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Pesquisa : D12.776.543.750.695.450 [Categoria DeCS]
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Texto completo SciELO Chile
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Id: biblio-950769
Autor: Matias, Carlos M; Dionísio, Jose C; Saggau, Peter; Quinta-Ferreira, Maria Emilia.
Título: Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers
Fonte: Biol. Res;47:1-6, 2014. ilus, graf.
Idioma: en.
Projeto: CNC; . MCTES. FCT; . FEDER. COMPETE.
Resumo: BACKGROUND: The hippocampal CA3 area contains large amounts of vesicular zinc in the mossy fiber terminals which is released during synaptic activity, depending on presynaptic calcium. Another characteristic of these synapses is the presynaptic localization of high concentrations of group II metabotropic glutamate receptors, specifically activated by DCG-IV. Previous work has shown that DCG-IV affects only mossy fiber-evoked responses but not the signals from associational-commissural afferents, blocking mossy fiber synaptic transmission. Since zinc is released from mossy fibers even for single stimuli and it is generally assumed to be co-released with glutamate, the aim of the work was to investigate the effect of DCG-IV on mossy fiber zinc signals. RESULTS: Studies were performed using the membrane-permeant fluorescent zinc probe TSQ, and indicate that DCG-IV almost completely abolishes mossy fiber zinc changes as it does with synaptic transmission. CONCLUSIONS: Zinc signaling is regulated by the activation of type II metabotropic receptors, as it has been previously shown for glutamate, further supporting the corelease of glutamate and zinc from mossy fibers.
Descritores: Zinco/metabolismo
Receptores de Glutamato Metabotrópico/metabolismo
Fibras Musgosas Hipocampais/efeitos dos fármacos
Ciclopropanos/farmacologia
Glicina/análogos & derivados
Anticonvulsivantes/farmacologia
-Vesículas Sinápticas/efeitos dos fármacos
Vesículas Sinápticas/metabolismo
Transdução de Sinais/efeitos dos fármacos
Ratos Wistar
Terminações Pré-Sinápticas/efeitos dos fármacos
Terminações Pré-Sinápticas/metabolismo
Transmissão Sináptica/efeitos dos fármacos
6-Ciano-7-nitroquinoxalina-2,3-diona/farmacologia
Estatísticas não Paramétricas
Ácido Glutâmico/metabolismo
Antagonistas de Aminoácidos Excitatórios/farmacologia
Fibras Musgosas Hipocampais/metabolismo
Glicina/farmacologia
Hipocampo/efeitos dos fármacos
Limites: Animais
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
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Id: biblio-1039283
Autor: Xie, Sanlin; Li, Jianzhong; Wang, Wentao; Chen, Xianming.
Título: Association of glutamate metabotropic receptor polymorphisms and sensorineural hearing loss in adults of different age groups / Associação entre polimorfismos do gene do receptor metabotrópico de glutamato 7 e perda auditiva neurossensorial em adultos de diferentes faixas etárias
Fonte: Braz. j. otorhinolaryngol. (Impr.);85(5):560-564, Sept.-Oct. 2019. tab.
Idioma: en.
Projeto: Natural Science Foundation of FuJian Province.
Resumo: Abstract Introduction: Sensorineural hearing loss is a common challenge all over the world, including a section of the young population. While there have been many published reports associating glutamate metabotropic receptor 7 with sensorineural hearing loss, there is no report, till date, about the association of glutamate metabotropic receptor 7 polymorphisms with sensorineural hearing loss at different ages. Objective: To test the association between the single nucleotide polymorphisms rs11928865 and rs11920109 of the glutamate metabotropic receptor 7 with sensorineural hearing loss in adults of different age groups. Methods: A total of 1661 subjects were studied. The individuals aged between 30 and 50, and between 51 and 70 years with sensorineural hearing loss comprised group A and group B, respectively. Individuals aged between 30 and 50; and between 51 and 70 years without hearing loss comprised control groups C and D, respectively. The MassARRAY method was used to analyze the genotypes. Results: The difference in genotypes for the glutamate metabotropic receptor 7 rs11928865 single nucleotide polymorphism between patients in the groups B and D was statistically significant (p = 0.018). The distribution frequencies of genotypes in patients that were aged between 30 and 50 years were not significantly different. The difference in genotypes for the rs11920109 single nucleotide polymorphism between the sensorineural hearing loss groups and control groups showed no statistical significance. Conclusion: The rs11928865 single nucleotide polymorphism was associated with the susceptibility to hearing loss in patients in group B but not with those in group A.

