrecellar, represent by tenascin-C and fibronectin, with finality of contribute for a best knowledge these lesions. Evaluated 05 cases of each lesion, as well as 05 specimen of normal oral mucosa with comparative finality. It was observed expression in interface conjunctive-epithelium, as well as in the proximity of blood vesseis in the fibrous hyperplasia, peripheral giant cell lesion and ossifying fibroma, evidencing your involvement in the process of improvement of the tissues. Our results demonstrate that those proteins can participate in the development these pathologies, fortifying as soon, your involvement in the process of improvement of the tissues.
Descritores: Imuno-Histoquímica
Fibronectinas
Tenascina
Tipo de Publ: Relatos de Casos
Responsável: BR310.1 - Biblioteca Professor Guilherme Simões Gomes


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Texto completo SciELO Brasil
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Id: lil-782150
Autor: Halpern, Bruno.
Título: Elevated irisin and alanine aminotransferase levels in hypothyroidism: role of oxidative stress?
Fonte: Arch. endocrinol. metab. (Online);60(2):89-91, Apr. 2016.
Idioma: en.
Descritores: Fibronectinas/sangue
Estresse Oxidativo/fisiologia
Alanina Transaminase/sangue
Hipotireoidismo/metabolismo
-Tireotropina/sangue
Fígado Gorduroso/metabolismo
Hipotireoidismo/sangue
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: lil-782155
Autor: Ateş, İhsan; Altay, Mustafa; Topçuoğlu, Canan; Yılmaz, Fatma Meriç.
Título: Circulating levels of irisin is elevated in hypothyroidism, a case-control study
Fonte: Arch. endocrinol. metab. (Online);60(2):95-100, Apr. 2016. tab, graf.
Idioma: en.
Resumo: Objective Our objective in this study was to determine the relationship between irisin hormone, which has a similar effect with thyroid hormones on adipose tissue and the metabolism, and the thyroid functions and the obesity secondary to thyroid disease. Subjects and methods Seventy-four patients were included in the study, of the patients, 37 were newly diagnosed with Hashimoto’s thyroiditis related hypothyroidism but not started on a treatment yet, and the remaining 37 were healthy volunteers without a known disease. Serum thyroid stimulating hormone (TSH), free thyroxin (fT4), anti-thyroglobulin and anti-thyroid peroxidase were measured and thyroid ultrasonography was performed in both groups. Serum irisin levels were measured using the commercially available ELISA kit. The hypothyroidism group had higher levels of irisin compared to the control group (2.77 ng/mL vs. 2.15 ng/mL respectively; p = 0.017). Results The hypothyroidism group had higher median levels of irisin in the obese patients than those in the control group (3.10 ng/mL vs. 2.10 ng/mL respectively; p = 0.013). Irisin level was negatively correlated with age in the whole population and patients with hypothyroidism (r = -0.255, p = 0.028; r = -0.346, p = 0.036 respectively). Irisin level was positively correlated with TSH (r = 0.247, p = 0.034) but negatively correlated with the fT4 (r = -0.316, p = 0.006) in the whole population. Obesity, fT4 and irisin levels were identified to be independent predictors in the diagnosis of hypothyroidism in the multivariable logistic regression analysis. Conclusion To the best of our knowledge, this study is the first in literature to identify that obesity, irisin level and fT4 level are independent risk factors for hypothyroidism.
Descritores: Fibronectinas/sangue
Doença de Hashimoto/fisiopatologia
Doença de Hashimoto/sangue
Hipotireoidismo/fisiopatologia
Hipotireoidismo/sangue
Obesidade/fisiopatologia
-Autoanticorpos/sangue
Glândula Tireoide/fisiopatologia
Pressão Sanguínea/fisiologia
Ensaio de Imunoadsorção Enzimática
Estudos de Casos e Controles
Modelos Logísticos
Tecido Adiposo/metabolismo
Fatores de Risco
Doença de Hashimoto/complicações
Hipotireoidismo/complicações
Limites: Humanos
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-887578
Autor: Trombeta, Joice Cristina dos Santos; Prestes, Jonato; Nascimento, Dahan da Cunha; Tibana, Ramires Alsamir; Pereira, Guilherme Borges; Lima, Thiago da Rosa; Fraga, Géssica Alves; Vieira-Junior, Roberto Carlos; Voltarelli, Fabrício Azevedo.
