Base de dados : LILACS
Pesquisa : D12.776.543.750.695.170 [Categoria DeCS]
Referências encontradas : 4 [refinar]
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Texto completo SciELO Brasil
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Id: lil-420279
Autor: Martins, S. R; De Oliveira, R. B; Ballejo, G.
Título: Activation of neural cholecystokinin-1 receptors induces relaxation of the isolated rat duodenum which is reduced by nitric oxide synthase inhibitors
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;39(2):271-275, Feb. 2006. ilus.
Idioma: en.
Resumo: Cholecystokinin (CCK) influences gastrointestinal motility, by acting on central and peripheral receptors. The aim of the present study was to determine whether CCK has any effect on isolated duodenum longitudinal muscle activity and to characterize the mechanisms involved. Isolated segments of the rat proximal duodenum were mounted for the recording of isometric contractions of longitudinal muscle in the presence of atropine and guanethidine. CCK-8S (EC50: 39; 95 percent CI: 4.1-152 nM) and cerulein (EC50: 58; 95 percent CI: 18-281 nM) induced a concentration-dependent and tetrodotoxin-sensitive relaxation. Nomeganitro-L-arginine (L-NOARG) reduced CCK-8S- and cerulein-induced relaxation (IC50: 5.2; 95 percent CI: 2.5-18 æM) in a concentration-dependent manner. The magnitude of 300 nM CCK-8S-induced relaxation was reduced by 100 æM L-NOARG from 73 ± 5.1 to 19 ± 3.5 percent in an L-arginine but not D-arginine preventable manner. The CCK-1 receptor antagonists proglumide, lorglumide and devazepide, but not the CCK-2 receptor antagonist L-365,260, antagonized CCK-8S-induced relaxation in a concentration-dependent manner. These findings suggest that CCK-8S and cerulein activate intrinsic nitrergic nerves acting on CCK-1 receptors in order to cause relaxation of the rat duodenum longitudinal muscle.
Descritores: Ceruletídeo/farmacologia
Duodeno/efeitos dos fármacos
Contração Muscular/efeitos dos fármacos
Óxido Nítrico Sintase/antagonistas & inibidores
Fragmentos de Peptídeos/farmacologia
Receptores da Colecistocinina/fisiologia
-Relação Dose-Resposta a Droga
Ratos Wistar
Limites: Animais
Responsável: BR1.1 - BIREME

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Texto completo SciELO Brasil
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Id: lil-340662
Autor: Saruc, M; Ozden, N; Turkel, N; Ayhan, S; Demir, M. A; Tuzcuoglu, I; Akarca, U. S; Yuceyar, H.
Título: Functional dyspepsia: relationship between clinical subgroups and Helicobacter pylori status in Western Turkey
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;36(6):747-751, June 2003. tab.
Idioma: en.
Conferência: Apresentado em: World Congress of Gastroenterology, Bangkok, Feb. 24- Mar. 1, 2002.
Resumo: The etiology of functional dyspepsia is not known. The objective of the present study was to determine the characteristics of functional dyspepsia in Western Turkey. We divided 900 patients with functional dyspepsia into three subgroups according to symptoms: ulcer-like (UL), 321 (35.6 percent), motility disorder-like (ML), 281 (31.2 percent), and the combination (C) of these symptoms, 298 (33.1 percent). All patients were submitted to endoscopic evaluation, with two biopsies taken from the cardia and corpus, and four from the antrum of the stomach. All biopsy samples were studied for Helicobacter pylori (Hp) density, chronic inflammation, activity, intestinal metaplasia, atrophy, and the presence of lymphoid aggregates by histological examination. One antral biopsy was used for the rapid urease test. Tissue cagA status was determined by PCR from an antral biopsy specimen by a random sampling method. We also determined the serum levels of tumor necrosis factor-alpha (TNF-alpha) and gastrin by the same method. Data were analyzed statistically by the Kolmogorov-Smirnov test and by analysis of variance. Hp and cagA positivity was significantly higher in the UL subgroup than in the others. The patients in the ML subgroup had the lowest Hp and cagA positivity and Hp density. The ML subgroup also showed the lowest level of Hp-induced inflammation among all subgroups. The serum levels of TNF-alpha and gastrin did not reveal any difference between groups. Our findings show a poor association of Hp with the ML subgroup of functional dyspepsia, but a stronger association with the UL and C subgroups
Descritores: Dispepsia
Infecções por Helicobacter
Helicobacter pylori
-Análise de Variância
Infecções por Helicobacter
Reação em Cadeia da Polimerase
Receptores da Colecistocinina
Estatísticas não Paramétricas
Fator de Necrose Tumoral alfa
Limites: Humanos
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME

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Id: lil-260222
Autor: Saavedra G., Victor.
Título: Rol del tejido adiposo / Adipose tissue role
Fonte: Rev. chil. obes;4(2):41-6, 1999.
Idioma: es.
Resumo: Currently the research on adipose tissue has yielded same insights of itïs function. On the embrionary state the differentiation between white adipose tissue and brown adipose tissue and brown adipose tissue signals different functions. The presence of multiple receptors and actions define itïs autocrine, paracline and endocrine roles
Descritores: Adipócitos
Tecido Adiposo/fisiologia
Metabolismo Energético/fisiologia
Receptor de Insulina
Receptores Adrenérgicos alfa
Receptores Adrenérgicos beta
Receptores da Colecistocinina
Receptores da Corticotropina
Receptores de Glucagon
Receptores da Somatotropina
Receptores dos Hormônios Tireóideos
-Tecido Adiposo/embriologia
Tecido Adiposo/crescimento & desenvolvimento
Proteínas/antagonistas & inibidores
Receptores de Glucocorticoides
Limites: Humanos
Responsável: CL2.1 - Biblioteca de Medicina

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Id: lil-186171
Autor: Lima-Leite, A. C; Fulcrand, P; Galleyrand, J. C; Berge, G; Aumelas, A; Bali, J. P; Castel, J; Martinez, J.
Título: Synthesis and biological activities of some human gastrin analogs
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;29(10):1253-63, Oct. 1996. ilus, tab.
Idioma: en.
Resumo: The synthesis of analogs of the C-terminal tridecapeptide of gastrin in described. These pseudopeptide analogs were obtained either by replacing the C-terminal phenylalanine amide with 2-phenylethytalcohol or with 2-phenylethylamine, or by replacing the peptid bond between Trp and Leu, or between Leu and Asp with an aminomethylene (CH2NH). The ability of these compounds to stimulate gastric acid secretion in anesthetized rats and to inhibit binding of labeled CCK-8 to isolated cells from rabbit fundic mucosa was tested. [desPhe13, Leu11]-HG-12-I-beta-phenylethylester 33, [desPhe13, Leu11]-HG-12-II-beta-phenylethylester 38 [desPhe13, Leu11]-HG-12-I-beta-phenylethylamide 32, and [desPhe13, Leu11]-HG-12-II-beta-phenylethylamide 37 acted as gastrin receptor antagonists, while [Trp10-((CH2NH)-Leu11]-HG-13-I 31 and (Trp10-((CH2NH)-Leu11]-HG-13-II 36 acted as agonists. Unexpectedly, [Leu11-((CH2NH)-Asp12]-HG-13-I 30 and [Leu11-((CH2NH)-Asp12]-HG-13-II 35 were almost devoid of affinity for the gastrin receptor.
Descritores: Ácido Gástrico/metabolismo
Receptores da Colecistocinina/antagonistas & inibidores
Peptídeos/síntese química
Limites: Humanos
Responsável: BR1.1 - BIREME

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