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Pesquisa : D12.776.503.280 [Categoria DeCS]
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Id: biblio-1132556
Autor: Lv, Fenghua; Wang, Zhuo; Huang, Yanli; Si, Aoyang; Chen, Yulei.
Título: CLEC3B protects H9c2 cardiomyocytes from apoptosis caused by hypoxia via the PI3K/Akt pathway
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;53(9):e9693, 2020. tab, graf.
Idioma: en.
Projeto: First Affiliated Hospital of Xinxiang Medical University.
Resumo: Ischemic heart disease (IHD) is one of the leading causes of death worldwide. C-type lectin domain family 3 member B (CLEC3B) is a C-type lectin superfamily member and is reported to promote tissue remodeling. The serum levels of CLEC3B are downregulated in patients with cardiovascular disease. However, the molecular mechanisms of CLEC3B in IHD is not well-characterized. Therefore, we overexpressed CLEC3B and silenced CLEC3B in H9c2 rat cardiomyocytes for the first time. We then constructed a model of IHD in vitro through culturing H9c2 cardiomyocytes in serum-free medium under oxygen-deficit conditions. Then, Cell Counting Kit-8 (CCK-8), flow cytometry, qRT-PCR, and western blot assays were performed to investigate cell viability, apoptosis, and expression levels of CLEC3B, phosphatidylinositol 3-kinase (PI3K), phosphorylated PI3K (p-PI3K), protein kinase B (Akt), phosphorylated Akt (p-Akt), and cleaved-caspase 3. We observed that the mRNA expression of CLEC3B was decreased in hypoxic H9c2 cardiomyocytes (P<0.05). Overexpression of CLEC3B increased cell viability (P<0.01), inhibited cell apoptosis (P<0.05), upregulated the levels of p-PI3K/PI3K and p-Akt/Akt (P<0.01 or P<0.05), and downregulated expression of cleaved-caspase 3 (P<0.001) in hypoxic H9c2 cardiomyocytes while silencing of CLEC3B caused the opposite results. Inhibition of the PI3K/Akt pathway reversed the protective effect of CLEC3B on hypoxic H9c2 cardiomyocytes. Our study demonstrated that CLEC3B alleviated the injury of hypoxic H9c2 cardiomyocytes via the PI3K/Akt pathway.
Descritores: Apoptose/fisiologia
Lectinas Tipo C/metabolismo
-Transdução de Sinais
Fosfatidilinositol 3-Quinases
Miócitos Cardíacos/fisiologia
Proteínas Proto-Oncogênicas c-akt/metabolismo
Fosfatidilinositol 3-Quinase
Hipóxia
Limites: Humanos
Animais
Ratos
Responsável: BR1.1 - BIREME


  2 / 11 LILACS  
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Id: biblio-977100
Autor: Cunha, Daiane de Oliveira; Leão-Cordeiro, Jacqueline Andréia Bernardes; Paula, Hellen da Silva Cintra de; Ataides, Fábio Silvestre; Saddi, Vera Aparecida; Vilanova-Costa, Cesar Augusto Sam Tiago; Silva, Antonio Márcio Teodoro Cordeiro.
Título: Association between polymorphisms in the genes encoding toll-like receptors and dectin-1 and susceptibility to invasive aspergillosis: a systematic review
Fonte: Rev. Soc. Bras. Med. Trop;51(6):725-730, Nov.-Dec. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Invasive aspergillosis is a common fungal infection in immunocompromised individuals. Some studies have shown that toll-like receptor and dectin-1 genetic polymorphisms may alter signaling pathways, thus increasing an individual's susceptibility to invasive aspergillosis. We investigated the pertinent literature to determine whether polymorphisms in the genes encoding toll-like receptors and dectin-1 increase the susceptibility to invasive aspergillosis. This study systematically reviewed the literature using the databases PubMed/PMC, Scopus, and Web of Science using the keywords invasive aspergillosis, polymorphism, Toll-like, and Dectin-1. From the initial search, 415 studies were found and according to our inclusion and exclusion criteria, eight studies were selected. Several studies described single-nucleotide polymorphisms (SNPs) that are associated with a greater susceptibility to invasive aspergillosis. These SNPs were found in the genes that encode toll-like receptors 1, 3, 4, and 5 and the gene that encodes dectin-1; upon activation, both cellular receptors initiate a signaling cascade that can result in the production of cytokines and chemokines. Thus, our literature review uncovered a significant association between polymorphisms in the genes that encode toll-like receptors and dectin-1 and invasive aspergillosis. More studies should be performed to better understand the relationship between toll-like receptor and dectin-1 genetic polymorphisms and invasive aspergillosis susceptibility.
