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Pesquisa : D12.776.395.550.200.700.300 [Categoria DeCS]
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Id: lil-757369
Autor: Delibasi, Tuncay; Karbek, Basak; Bozkurt, Nujen Colak; Cakir, Evrim; Gungunes, Askin; Ünsal, Ölknur Öztürk; Aslan, Muyesser Sayki; Cakal, Erman.
Título: Circulating E-selectin levels and insulin resistance are associated with early stages of atherosclerosis in nonfunctional adrenal incidentaloma
Fonte: Arch. endocrinol. metab. (Online);59(4):310-317, Aug. 2015. tab, ilus.
Idioma: en.
Resumo: Objective To evaluate circulating E-selectin levels in patients with nonfunctional adrenal incidentaloma (NFA) in relation to insulin resistance and early atherosclerosis.Subjects and methods A total of 40 patients with NFA (mean [SD] age: 55.6 [10.7] years; 70% were females) and 35 controls (mean [SD] age: 51.5 [8.1] years; 71.4% were females) selected from age-, gender- and body mass index (BMI)- matched healthy subjects were enrolled. Serum hsCRP, lipid profile, insulin levels and the homeostasis model assessment of insulin resistance (HOMA-IR) were evaluated. High-resolution B-mode ultrasonography was performed. Serum levels of E-selectin were evaluated by enzyme-linked immunosorbent assay.Results Patients with NFA had significantly higher values for E-selectin (14.9 (4.8) vs. 12.2 (4.1) ng/mL, p < 0.01) and CIMT (0.6 (0.1) vs. 0.5 (0.1) mm, p < 0.05) than controls. Serum E-selectin levels showed a statistically significant association with hsCRP (r = 0.751, p < 0.001), HOMA-IR (r = 0.575, p < 0.001) and CIMT (r = 0.762, p < 0.001). CIMT (Carotid intima media thickness) was increased in patients with NFA patients with NFA were more insulin resistant than controls and statistically significant relationship was found between size of tumor and HOMA-IR (r = 0.361, p < 0.001).Conclusion In conclusion, based on significantly higher values for E-selectin, CIMT and HOMA-IR in patients with NFA than controls along with significant correlation of E-selectin levels to CIMT, HOMA-IR and hs-CRP, our findings seems to indicate an increased risk of early atherosclerosis and impaired endothelial function in NFA patients, particularly in case of insulin resistance.
Descritores: Resistência à Insulina
Neoplasias das Glândulas Suprarrenais/sangue
Selectina E/sangue
Aterosclerose/sangue
Espessura Intima-Media Carotídea
-Proteína C-Reativa/análise
Ensaio de Imunoadsorção Enzimática
Biomarcadores/sangue
Estudos de Casos e Controles
Neoplasias das Glândulas Suprarrenais/complicações
Diagnóstico Precoce
Aterosclerose/etiologia
Aterosclerose/patologia
Homeostase
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-827784
Autor: Almeida-Pititto, Bianca de; Ribeiro-Filho, Fernando Flexa; Barreto, Sandhi; Duncan, Bruce B; Schmidt, Maria Inês; Lotufo, Paulo A; Bensenor, Isabela M; Ferreira, Sandra R G.
Título: Circulating early biomarkers of atherogenesis in participants of the Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease
Fonte: Arch. endocrinol. metab. (Online);60(6):573-581, Nov.-Dec. 2016. tab, graf.
Idioma: en.
Projeto: National Research Council; . National Research Council; . National Research Council; . National Research Council; . National Research Council; . National Research Council.
Resumo: ABSTRACT Objective Our aim was to describe the distribution of selected biomarkers according to age and sex, adjusted for HOMA-IR and adiposity, in a subset of middle-aged individuals of Brazilian Longitudinal Study of Adult Health-ELSA without diabetes mellitus or CVD. Subjects and methods This cross-sectional study was conducted in 998 participants of the ELSA-Brasil without diabetes and/or cardiovascular disease. In addition to the traditional risk factors, several biomarkers concentrations were compared according to sex, age groups (35-44; 45-54 yrs) and HOMA-IR tertiles. Linear regression was used to examine independent associations of sex and age with selected novel biomarkers, adjusted for body adiposity and HOMA-IR. Results Fifty-five percent were women. Men had higher mean values of body mass index, waist circumference, blood pressure, plasma glucose, HOMA-IR, worse lipid profile and higher E-selectin and lower leptin concentrations than women; while women had higher levels of HDL-cholesterol and leptin than men. Mean values of waist circumference, systolic BP, plasma glucose and apolipoprotein B (Apo B) increased with age in both sexes. Leptin and E-selectin concentrations increased across HOMA-IR tertiles. Independent associations of Apo B with age were found only in male sex, while of leptin with body mass index and HOMA-IR, and of E-selectin with HOMA-IR in both sexes. Conclusions In conclusion, our data indicate age, sex, adiposity and, consequently, insulin resistance, influence circulating levels of Apo B, leptin and E-selectin, suggesting that those aspects should be taken into consideration when assessing these parameters for research or clinical purposes in individuals at relatively low cardiometabolic risk.
Descritores: Aterosclerose/sangue
Adiposidade
-Apolipoproteínas B/sangue
Brasil
Resistência à Insulina
Biomarcadores/sangue
Fatores Sexuais
Estudos Transversais
Fatores Etários
Selectina E/sangue
Leptina/sangue
Circunferência da Cintura
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-633003
Autor: Navarro-Hernández, Rosa Elena; Vázquez-Del Mercado, Mónica; Oregón-Romero, Edith; Muñoz-Valle, José Francisco.
Título: Polimorfismos de nucleótido simple en moléculas de adhesión y parámetros clínicos en artritis reumatoide / Single nucleotid polymorphisms of adhesion molecules and clinical parameters in rheumatoid arthritis
Fonte: Acta bioquím. clín. latinoam;41(2):193-202, abr.-jun. 2007. ilus, graf, tab.
Idioma: es.
Resumo: Se investigó la relación entre los polimorfismos de E-selectina, la molécula de adhesión vascular-1 (VCAM1) y la molécula de adhesión intercelular-1 (ICAM1) con el perfil de lípidos y marcadores clínicos de inflamación en artritis reumatoide (AR). Se incluyeron 60 pacientes con AR clasificados de acuerdo a los criterios del American College of Rheumatology (ACR, 1987) y 60 controles clínicamente sanos (CCS), no relacionados entre sí, definidos como población de mestizos mexicanos. Los genotipos se caracterizaron por la técnica de PCR-RFLP. La velocidad de sedimentación globular (VSG), factor reumatoideo (FR), concentración de fibrinógeno (FB), proteína C reactiva (PCR) y perfil de lípidos, se realizaron por métodos convencionales. El análisis estadístico se efectuó con SPSS v10.0. La VSG correlacionó con PCR, FR, FB y cHDL, (r=0,507; 0,296; 0,475 y -0,308, respectivamente); PCR con FB (r=0,613), p<0,05. El alelo 1238G se asoció con FR y Apo-B; y el alelo 721A, con cHDL y cLDL (p<0,05). Los datos muestran que los niveles de FB, cHDL, y los alelos 721A de ICAM1 y 1238G de VCAM1 se asocian con los marcadores clínicos de inflamación. Existen diferencias entre la distribución de los polimorfismos en este estudio y las reportadas para población oriental, caucásica y turca.