Resumo Introdução: A perda auditiva neurossensorial é um desafio comum no mundo todo, inclui uma parte da população jovem. Embora haja muitos relatos que associem o gene do receptor metabotrópico de glutamato 7 com perda auditiva neurossensorial, não há relato, até a presente data, sobre a associação de polimorfismos do receptor metabotrópico de glutamato 7 com perda auditiva neurossensorial em diferentes faixas etárias. Objetivo: Testar a associação entre os polimorfismos de nucleotídeo único, rs11928865 e rs11920109 do receptor metabotrópico de glutamato 7 e perda auditiva neurossensorial em adultos de diferentes faixas etárias. Método: Um total de 1661 indivíduos foram estudados. Os indivíduos com idade entre 30 e 50 anos e entre 51 e 70 anos com perda auditiva neurossensorial constituíram o grupo A e o grupo B, respectivamente. Indivíduos com idade entre 30 e 50 anos; e entre 51 e 70 anos sem perda auditiva foram os grupos controle C e D, respectivamente. O método MassARRAY foi utilizado para analisar os genótipos. Resultados: A diferença nos genótipos para o polimorfismo de nucleotídeo único rs11928865 do gene receptor metabotrópico de glutamato 7 entre os pacientes dos Grupos B e D foi estatisticamente significante (p = 0,018). As frequências de distribuição dos genótipos nos pacientes entre 30 e 50 anos não foram significantemente diferentes. A diferença nos genótipos para o polimorfismo de nucleotídeo único rs11920109 entre os grupos com perda auditiva neurossensorial e os grupos controle não mostrou significância estatística. Conclusão: O polimorfismo de nucleotídeo único rs11928865 foi associado à suscetibilidade para perda auditiva em pacientes do grupo B, mas não àqueles do grupo A.
Descritores: Receptores de Glutamato Metabotrópico/genética
Polimorfismo de Nucleotídeo Único/genética
Perda Auditiva Neurossensorial/genética
-Reação em Cadeia da Polimerase
Fatores Etários
Distribuição por Idade
Frequência do Gene
Genótipo
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


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Id: lil-575044
Autor: Castro, Vanessa de; Martín-López, Mercedes; Navarro, José Francisco.
Título: Efectos de la administración de LY354740, un agonista selectivo del grupo II de receptores metabotrópicos de glutamato, sobre la conducta agresiva en ratones / Effects of LY354740, a selective agonist of Glutamate metabotropic group II receptors, on aggressive behavior in mice
Fonte: Univ. psychol;9(3):617-626, sept. 2010.
Idioma: es.
Resumo: Estudios recientes han demostrado una implicación de los receptores metabotrópicos mGlu1 y mGlu5 en la regulación de la conducta agresiva. Este trabajo examina el efecto de la administración de LY354740 (4-16 mg/kg ip), un agonista selectivo de los receptores metabotrópicos del grupo II (mGlu2/3), en encuentros agonísticos entre ratones macho, utilizando un modelo de agresión inducida por aislamiento. Treinta minutos tras la administración del fármaco, se llevaron a cabo interacciones agonísticas de 10 min de duración entre un animal aislado y un oponente anósmico en un área neutral. Dichos encuentros fueron grabados, para su posterior análisis etológico, estimándose el tiempo pasado por los ratones en cada una de diez categorías conductuales. LY354740 (12 y 16 mg/kg) redujo significativamente las conductas ofensivas, sin afectar la motilidad, en comparación con el grupo control. Estos resultados sugieren una implicación de los receptores mGlu del grupo II, en la modulación de la agresión.

Recent studies have demonstrated that glutamate metabotropic receptors mGlu1 and mGlu5 are involved in the regulation of aggressive behaviour. This study examines the effect of the administration of LY354740 (4-16 mg/kg i.p.), a selective group II metabotropic receptors agonist (mGlu2/3), using an isolation-induced aggression model. Individually housed mice were exposed to anosmic opponents 30 min after drug administration. Ten min of diadic interactions were staged between a singly housed and an anosmic mouse in a neutral area. The encounters were videotaped and the accumulated time allocated by subjects to ten broad behavioural categories was estimated using an ethologically based analysis. LY354740 (12 and 16 mg/kg) significantly reduced offensive behaviours, without affecting immobility, as compared with the control group. These results suggest an implication of mGlu group II receptors in the modulation of aggression.
Descritores: Receptores de Glutamato Metabotrópico
-Ratos/psicologia
Limites: Animais
Responsável: CO185.1 - Biblioteca Alfonso Borrero Cabal, S. J.