Descritores: Aspergilose/genética
Predisposição Genética para Doença/genética
Polimorfismo de Nucleotídeo Único/genética
Lectinas Tipo C/genética
Receptores Toll-Like/genética
Limites: Humanos
Tipo de Publ: Revisão Sistemática
Responsável: BR1.1 - BIREME


  3 / 11 LILACS  
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Vasconcelos, Dewton de Moraes
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Id: biblio-1155584
Autor: Vasconcelos, Dewton de Moraes; Bertolini, Dalton Luís; Ferreira, Maurício Domingues.
Título: Chronic mucocutaneous candidiasis associated with paracoccidioidomycosis in a patient with mannose receptor deficiency: First case reported in the literature
Fonte: Rev. Soc. Bras. Med. Trop;54:e0008-22021, 2021. tab, graf.
Idioma: en.
Resumo: Abstract We describe the first report of a patient with chronic mucocutaneous candidiasis associated with disseminated and recurrent paracoccidioidomycosis. The investigation demonstrated that the patient had a mannose receptor deficiency, which would explain the patient's susceptibility to chronic infection by Candida spp. and systemic infection by paracoccidioidomycosis. Mannose receptors are responsible for an important link between macrophages and fungal cells during phagocytosis. Deficiency of this receptor could explain the susceptibility to both fungal species, suggesting the impediment of the phagocytosis of these fungi in our patient.
Descritores: Paracoccidioidomicose/complicações
Paracoccidioidomicose/diagnóstico
Candidíase Mucocutânea Crônica/complicações
Candidíase Mucocutânea Crônica/genética
-Receptores de Superfície Celular
Lectinas Tipo C
Lectinas de Ligação a Manose
Limites: Humanos
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


  4 / 11 LILACS  
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Id: lil-743341
Autor: Barbosa, Paulo Sérgio Ferreira.
Título: Efeitos renais de miotoxinas e lectinas purificadas dos venenos das serpentes Bothrops jararacussu e Bthrops moojeni [Manuscrito]: papel da ciclooxigenase e endotelina / Renal effects of myotoxins and lectins purified from Bothrops venoms of snakes and jararacussu Bthrops moojeni [manuscript]: role of cyclooxygenase and endothelin.
Fonte: Fortaleza; s.n; 2006.
Idioma: pt.
Tese: Apresentada a Universidade Federal de Ceará para obtenção do grau de Doutor.
Resumo: A insuficiência renal aguda é uma das complicações mais frequentes nos envenenamentos ofídicos. Contudo, a sua patogênese permanece obscura. Em nossos estudos foram avaliados os efeitos renais causados pelas miotoxinas purificadas dos venenos das serpentes Bothrops jararacussu (Bthtx I, Lys 49 e Bthtx II, Asp 49) e Bothrops moojeni (BmTx I, Lys 49), assim como pelas lectinas dos venenos de Bothrops moojeni (BmLec) e Bothrops jararacussu (BJcuL). Tentando avaliar o mecanismo envolvido nos efeitos renais das substâncias acima mencionadas, foram testados os efeitos da indometacina, um bloqueador inespecífico de ciclooxigenase. Adicionalmente, foram avaliados os efeitos inibitórios do Tezosentan, um bloqueador de receptor de endotelina, nos efeitos renais causados pelo miotoxina I da serpente Bothrops moojeni. Para tanto, as miotoxinas, na dosagem de 5μg/mL, ou as lectinas, na dosagem de 10μg/mL foram adicionadas 30 minutos depois do início dos experimentos. Contudo, a indometacina e o tezosentan foram adicionados no sistema de perfusão sempre no início de cada experimento na dosagem de 10μg/mL. Os efeitos renais foram comparados com um grupo controle, onde os rins foram perfundidos somente com a solução de Krebs-Henseleit modificada. Bthtx I, Bthtx II e BmLec aumentaram a pressão de perfusão (C120 = 110,28 +- 3,09, Bthtx I120 = 171,20 +- 6,3*, Bthtx II120 = 175,50 +- 7,20* e BmLec120 = 152,50 +- 2,10*), a resit~encia vascular renal (C120 = 5,46 +- 0,54, Bthtx I120 = 8,62 +- 0,37*, Bthtx II120 = 8,90 +- 0,36* e BmLec120 = 7,77 +- 0,30*), o fluxo urinário (C120 = 0,143 +- 0,008, Bthtx I120 = 0,326 +- 0,048*, Bthtx II120 = 0,373 +- 0,085* e BmLec120 = 0,085 +- 0,007*), o ritmo de filtração glomerular (C120 = 0,678 +- 0,065, Bthtx I120 = 0,855 +- 0,133*, Bthtx II120 = 1,224 +- 0,282* e BmLec120 = 1,037 +- 0,055*) e a excreção de sódio potássio e cloreto (ENa+, EK+, ECl-)...
