Base de dados : LILACS
Pesquisa : D12.776.543.512.500.330 [Categoria DeCS]
Referências encontradas : 3 [refinar]
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Texto completo SciELO Brasil
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Id: lil-357538
Autor: Mohabatkar, H; Kar, S. K.
Título: Prediction of exposed domains of envelope glycoprotein in Indian HIV-1 isolates and experimental confirmation of their immunogenicity in humans
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;37(5):675-681, May 2004. tab.
Idioma: en.
Resumo: We describe the impact of subtype differences on the seroreactivity of linear antigenic epitopes in envelope glycoprotein of HIV-1 isolates from different geographical locations. By computer analysis, we predicted potential antigenic sites of envelope glycoprotein (gp120 and gp4l) of this virus. For this purpose, after fetching sequences of proteins of interest from data banks, values of hydrophilicity, flexibility, accessibility, inverted hydrophobicity, and secondary structure were considered. We identified several potential antigenic epitopes in a B subtype strain of envelope glycoprotein of HIV-1 (IIIB). Solid- phase peptide synthesis methods of Merrifield and Fmoc chemistry were used for synthesizing peptides. These synthetic peptides corresponded mainly to the C2, V3 and CD4 binding sites of gp120 and some parts of the ectodomain of gp41. The reactivity of these peptides was tested by ELISA against different HIV-1-positive sera from different locations in India. For two of these predicted epitopes, the corresponding Indian consensus sequences (LAIERYLKQQLLGWG and DIIGDIRQAHCNISEDKWNET) (subtype C) were also synthesized and their reactivity was tested by ELISA. These peptides also distinguished HIV-1-positive sera of Indians with C subtype infections from sera from HIV-negative subjects.
Descritores: Ensaio de Imunoadsorção Enzimática
Proteína gp120 do Envelope de HIV
Proteína gp41 do Envelope de HIV
HIV-1
Imunogenética
-Índia
Limites: Humanos
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
Bongertz, Vera
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Id: lil-334256
Autor: Bongertz, Vera; Ouverney, Elaine Priscilla; Teixeira, Sylvia L. M; Silva-de-Jesus, Carlos; Hacker, Mariana A; Morgado, Mariza G; Bastos, Francisco I.
Título: Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals
Fonte: Mem. Inst. Oswaldo Cruz;98(2):209-212, Mar. 15, 2003. tab, graf.
Idioma: en.
Resumo: Sera from infected injection drug users (IDU) have shown to have antibodies against synthetic human immunodeficiency virus-1 (HIV-1) envelope peptides more frequently. In this study, reactivity of 48 IDU plasma were compared to 60 plasmas obtained from sexually infected individuals (S). The overall reactivity of plasma from IDU compared to S was higher, and the reactivity titers were much higher for IDU plasma than S. IDU plasma also showed a broader antibody response. The higher reactivity titers were observed mainly for the gp41 immunodominant epitope and V3 peptides corresponding to the consensus sequences of HIV-1 subtypes/variants prevalent in Brazil (B, F, C) indicating the specificity in the higher immune response of IDU
Descritores: Anticorpos Anti-HIV
Proteína gp120 do Envelope de HIV
Proteína gp41 do Envelope de HIV
Infecções por HIV
HIV-1
Fragmentos de Peptídeos
-Reações Cruzadas
Progressão da Doença
Ensaio de Imunoadsorção Enzimática
Infecções por HIV
Prognóstico
Comportamento Sexual
Abuso de Substâncias por Via Intravenosa
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Longo, I. M
Id: lil-86771
Autor: Hernández, H. J; Longo, I. M; Peixinho, Z. F; Lacouture, C; Mendes, Nelson Figueiredo.
Título: ELISA de tercera generación empleando un peptido sintético para detectar anti-HIV: método rápido y de bajo costo (carta) / Third generation ELISA using a synthetic peptide to detect anti-HIV: a rapid and low cost method (letter)
Fonte: Medicina (B.Aires);50(1):87-8, 1990. ilus.
Idioma: es.
Descritores: Sorodiagnóstico da AIDS/métodos
Ensaio de Imunoadsorção Enzimática/métodos
Anticorpos Anti-HIV/análise
Proteína gp41 do Envelope de HIV
-Complexo Relacionado com a AIDS/diagnóstico
Custos e Análise de Custo
Limites: Humanos
Tipo de Publ: Carta
Responsável: BR1.1 - BIREME



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