The genotypes were characterized using the polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) technique. The ESR (erythrocyte sedimentation rate), RF (rheumatoid factor), fibrinogen (FB), C-reactive protein (CRP) and lipid profile were measured by routine methods. Statistical analysis was performed using SPSS v10.0. The significant Pearson´s correlations were: ESR with CRP, RF, FB and HDLc, (r=0.507, 0.296, 0.475, and -0.308, respectively); CRP with FB (r=0.613), p<0.05. The results showed an association with A allele of ICAM1 polymorphism and serum levels of HDLc and LDLc; and Apo-B and FR showed an association with C allele of VCAM1 polymorphism (p<0.05). Data shows that FB and HDLc levels, and ICAM1 polymorphism allele 721A and VCAM1 polymorphism allele 1238G are associated with clinical inflammation markers in RA. Our Mexican-mestizo population showed differences with many reports (from English, American, Turkish, Japanese, Chinese, Italian, and Korean populations).
Descritores: Polimorfismo Genético/genética
Artrite Reumatoide/genética
Molécula 1 de Adesão Intercelular/genética
Molécula 1 de Adesão de Célula Vascular/genética
Selectina E/genética
Selectina E/sangue
-Valores de Referência
Fator Reumatoide/sangue
Fibrinogênio
Molécula 1 de Adesão Intercelular/sangue
Molécula 1 de Adesão de Célula Vascular/sangue
Selectina E/fisiologia
México
Limites: Humanos
Tipo de Publ: Relatos de Casos
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco


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Id: biblio-870801
Autor: Dourado, Letícia Barbosa Kawano.
Título: Ativação endotelial na granulomatose com poliangeíte (granulomatose de Wegener) / Endothelial activation in granulomatosis with polyangiits.
Fonte: São Paulo; s.n; 2015. [69] p. ilus, tab, graf.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Faculdade de Medicina para obtenção do grau de Doutor.
Resumo: INTRODUÇÃO: Eventos vasculares e imunológicos são centrais na patogênese da granulomatose com poliangeíte (GPA). Moléculas de adesão celular tem papel fundamental no recrutamento de células inflamatórias do sangue para os tecidos. Diferentes leitos vasculares apresentam particularidades na expressão de moléculas de adesão celular explicando talvez parte da especificidade da GPA por determinados órgãos. A elevação no nível sérico de moléculas de adesão celular e aumento da expressão destas em amostras de biópsia renal já foram demonstrados em pacientes com vasculite ANCA associada. No entanto, o fenômeno ainda não foi estudado in situ no pulmão. OBJETIVO: O objetivo deste estudo foi analisar o padrão de expressão endotelial pulmonar de três moléculas de adesão celular na GPA, in situ: molécula de adesão intercelular 1 (ICAM-1), molécula e adesão vascular 1 (VCAM-1) e E-selectina. MÉTODOS: Examinou-se a expressão endotelial de ICAM-1, VCAM-1, E-selectina usando marcação imuno-histoquímica em secções de pulmão fixadas e parafinadas de lesões de GPA (n = 8 casos, 90 secções transversais de vasos analisados). Foram também analisados controles positivos: amostras de pulmão de doença intersticial associada à esclerodermia (SScl) (n = 8 casos, 96 secções transversais de vasos analisados) e controles negativos (n = 9 casos, 90 secções transversais de vasos analisados). A quantificação imuno-histoquímica foi realizada no aumento de 400x usando a técnica de point-counting. RESULTADOS: ICAM-1: A expressão endotelial mediana de ICAM-1 esteve aumentada de forma semelhante na GPA e na SScl (81% and 73%, respectivamente; p = 0.97). A comparação com o grupo controle (26.3%) revelou diferença estatisticamente significativa entre controle e GPA (p <0.001) quanto entre controle e SScl (p = 0.017). VCAM-1: A expressão mediana de VCAM-1 esteve significativamente aumentada na GPA se comparada a SScl (79.5% vs 41.4%; p = 0.012), no entanto, a expressão endotelial de VCAM-1 nos...

INTRODUCTION: Vascular and immunologic processes are central to the pathogenesis of granulomatosis with polyangiitis (GPA). Endothelial cellular adhesion molecules have a central role in recruiting leukocytes to sites of inflammation. Moreover, different vascular beds are phenotypically and functionally distinct with regard to expression of cellular adhesion molecules. They have been shown to be elevated in sera and in renal biopsies of patients with active ANCA-associated vasculitis. Despite of that, the expression of cellular adhesion molecules has not been studied in situ in the lungs. OBJECTIVE: Within this context, the aim of this study was to analyze the in situ pulmonary endothelial immunohistochemical pattern of expression of three cellular adhesion molecules in GPA: intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and E-selectin . METHODS: For such, we examined formalin-fixed, paraffin-embedded sections of lung lesions of GPA (n = 8 cases, 90 transverse sections of pulmonary vessels), negative controls which were obtained from autopsies ( n = 9 cases, 90 transverse sections of pulmonary vessels analyzed) and positive controls which were cases of interstitial lung disease associated with systemic sclerosis (SScl) (n = 8 cases, 96 transverse sections of pulmonary vessels). The quantification of the immunohistochemical staining was performed at x400 magnification using the technique of point-counting, previously described. RESULTS: ICAM-1: Median endothelial expression of ICAM-1 was similarly enhanced in GPA and SScl (81% and 73%, respectively; p = 0.97). When compared to controls (26.3%), both GPA (p <0.001) and SScl (p = 0.017) had significantly higher endothelial expression of ICAM-1. VCAM-1: Median endothelial expression of VCAM-1 was significantly enhanced in GPA when compared to SScl (79.5% vs 41.4%; p = 0.012), however the endothelial expression of VCAM-1 in the controls was also moderately enhanced (49.8%)...
Descritores: Moléculas de Adesão Celular
Selectina E
Endotélio Vascular
Granulomatose com Poliangiite
Responsável: BR66.1 - Divisão de Biblioteca e Documentação
BR66.1