Título: New insights into the effects of irisin levels in HIV-infected subjects: correlation with adiposity, fat-free mass, and strength parameters
Fonte: Arch. endocrinol. metab. (Online);61(4):382-390, July-Aug. 2017. tab, graf.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de Mato Grosso.
Resumo: ABSTRACT Objective Patients infected with the human immunodeficiency virus (HIV) have an increased risk of metabolic disorders and alterations on irisin levels. Therefore, the purpose of the current investigation was to quantify the circulating irisin concentration in HIV-infected subjects under highly active antiretroviral therapy and to determine possible correlations between irisin levels with fat mass, fat-free mass, body mass index (BMI), and muscle strength. Subjects and methods Cross-sectional study of 10 men (36.7 ± 11.3 years) and 10 women (42.5 ± 10.3 years) infected with HIV, recruited from the Specialized Service Center in the State Center of Reference for High and Medium Complexity. Blood samples were collected to determine plasma irisin levels, glucose, HDL, total cholesterol, triglycerides, and LDL. Body composition (fat mass, fat-free mass) and anthropometrics (body mass index; BMI) were measured by bioelectrical impedance. Muscle strength was assessed using a mechanic hand dynamometer and one maximum repetition tests. Results Irisin levels correlated positively with fat mass (r = 0.67; p = 0.001) and BMI (r = 0.48; p = 0.036). In contrast, there was an inverse correlation between irisin levels and fat-free mass (r = -0.41; p = 0.008) and five strength parameters: right hand grip (r = -0.46; p = 0.044); left hand grip (r = -0.50; p = 0.027), relative hand grip (r = -0.79; p = 0.001), bench press (r = -0.58; p = 0.009), leg press (r = -0.40; p = 0.085), and biceps curl (r = -0.059; p = 0.009). Conclusion Irisin levels correlated positively with body fat and negatively with fat-free mass and strength parameters in HIV-infected patients. Female patients infected with HIV receiving highly active antiretroviral therapy have higher levels of irisin compared with men in a similar circumstance.
Descritores: Infecções por HIV/sangue
Tecido Adiposo/efeitos dos fármacos
Tecido Adiposo/patologia
Fibronectinas/sangue
-Composição Corporal/efeitos dos fármacos
Infecções por HIV/metabolismo
Infecções por HIV/tratamento farmacológico
Fatores Sexuais
Estudos Transversais
Fibronectinas/metabolismo
Fibronectinas/farmacologia
Força da Mão
Terapia Antirretroviral de Alta Atividade
Antirretrovirais/uso terapêutico
Força Muscular/efeitos dos fármacos
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-887604
Autor: Bonfante, Ivan Luiz Padilha; Chacon-Mikahil, Mara Patricia Traina; Brunelli, Diego Trevisan; Gáspari, Arthur Fernandes; Duft, Renata Garbellini; Oliveira, Alexandre Gabarra; Araujo, Tiago Gomes; Saad, Mario Jose Abdalla; Cavaglieri, Cláudia Regina.
Título: Obese with higher FNDC5/Irisin levels have a better metabolic profile, lower lipopolysaccharide levels and type 2 diabetes risk
Fonte: Arch. endocrinol. metab. (Online);61(6):524-533, Dec. 2017. tab, graf.
Idioma: en.
Projeto: Foundation of São Paulo Research (FAPESP).