Descritores: Bothrops
Lectinas Tipo C
Fosfolipases A
Responsável: BR6.1 - BCS - Biblioteca de Ciências da Saúde


  5 / 11 LILACS  
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Alcantara, Luiz Carlos Junior
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Id: lil-705822
Autor: Costa, Giselle Calasans de Souza; Jesus, Jaqueline Goes; Rego, Filipe Ferreira de Almeida; Santos, Edson Souza; Galvão-Castro, Bernardo; Gonçalves, Marilda de Souza; Alcantara, Luiz Carlos Júnior.
Título: Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil
Fonte: Mem. Inst. Oswaldo Cruz;109(2):250-255, abr. 2014. tab, graf.
Idioma: en.
Resumo: Studies on human genetic variations are a useful source of knowledge about human immunodeficiency virus (HIV)-1 infection. The Langerin protein, found at the surface of Langerhans cells, has an important protective role in HIV-1 infection. Differences in Langerin function due to host genetic factors could influence susceptibility to HIV-1 infection. To verify the frequency of mutations in the Langerin gene, 118 samples from HIV-1-infected women and 99 samples from HIV-1-uninfected individuals were selected for sequencing of the promoter and carbohydrate recognition domain (CRD)-encoding regions of the Langerin gene. Langerin promoter analysis revealed two single nucleotide polymorphisms (SNPs) and one mutation in both studied groups, which created new binding sites for certain transcription factors, such as NFAT5, HOXB9.01 and STAT6.01, according to MatInspector software analysis. Three SNPs were observed in the CRD-encoding region in HIV-1-infected and uninfected individuals: p.K313I, c.941C>T and c.983C>T. This study shows that mutations in the Langerin gene are present in the analysed populations at different genotypic and allelic frequencies. Further studies should be conducted to verify the role of these mutations in HIV-1 susceptibility.
Descritores: Antígenos CD/genética
Infecções por HIV/genética
HIV-1
Lectinas Tipo C/genética
Mutação
Lectinas de Ligação a Manose/genética
Polimorfismo de Nucleotídeo Único/genética
Regiões Promotoras Genéticas/genética
-Brasil
Genótipo
Frequência do Gene/genética
Predisposição Genética para Doença/genética
Interações Hidrofóbicas e Hidrofílicas
Proteínas de Homeodomínio/genética
Reação em Cadeia da Polimerase
Análise de Sequência de DNA
/genética
STATABDOMEN, ACUTE TRANSCRIPTION FACTOR/genética
Fatores de Transcrição/genética
Limites: Adulto
Idoso
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  6 / 11 LILACS  
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Id: lil-633530
Autor: Rojas Bilbao, Erica A.; Chirife, Ana María; Llorio, Darío; Giménez, Lliliana B.; Marino, Lina; Rosso, Diego A..
Título: Neoplasia hematodérmica CD4+ CD56+ en la infancia / Hematodermic CD4+ CD56+ neoplasm in childhood
Fonte: Medicina (B.Aires);68(2):147-150, mar.-abr. 2008. ilus.
Idioma: es.