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Id: lil-764122
Autor: Çakar, Mustafa; Balta, Şevket; Şarlak, Hakan; Akhan, Muharrem; Demirkol, Sait; Karaman, Murat; Ay, Seyit Ahmet; Kurt, Ömer; Çayci, Tuncer; İnal, Satılmış; Demirbaş, Şeref.
Título: Arterial stiffness and endothelial inflammation in prediabetes and newly diagnosed diabetes patients
Fonte: Arch. endocrinol. metab. (Online);59(5):407-413, Oct. 2015. tab, graf.
Idioma: en.
Resumo: ObjectiveThere is a growing body of data supporting the association between diabetes and microcirculatory disfunction. We aimed to study e-selectin levels, and their associations with serum markers of inflammation and arterial stiffness in prediabetes and newly diagnosed diabetes patients in this study.Subjects and methodsSixty patients (25 females) with a newly established elevated fasting serum glucose [20 impaired fasting glucose (IFG), 20 impaired glucose tolerance (IGT), 20 newly diagnosed diabetes (T2DM)] and 17 healthy controls (13 females) were included in the study. Serum e-selectin and hs-CRP levels, and arterial stiffness parameters of the patients were studied.ResultsFasting serum glucose was the most important predictor of serum e-selectin levels. Pulse wave velocity and central aortic pressures were significantly higher in IFG, IGT and T2DM groups, compared to controls (p = 0.001, < 0.001, 0.013 and 0.015, 0.002, 0.009, respectively). The mean arterial pressure did not show any significant association with serum e-selectin and hs-CRP levels (β coefficient: 0.092, p = 0.358; and β coefficient: 0.189, p = 0.362, respectively).ConclusionPrediabetes patients have increasing e-selectin levels through the diagnosis of T2DM. E-selectin is associated with serum glucose levels. Prediabetic and newly diagnosed diabetics have higher arterial stiffness measurements. Serum e-selectin may be a good marker of endothelial inflammation and dysfunction increasing in parallel with serum glucose levels, predicting future cardiovascular events.
Descritores: Proteína C-Reativa/análise
/metabolismo
DIABETES MELLITUS, TYPE TEMEFOS/metabolismo
Selectina E/sangue
Endotélio Vascular/metabolismo
Estado Pré-Diabético/metabolismo
Rigidez Vascular/fisiologia
-Biomarcadores/sangue
Glicemia/análise
Estudos de Casos e Controles
/fisiopatologia
DIABETES MELLITUS, TYPE TEMEFOS/fisiopatologia
Endotélio Vascular/fisiopatologia
Jejum/sangue
Teste de Tolerância a Glucose
Microcirculação
Análise de Onda de Pulso
Estado Pré-Diabético/fisiopatologia
Fatores de Risco
Limites: Adulto
Idoso
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-750695
Autor: Castello-Simões, Viviane; Minatel, Vinicius; Karsten, Marlus; Simões, Rodrigo Polaquini; Perseguini, Natália Maria; Milan, Juliana Cristina; Arena, Ross; Neves, Laura Maria Tomazi; Borghi-Silva, Audrey; Catai, Aparecida Maria.
Título: Circulatory and Ventilatory Power: Characterization in Patients with Coronary Artery Disease / Potência Circulatória e Ventilatória: Caracterização em Pacientes com Doença Arterial Coronariana
Fonte: Arq. bras. cardiol;104(6):476-485, 06/2015. tab, graf.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); . Conselho Nacional de Desenvolvimento Científico e Tenológico (CNPq).
Resumo: Background: Circulatory power (CP) and ventilatory power (VP) are indices that have been used for the clinical evaluation of patients with heart failure; however, no study has evaluated these indices in patients with coronary artery disease (CAD) without heart failure. Objective: To characterize both indices in patients with CAD compared with healthy controls. Methods: Eighty-seven men [CAD group = 42 subjects and healthy control group (CG) = 45 subjects] aged 40–65 years were included. Cardiopulmonary exercise testing was performed on a treadmill and the following parameters were measured: 1) peak oxygen consumption (VO2), 2) peak heart rate (HR), 3) peak blood pressure (BP), 4) peak rate-pressure product (peak systolic HR x peak BP), 5) peak oxygen pulse (peak VO2/peak HR), 6) oxygen uptake efficiency (OUES), 7) carbon dioxide production efficiency (minute ventilation/carbon dioxide production slope), 8) CP (peak VO2 x peak systolic BP) and 9) VP (peak systolic BP/carbon dioxide production efficiency). Results: The CAD group had significantly lower values for peak VO2 (p < 0.001), peak HR (p < 0.001), peak systolic BP (p < 0.001), peak rate-pressure product (p < 0.001), peak oxygen pulse (p = 0.008), OUES (p < 0.001), CP (p < 0.001), and VP (p < 0.001) and significantly higher values for peak diastolic BP (p = 0.004) and carbon dioxide production efficiency (p < 0.001) compared with CG. Stepwise regression analysis showed that CP was influenced by group (R2 = 0.44, p < 0.001) and VP was influenced by both group and number of vessels with stenosis after treatment (interaction effects: R2 = 0.46, p < 0.001). Conclusion: The indices CP and VP were lower in men with CAD than healthy controls. .