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Id: lil-557741
Autor: Hünig, Guillermo Joaquin.
Título: Alteraciones de la Corteza Prefrontal en la esquizofrenia (Tercera parte) / Alterations in the Prefrontal Cortex in Schizophrenia (Third Part)
Fonte: Psicofarmacologia (B. Aires);9(54):25-33, feb. 2009.
Idioma: es.
Resumo: La Corteza Prefrontal (CPF) y específicamente la Corteza Prefrontal Dorso Lateral es una corteza de asociación heteromodal, particular y selectivamente alterada en la esquizofrenia. La CPFDL (Corteza Prefrontal Dorso Lateral) presenta disminución selectiva de su conectividad sináptica, con disminución del neuropilo y del tamaño de los somas neuronales, con aumento de la densidad neuronal. Hay disminución de las aferencias provenientes del ATV (área tegmental ventral) en las capas medias y de las provenientes del NDM (núcleo dorso medial) del Tálamo en las medias y profundas, con disminución del volumen del mismo. Las alteraciones se agravan con el podado fisiológico en la adolescencia, produciendo fallas en los circuitos córtico-talámicos, córtico-estrio-tálamo-corticales y córtico-tálamo-cerebelares, con fallas en la regulación del filtro talámico y estados de hiperdopaminergia subcortical secundaria, relacionados con los síntomas positivos de la enfermedad. Esta revisión será presentada en tres partes. En la primera y segunda parte del trabajo se desarrollaron las alteraciones cognitivas descriptas en la esquizofrenia, específicamente la Memoria de Trabajo y la circuitería de la Corteza Prefrontal. En la tercera parte se tratará la importancia de la neurotransmisión dopaminérgica y neurofisiopatología de la CPF en la esquizofrenia.

The Prefrontal Cortex (PFC), and specifically, the Dorsolateral Prefrontal Cortex is a heteromodal association cortex, which is particularly and selectively altered in schizophrenia. The DLPC (Dorsolateral Prefrontal Cortex) displays a selective decrease of its synaptic connectivity, with a reduction of the neuropile as well as the size of neural somas, with an increased neural density. There is a decrease in the afferents of the ventral tegmental area (VTA), in the medium layers and the layers of the MDN (medial dorsal nucleus) of the Thalamus, in the medium and deep layers, with a reduction of its volume. Alterations become worse with physiological crop in adolescence, leading to impairments of the corticothalamic, cortico-striatal-thalamic-cortical and cortico-thalamic-cerebellar circuits, with impairments in the regulation of the thalamic filter, and states of secondary subcortical hyperdopaminergia, associated with the pisitive symptoms of the disease. This review will be divided in three parts. The first and the second part consist in the cognitive alterations described in schizophrenia, specifically, the Working Memory as well as the Prefrontal Cortex circuitry. The Third part deals with the importance of dopaminergic neurotransmission and the neurophysiopathology of the PFC in schizophrenia.
Descritores: Ciência Cognitiva
Córtex Pré-Frontal/fisiopatologia
Esquizofrenia/fisiopatologia
GABAérgicos
Transtornos da Memória
Receptores de Dopamina D1
Receptores de Glutamato Metabotrópico
Limites: Humanos
Responsável: AR392.1 - Biblioteca


