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Id: biblio-950885
Autor: Xing, Haijie; Chen, Xiangdong; Han, Yaofeng.
Título: Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma
Fonte: Biol. Res;50:37, 2017. tab, graf.
Idioma: en.
Projeto: Nature Science Foundation from the Sci-Tech Department of Hainan Province; . Shenzhen strategic emerging industry development special fund project; . Shenzhen science and technology innovation fund project.
Resumo: BACKGROUND: Regenerating gene IA (REGIA) plays an important role in tissue regeneration and tumors prognosis of epithelium origin. However, the role of REGIA in nasopharyngeal carcinoma (NPC) is unclear. This study aims to investigate the expression and function of REG1A in NPC. RESULTS: We have found that there was 63 patients with REGIA positive expression of 155 patients in this study (40.65%). The positive expression rate of REGIA was 30.50, 44.44 and 47.83% in stage T2, T3 and T4 patients, respectively. The REGIA expression was significantly difference in T2 and T4 stage tumors or T2 and T3-T4 stage. The positive expression rate of REGIA was found to be higher in patients with cervical lymph node persistence than those with cervical lymph node complete regression. Patients with negative REGIA expression had a better overall survival and free survival than those with REGIA positive expression. In addition, according to the univariate and multivariate analysis, the REGIA expression was an independent adverse prognostic factor for NPC patients. CONCLUSION: REGIA expression was a useful biomarker in NPC patients for assessing T stage and survival.
Descritores: Carcinoma/genética
Carcinoma/patologia
Neoplasias Nasofaríngeas/genética
Neoplasias Nasofaríngeas/patologia
Litostatina/genética
-Prognóstico
Biópsia
Imuno-Histoquímica
Carcinoma/mortalidade
Carcinoma/terapia
Biomarcadores Tumorais/análise
Neoplasias Nasofaríngeas/mortalidade
Neoplasias Nasofaríngeas/terapia
Análise Multivariada
Estatísticas não Paramétricas
Progressão da Doença
Litostatina/fisiologia
Carcinoma Nasofaríngeo
Invasividade Neoplásica/patologia
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: CL1.1 - Biblioteca Central



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