Resumo: La neoplasia hematodérmica CD4+ CD56+ con fenotipo de célula dendrítica plasmocitoide es una rara y agresiva neoplasia recientemente reconocida por la WHO-EORTC classification. Afecta adultos de edad media y ancianos, siendo muy pocos los casos descriptos en niños. Presentamos el caso de una niña de 12 años con grave retraso mental, estigmas genéticos y múltiples lesiones cutáneas localizadas en miembros inferiores y superiores. Histológicamente se observó un infiltrado dérmico difuso de células pequeñas y medianas con expresión de CD4, CD56, CD43 y S100 así como de marcadores dendríticos plasmocitoides: CD 123 y BDCA-2 confirmados por citometría de flujo, sin compromiso de sangre periférica ni médula ósea. Cumpliendo dos semanas de tratamiento para leucemia linfoblástica aguda evolucionó con remisión clínica de las lesiones cutaneas.

Hematodermic CD4+ CD56+ neoplasm with plasmacytoid dendritic cell phenotype is a rare and aggressive neoplasm recently recognized by the WHO-EORTC classification. It generally appears in elderly adults, exceptionally in childhood. We present a 12-year-old girl with severe mental retardation, genetic clinical features and multiple nodular cutaneous lesions on legs and arms. Histologically the nodules showed diffuse dermal infiltrate of medium and small cells and expression of CD4, CD56, CD43, S100 and plasmacytoid dendritic markers: CD123, BDCA-2 under flow cytometry study. Peripheral blood and bone marrow were not involved. Clinical remission of cutaneous lesions was observed after two weeks of acute lymphoblastic leukemia therapy.
Descritores: ANTIGENS, CDABBREVIATIONS AS TOPIC
ANTIGENS, CDACANTHOSIS NIGRICANS
Biomarcadores Tumorais
Linfoma/patologia
Neoplasias Cutâneas/patologia
-Diagnóstico Diferencial
Células Dendríticas/imunologia
Células Dendríticas/patologia
Citometria de Fluxo
/análise
INTERLEUKIN-ABATTOIRS RECEPTOR ALPHA SUBUNIT/análise
Células Matadoras Naturais/imunologia
Lectinas Tipo C/análise
Linfoma/imunologia
Glicoproteínas de Membrana/análise
Receptores Imunológicos/análise
Neoplasias Cutâneas/imunologia
Limites: Criança
Feminino
Humanos
Tipo de Publ: Relatos de Casos
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas


  7 / 11 LILACS  
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Id: lil-624024
Autor: Rosanas-Urgell, Anna; Martin-Jaular, Lorena; Ricarte-Filho, Julio; Ferrer, Mireia; Kalko, Susana; Kimura, Edna; del Portillo, Hernando A.
Título: Expression of non-TLR pattern recognition receptors in the spleen of BALB/c mice infected with Plasmodium yoelii and Plasmodium chabaudi chabaudi AS
Fonte: Mem. Inst. Oswaldo Cruz;107(3):410-415, May 2012. ilus, graf, tab.
Idioma: en.
Projeto: CNPq; . FAPESP; . European Community's Seventh Framework Programme; . Spanish Ministry of Science and Innovation.
Resumo: The spleen plays a crucial role in the development of immunity to malaria, but the role of pattern recognition receptors (PRRs) in splenic effector cells during malaria infection is poorly understood. In the present study, we analysed the expression of selected PRRs in splenic effector cells from BALB/c mice infected with the lethal and non-lethal Plasmodium yoelii strains 17XL and 17X, respectively, and the non-lethal Plasmodium chabaudi chabaudi AS strain. The results of these experiments showed fewer significant changes in the expression of PRRs in AS-infected mice than in 17X and 17XL-infected mice. Mannose receptor C type 2 (MRC2) expression increased with parasitemia, whereas Toll-like receptors and sialoadhesin (Sn) decreased in mice infected with P. chabaudi AS. In contrast, MRC type 1 (MRC1), MRC2 and EGF-like module containing mucin-like hormone receptor-like sequence 1 (F4/80) expression decreased with parasitemia in mice infected with 17X, whereas MRC1 an MRC2 increased and F4/80 decreased in mice infected with 17XL. Furthermore, macrophage receptor with collagenous structure and CD68 declined rapidly after initial parasitemia. SIGNR1 and Sn expression demonstrated minor variations in the spleens of mice infected with either strain. Notably, macrophage scavenger receptor (Msr1) and dendritic cell-associated C-type lectin 2 expression increased at both the transcript and protein levels in 17XL-infected mice with 50% parasitemia. Furthermore, the increased lethality of 17X infection in Msr1 -/- mice demonstrated a protective role for Msr1. Our results suggest a dual role for these receptors in parasite clearance and protection in 17X infection and lethality in 17XL infection.