Fundamento: Os índices da Potência Circulatória (PC) e Potência Ventilatória (PV) têm sido utilizados para avaliação clínica de pacientes com insuficiência cardíaca, mas nenhum estudo avaliou esses índices em pacientes com Doença Arterial Coronariana (DAC). Objetivo: Caracterizar ambos os índices em pacientes com DAC comparados a indivíduos saudáveis. Métodos: Oitenta e sete homens [grupo DAC = 42 sujeitos e, grupo controle (GC) = 45 sujeitos] com idade entre 45 e 65 anos foram incluídos. Um Teste de Exercício Cardiopulmonar (TECP) foi realizado em esteira e as seguintes variáveis foram obtidas: 1) consumo de oxigênio (VO2) pico; 2) Frequência Cardíaca (FC) pico; 3) Pressão Arterial (PA) pico; 4) duplo produto pico (PA sistólica pico x FC pico); 5) pulso de oxigênio pico (VO2 pico dividido pela FC pico); 6) eficiência ventilatória para o consumo de oxigênio (OUES); 7) eficiência ventilatória para a produção de dióxido de carbono (VE/VCO2 slope); 8) PC (VO2 pico x PA sistólica pico); e 9) PV (PA sistólica pico dividido pelo VE/VCO2 slope). Resultados: O grupo DAC apresentou valores significativamente menores das seguintes variáveis no pico do exercício: VO2 (p < 0,001), FC (p < 0,001), PA sistólica (p < 0,001), duplo produto (p < 0,001), pulso de oxigênio (p = 0,008), OUES (p < 0,001), PC (p < 0,001) e PV (p < 0,001), e valores significativamente maiores de PA diastólica (p = 0,004) e VE/VCO2 slope (p < 0,001) em relação ao GC. Uma análise de regressão pelo método stepwise mostrou que a PC foi influenciada pelo grupo (R2 = 0,44, p < 0,001) e a PV tanto pelo grupo quanto pelo número de vasos com estenose pós tratamento (efeito de interação: R2 = 0,46, p < 0,001). Conclusion: Os índices da PC e PV foram menores em homens com DAC comparados ao GC, podendo dessa forma ser utilizados na caracterização dessa população. .
Descritores: Óxido de Alumínio/toxicidade
Moléculas de Adesão Celular/metabolismo
Adesão Celular/efeitos dos fármacos
Endotélio Vascular/efeitos dos fármacos
Nanopartículas Metálicas/toxicidade
-Células Cultivadas
Moléculas de Adesão Celular/genética
Relação Dose-Resposta a Droga
Selectina E/genética
Selectina E/metabolismo
Endotélio Vascular/metabolismo
Endotélio Vascular/ultraestrutura
Expressão Gênica/efeitos dos fármacos
Molécula 1 de Adesão Intercelular/genética
Molécula 1 de Adesão Intercelular/metabolismo
Microscopia Eletrônica de Transmissão/métodos
Monócitos/efeitos dos fármacos
Monócitos/metabolismo
Monócitos/ultraestrutura
Tamanho da Partícula
RNA Mensageiro/metabolismo
Suínos
Molécula 1 de Adesão de Célula Vascular/genética
Molécula 1 de Adesão de Célula Vascular/metabolismo
Limites: Animais
Humanos
Tipo de Publ: Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-723896
Autor: Du, T.; Tan, Z..
Título: Relationship between deep venous thrombosis and inflammatory cytokines in postoperative patients with malignant abdominal tumors
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;47(11):1003-1007, 11/2014. tab.
Idioma: en.
Resumo: Deep venous thrombosis (DVT) is a common surgical complication in cancer patients and evidence that inflammation plays a role in the occurrence of DVT is increasing. We studied a population of cancer patients with abdominal malignancies with the aim of investigating whether the levels of circulating inflammatory cytokines were associated with postoperative DVT, and to determine the levels in DVT diagnoses. The serum levels of C-reactive protein (CRP), interleukins (IL)-6 and IL-10, nuclear transcription factor-κB (NF-κB) and E-selectin (E-Sel) were determined in 120 individuals, who were divided into 3 groups: healthy controls, patients with and patients without DVT after surgery for an abdominal malignancy. Data were analyzed by ANOVA, Dunnet's T3 test, chi-square test, and univariate and multivariate logistic regression as needed. The CRP, IL-6, NF-κB, and E-Sel levels in patients with DVT were significantly higher than those in the other groups (P<0.05). The IL-10 level was higher in patients with DVT than in controls but lower than in patients without DVT. Univariate analysis revealed that CRP, IL-6, NF-κB, and E-Sel were statistically associated with the risk of DVT (OR=1.98, P=0.002; OR=1.17, P=0.000; OR=1.03, P=0.042; and OR=1.38, P=0.003; respectively), whereas IL-10 had a protective effect (OR=0.94, P=0.011). Multivariate analysis showed that E-Sel was an independent risk factor (OR=1.41, P=0.000). Thus, this study indicated that an increased serum level of E-Sel was associated with increased DVT risk in postoperative patients with abdominal malignancy, indicating that E-Sel may be a useful predictor of diagnosis of DVT.
Descritores: Neoplasias Abdominais/cirurgia
Mediadores da Inflamação/metabolismo
Trombose Venosa/etiologia
-Neoplasias Abdominais/sangue
Proteína C-Reativa/análise
Estudos de Casos e Controles
Citocinas/sangue
Selectina E/sangue
/sangue
INTERLEUKIN-ABDOMEN, ACUTE/sangue
/sangue
INTERLEUKIN-ABDUCENS NERVE/sangue
NF-kappa B/sangue
Período Pós-Operatório
Medição de Risco
Fatores de Risco
Limites: Adulto
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-672513
Autor: Rassoul, F; Richter, V; Kistner, C; Wisser, D; Reichert, B.
Título: Soluble cell adhesion molecules and parameters of lipoprotein metabolism in patients with severe burns / Moléculas de adhesión celular soluble y parámetros del metabolismo de la lipoproteína en pacientes con quemaduras severas
Fonte: West Indian med. j;58(5):417-421, Nov. 2009. ilus, tab.
Idioma: en.
Resumo: BACKGROUND: The role of leukocyte adhesion molecules in patients with burns and their relationship to other parameters of inflammation and lipid metabolism is only recently beginning to be explored. Therefore, we investigated the temporal changes in the levels of soluble cell adhesion molecules and other parameters of inflammation and lipoprotein metabolism in patients with thermal injury. MATERIALS AND METHODS: The serum levels of soluble adhesion molecules, intercellular cell adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), and sE-selectin, C-reactive protein (CRP) and fibrinogen in seven patients with severe burns over a 30- day period were measured to determine the involvement of these factors in the pathophysiology of severe burns. Serum levels of sICAM-1, sVCAM-1 and sE-selectin were determined by ELISA. Furthermore, total cholesterol, high-density lipoprotein cholesterol (HDL chol), low-density lipoprotein cholesterol (LDL chol) and triglycerides (TG) were measured. RESULTS: Blood levels of sICAM-1, sVCAM-1, CRP and fibrinogen increased with maximum values six days after thermal injury. In contrast, serum levels of sE-selectin were elevated two days after thermal injury. The sICAM-1, sVCAM-1 and sE-selectin levels correlated significantly with both the CRP and the fibrinogen levels. Plasma total cholesterol, HDL cholesterol and LDL cholesterol decreased with minimum values four days after thermal injury. Furthermore, an increase of triglyceride levels was observed. CONCLUSION: The observed inflammatory response of soluble cell adhesion molecules could be useful in monitoring endothelial activation immediately following thermal injury. Further studies involving a larger number of patients with burns should help to clarify the extent to which measured parameters, especially the temporal changes of sCAMs, could be relevant in assessing the morbidity of patients with thermal injury.

