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Id: lil-323346
Autor: Avalos, Ana María; Labra, Cecilia V; Quest, Andrew F G; Leyton, Lisette.
Título: Signaling triggered by Thy-1 interaction with beta 3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function
Fonte: Biol. Res;35(2):231-238, 2002. ilus.
Idioma: en.
Projeto: Fundación Andes; . Fogarty-NIH; . FONDECYT; . ICGEB.
Resumo: Thy-1 is an abundant neuronal glycoprotein in mammals. Despite such prevalence, Thy-1 function remains largely obscure in the absence of a defined ligand. Recently described evidence that Thy-1 interacts with beta 3 integrin on astrocytes will be discussed. Thy-1 binding to beta 3 integrin triggers tyrosine phosphorylation of focal adhesion proteins in astrocytes, thereby promoting focal adhesion formation, cell attachment and spreading. Thy-1 has been reported to modulate neurite outgrowth by triggering a cellular response in neurons. However, our data indicate that Thy-1 can also initiate signaling events that promote adhesion of adjacent astrocytes to the underlying surface. Preliminary results suggest that morphological changes observed in the actin cytoskeleton of astrocytes as a consequence of Thy-1 binding is mediated by small GTPases from the Rho family. Our findings argue that Thy-1 functions in a bimodal fashion, as a receptor on neuronal cells and as a ligand for beta 3 integrin receptor on astrocytes. Since Thy-1 is implicated in the inhibition of neurite outgrowth, signaling events in astrocytes are likely to play an important role in this process
Descritores: Antígenos Thy-1
Astrócitos
Glicoproteínas da Membrana de Plaquetas
Transdução de Sinais
-Antígenos Thy-1
Astrócitos
Glicoproteínas da Membrana de Plaquetas
Receptores de Vitronectina
Proteínas rho de Ligação ao GTP
Limites: Humanos
Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-265136
Autor: Savaris, Ricardo; Zetter, Cláudio G.
Título: As integrinas na avaliação da receptividade uterina / Integrins in uterine receptivity valuation
Fonte: Femina;28(3):119-21, abr. 2000.
Idioma: pt.
Descritores: Endométrio/metabolismo
Infertilidade Feminina/metabolismo
Integrinas
-Receptores de Vitronectina
Limites: Humanos
Feminino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: BR1365.1 - Biblioteca Biomédica A - CB/A



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