Resumo: ABSTRACT Objective: Thus, the aim of this study was to compare if higher or smaller fibronectin type 3 domain-containing protein 5 (FNDC5)/irisin levels are associated with inflammatory and metabolic markers, caloric/macronutrient intake, physical fitness and type 2 diabetes mellitus (T2DM) risk in obese middle-aged men, and also to correlate all variables analyzed with FNDC5/irisin. Subjects and methods: On the basis of a cluster study, middle-aged obese men (IMC: 31.01 ± 1.64 kg/m2) were divided into groups of higher and smaller levels of FNDC5/irisin. The levels of leptin, resistin, adiponectin, tumor necrosis factor alpha (TNFα), interleukin 6 and 10 (IL6, IL10), lipopolysaccharide (LPS), glucose, insulin, glycated hemoglobin, insulin resistance and sensibility, lipid profile, risk of T2DM development, body composition, rest energy expenditure, caloric/macronutrient intake and physical fitness were measured. Results: The higher FNDC5/ irisin group presented improved insulin sensibility (homeostasis model assessment - sensibility (HOMA-S) (p = 0.01) and QUICKI index (p < 0.01)), insulin (p = 0.02) and triglyceride levels (p = 0.01), lower insulin resistance (homeostasis model assessment - insulin resistance (HOMA-IR) (p = 0.01), triglycerides/glucose (TYG index) (p = 0.02), neck circumference (p = 0.02), risk of T2DM development (p = 0.02), tendency to decrease serum resistin (p = 0.08) and significant lower LPS levels (p = 0.02). Inverse correlations between FNDC5/irisin and body weight (r −0.46, p = 0.04), neck circumference (r −0.51, p = 0.02), free fat mass (r −0.49, p = 0.02), triglycerides (r −0.43, p = 0.05) and risk of developing T2DM (r −0.61, p = 0.04) were observed. Conclusions: These results suggest that higher FNDC5/irisin levels in obese middle-aged men are related to a better metabolic profile and lower risk of T2DM development and serum LPS, a potential inducer of insulin resistance.
Descritores: Lipopolissacarídeos/sangue
Fibronectinas/sangue
Diabetes Mellitus Tipo 2/etiologia
Obesidade/complicações
-Pressão Sanguínea/fisiologia
Ingestão de Energia/fisiologia
Biomarcadores/sangue
Estudos Transversais
Fatores de Risco
Diabetes Mellitus Tipo 2/fisiopatologia
Diabetes Mellitus Tipo 2/sangue
Teste de Esforço
Aptidão Cardiorrespiratória/fisiologia
Obesidade/fisiopatologia
Obesidade/sangue
Limites: Humanos
Masculino
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-887612
Autor: Tabak, Omur; Simsek, Gonul; Erdenen, Fusun; Sozer, Volkan; Hasoglu, Tuna; Gelisgen, Remise; Altunoglu, Esma; Muderrisoglu, Cuneyt; Senyigit, Abdulhalim; Uzun, Hafize.
Título: The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome
Fonte: Arch. endocrinol. metab. (Online);61(6):515-523, Dec. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective We wanted to investigate whether there is a relationship between circulating irisin, retinol binding protein-4 (RBP-4), adiponectin and proinflammatory mediators implicated in the development of insulin resistance (IR) in metabolic syndrome (MetS). Subjects and methods In 180 individuals, including controls and patients with MetS, we measured fasting plasma insulin, high sensitivity C-reactive protein (hsCRP), pentraxin-3 (PTX-3), interleukin-33 (IL-33), irisin, RBP-4, and adiponectin using ELISA kits. Results While fasting plasma hsCRP, PTX-3, IL-33, irisin, RBP-4 concentrations were higher, adiponectin levels were lower in patients with MetS than in controls. A correlation analysis revealed that plasma irisin levels were positively associated with MetS components such as waist circumference and waist-hip ratio, low density lipoprotein (LDL) and markers of systemic inflammation such as PTX-3, hsCRP, uric acid, and RBP-4. Adiponectin levels were negatively associated with waist circumference, waist-hip ratio, PTX-3 and LDL. Conclusions Although the precise mechanisms are still unclear, irisin, RBP-4, adiponectin and PTX-3 are hallmarks of the MetS, which is related to low-grade inflammation. It is conceivable that irisin and adiponectin might contribute to the development of MetS and may also represent novel MetS components. Future clinical studies are needed to confirm and extend these data.
Descritores: Fibronectinas/sangue
Mediadores da Inflamação/sangue
Síndrome Metabólica/sangue
Adiponectina/sangue
Proteínas Plasmáticas de Ligação ao Retinol/análise
-Ensaio de Imunoadsorção Enzimática
Biomarcadores/sangue
Estudos de Casos e Controles
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: BR1.1 - BIREME



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