ANTECEDENTES: El papel de las moléculas de adhesión leucocitaria en pacientes con quemaduras y su relación con otros parámetros de inflamación y metabolismo de lípidos ha comenzado a ser explorados sólo recientemente. Por lo tanto, investigamos los cambios temporales en los niveles de las moléculas de adhesión celular solubles y otros parámetros de inflamación y metabolismo de las lipoproteínas en pacientes con daños térmicos. MATERIALES Y MÉTODOS: Los niveles de suero de las moléculas de adhesión solubles, las moléculas 1 de adhesión intracelular (sICAM-1), las moléculas 1 de adhesión celular vascular (sVCAM-1) y sE-selectina, la proteína reactiva C (CRP), y el fibrinógeno en siete pacientes con quemaduras severas en un período de 30 días, fueron medidas a fin de determinar la participación de estos factores en la patofisiología de las quemaduras severas. Los niveles séricos de sICAM-1, sVCAM-1 y sE-selectina fueron determinados mediante ELISA. Además, se midieron el colesterol total, el colesterol de lipoproteína de alta densidad (HDL col), el colesterol de lipoproteína de baja densidad (LDL col), y los triglicéridos. RESULTADOS: Los niveles de sangre de sICAM-1, sVCAM-1, CRP y fibrinógeno aumentaron a valores máximos, seis días después del daño térmico. Los niveles de sICAM-1, sVCAM-1 y sE-selectina tuvieron una correlación significativa tanto con la CRP como con los niveles de fibrinógeno. El colesterol total de plasma, el colesterol HDL y el colesterol LDL disminuyeron a valores mínimos cuatro días después del daño térmico. Además, se observó un aumento en los niveles de triglicéridos. CONCLUSIÓN: La respuesta inflamatoria observada de las moléculas de adhesión celular soluble puede ser útil para monitorear la activación endotelial inmediatamente luego del daño térmico. Estudios ulteriores que comprendan un gran número de pacientes con quemaduras deben ayudar a aclarar hasta que punto los parámetros medidos, especialmente los cambios temporales de sCAMs, pudieran ser relevantes a la hora de evaluar la morbilidad de los pacientes con heridas térmicas.
Descritores: Queimaduras/sangue
Moléculas de Adesão Celular/sangue
Inflamação/sangue
Lipoproteínas/sangue
-Biomarcadores/sangue
Proteína C-Reativa/análise
HDL-Colesterol/sangue
LDL-Colesterol/sangue
Selectina E/sangue
Fibrinogênio/análise
Molécula 1 de Adesão Intercelular/sangue
Projetos Piloto
Triglicerídeos/sangue
Molécula 1 de Adesão de Célula Vascular/sangue
Limites: Adolescente
Adulto
Idoso
Feminino
Humanos
Masculino
Adulto Jovem
Responsável: BR1.1 - BIREME