Descritores: Lectinas Tipo C/imunologia
Malária/parasitologia
Lectinas de Ligação a Manose/imunologia
Plasmodium chabaudi/imunologia
Plasmodium yoelii/imunologia
Receptores de Superfície Celular/imunologia
Receptores Depuradores/imunologia
Baço/parasitologia
Receptores Toll-Like/imunologia
-Citometria de Fluxo
Lectinas Tipo C/genética
Camundongos Endogâmicos BALB C
Análise em Microsséries
Malária/imunologia
Lectinas de Ligação a Manose/genética
Parasitemia/imunologia
Receptores de Superfície Celular/genética
Receptores Depuradores/genética
Baço/imunologia
Receptores Toll-Like/genética
Limites: Animais
Feminino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  8 / 11 LILACS  
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Id: lil-557178
Autor: Barbosa, P. S. F; Martins, A. M. C; Toyama, M. H; Joazeiro, P. P; Beriam, L. O. S; Fonteles, M. C; Monteiro, H. S. A.
Título: Purification and biological effects of a C-type lectin isolated from bothrops moojeni
Fonte: J. venom. anim. toxins incl. trop. dis;16(3):493-504, 2010. ilus, graf, tab.
Idioma: en.
Resumo: Snake venom proteins from the C-type lectin family have very distinct biological activities despite their highly conserved primary structure, which is homologous to the carbohydrate recognition region of true C-type lectins. We purified a lectin-like protein (BmLec) from Bothrops moojeni venom and investigated its effect on platelet aggregation, insulin secretion, antibacterial activity, and isolated kidney cells. The BmLec was purified using two chromatographic steps: affinity chromatography and reverse phase high performance liquid chromatography (HPLC). BmLec showed a dose-dependent platelet aggregation and significantly decreased the bacterial growth rate in approximately 15 percent. During scanning electron microscopy, the profile of Xanthomonas axonopodis pv. passiflorae treated with lectin disclosed a high vesiculation and membrane rupture. BmLec induced a strong and significant increase in insulin secretion at 2.8 and 16.7 mM glucose concentrations, and this effect was seen in the presence of EGTA in both experiments. BmLec (10 µg/mL) increased the perfusion pressure, renal vascular resistance and urinary flow. The glomerular filtration rate and percentages of sodium, potassium and chloride tubular transport were reduced at 60 minutes of perfusion. Renal alterations caused by BmLec were completely inhibited by indomethacin in all evaluated parameters. In conclusion, the C-type lectin isolated from Bothrops moojeni affected platelet aggregation, insulin secretion, antibacterial activity and isolated kidney function.
Descritores: Bothrops
Venenos de Crotalídeos
Insulina
Rim
Lectinas Tipo C/isolamento & purificação
Agregação Plaquetária
-Cromatografia Líquida de Alta Pressão/métodos
Limites: Animais
Responsável: BR33.1 - Divisão Técnica de Biblioteca e Documentação


  9 / 11 LILACS  
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Texto completo SciELO Saúde Pública
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Id: lil-492103
Autor: Rodrigues, Roberta; Gabetta, Carmen S; Pedro, Karla P; Valdetaro, Fabio; Fernandes, Maria I. M; Magalhães, Patrícia K. R; Januário, José N; Maciel, Léa M. Z.
Título: Cystic fibrosis and neonatal screening / Fibrose cística e a triagem neonatal
Fonte: Cad. saúde pública = Rep. public health;24(supl.4):s475-s484, 2008. ilus.
Idioma: en.
Resumo: The clinical and diagnostic aspects of cystic fibrosis have been extensively reviewed, with an emphasis on neonatal screening. This systematic literature review involved a search for relevant contributions in the PubMed and SciELO databases. The first references to cystic fibrosis date to the Middle Ages. Cystic fibrosis is the most frequent autosomal recessive hereditary disease among Caucasians (1:2,000 to 3,500). More than 1,000 mutations lead to the disease, the most common being "F508, with 70 percent prevalence among Canadian, Northern European, and American Caucasians and 23 to 55 percent prevalence among Brazilians. The basic defect is in chloride ion secretion. Cystic fibrosis screening has long been controversial, and after almost three decades, there are few nationwide programs (most are regional or local). However, the U.S. Centers for Disease Control and Prevention (CDC) has concluded that screening for cystic fibrosis is justified. The lack of a specific screening test and the ethnic heterogeneity of the Brazilian population pose challenges for neonatal screening.

