Base de dados : LILACS
Pesquisa : D12.776.395.550.479 [Categoria DeCS]
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Id: biblio-1038308
Autor: Ataei, Mitra; Behfarjam, Farinaz; Jadali, Zohreh.
Título: TIM-3 genetic variants and risk of Behçet disease in the Iranian population
Fonte: An. bras. dermatol;94(4):429-433, July-Aug. 2019. tab.
Idioma: en.
Resumo: Abstract: Background: Behçet disease is a prototypical systemic autoimmune disease, caused by a complex interplay between environmental and genetic factors. The transmembrane immunoglobulin and mucin domain-3 (TIM-3) is a distinct member of the TIM family that is preferentially expressed on Th1 cells and plays a role in Th1-mediated autoimmune or inflammatory diseases, such as Behçet disease. Objective: The aim of this study was to test the potential association between TIM-3 gene polymorphisms and Behçet disease. Methods: Two single-nucleotide polymorphisms of TIM-3 (rs9313439 and rs10515746) were genotyped in 212 patients with Behçet disease and 200 healthy controls. Typing of the polymorphisms was performed using multiplex PCR amplification. Results: There were no significant differences in allele and genotype frequencies between the Behçet disease patients and controls who were successfully genotyped. Similar results were also found after stratification by gender, age, or clinical features. Study limitations: Lack of studies on various racial or ethnic groups and small sample size. Conclusion: This study failed to demonstrate any association between the tested TIM-3 polymorphisms and Behçet disease.
Descritores: Síndrome de Behçet/genética
Polimorfismo de Nucleotídeo Único
Receptor Celular 2 do Vírus da Hepatite A/genética
-Estudos de Casos e Controles
Modelos Logísticos
Fatores de Risco
Medição de Risco
Alelos
Estudos de Associação Genética
Reação em Cadeia da Polimerase Multiplex
Frequência do Gene
Irã (Geográfico)
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-889123
Autor: Joelsons, G; Domenico, T; Gonçalves, LF; Manfro, RC.
Título: Non-invasive messenger RNA transcriptional evaluation in human kidney allograft dysfunction
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(7):e6904, 2018. tab, graf.
Idioma: en.
Resumo: The aim of the present study was to evaluate messenger RNA expression in kidney allograft recipients. Forty-four kidney transplant recipients were evaluated up to three months after grafting. After transplantation, peripheral blood samples were drawn sequentially for real-time polymerase chain reaction analyses of perforin and TIM-3 genes. Biopsies were obtained to evaluate acute graft dysfunction and interpreted according to the Banff classification. Eight patients presented episodes of acute rejection. Recipients with rejection had significantly higher levels of TIM-3 mRNA transcripts compared to those without rejection (median gene expression 191.2 and 36.9 mRNA relative units, respectively; P<0.0001). Also, perforin gene expression was higher in patients with rejection (median gene expression 362.0 and 52.8 mRNA relative units; P<0.001). Receiver operating characteristic curves showed that the area under the curve (AUC) for the TIM-3 gene was 0.749 (95%CI: 0.670-0.827). Perforin gene mRNA expression provided an AUC of 0.699 (95%CI: 0.599 to 0.799). Overall accuracy of gene expression was 67.9% for the TIM-3 gene and 63.6% for the perforin gene. Combined accuracy was 76.8%. Negative predictive values were 95.3% for the TIM-3 gene, 95.5% for the perforin gene, and 95.4% in the combined analyses. Gene expression was significantly modulated by rejection treatment decreasing 64.1% (TIM-3) and 90.9% (perforin) compared to the median of pre-rejection samples. In conclusion, the longitudinal approach showed that gene profiling evaluation might be useful in ruling out the diagnosis of acute rejection and perhaps evaluating the efficacy of treatment.
Descritores: Rejeição de Enxerto/sangue
Receptor Celular 2 do Vírus da Hepatite A/sangue
Transplante de Rim/efeitos adversos
Perforina/sangue
-Aloenxertos
Biomarcadores/sangue
Expressão Gênica
Rejeição de Enxerto/diagnóstico
Reação em Cadeia da Polimerase em Tempo Real
Transcrição Genética
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME



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