  9 / 16 LILACS  
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Id: lil-666013
Autor: International Braz J Urol; Fan, Lian-hui; He, Long; Cao, Zhi-qiang; Xiang, Jun; Liu, Long.
Título: Effect of ischemia preconditioning on renal ischemia/reperfusion injury in rats
Fonte: Int. braz. j. urol;38(6):842-854, Nov-Dec/2012. tab, graf.
Idioma: en.
Resumo: Objective

To study the effect of ischemia preconditioning (IP) on renal ischemia/reperfusion (I/R)-associated functional injury and expression of renal adhesion molecules in rats. Materials and Methods

The ischemia preconditioning plan adopted in this experiment involved renal warm ischemia for 6 min. and blood flow for 4 min., repeated four times. The Wistar rat kidneys used for warm ischemia preconditioning were subjected to 60 min of renal warm ischemia followed by reperfusion. The rat kidneys with ischemia/reperfusion were compared with the ischemia preconditioning group to observe rat renal function and changes in the expression of renal adhesion molecules ICAM-1, P--Selectin, and E-Selectin. Results

The expression of rat renal adhesion molecules (ICAM-1, P-Selectin, and E-Selectin) with ischemia preconditioning was significantly lower than that of the ischemia/reperfusion group. Serum creatinine was significantly lower than that in the ischemia/reperfusion group after 48 hours. Conclusions

Ischemia preconditioning has a protective effect on renal function. Reduced expression of renal adhesion molecules is likely a mechanism involved in the observed protection. .