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Amado, Débora
Cavalheiro, Esper Abräo
Id: lil-383547
Autor: Funke, Marcelo Giovedi; Costa, Maricília da Silva; Amado, Débora; Cavalheiro, Esper Abrão; Naffah-Mazzacoratti, Maria da Graça.
Título: Calcium homeostasis and temporal lobe epilepsy
Fonte: Arq. neuropsiquiatr;61(supl.1):8-14, set. 2003. ilus.
Idioma: en.
Descritores: /metabolismo
CA(TEMEFOS+)-TRANSPORTING ATPASE/metabolismo
Cálcio/metabolismo
Epilepsia do Lobo Temporal/metabolismo
Homeostase
Hipocampo/metabolismo
Receptores de Glutamato Metabotrópico/metabolismo
-Cálcio/fisiologia
Membrana Celular/metabolismo
Retículo Endoplasmático/metabolismo
Imuno-Histoquímica
Ratos Wistar
Fatores de Tempo
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
Texto completo
Id: lil-249380
Autor: Molchanov, M. L; Guimarães, F. S.
Título: Defense reaction induced by a metabotropic glutamate receptor agonist microinjected into the dorsal periaqueductal gray of rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;32(12):1533-7, Dec. 1999. graf.
Idioma: en.
Conferência: Apresentado em: International Neurobiology Course, Ribeiräo Preto, May 20-27 1998.
Resumo: The behavioral effects of trans-(+ or -)-1-amino-1,3-cyclopentanedicarboxylic acid (t-ACPD), a metabotropic glutamate receptor (mGluR) agonist, or 0.9 per cent (w/v) saline, injected into the dorsal periaqueductal gray (DPAG), was investigated. Male Wistar rats showed defense reactions characterized by jumps toward the top edges of the cages (saline = 0 vs t-ACPD = 6.0, medians P<0.05) and gallops (saline = 0 vs t-ACPD = 10.0, medians P<0.05) during the 60-s period after the beginning of the injection. In another experiment animals were placed inside an open arena for 5 min immediately after injection. Their behavior was recorded by a video camera and a computer program analyzed the videotapes. Eleven of fifteen rats injected with t-ACPD showed a short-lasting (about 1 min) flight reaction. No saline-treated animal showed this reaction (P<0.0005, chi-square test). The drug induced an increase in turning behavior (P = 0.002, MANOVA) and a decrease in the number of rearings (P<0.001, MANOVA) and grooming episodes (P<0.001, MANOVA). These results suggest that mGluRs play a role in the control of defense reactions in the DPAG.
Descritores: Cicloleucina/análogos & derivados
Mecanismos de Defesa
Fármacos Neuroprotetores/farmacologia
Substância Cinzenta Periaquedutal
Receptores de Glutamato Metabotrópico/agonistas
-Microinjeções
Ratos Wistar
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Bianchin, Marino
Id: lil-191374
Autor: Bianchin, Marino; Fin, Cyntia; Wolfman, Claudia; Schmitz, Paulo K; Silva, Ricardo C. da; Medina, Jorge H; Izquierdo, Ivan.
Título: Memory of inhibitory avoidance in the rat is regulated by glutamate metabotropic receptors and by calcium/calmodulin kinase II in the hippocampus
Fonte: Ciênc. cult. (Säo Paulo);47(3):193-5, May-Jun. 1995. tab.
Idioma: en.
Resumo: We studied the effect on memory of the bilateral intrahippocampal posttraining infusion of the glutamate metabotropic receptor (mGLUR) agonist, 1S,2R-aminocyclopentane dicarboxylate (ACPD), of the mGLUR antagonist, [RS]-alpha-methyl-4-carboxyphenyl glycine (MCPG), and of the inhibitor of calcium/calmodulin protein kinase II (CaM II), 1-[N,O-Bis (5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine (KN62). Male Wistar rats were implanted with cannulae in the CA1 region of the dorsal hippocampus. After recovery from surgery they were trained in a step-down inhibitory avoidance task and tested for retention 24 h later. Immediately or 180 min after training they received an intrahippocampal infusion of saline (0.5 mul), KN62 (100 mumoles), ACPD (20 nmoles), MCPG (13 nmoles) or of ACPD plus MCPG in 0.5 mul of saline. When given immediately after training, KN62 and MCPG were amnestic and ACPD caused memory facilitation and antagonized the effect od MCPG. When given 180 min after training, the drugs had no effect on memory. The results indicate that the early phase of memory is regulated by mGLURs in the hippocampus and requires CaM II activity. The data support the suggestion that memory involves long-term potentiation in the hippocampus.
Descritores: Proteínas Quinases Dependentes de Cálcio-Calmodulina
Hipocampo
Memória/efeitos dos fármacos
Receptores de Glutamato Metabotrópico
-Proteínas Quinases Dependentes de Cálcio-Calmodulina/antagonistas & inibidores
Potenciação de Longa Duração
Ratos Wistar
Receptores de Glutamato Metabotrópico/agonistas
Receptores de Glutamato Metabotrópico/antagonistas & inibidores
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME



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