Aspectos clínicos e diagnósticos da fibrose cística são revistos de modo abrangente, com ênfase na triagem neonatal. Esta revisão sistematizada da literatura envolveu busca de contribuições relevantes nos bancos de dados PubMed e SciELO. Referências sobre fibrose cística existem desde a Idade Média. É a doença hereditária autossômica recessiva mais freqüente em caucasianos (1:2.000 a 3.500). Mais de mil mutações levam à doença, a mais comum: "F508 (prevalência: 70 por cento em caucasianos canadenses, americanos e norte-europeus; de 23 a 55 por cento em brasileiros). O defeito básico ocorre na secreção do íon cloro. Sua triagem é assunto polêmico e apesar de estar disponível há quase três décadas, por meio de diferentes protocolos, poucos programas de abrangência nacional existem. Entretanto, o Centers for Disease Control and Prevention, dos Estados Unidos, afirma que o rastreamento neonatal para fibrose cística é justificado. A falta de um teste específico e a heterogeneidade étnica da população brasileira dificultam sua triagem neonatal.
Descritores: Fibrose Cística/diagnóstico
Triagem Neonatal
-Grupo com Ancestrais do Continente Africano
Antígenos de Neoplasias/sangue
Regulador de Condutância Transmembrana em Fibrose Cística/sangue
Regulador de Condutância Transmembrana em Fibrose Cística/genética
Fibrose Cística/genética
DNA
Grupo com Ancestrais do Continente Europeu
Imuno-Histoquímica
Incidência
Lectinas Tipo C/sangue
Diagnóstico Pré-Natal
Tripsina/sangue
Biomarcadores Tumorais/sangue
Estados Unidos/epidemiologia
Limites: Humanos
Recém-Nascido
Tipo de Publ: Revisão
Responsável: BR526.1 - Biblioteca de Saúde Pública


  10 / 11 LILACS  
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Id: lil-485211
Autor: Martins, Priscila Raquel; Gameiro, Maria Carolina; Castoldi, Lindsey; Romagnoli, Graziela Gorete; Lopes, Fabiane Catanho; Pinto, Andréa Vanessa Ferreira da Silva; Loyola, Wagner; Kaneno, Ramon.
Título: Polysaccharide-rich fraction of Agaricus brasiliensis enhances the candidacidal activity of murine macrophages
Fonte: Mem. Inst. Oswaldo Cruz;103(3):244-250, May 2008. ilus, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: A polysaccharide-rich fraction (ATF) of medicinal mushroom Agaricus brasiliensis was evaluated on the candidacidal activity, H2O2 and nitric oxide (NO) production, and expression of mannose receptors by murine peritoneal macrophages. Mice received three intraperitoneal (i.p.) injections of ATF and after 48 h their peritoneal resident macrophages were assayed against Candida albicans yeast forms. The treatment increased fungicidal activity and it was associated with higher levels of H2O2, whereas NO production was not affected. We also found that the treatment enhances mannose receptor expression by peritoneal macrophages, which are involved in the attachment and phagocytosis of non-opsonized microorganisms. Treatment of animals with ATF was able to enhance the clearance of C. albicans during the first 6 h after the experimental i.p. infection. Our results suggest that this extract can increase host resistance against some infectious agents through the stimulation of microbicidal activity of macrophages.
Descritores: Agaricus/química
Candida albicans/imunologia
Macrófagos Peritoneais/imunologia
Polissacarídeos/farmacologia
-Candida albicans/efeitos dos fármacos
Peróxido de Hidrogênio/imunologia
Lectinas Tipo C/imunologia
Camundongos Endogâmicos BALB C
Macrófagos Peritoneais/efeitos dos fármacos
Macrófagos Peritoneais/microbiologia
Lectinas de Ligação a Manose/imunologia
Óxido Nítrico/biossíntese
Fagocitose/efeitos dos fármacos
Polissacarídeos/isolamento & purificação
Receptores de Superfície Celular/imunologia
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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