Descritores: Precondicionamento Isquêmico/métodos
Rim/irrigação sanguínea
Traumatismo por Reperfusão/prevenção & controle
-Moléculas de Adesão Celular/análise
Creatinina/sangue
Modelos Animais de Doenças
Selectina E/análise
Imuno-Histoquímica
Rim/patologia
Selectina-P/análise
Ratos Wistar
Traumatismo por Reperfusão/patologia
Fatores de Tempo
Limites: Animais
Feminino
Masculino
Ratos
Responsável: BR1.1 - BIREME


  10 / 16 LILACS  
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Autor: Velarde, María S.; Carrizo, Teresita del R.; Prado, María M.; Díaz, Elba I.; Fonio, María C.; Bazán, María C.; Abregú, Adela V..
Título: Marcadores de inflamación y disfunción endotelial en niños con diabetes tipo 1 / Inflammation markers and endothelial disfunction in children with type 1 diabetes
Fonte: Medicina (B.Aires);70(1):44-48, feb. 2010. ilus, tab.
Idioma: es.
Resumo: Se ha hallado un estado inflamatorio subclínico ha sido informado en la fase temprana de la diabetes, el cual incrementa los niveles séricos de citoquinas que inducen la síntesis de proteínas de fase aguda como la proteína C reactiva (PCR) y el fibrinógeno (Fg), y estimula la expresión endotelial de moléculas de adhesión. Se estudiaron 30 pacientes (15 varones y 15 mujeres) con diabetes tipo 1 (DT1), de 11.8 ± 2.1 años de edad y 3.9 ± 3.2 años de evolución de la enfermedad, sin complicaciones vasculares. Se realizó recuento de leucocitos, velocidad de sedimentación globular (VSG), glucemia en ayunas, hemoglobina glicosilada (HbA1c), Fg, PCR ultrasensible (uPCR), determinación E-selectina soluble (sE-S), molécula de adhesión vascular celular 1 (VCAM-1) y microalbuminuria. Se encontraron niveles aumentados de uPCR, sE-S y VCAM-1 en los pacientes diabéticos comparados con el grupo control [0.60 (0.30-1.25) vs. 0.20 (0.20-0.65) mg/l, p = 0.013], [108 (60-150) vs. 68 (56-82) ng/ml, p = 0.0031] y [750 (708-826) vs. 721 (674-751) ng/ml, p = 0.039] respectivamente. Al agrupar a los diabéticos de acuerdo a la duración de la enfermedad (= 3 y > de 3 años), los valores de uPCR fueron mayores en el segundo grupo. La uPCR se correlacionó con sE-S (r = 0.44, p = 0.03) y con VCAM-1 (r = 0.49, p = 0.02). Estos resultados sugieren la presencia de un estado proinflamatorio y de activación endotelial estrechamente asociados en la DT1.

A subclinical inflammation state was detected in the early step of diabetes, which increases the serum levels of cytokines that induce acute-phase protein synthesis as C-reactive protein (PCR) and fibrinogen (Fg), stimulating the endothelial disfunction of adhesion molecules. Thirty patients (15 boys, 15 girls) with type 1 diabetes (DT1), without vascular complications, were studied. Their mean age and duration of diabetes were 11.8 ± 2.1 and 3.9 ± 3.2 years, respectively. The laboratory parameters evaluated were: blood leukocytes count, globular sedimentation velocity, fasting glycemia, glycosylated hemoglobin (HbA1c), high sensitivity PCR (uPCR), plasma soluble E-selectin (sE-S), sVCAM-1 and microalbuminuria. Increased levels of uPCR, sE-S and VCAM-1 were found, compared with the control group control [0.60 (0.30-1.25) vs. 0.20 (0.20-0.65) mg/l, p = 0.013], [108 (60- 150) vs. 68 (56-82) ng/ml, p = 0.0031] y [750 (708-826) vs. 721 (674-751) ng/ml, p = 0.039] respectively. When diabetic patients were grouped according to duration of disease (= 3 and > de 3 years), uPCR values were higher in the second group. uPCR levels were better correlated with sE-S (r = 0.44, p = 0.03) and VCAM-1 (r = 0.49, p = 0.02). These results suggest the presence of pro-inflammatory and endothelial activation states, which are strongly associated with DT1.
Descritores: Biomarcadores/sangue
Doenças Cardiovasculares/sangue
Diabetes Mellitus Tipo 1/sangue
Angiopatias Diabéticas/sangue
Endotélio Vascular/fisiopatologia
Inflamação/fisiopatologia
-Aterosclerose/sangue
Aterosclerose/etiologia
Proteína C-Reativa/análise
Doenças Cardiovasculares/etiologia
Selectina E/sangue
Fibrinogênio/análise
Fibrinogênio/biossíntese
Hemoglobina A Glicada/análise
Molécula 1 de Adesão de Célula Vascular/sangue
Limites: Adolescente
Criança
Feminino
Humanos
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas



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