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Pesquisa : D12.776.395.550.469 [Categoria DeCS]
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Id: biblio-892897
Autor: Benli, Erdal; Ayyildiz, Sema Nur; Cirrik, Selma; Noyan, Tevfik; Ayyildiz, Ali; Cirakoglu, Abdullah.
Título: Early term effect of ureterorenoscopy (URS) on the Kidney: research measuring NGAL, KIM-1, FABP and CYS C levels in urine
Fonte: Int. braz. j. urol;43(5):887-895, Sept.-Oct. 2017. tab.
Idioma: en.
Projeto: Ordu University Scientific Research Projects Coordination Department.
Resumo: ABSTRACT Aim: URS is a very commonly used procedure for treatment of ureter stones. Increased hydrostatic pressure in the collecting system linked to fluids used during the procedure may cause harmful effects on the kidney. The aim of this study is to determine whether the URS procedure has a negative effect on the kidney by investigating NGAL, KIM-1, FABP and Cys C levels in urine. Material and Methods: This study included 30 patients undergoing ureterorenoscopy (URS) for ureter stones. Urine samples were collected 5 times; before the URS procedure (control) and at 1, 3, 5 and 12 hours following the procedure. NGAL, KIM-1, FBAP and Cys C levels were measured in urine and compared with the control values. Results: The NGAL levels in urine before the procedure and at 1, 3, 5 and 12 hours after the procedure were 34.59±35.34; 62.72±142.32; 47.15±104.48; 45.23±163.16 and 44.99±60.79ng/mL, respectively (p=0.001). Similarly, the urinary KIM-1, FABP and Cys C levels were found to increase compared to control values; however this increase did not reach statistical significance (p >0.05). Conclusions: After the URS procedure, there were important changes in NGAL, FABP, KIM-1 and Cys C levels. These changes reached statistical significance for NGAL, but did not reach significance for the other parameters. In conclusion, the URS procedure significantly affects the kidney; however, this effect disappears over time.
Descritores: Biomarcadores/urina
Cálculos Ureterais/cirurgia
Ureteroscopia/métodos
Pessoa de Meia-Idade
-Cálculos Ureterais/urina
Cistatinas/urina
Ureteroscopia/efeitos adversos
Proteínas de Ligação a Ácido Graxo/urina
Lipocalina-2/urina
Receptor Celular 1 do Vírus da Hepatite A/análise
Limites: Humanos
Masculino
Feminino
Adulto
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-839292
Autor: Lobato, GR; Lobato, MR; Thomé, FS; Veronese, FV.
Título: Performance of urinary kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, and N-acetyl-beta-D-glucosaminidase to predict chronic kidney disease progression and adverse outcomes
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(5):e6106, 2017. tab.
Idioma: en.
Resumo: Urinary biomarkers can predict the progression of chronic kidney disease (CKD). In this study, kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and N-acetyl-β-D-glucosaminidase (NAG) were correlated with the stages of CKD, and the association of these biomarkers with CKD progression and adverse outcomes was determined. A total of 250 patients, including 111 on hemodialysis, were studied. Urinary KIM-1, NGAL, and NAG were measured at baseline. Patients not on dialysis at baseline who progressed to a worse CKD stage were compared with those who did not progress. The association of each biomarker and selected covariates with progression to more advanced stages of CKD, end-stage kidney disease, or death was evaluated by Poisson regression. NGAL was moderately correlated (rs=0.467, P<0.001) with the five stages of CKD; KIM-1 and NAG were also correlated, but weakly. Sixty-four patients (46%) progressed to a more advanced stage of CKD. Compared to non-progressors, those patients exhibited a trend to higher levels of KIM-1 (P=0.064) and NGAL (P=0.065). In patients not on dialysis at baseline, NGAL was independently associated with progression of CKD, ESKD, or death (RR=1.022 for 300 ng/mL intervals; CI=1.007-1.037, P=0.004). In patients on dialysis, for each 300-ng/mL increase in urinary NGAL, there was a 1.3% increase in the risk of death (P=0.039). In conclusion, urinary NGAL was associated with adverse renal outcomes and increased risk of death in this cohort. If baseline urinary KIM-1 and NGAL predict progression to worse stages of CKD is something yet to be explored.
Descritores: Acetilglucosaminidase/urina
Receptor Celular 1 do Vírus da Hepatite A/análise
Lipocalina-2/urina
Insuficiência Renal Crônica/patologia
Insuficiência Renal Crônica/urina
-Fatores Etários
Análise de Variância
Biomarcadores/urina
Creatinina/sangue
Creatinina/urina
Progressão da Doença
Taxa de Filtração Glomerular
Valor Preditivo dos Testes
Padrões de Referência
Valores de Referência
Diálise Renal
Insuficiência Renal Crônica/complicações
Insuficiência Renal Crônica/fisiopatologia
Reprodutibilidade dos Testes
Fatores de Risco
Fatores Sexuais
Estatísticas não Paramétricas
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME



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